RU2019127198A - Структура ядро-оболочка, получение, лекарственное средство для наружного применения, средство в виде ленты и косметический продукт - Google Patents
Структура ядро-оболочка, получение, лекарственное средство для наружного применения, средство в виде ленты и косметический продукт Download PDFInfo
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- RU2019127198A RU2019127198A RU2019127198A RU2019127198A RU2019127198A RU 2019127198 A RU2019127198 A RU 2019127198A RU 2019127198 A RU2019127198 A RU 2019127198A RU 2019127198 A RU2019127198 A RU 2019127198A RU 2019127198 A RU2019127198 A RU 2019127198A
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- core
- surfactant
- shell structure
- fatty acid
- structure according
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- 239000002537 cosmetic Substances 0.000 title claims 2
- 239000003814 drug Substances 0.000 title claims 2
- 229940079593 drug Drugs 0.000 title claims 2
- 239000004094 surface-active agent Substances 0.000 claims 14
- 239000011258 core-shell material Substances 0.000 claims 13
- 235000014113 dietary fatty acids Nutrition 0.000 claims 12
- 229930195729 fatty acid Natural products 0.000 claims 12
- 239000000194 fatty acid Substances 0.000 claims 12
- 239000004480 active ingredient Substances 0.000 claims 9
- -1 sorbitan fatty acid esters Chemical class 0.000 claims 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 6
- 150000004665 fatty acids Chemical class 0.000 claims 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 150000002430 hydrocarbons Chemical group 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 1
- 229930195734 saturated hydrocarbon Natural products 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 229930195735 unsaturated hydrocarbon Chemical group 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/04—Dispersions; Emulsions
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- A—HUMAN NECESSITIES
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
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- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
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- A—HUMAN NECESSITIES
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- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
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- A—HUMAN NECESSITIES
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
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- A—HUMAN NECESSITIES
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Birds (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Dispersion Chemistry (AREA)
- Emergency Medicine (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Nanotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Geometry (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Otolaryngology (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (19)
1. Структура ядро-оболочка, содержащая:
ядро, содержащее активный ингредиент, и
оболочку, содержащую поверхностно-активное вещество, имеющее величину HLB от 4 до 14,
причем ядро является твердым, и
поверхностно-активное вещество содержит насыщенную углеводородную группу, имеющую от 7 до 15 атомов углерода, или ненасыщенную углеводородную группу, имеющую от 7 до 17 атомов углерода.
2. Структура ядро-оболочка по п.1,
где поверхностно-активное вещество представляет собой поверхностно-активное вещество, образованное путем связывания спирта с жирной кислотой через сложноэфирную связь или амидную связь, и
спирт имеет молекулярную массу в диапазоне от 70 г/моль до 330 г/моль.
3. Структура ядро-оболочка по п.1 или 2, где поверхностно-активное вещество включает по меньшей мере одно вещество, выбранное из группы, состоящей из сложных эфиров сорбитана и жирных кислот, сложных эфиров глицерина и жирных кислот, сложных эфиров пропиленгликоля и жирных кислот и алканоламидов жирных кислот.
4. Структура ядро-оболочка по любому из пп.1-3, где поверхностно-активное вещество включает по меньшей мере одно вещество, выбранное из группы, состоящей из сложных эфиров сорбитана и жирных кислот, сложных эфиров глицерина и жирных кислот и сложных эфиров пропиленгликоля и жирных кислот.
5. Структура ядро-оболочка по п.3 или 4, где сложный эфир глицерина и жирной кислоты представляет собой по меньшей мере одно вещество, выбранное из сложных эфиров моноглицерина и жирных кислот, сложных эфиров диглицерина и жирных кислот и сложных эфиров триглицерина и жирных кислот.
6. Структура ядро-оболочка по любому из пп.1-5, где массовое соотношение между активным ингредиентом и поверхностно-активным веществом (активный ингредиент:поверхностно-активное вещество) составляет от 1:0,5 до 1:100.
7. Структура ядро-оболочка по любому из пп.1-6, где массовое соотношение между активным ингредиентом и поверхностно-активным веществом (активный ингредиент:поверхностно-активное вещество) составляет от 1:5 до 1:100.
8. Структура ядро-оболочка по любому из пп.1-6, где массовое соотношение между активным ингредиентом и поверхностно-активным веществом (активный ингредиент:поверхностно-активное вещество) составляет от 1:0,5 до 1:5.
9. Структура ядро-оболочка по любому из пп.1-6, где массовое соотношение между активным ингредиентом и поверхностно-активным веществом (активный ингредиент:поверхностно-активное вещество) составляет от 1:0,5 до 1:2.
10. Состав, содержащий структуру ядро-оболочка по любому из пп.1-9.
11. Лекарственное средство для наружного применения, содержащее структуру ядро-оболочка по любому из пп.1-9.
12. Препарат в виде ленты, содержащий структуру ядро-оболочка по любому из пп.1-9.
13. Косметическое средство, содержащее структуру ядро-оболочка по любому из пп.1-9.
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2017022175 | 2017-02-09 | ||
| JP2017-022175 | 2017-02-09 | ||
| JP2017109314 | 2017-06-01 | ||
| JP2017-109314 | 2017-06-01 | ||
| JP2017-183328 | 2017-09-25 | ||
| JP2017183328 | 2017-09-25 | ||
| PCT/JP2018/004232 WO2018147333A1 (ja) | 2017-02-09 | 2018-02-07 | コアシェル構造体、製剤、外用薬、テープ剤及び化粧品 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2019127198A true RU2019127198A (ru) | 2021-03-09 |
| RU2019127198A3 RU2019127198A3 (ru) | 2021-03-09 |
| RU2754031C2 RU2754031C2 (ru) | 2021-08-25 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2019127198A RU2754031C2 (ru) | 2017-02-09 | 2018-02-07 | Структура ядро-оболочка, получение, лекарственное средство для наружного применения, средство в виде ленты и косметический продукт |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US20190117777A1 (ru) |
| EP (1) | EP3453404B1 (ru) |
| JP (3) | JP6370520B1 (ru) |
| KR (1) | KR102397632B1 (ru) |
| CN (1) | CN109310777B (ru) |
| AU (1) | AU2018218868B2 (ru) |
| CA (1) | CA3052757A1 (ru) |
| ES (1) | ES2888323T3 (ru) |
| IL (1) | IL268165B (ru) |
| MX (1) | MX393464B (ru) |
| MY (1) | MY198393A (ru) |
| RU (1) | RU2754031C2 (ru) |
| SG (1) | SG11201906165PA (ru) |
| TW (1) | TWI793103B (ru) |
| WO (1) | WO2018147333A1 (ru) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX393464B (es) * | 2017-02-09 | 2025-03-11 | Sekisui Chemical Co Ltd | Estructura de nucleo-envoltura, preparacion, medicina para aplicacion externa, agente de cinta y producto cosmetico. |
| US12290501B2 (en) * | 2017-07-19 | 2025-05-06 | Teikoku Seiyaku Co., Ltd. | Rivastigmine-containing transdermal absorption preparation |
| US12296014B2 (en) | 2018-09-07 | 2025-05-13 | Farnex Incorporated | External preparation comprising non-lamellar liquid crystal-forming lipid |
| JP6767605B1 (ja) * | 2019-03-29 | 2020-10-14 | 積水化学工業株式会社 | コアシェル構造体、製剤、外用薬、テープ剤及び化粧品 |
| JP7227271B2 (ja) * | 2019-09-13 | 2023-02-21 | 積水化学工業株式会社 | 製剤 |
| KR102304645B1 (ko) * | 2020-01-29 | 2021-09-23 | 한남대학교 산학협력단 | 나노캡슐을 사용한 탈모방지용 샴푸 조성물 |
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|---|---|---|---|---|
| JPS4843494B1 (ru) | 1970-12-10 | 1973-12-19 | ||
| JPS5261204A (en) | 1975-11-12 | 1977-05-20 | Kuraray Co | Production of dull leather like sheet article with excellent pearl feeling |
| US8268791B2 (en) | 2004-08-25 | 2012-09-18 | Aegis Therapeutics, Llc. | Alkylglycoside compositions for drug administration |
| EP1785131A4 (en) * | 2004-08-31 | 2009-03-11 | Aspion Co Ltd | EXTERNAL PREPARATION OF TYPE S / O |
| EP1978997A1 (en) | 2005-12-22 | 2008-10-15 | Apollo Life Sciences Limited | Transdermal delivery of pharmaceutical agents |
| JP5618307B2 (ja) * | 2009-07-09 | 2014-11-05 | 国立大学法人九州大学 | 水溶性薬物キャリア及びその製造方法 |
| JP5531230B2 (ja) | 2009-07-16 | 2014-06-25 | 公益財団法人宮崎県産業振興機構 | 油性外用製剤及びその製造方法 |
| JPWO2011059037A1 (ja) * | 2009-11-12 | 2013-04-04 | 学校法人日本大学 | 外用医薬組成物 |
| JP5676139B2 (ja) * | 2010-05-14 | 2015-02-25 | 富士フイルム株式会社 | クレンジング化粧料 |
| JP6058604B2 (ja) * | 2014-09-19 | 2017-01-11 | 積水化学工業株式会社 | コアシェル構造体及びそれを含有するｓ／ｏ型サスペンション |
| JP2016179963A (ja) * | 2015-03-24 | 2016-10-13 | 積水化学工業株式会社 | コアシェル構造体を含有する製剤 |
| JP2017014128A (ja) * | 2015-06-29 | 2017-01-19 | 積水化学工業株式会社 | コアシェル構造体及びそれを含有する製剤 |
| JP6097340B2 (ja) * | 2015-06-29 | 2017-03-15 | 積水化学工業株式会社 | 製剤 |
| WO2016043323A1 (ja) * | 2014-09-19 | 2016-03-24 | 積水化学工業株式会社 | 製剤及びその製造方法 |
| JP2016179962A (ja) | 2015-03-24 | 2016-10-13 | 積水化学工業株式会社 | コアシェル構造体を含有する製剤 |
| JP6148416B2 (ja) | 2015-06-29 | 2017-06-14 | 積水化学工業株式会社 | コアシェル構造体及び外用剤 |
| US20170014417A1 (en) | 2015-07-14 | 2017-01-19 | Lipp Life Sciences Llc | Pharmaceutical administration system for the transdermal application of vardenafil |
| MX393464B (es) * | 2017-02-09 | 2025-03-11 | Sekisui Chemical Co Ltd | Estructura de nucleo-envoltura, preparacion, medicina para aplicacion externa, agente de cinta y producto cosmetico. |
-
2018
- 2018-02-07 MX MX2019008972A patent/MX393464B/es unknown
- 2018-02-07 KR KR1020197021711A patent/KR102397632B1/ko active Active
- 2018-02-07 EP EP18751519.2A patent/EP3453404B1/en active Active
- 2018-02-07 CA CA3052757A patent/CA3052757A1/en active Pending
- 2018-02-07 ES ES18751519T patent/ES2888323T3/es active Active
- 2018-02-07 SG SG11201906165PA patent/SG11201906165PA/en unknown
- 2018-02-07 WO PCT/JP2018/004232 patent/WO2018147333A1/ja not_active Ceased
- 2018-02-07 US US16/089,309 patent/US20190117777A1/en not_active Abandoned
- 2018-02-07 JP JP2018513019A patent/JP6370520B1/ja active Active
- 2018-02-07 CN CN201880002393.6A patent/CN109310777B/zh active Active
- 2018-02-07 AU AU2018218868A patent/AU2018218868B2/en active Active
- 2018-02-07 MY MYPI2019004132A patent/MY198393A/en unknown
- 2018-02-07 RU RU2019127198A patent/RU2754031C2/ru active
- 2018-02-09 TW TW107104735A patent/TWI793103B/zh active
- 2018-07-10 JP JP2018130742A patent/JP6386691B1/ja active Active
- 2018-08-08 JP JP2018149074A patent/JP2019052138A/ja active Pending
-
2019
- 2019-07-18 IL IL268165A patent/IL268165B/en unknown
-
2020
- 2020-08-11 US US16/990,634 patent/US12201691B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| MX2019008972A (es) | 2019-09-10 |
| EP3453404B1 (en) | 2021-06-02 |
| US20190117777A1 (en) | 2019-04-25 |
| EP3453404A4 (en) | 2020-03-04 |
| JP6386691B1 (ja) | 2018-09-05 |
| JP2019052135A (ja) | 2019-04-04 |
| JPWO2018147333A1 (ja) | 2019-02-14 |
| US12201691B2 (en) | 2025-01-21 |
| US20200368356A1 (en) | 2020-11-26 |
| KR20190112266A (ko) | 2019-10-04 |
| MY198393A (en) | 2023-08-28 |
| BR112019014180A2 (pt) | 2020-02-11 |
| IL268165B (en) | 2022-01-01 |
| CN109310777A (zh) | 2019-02-05 |
| CA3052757A1 (en) | 2018-08-16 |
| JP2019052138A (ja) | 2019-04-04 |
| JP6370520B1 (ja) | 2018-08-08 |
| WO2018147333A1 (ja) | 2018-08-16 |
| ES2888323T3 (es) | 2022-01-03 |
| KR102397632B1 (ko) | 2022-05-17 |
| CN109310777B (zh) | 2021-07-30 |
| EP3453404A1 (en) | 2019-03-13 |
| RU2754031C2 (ru) | 2021-08-25 |
| TW201831167A (zh) | 2018-09-01 |
| MX393464B (es) | 2025-03-11 |
| AU2018218868A1 (en) | 2019-08-01 |
| IL268165A (en) | 2019-09-26 |
| TWI793103B (zh) | 2023-02-21 |
| RU2019127198A3 (ru) | 2021-03-09 |
| SG11201906165PA (en) | 2019-08-27 |
| AU2018218868B2 (en) | 2023-06-29 |
| NZ755064A (en) | 2024-11-29 |
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