RU2018109922A - Ортопедический имплант, имеющий покрытие из кристаллического гидроксиапатита, содержащего галлий, и способы его изготовления - Google Patents
Ортопедический имплант, имеющий покрытие из кристаллического гидроксиапатита, содержащего галлий, и способы его изготовления Download PDFInfo
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- RU2018109922A RU2018109922A RU2018109922A RU2018109922A RU2018109922A RU 2018109922 A RU2018109922 A RU 2018109922A RU 2018109922 A RU2018109922 A RU 2018109922A RU 2018109922 A RU2018109922 A RU 2018109922A RU 2018109922 A RU2018109922 A RU 2018109922A
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- Prior art keywords
- hydroxyapatite
- orthopedic implant
- layer
- xrd
- implant according
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- 239000007943 implant Substances 0.000 title claims 17
- 230000000399 orthopedic effect Effects 0.000 title claims 17
- 229910052733 gallium Inorganic materials 0.000 title claims 5
- GYHNNYVSQQEPJS-UHFFFAOYSA-N Gallium Chemical compound [Ga] GYHNNYVSQQEPJS-UHFFFAOYSA-N 0.000 title claims 3
- 239000011248 coating agent Substances 0.000 title 1
- 238000000576 coating method Methods 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims 18
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims 17
- 229910052751 metal Inorganic materials 0.000 claims 6
- 239000002184 metal Substances 0.000 claims 6
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims 2
- -1 gallium ions Chemical class 0.000 claims 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- GROMGGTZECPEKN-UHFFFAOYSA-N sodium metatitanate Chemical compound [Na+].[Na+].[O-][Ti](=O)O[Ti](=O)O[Ti]([O-])=O GROMGGTZECPEKN-UHFFFAOYSA-N 0.000 claims 1
- 239000010936 titanium Substances 0.000 claims 1
- 229910052719 titanium Inorganic materials 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
- A61L27/045—Cobalt or cobalt alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/025—Other specific inorganic materials not covered by A61L27/04 - A61L27/12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
- A61L27/047—Other specific metals or alloys not covered by A61L27/042 - A61L27/045 or A61L27/06
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
- A61L27/06—Titanium or titanium alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/30—Inorganic materials
- A61L27/32—Phosphorus-containing materials, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D1/00—Processes for applying liquids or other fluent materials
- B05D1/18—Processes for applying liquids or other fluent materials performed by dipping
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- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B25/00—Phosphorus; Compounds thereof
- C01B25/16—Oxyacids of phosphorus; Salts thereof
- C01B25/26—Phosphates
- C01B25/32—Phosphates of magnesium, calcium, strontium, or barium
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/02—Methods for coating medical devices
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Inorganic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Organic Chemistry (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Claims (16)
1. Ортопедический имплантат, содержащий металлическую поверхность и слой гидроксиапатита, нанесенный на по меньшей мере часть металлической поверхности, причем слой гидроксиапатита содержит ионы галлия, причем слой гидроксиапатита является кристаллическим.
2. Ортопедический имплантат по п. 1, в котором слой гидроксиапатита при проведении XRD образует пик (002) XRD, который сдвинут на угол 2θ от около 0,001° до около 0,5° по сравнению с пиком (002) XRD кристаллического гидроксиапатита без галлия.
3. Ортопедический имплантат по п. 1, в котором слой гидроксиапатита при проведении XRD образует пик (002) XRD, который соответствует сдвигу на d-расстояние от около 0,001 Å до около 0,05 Å по сравнению с пиком (002) XRD кристаллического гидроксиапатита без галлия.
4. Ортопедический имплантат по п. 1, в котором слой гидроксиапатита имеет средний размер кристаллита менее около 75 нм.
5. Ортопедический имплантат по п. 1, в котором слой гидроксиапатита имеет средний размер кристаллита менее около 75 нм в направлении [001].
6. Ортопедический имплантат по п. 1, в котором слой гидроксиапатита при проведении XRD образует пик (002) XRD и пик (112) XRD, и при этом пик (002) XRD имеет интенсивность, которая в 1,5-10 раз превышает интенсивность пика (112) XRD.
7. Ортопедический имплантат по п. 1, в котором слой гидроксиапатита непрерывно растворяется в течение более 24 часов in vitro.
8. Ортопедический имплантат по п. 1, в котором слой гидроксиапатита содержит от около 0% масс. до около 5% масс. карбоната.
9. Ортопедический имплантат по п. 1, в котором ионы галлия составляют от около 0,01% масс. до около 10% масс. слоя гидроксиапатита.
10. Ортопедический имплантат по п. 1, в котором слой гидроксиапатита находится в контакте с металлической поверхностью.
11. Ортопедический имплантат по п. 10, в котором металлическая поверхность содержит титанат.
12. Ортопедический имплантат по п. 11, в котором металлическая поверхность содержит титанат натрия.
13. Ортопедический имплантат по п. 1, в котором металлическая поверхность представляет собой титановую поверхность, обработанную гидроксидом.
14. Ортопедический имплантат по п. 1, в котором слой гидроксиапатита имеет кристалличность от около 70% масс. до около 100% масс.
15. Ортопедический имплантат по п. 1, в котором слой гидроксиапатита имеет фазовую чистоту кристаллического гидроксиапатита более 90%.
16. Ортопедический имплантат по п. 1, в котором слой гидроксиапатита имеет площадь поверхности от около 15 м2/г до около 200 м2/г.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15/472,186 US10537658B2 (en) | 2017-03-28 | 2017-03-28 | Orthopedic implant having a crystalline gallium-containing hydroxyapatite coating and methods for making the same |
| US15/472,186 | 2017-03-28 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2018109922A true RU2018109922A (ru) | 2019-09-23 |
| RU2018109922A3 RU2018109922A3 (ru) | 2021-07-07 |
| RU2764748C2 RU2764748C2 (ru) | 2022-01-20 |
Family
ID=61628180
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018109922A RU2764748C2 (ru) | 2017-03-28 | 2018-03-21 | Ортопедический имплант, имеющий покрытие из кристаллического гидроксиапатита, содержащего галлий, и способы его изготовления |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US10537658B2 (ru) |
| EP (1) | EP3381480B1 (ru) |
| JP (2) | JP2018164734A (ru) |
| CN (1) | CN108653813B (ru) |
| AU (1) | AU2018201743B2 (ru) |
| BR (1) | BR102018006188A2 (ru) |
| CA (1) | CA2999426A1 (ru) |
| RU (1) | RU2764748C2 (ru) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10537661B2 (en) | 2017-03-28 | 2020-01-21 | DePuy Synthes Products, Inc. | Orthopedic implant having a crystalline calcium phosphate coating and methods for making the same |
| US10537658B2 (en) | 2017-03-28 | 2020-01-21 | DePuy Synthes Products, Inc. | Orthopedic implant having a crystalline gallium-containing hydroxyapatite coating and methods for making the same |
| KR102109949B1 (ko) * | 2018-12-14 | 2020-05-11 | 전남대학교산학협력단 | 염화물과 펄스 전원을 이용한 티타늄 임플란트 재료의 표면 처리 방법 및 그로부터 표면 처리된 티타늄 임플란트 |
| JP7304213B2 (ja) * | 2019-06-12 | 2023-07-06 | 日本特殊陶業株式会社 | 生体適合部材 |
| US20200405908A1 (en) * | 2019-06-28 | 2020-12-31 | DePuy Synthes Products, Inc. | Ion incorporated plasma sprayed hydroxyapatite coatings and method of making the same |
| CN112176272B (zh) * | 2020-09-09 | 2022-03-01 | 西南科技大学 | 一种等离子喷涂制备羟基磷灰石涂层的方法 |
| CN114890400B (zh) * | 2022-06-15 | 2023-12-01 | 杭州彗搏科技有限公司 | 纳米晶体羟基磷灰石骨修复颗粒、制备方法及应用 |
| EP4574180A1 (de) * | 2023-12-19 | 2025-06-25 | Andreas Haas | Modifiziertes knochenersatzmaterial |
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| US10537661B2 (en) * | 2017-03-28 | 2020-01-21 | DePuy Synthes Products, Inc. | Orthopedic implant having a crystalline calcium phosphate coating and methods for making the same |
| US10537658B2 (en) | 2017-03-28 | 2020-01-21 | DePuy Synthes Products, Inc. | Orthopedic implant having a crystalline gallium-containing hydroxyapatite coating and methods for making the same |
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2017
- 2017-03-28 US US15/472,186 patent/US10537658B2/en active Active
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2018
- 2018-03-09 AU AU2018201743A patent/AU2018201743B2/en active Active
- 2018-03-13 EP EP18161421.5A patent/EP3381480B1/en active Active
- 2018-03-21 RU RU2018109922A patent/RU2764748C2/ru active
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- 2018-03-27 JP JP2018059429A patent/JP2018164734A/ja active Pending
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| US20210402055A1 (en) | 2021-12-30 |
| CN108653813B (zh) | 2022-04-19 |
| CA2999426A1 (en) | 2018-09-28 |
| RU2764748C2 (ru) | 2022-01-20 |
| US20180280566A1 (en) | 2018-10-04 |
| US11141505B2 (en) | 2021-10-12 |
| EP3381480A1 (en) | 2018-10-03 |
| AU2018201743B2 (en) | 2022-12-15 |
| JP2023060086A (ja) | 2023-04-27 |
| CN108653813A (zh) | 2018-10-16 |
| US10537658B2 (en) | 2020-01-21 |
| AU2018201743A1 (en) | 2018-10-18 |
| US11793907B2 (en) | 2023-10-24 |
| RU2018109922A3 (ru) | 2021-07-07 |
| JP2018164734A (ja) | 2018-10-25 |
| US20240009347A1 (en) | 2024-01-11 |
| EP3381480B1 (en) | 2022-05-25 |
| US20200129662A1 (en) | 2020-04-30 |
| JP7571177B2 (ja) | 2024-10-22 |
| BR102018006188A2 (pt) | 2019-01-02 |
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