[go: up one dir, main page]

MX2010002179A - Composicion para el tratamiento de enfermedades neoplasicas. - Google Patents

Composicion para el tratamiento de enfermedades neoplasicas.

Info

Publication number
MX2010002179A
MX2010002179A MX2010002179A MX2010002179A MX2010002179A MX 2010002179 A MX2010002179 A MX 2010002179A MX 2010002179 A MX2010002179 A MX 2010002179A MX 2010002179 A MX2010002179 A MX 2010002179A MX 2010002179 A MX2010002179 A MX 2010002179A
Authority
MX
Mexico
Prior art keywords
taxane
methods
administration
treatment
neoplastic disease
Prior art date
Application number
MX2010002179A
Other languages
English (en)
Inventor
Jacob Hendrik Beijnen
Johannes Henricus Matthias Schellens
Johannes Moes
Bastiaan Nuijen
Original Assignee
Stichting Het Nl Kanker I
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0716591A external-priority patent/GB0716591D0/en
Application filed by Stichting Het Nl Kanker I filed Critical Stichting Het Nl Kanker I
Publication of MX2010002179A publication Critical patent/MX2010002179A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Composiciones farmac?uticas y m?todos para el tratamiento de enfermedad neopl?sica y que comprenden la combinaci?n de un taxano, tal como docetaxel, con un inhibidor de CYP3A4, tal como ritonavir. Tambi?n est?n incluidos los m?todos de tratamiento de enfermedad neopl?sica que incorpora la administraci?n de un taxano y la administraci?n un inhibidor de CYP3A4, ya sea simult?neamente o separadamente. Adem?s, se incluyen kits para llevar a cabo los m?todos. Tambi?n se incluyen composiciones farmac?uticas s?lidas con taxano para administraci?n oral que comprenden un taxano sustancialmente amorfo, un portador y un tensoactivo.
MX2010002179A 2007-08-24 2008-08-22 Composicion para el tratamiento de enfermedades neoplasicas. MX2010002179A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US95776407P 2007-08-24 2007-08-24
GB0716591A GB0716591D0 (en) 2007-08-24 2007-08-24 Composition
PCT/GB2008/002854 WO2009027644A2 (en) 2007-08-24 2008-08-22 Composition

Publications (1)

Publication Number Publication Date
MX2010002179A true MX2010002179A (es) 2010-04-27

Family

ID=39985965

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010002179A MX2010002179A (es) 2007-08-24 2008-08-22 Composicion para el tratamiento de enfermedades neoplasicas.

Country Status (11)

Country Link
US (1) US20110207804A1 (es)
EP (1) EP2190413B1 (es)
KR (1) KR101544498B1 (es)
AR (1) AR073123A1 (es)
AU (1) AU2008291930B2 (es)
CA (1) CA2696622C (es)
CL (1) CL2009001766A1 (es)
IL (1) IL204115B (es)
MX (1) MX2010002179A (es)
WO (1) WO2009027644A2 (es)
ZA (1) ZA201001304B (es)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8017395B2 (en) 2004-12-17 2011-09-13 Lifescan, Inc. Seeding cells on porous supports
CN101484575B (zh) 2005-06-08 2013-10-02 森托科尔公司 用于眼变性的细胞疗法
US8741643B2 (en) 2006-04-28 2014-06-03 Lifescan, Inc. Differentiation of pluripotent stem cells to definitive endoderm lineage
US9080145B2 (en) 2007-07-01 2015-07-14 Lifescan Corporation Single pluripotent stem cell culture
KR101617243B1 (ko) 2007-07-31 2016-05-02 라이프스캔, 인코포레이티드 인간 배아 줄기 세포의 분화
US9089544B2 (en) * 2007-08-24 2015-07-28 Slotervaart Participaties Bv Composition
WO2009070592A2 (en) 2007-11-27 2009-06-04 Lifescan, Inc. Differentiation of human embryonic stem cells
CA2715878C (en) 2008-02-21 2017-06-13 Centocor Ortho Biotech Inc. Methods, surface modified plates and compositions for cell attachment, cultivation and detachment
KR20180018839A (ko) 2008-06-30 2018-02-21 얀센 바이오테크 인코포레이티드 만능 줄기 세포의 분화
MX349178B (es) 2008-10-31 2017-07-17 Centocor Ortho Biotech Inc Diferenciación de células madre embrionarias humanas al linaje endocrino pancreático.
CN102272291B (zh) 2008-10-31 2018-01-16 詹森生物科技公司 人胚胎干细胞向胰腺内分泌谱系的分化
ES2584053T3 (es) 2008-11-20 2016-09-23 Janssen Biotech, Inc. Métodos y composiciones para la unión de células y cultivo en sustratos planos
MX2011005288A (es) 2008-11-20 2011-06-01 Centocor Ortho Biotech Inc Celulas madre pluripotentes en microportadores.
US10076544B2 (en) 2009-07-20 2018-09-18 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
AU2010276440B2 (en) 2009-07-20 2014-07-03 Janssen Biotech Inc. Differentiation of human embryonic stem cells
CA2768720C (en) 2009-07-20 2018-12-18 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
PT2519231T (pt) * 2009-10-01 2017-05-25 Janssen Pharmaceutica Nv Inibidores do proteassoma para tratamento do cancro
CA2784415C (en) 2009-12-23 2019-06-18 Jean Xu Differentiation of human embryonic stem cells
WO2011079018A2 (en) 2009-12-23 2011-06-30 Centocor Ortho Biotech Inc. Differentiation of human embryonic stem cells
WO2011086194A1 (en) * 2010-01-18 2011-07-21 Cephalon France Improved oral lysophilisates containing pvp/va
US9969981B2 (en) 2010-03-01 2018-05-15 Janssen Biotech, Inc. Methods for purifying cells derived from pluripotent stem cells
KR101903562B1 (ko) 2010-05-12 2018-10-02 얀센 바이오테크 인코포레이티드 인간 배아 줄기 세포의 분화
RU2627168C2 (ru) 2010-08-31 2017-08-03 Янссен Байотек, Инк. Дифференцирование эмбриональных стволовых клеток человека
RU2620938C2 (ru) 2010-08-31 2017-05-30 Янссен Байотек, Инк. Дифференцирование эмбриональных стволовых клеток человека
MX348537B (es) 2010-08-31 2017-06-07 Janssen Biotech Inc Diferencia de celulas madre pluripotentes.
CN105143446B (zh) 2011-12-22 2020-11-03 詹森生物科技公司 人胚胎干细胞分化成单一激素胰岛素阳性细胞
US9434920B2 (en) 2012-03-07 2016-09-06 Janssen Biotech, Inc. Defined media for expansion and maintenance of pluripotent stem cells
KR102285014B1 (ko) 2012-06-08 2021-08-03 얀센 바이오테크 인코포레이티드 인간 배아 줄기 세포의 췌장 내분비 세포로의 분화
WO2014078576A2 (en) * 2012-11-14 2014-05-22 Abon Pharmaceuticals, Llc Oral transmucosal drug delivery system
KR20150103203A (ko) 2012-12-31 2015-09-09 얀센 바이오테크 인코포레이티드 췌장 내분비 세포 내로의 분화를 위한 인간 만능 세포의 현탁 및 클러스터링
EP4219683A1 (en) 2012-12-31 2023-08-02 Janssen Biotech, Inc. Differentiation of human embryonic stem cells into pancreatic endocrine cells using hb9 regulators
RU2658488C2 (ru) 2012-12-31 2018-06-21 Янссен Байотек, Инк. Способ получения клеток, экспрессирующих маркеры, характерные для панкреатических эндокринных клеток
US10370644B2 (en) 2012-12-31 2019-08-06 Janssen Biotech, Inc. Method for making human pluripotent suspension cultures and cells derived therefrom
WO2015152433A1 (en) * 2014-03-31 2015-10-08 Hanmi Pharm. Co., Ltd. Amorphous solid dispersion comprising paclitaxel, tablet comprising the same, and method for preparing the same
EP3143127B1 (en) 2014-05-16 2021-07-14 Janssen Biotech, Inc. Use of small molecules to enhance mafa expression in pancreatic endocrine cells
WO2016198983A1 (en) 2015-06-09 2016-12-15 Bend Research Inc. Formulations to achieve rapid dissolution of drug from spray-dried dispersions in capsules
MA45479A (fr) 2016-04-14 2019-02-20 Janssen Biotech Inc Différenciation de cellules souches pluripotentes en cellules de l'endoderme de l'intestin moyen
TWI833710B (zh) 2017-10-06 2024-03-01 香港商慧源香港創新有限公司 高單位含量口服型紫杉烷組合物及方法
CA3124319C (en) 2018-12-21 2023-07-04 Modra Pharmaceuticals B.V. Combination treatment for solid tumors using docetaxel and a cyp3a inhibitor
EP3897610B1 (en) * 2018-12-21 2025-04-16 Modra Pharmaceuticals B.V. Cancer treatment using docetaxel by controlling peak plasma levels
GB202201935D0 (en) 2022-02-14 2022-03-30 Modra Pharmaceuticals B V Methods and compositions for treating cancer in taxane-resistant patients
AU2022368370B2 (en) * 2022-03-08 2025-02-20 Cnpharm Co., Ltd. Pharmaceutical composition containing docetaxel or pharmaceutically acceptable salt thereof and preparation method therefor
KR102849835B1 (ko) 2022-06-29 2025-08-27 주식회사 나노메디팜 다중 작용 기전을 가지는 초미립 크기의 항암 약물이 탑재된 나노 약물전달 플랫폼, 이를 포함하는 약제학적 조성물 및 그 제조 방법
EP4385507A1 (en) 2022-12-13 2024-06-19 Stichting Het Nederlands Kanker Instituut- Antoni van Leeuwenhoek Ziekenhuis Combination treatment for solid tumors using cabazitaxel and a cyp3a inhibitor

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6610317B2 (en) * 1999-05-27 2003-08-26 Acusphere, Inc. Porous paclitaxel matrices and methods of manufacture thereof
DE60024811T3 (de) 1999-05-27 2010-01-07 Acusphere, Inc., Watertown Poröse arzneistoffmatrizen und deren herstellungsverfahren
US20080305173A1 (en) * 2001-07-31 2008-12-11 Beuford Arlie Bogue Amorphous drug beads
US8071133B2 (en) * 2001-08-20 2011-12-06 Stiefel Laboratories, Inc. Oral dosage forms of water insoluble drugs and methods of making the same
GEP20063806B (en) * 2001-12-20 2006-04-25 Bristol Myers Squibb Co Pharmaceutical compositions of orally active taxane derivatives having enhanced bioavailability
AU2003256157A1 (en) * 2002-08-05 2004-02-23 Dsm Ip Assets B.V. Oral dosage forms of water insoluble drugs and methods of making the same
KR100508518B1 (ko) * 2002-11-13 2005-08-17 한미약품 주식회사 초임계유체 공정을 이용한 파클리탁셀 고체분산체의 제조방법 및 이 방법으로 제조된 파클리탁셀 고체분산체
WO2006026592A2 (en) * 2004-08-27 2006-03-09 Spherics, Inc. Oral administration of poorly absorbed drugs, methods and compositions related thereto
KR20080003322A (ko) * 2005-02-24 2008-01-07 엘란 파마 인터내셔널 리미티드 도세탁셀 및 이의 유사체의 나노입자 배합물
CA2680106A1 (en) * 2007-03-23 2008-10-02 H. William Bosch Gamma radiation sterilized nanoparticulate docetaxel compositions and methods for making the same

Also Published As

Publication number Publication date
CA2696622A1 (en) 2009-03-05
AU2008291930A1 (en) 2009-03-05
EP2190413B1 (en) 2015-01-28
CL2009001766A1 (es) 2010-07-09
KR20100044237A (ko) 2010-04-29
EP2190413A2 (en) 2010-06-02
ZA201001304B (en) 2013-08-28
AR073123A1 (es) 2010-10-13
WO2009027644A2 (en) 2009-03-05
KR101544498B1 (ko) 2015-08-17
HK1144390A1 (en) 2011-02-18
CA2696622C (en) 2016-07-19
US20110207804A1 (en) 2011-08-25
IL204115B (en) 2019-05-30
AU2008291930B2 (en) 2014-04-17
WO2009027644A3 (en) 2009-12-17
WO2009027644A8 (en) 2009-04-30

Similar Documents

Publication Publication Date Title
MX2010002179A (es) Composicion para el tratamiento de enfermedades neoplasicas.
WO2007146965A3 (en) Compounds for the treatment of periodontal disease
WO2006012527A8 (en) Bivalent linkers and conjugates thereof
EA200802390A1 (ru) Конъюгаты аналогов азиридилэпотилона и фармацевтические композиции, содержащие их
SG164368A1 (en) Treatment of cancer
ZA200805989B (en) Taxane pharmaceutical formulation, solid taxane composition, method for preparing the solid taxane composition, composition for solubilising said solid taxane composition and set of elements (kit) for the injectable taxane formulation
CL2007002640A1 (es) Compuestos derivados de 3-(6-oxo-1,6-dihidro-piridin-3-il)-benzamida; composicion farmaceutica; y uso en el tratamiento del cancer.
CL2007002642A1 (es) Compuestos derivados de 3-(6-oxo-1,6-dihidro-piridin-3-il)-benzamida; composicion farmaceutica; y uso en el tratamiento del cancer.
MX2009003038A (es) Derivados de quinazolinona 5-sustituidos como agentes antitumorales.
MY157661A (en) Bendamustine pharmaceutical compositions
CL2008001373A1 (es) Compuestos derivados de fenilamino-benceno sustituidos; metodo de preparacion; composicion farmaceutica; kit farmceuticos; y uso de dichos compuestos en el tratamiento del cancer.
UA103319C2 (en) Thiazole- and oxazole-benzene sulfonamide compounds
MY154909A (en) Novel thiophene derivatives
CL2007003774A1 (es) Compuestos derivados de quinazolina sustituidos, inhibidores de quinasa; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, aterosclerosis y artritis.
IL195256A0 (en) Compositions of r(+)and s(-)pramipexole and methods of using the same
TW200800967A (en) Benzimidazole thiophene compounds
NO20075111L (no) Farmasoytisk sammensetning
IL193024A0 (en) Levetiracetam formulations and methods for their manufacture
NZ579478A (en) Epha3 antibodies for the treatment of solid tumors
WO2010121164A3 (en) 1,4-benzodiazepinone compounds and their use in treating cancer
WO2008027600A3 (en) Imatinib compositions
WO2009071689A3 (de) 5-halogen-substituierte oxindol-derivate und ihre verwendung zur behandlung von vasopressin-abhängigen erkrankungen
TW200730518A (en) Crystalline forms of docetaxel and processes for their preparation
CL2008003659A1 (es) Compuestos derivados de 6-(4-bencilpiperazin-1-il)pirimidin-4-ona, moduladores de la enzima estearoil-coa-desaturasa 1; procedimiento de preparacion; composicin farmaceutica; y uso en el tratamiento y profilaxis de la obesidad.
CL2008000629A1 (es) Compuestos macrociclicos derivados de 6-aril-4-mercapto-[1.3.5]triazina/[1.3]pirimidin-2-amina; composicion farmaceutica, utiles en el tratamiento del cancer.

Legal Events

Date Code Title Description
FG Grant or registration