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AU2001272476A1 - Piperidines for use as orexin receptor antagonists - Google Patents

Piperidines for use as orexin receptor antagonists

Info

Publication number
AU2001272476A1
AU2001272476A1 AU2001272476A AU7247601A AU2001272476A1 AU 2001272476 A1 AU2001272476 A1 AU 2001272476A1 AU 2001272476 A AU2001272476 A AU 2001272476A AU 7247601 A AU7247601 A AU 7247601A AU 2001272476 A1 AU2001272476 A1 AU 2001272476A1
Authority
AU
Australia
Prior art keywords
optionally substituted
phenyl
heteroatoms selected
heteroaryl group
group containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001272476A
Inventor
Clive Leslie Branch
Christopher Norbert Johnson
Geoffrey Stemp
Kevin Thewlis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0014823A external-priority patent/GB0014823D0/en
Priority claimed from GB0027704A external-priority patent/GB0027704D0/en
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Publication of AU2001272476A1 publication Critical patent/AU2001272476A1/en
Abandoned legal-status Critical Current

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
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Abstract

Disclosed are compounds of formula (I):wherein:Y represents a group (CH2)n, wherein n represents 0, 1 or 2;R<1 >is phenyl, naphthyl, a mono or bicyclic heteroaryl group containing up to 3 heteroatoms selected from N, O and S; or a group NR<3>R<4 >wherein one of R<3 >and R<4 >is hydrogen or optionally substituted (C1-4)alkyl and the other is phenyl, naphthyl or a mono or bicyclic heteroaryl group containing up to 3 heteroatoms selected from N, O and S, or R<3 >and R<4 >together with the N atom to which they are attached form a 5 to 7-membered cyclic amine which has an optionally fused phenyl ring; any of which R<1 >groups may be optionally substituted;R<2 >represents phenyl or a 5- or 6-membered heteroaryl group containing up to 3 heteroatoms selected from N, O and S, wherein the phenyl or heteroaryl group is substituted by R<5>, and further optional substituents; or R<2 >represents an optionally substituted bicyclic aromatic or bicyclic heteroaromatic group containing up to 3 heteroatoms selected from N, O and S;R<5 >represents an optionally substituted (C1-4)alkoxy, halo, optionally substituted (C1-6)alkyl, optionally substituted phenyl, or an optionally substituted 5- or 6-membered heterocyclic ring containing up to 3 heteroatoms selected from N, O and S; or pharmaceutically acceptable salts thereof.
AU2001272476A 2000-06-16 2001-06-13 Piperidines for use as orexin receptor antagonists Abandoned AU2001272476A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0014823 2000-06-16
GB0014823A GB0014823D0 (en) 2000-06-16 2000-06-16 Compounds
GB0027704A GB0027704D0 (en) 2000-11-11 2000-11-11 Compounds
GB0027704 2000-11-11
PCT/EP2001/006752 WO2001096302A1 (en) 2000-06-16 2001-06-13 Piperidines for use as orexin receptor antagonists

Publications (1)

Publication Number Publication Date
AU2001272476A1 true AU2001272476A1 (en) 2001-12-24

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AU2001272476A Abandoned AU2001272476A1 (en) 2000-06-16 2001-06-13 Piperidines for use as orexin receptor antagonists

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US (1) US6677354B2 (en)
EP (1) EP1289955B1 (en)
JP (1) JP4611608B2 (en)
AT (1) ATE293101T1 (en)
AU (1) AU2001272476A1 (en)
CA (1) CA2450922C (en)
DE (1) DE60110066T2 (en)
ES (1) ES2238458T3 (en)
PT (1) PT1289955E (en)
WO (1) WO2001096302A1 (en)

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Publication number Priority date Publication date Assignee Title
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