RU2021100063A - Дифференцировка плюрипотентных стволовых клеток в клетки кишечной энтодермы средней кишки - Google Patents
Дифференцировка плюрипотентных стволовых клеток в клетки кишечной энтодермы средней кишки Download PDFInfo
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- RU2021100063A RU2021100063A RU2021100063A RU2021100063A RU2021100063A RU 2021100063 A RU2021100063 A RU 2021100063A RU 2021100063 A RU2021100063 A RU 2021100063A RU 2021100063 A RU2021100063 A RU 2021100063A RU 2021100063 A RU2021100063 A RU 2021100063A
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- Prior art keywords
- cells
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- midgut
- intestinal endoderm
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- 230000000968 intestinal effect Effects 0.000 title claims 26
- 210000004027 cell Anatomy 0.000 title claims 17
- 230000004069 differentiation Effects 0.000 title 1
- 210000001778 pluripotent stem cell Anatomy 0.000 title 1
- 210000004039 endoderm cell Anatomy 0.000 claims 15
- 210000001900 endoderm Anatomy 0.000 claims 12
- 108010004460 Gastric Inhibitory Polypeptide Proteins 0.000 claims 2
- 102100039994 Gastric inhibitory polypeptide Human genes 0.000 claims 2
- 102400000322 Glucagon-like peptide 1 Human genes 0.000 claims 2
- 101000886868 Homo sapiens Gastric inhibitory polypeptide Proteins 0.000 claims 2
- 108091023040 Transcription factor Proteins 0.000 claims 2
- 102000040945 Transcription factor Human genes 0.000 claims 2
- 102100027211 Albumin Human genes 0.000 claims 1
- 108010083123 CDX2 Transcription Factor Proteins 0.000 claims 1
- 102000006277 CDX2 Transcription Factor Human genes 0.000 claims 1
- 102100023855 Heart- and neural crest derivatives-expressed protein 1 Human genes 0.000 claims 1
- 102100029284 Hepatocyte nuclear factor 3-beta Human genes 0.000 claims 1
- 102100030307 Homeobox protein Hox-A13 Human genes 0.000 claims 1
- 102100020762 Homeobox protein Hox-C5 Human genes 0.000 claims 1
- 101000693913 Homo sapiens Albumin Proteins 0.000 claims 1
- 101001065295 Homo sapiens Fas-binding factor 1 Proteins 0.000 claims 1
- 101000905239 Homo sapiens Heart- and neural crest derivatives-expressed protein 1 Proteins 0.000 claims 1
- 101001062347 Homo sapiens Hepatocyte nuclear factor 3-beta Proteins 0.000 claims 1
- 101001002966 Homo sapiens Homeobox protein Hox-C5 Proteins 0.000 claims 1
- 101001139130 Homo sapiens Krueppel-like factor 5 Proteins 0.000 claims 1
- 101001063456 Homo sapiens Leucine-rich repeat-containing G-protein coupled receptor 5 Proteins 0.000 claims 1
- 101000738523 Homo sapiens Pancreas transcription factor 1 subunit alpha Proteins 0.000 claims 1
- 101000687905 Homo sapiens Transcription factor SOX-2 Proteins 0.000 claims 1
- 101000711846 Homo sapiens Transcription factor SOX-9 Proteins 0.000 claims 1
- 102100020680 Krueppel-like factor 5 Human genes 0.000 claims 1
- 102100031036 Leucine-rich repeat-containing G-protein coupled receptor 5 Human genes 0.000 claims 1
- 102100037878 Pancreas transcription factor 1 subunit alpha Human genes 0.000 claims 1
- 102100041030 Pancreas/duodenum homeobox protein 1 Human genes 0.000 claims 1
- 101710183548 Pyridoxal 5'-phosphate synthase subunit PdxS Proteins 0.000 claims 1
- 102100024270 Transcription factor SOX-2 Human genes 0.000 claims 1
- 102100034204 Transcription factor SOX-9 Human genes 0.000 claims 1
- 108010021685 homeobox protein HOXA13 Proteins 0.000 claims 1
- GCYXWQUSHADNBF-AAEALURTSA-N preproglucagon 78-108 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 GCYXWQUSHADNBF-AAEALURTSA-N 0.000 claims 1
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Claims (18)
1. Популяция по существу клеток кишечной энтодермы средней кишки, где популяция клеток является инкапсулированной.
2. Популяция по существу клеток кишечной энтодермы средней кишки по п. 1, где популяция клеток является микро-инкапсулированной.
3. Популяция по существу клеток кишечной энтодермы средней кишки по п. 1, где популяция клеток является макро-инкапсулированной.
4. Популяция по существу клеток кишечной энтодермы средней кишки по любому из пп. 1-3, где клетки кишечной энтодермы средней кишки экспрессируют CDX2 и FOXA2.
5. Популяция по существу клеток кишечной энтодермы средней кишки по любому из пп. 1-4, где клетки кишечной энтодермы средней кишки экспрессируют транскрипционные факторы, выбранные из группы, состоящей из SOX9, PDX1, KLF5 и HOXC5.
6. Популяция по существу клеток кишечной энтодермы средней кишки по любому из пп. 1-5, где клетки кишечной энтодермы средней кишки не экспрессируют транскрипционные факторы, выбранные из группы, состоящей из SOX2, ALB, PTF1A, HOXA13 и LGR5.
7. Популяция по существу клеток кишечной энтодермы средней кишки по любому из пп. 1-6, где клетки кишечной энтодермы средней кишки не экспрессируют HAND1.
8. Популяция по существу клеток кишечной энтодермы средней кишки по любому из пп. 1-7, где популяция содержит более 70% клеток кишечной энтодермы средней кишки.
9. Популяция по существу клеток кишечной энтодермы средней кишки по п. 8, где популяция содержит более 80% клеток кишечной энтодермы средней кишки.
10. Популяция по существу клеток кишечной энтодермы средней кишки по п. 8, где популяция содержит более 90% клеток кишечной энтодермы средней кишки.
11. Популяция по существу клеток кишечной энтодермы средней кишки по любому из пп. 1-10, где популяция содержит менее чем 20% мезенхимальных клеток.
12. Популяция по существу клеток кишечной энтодермы средней кишки по п. 11, где популяция содержит менее чем 10% мезенхимальных клеток.
13. Популяция по существу клеток кишечной энтодермы средней кишки по п. 11, где популяция содержит менее чем 1% мезенхимальных клеток.
14. Популяция по существу клеток кишечной энтодермы средней кишки по любому из пп. 1-10, где популяция не включает мезенхимальные клетки.
15. Популяция по существу клеток кишечной энтодермы средней кишки по любому из пп. 1-14, где популяция экспрессирует инкретиновый гормон.
16. Популяция по существу клеток кишечной энтодермы средней кишки по п. 15, где инкретиновый гормон включает глюкагонподобный пептид 1 (GLP-1), глюкозозависимый инсулинотропный полипептид (GIP) или оба из них.
17. Популяция по существу клеток кишечной энтодермы средней кишки по любому из пп. 1-16, где клетки энтодермы средней кишки представляют собой L-клетки.
18. Популяция по существу клеток кишечной энтодермы средней кишки по любому из пп. 1-16, где клетки энтодермы средней кишки представляют собой K-клетки.
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| WO2020243663A1 (en) | 2019-05-31 | 2020-12-03 | W. L. Gore & Associates, Inc. | A biocompatible membrane composite |
| CA3139292C (en) | 2019-05-31 | 2025-06-10 | Viacyte, Inc. | CELL ENCAPSULATION DEVICES WITH REGULATED OXYGEN DIFFUSION DISTANCES |
| CN110540962B (zh) * | 2019-08-28 | 2022-02-25 | 北京协同创新研究院 | 一种制备人定型内胚层细胞的方法 |
| CN116234924A (zh) * | 2020-07-30 | 2023-06-06 | 国立研究开发法人理化学研究所 | 膀胱类器官及其制造方法 |
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- 2022-06-10 JP JP2022094028A patent/JP2022132249A/ja active Pending
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