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RU2018109950A - Ортопедический имплантат, имеющий покрытие из кристаллического фосфата кальция, и способы его получения - Google Patents

Ортопедический имплантат, имеющий покрытие из кристаллического фосфата кальция, и способы его получения Download PDF

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RU2018109950A
RU2018109950A RU2018109950A RU2018109950A RU2018109950A RU 2018109950 A RU2018109950 A RU 2018109950A RU 2018109950 A RU2018109950 A RU 2018109950A RU 2018109950 A RU2018109950 A RU 2018109950A RU 2018109950 A RU2018109950 A RU 2018109950A
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orthopedic implant
calcium phosphate
layer
implant according
metal surface
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RU2018109950A
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RU2018109950A3 (ru
RU2766113C2 (ru
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Раджендра КАСИНАТХ
Крэйг ЭРНСБЕРГЕР
Стефани ВАСС
Стивен Н. ДЖАЙНН
Хайбо КЬЮ
Вэйдун ТУН
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Депуи Синтез Продактс, Инк.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/30—Inorganic materials
    • A61L27/32—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/04—Metals or alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/04—Metals or alloys
    • A61L27/045—Cobalt or cobalt alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/04—Metals or alloys
    • A61L27/06—Titanium or titanium alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B25/00—Phosphorus; Compounds thereof
    • C01B25/16—Oxyacids of phosphorus; Salts thereof
    • C01B25/26—Phosphates
    • C01B25/32—Phosphates of magnesium, calcium, strontium, or barium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/112—Phosphorus-containing compounds, e.g. phosphates, phosphonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2420/00—Materials or methods for coatings medical devices
    • A61L2420/02—Methods for coating medical devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D1/00—Processes for applying liquids or other fluent materials
    • B05D1/18—Processes for applying liquids or other fluent materials performed by dipping
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D3/00—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials
    • B05D3/002—Pretreatement
    • C—CHEMISTRY; METALLURGY
    • C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
    • C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
    • C23C16/00—Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes
    • C23C16/22—Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the deposition of inorganic material, other than metallic material
    • C23C16/30—Deposition of compounds, mixtures or solid solutions, e.g. borides, carbides, nitrides
    • C23C16/40—Oxides
    • C23C16/405—Oxides of refractory metals or yttrium
    • C—CHEMISTRY; METALLURGY
    • C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
    • C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
    • C23C16/00—Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes
    • C23C16/44—Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating
    • C23C16/455—Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating characterised by the method used for introducing gases into reaction chamber or for modifying gas flows in reaction chamber
    • C23C16/45523—Pulsed gas flow or change of composition over time
    • C23C16/45525—Atomic layer deposition [ALD]
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25D—PROCESSES FOR THE ELECTROLYTIC OR ELECTROPHORETIC PRODUCTION OF COATINGS; ELECTROFORMING; APPARATUS THEREFOR
    • C25D9/00—Electrolytic coating other than with metals
    • C25D9/04—Electrolytic coating other than with metals with inorganic materials

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)

Claims (14)

1. Ортопедический имплантат, содержащий металлическую поверхность и слой фосфата кальция, нанесенный на по меньшей мере часть металлической поверхности, причем слой фосфата кальция при проведении рентгеновской дифракции образует дифракционный пик (002) и дифракционный пик (112), и при этом дифракционный пик (002) имеет интенсивность, которая в 1,5-10 раз больше интенсивности дифракционного пика (112).
2. Ортопедический имплантат по п. 1, в котором слой фосфата кальция представляет собой гидроксиапатит.
3. Ортопедический имплантат по п. 2, в котором слой фосфата кальция имеет средний размер кристаллита от около 50 нм до около 100 нм в направлении [001].
4. Ортопедический имплантат по п. 2, в котором слой фосфата кальция непрерывно растворяется в течение более 24 часов in vitro.
5. Ортопедический имплантат по п. 2, в котором слой фосфата кальция содержит от около 0% масс. до около 5% масс. карбоната.
6. Ортопедический имплантат по п. 2, в котором покрытие находится в контакте с металлической поверхностью.
7. Ортопедический имплантат по п. 6, в котором металлическая поверхность содержит титанат.
8. Ортопедический имплантат по п. 7, в котором металлическая поверхность содержит титанат натрия.
9. Ортопедический имплантат по п. 2, в котором гидроксиапатит имеет кристалличность от около 70% масс. до около 100% масс.
10. Ортопедический имплантат по п. 2, в котором слой фосфата кальция имеет фазовую чистоту кристаллического гидроксиапатита более 90%.
11. Ортопедический имплантат по п. 2, в котором слой фосфата кальция имеет прочность на сдвиг от около 20 МПа до около 80 МПа при определении в соответствии с ASTM F1044.
12. Ортопедический имплантат по п. 2, в котором слой фосфата кальция имеет прочность на растяжение от около 50 МПа до около 100 МПа при определении в соответствии с ASTM F1147.
13. Ортопедический имплантат по п. 2, в котором слой фосфата кальция в отсутствие красителей является прозрачным или светопрозрачным.
14. Ортопедический имплантат по п. 2, в котором слой фосфата кальция имеет площадь поверхности от около 15 м2/г до около 200 м2/г.
RU2018109950A 2017-03-28 2018-03-21 Ортопедический имплантат, имеющий покрытие из кристаллического фосфата кальция, и способы его получения RU2766113C2 (ru)

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Application Number Priority Date Filing Date Title
US15/472,189 US10537661B2 (en) 2017-03-28 2017-03-28 Orthopedic implant having a crystalline calcium phosphate coating and methods for making the same
US15/472,189 2017-03-28

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RU2018109950A true RU2018109950A (ru) 2019-09-23
RU2018109950A3 RU2018109950A3 (ru) 2021-07-05
RU2766113C2 RU2766113C2 (ru) 2022-02-08

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EP (2) EP3381481B1 (ru)
JP (2) JP7118683B2 (ru)
CN (1) CN108686268B (ru)
AU (1) AU2018201742B2 (ru)
BR (1) BR102018006213A2 (ru)
CA (1) CA2999552A1 (ru)
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Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10537661B2 (en) 2017-03-28 2020-01-21 DePuy Synthes Products, Inc. Orthopedic implant having a crystalline calcium phosphate coating and methods for making the same
US10537658B2 (en) * 2017-03-28 2020-01-21 DePuy Synthes Products, Inc. Orthopedic implant having a crystalline gallium-containing hydroxyapatite coating and methods for making the same
KR102109949B1 (ko) * 2018-12-14 2020-05-11 전남대학교산학협력단 염화물과 펄스 전원을 이용한 티타늄 임플란트 재료의 표면 처리 방법 및 그로부터 표면 처리된 티타늄 임플란트
US10700128B1 (en) 2018-12-21 2020-06-30 Micron Technology, Inc. Three-dimensional memory array
EP4159165B1 (en) * 2020-05-29 2025-06-04 Kyocera Corporation Stem for artificial joint
US20220183846A1 (en) 2020-12-10 2022-06-16 Depuy Ireland Unlimited Company Acetabular implant with predetermined modulus and method of manufacturing same
CN115382016B (zh) * 2021-05-19 2023-06-23 北京荷月顺畅生物科技有限公司 一种抗癌用仿生骨材料以及包含该仿生骨材料的药用组合物及其制备方法

Family Cites Families (187)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62156259A (ja) 1985-12-27 1987-07-11 Nippon Carbon Co Ltd 繊維強化金属の製造方法
US6120502A (en) 1988-06-13 2000-09-19 Michelson; Gary Karlin Apparatus and method for the delivery of electrical current for interbody spinal arthrodesis
DE3844155C2 (de) 1988-12-23 1994-01-27 Johnson & Johnson Professional Endoprothese und Verfahren zu ihrer Herstellung
JPH0773600B2 (ja) * 1989-09-08 1995-08-09 株式会社村田製作所 生体活性水酸アパタイト膜のコーティング法
ATE195424T1 (de) 1990-01-12 2000-09-15 New York Society Verfahren zur verbesserung der wundheilung und gewebeerneuerung
US5164187A (en) 1990-04-05 1992-11-17 Norian Corporation Hydroxyapatite prosthesis coatings
DE4033308A1 (de) 1990-10-19 1992-04-23 Draenert Klaus Implantat und verfahren zu seiner herstellung
US5137709A (en) 1991-02-15 1992-08-11 The Dow Chemical Company Layered mixed metal hydroxides for the stabilization of radioactive colloids
FR2681235B1 (fr) 1991-09-13 1993-11-12 Itac Var Implant Materiel d'osteosynthese a face de contact osseux recouverte par un revetement de surface.
US5769897A (en) 1991-12-13 1998-06-23 Haerle; Anton Synthetic bone
US5478237A (en) 1992-02-14 1995-12-26 Nikon Corporation Implant and method of making the same
US5558517A (en) 1992-02-24 1996-09-24 Clemson University Polymeric prosthesis having a phosphonylated surface
FI91713C (fi) 1992-04-23 1994-08-10 Axidental Oy Uusia bioaktiivisia pinnotteita ja niiden valmistus ja käyttö
DE9208752U1 (de) 1992-06-28 1992-12-24 Artos medizinische Produkte GmbH, 1000 Berlin Hüftpfannenendoprothese
US5565502A (en) 1993-03-24 1996-10-15 Children's Medical Center Corporation Isolation of the calcium-phosphate crystals of bone
US5763092A (en) 1993-09-15 1998-06-09 Etex Corporation Hydroxyapatite coatings and a method of their manufacture
NL9302200A (nl) 1993-12-16 1995-07-17 Endocare Ag Elliptische acetabulumcomponent voor een heupprothese.
US5593451A (en) 1994-06-01 1997-01-14 Implex Corp. Prosthetic device and method of implantation
US5906827A (en) 1994-06-03 1999-05-25 Creative Biomolecules, Inc. Matrix for the manufacture of autogenous replacement body parts
US6398815B1 (en) 2000-01-30 2002-06-04 Diamicron, Inc. Prosthetic joint having at least one superhard articulation surface
DE19501995A1 (de) 1995-01-11 1996-07-18 Effner Biomet Gmbh Endoprothese
US5675001A (en) 1995-03-14 1997-10-07 Hoffman/Barrett, L.L.C. Heteroatom-functionalized porphyrazines and multimetallic complexes and polymers derived therefrom
FR2733409B1 (fr) 1995-04-27 1997-10-24 Howmedica France Cotyle pour prothese de hanche
AU6423796A (en) 1995-08-29 1997-03-06 Johnson & Johnson Professional, Inc. Bone prosthesis with protected coating for penetrating bone intergrowth
FR2739018B1 (fr) 1995-09-22 1998-01-02 Medinov Prothese totale trochitero-acromiale de l'epaule
EP1011541B1 (de) 1995-11-09 2003-10-01 Mathys Medizinaltechnik AG Femurkomponente für eine hüftendoprothese
IT1288038B1 (it) 1996-04-30 1998-09-10 Flametal S P A Procedimento per la preparazione di rivestimenti di idrossiapatite
DE69720316T2 (de) 1996-05-10 2004-04-01 Chienna B.V. Vorrichtung zur Aufnahme und Freigabe von biologisch aktiven Substanzen
ATE228805T1 (de) 1996-05-14 2002-12-15 Bruno Balay Zementfrei verankertes hüftgelenkpfannenimplantat
US6126690A (en) 1996-07-03 2000-10-03 The Trustees Of Columbia University In The City Of New York Anatomically correct prosthesis and method and apparatus for manufacturing prosthesis
US6203822B1 (en) 1996-09-03 2001-03-20 University Of Iowa Research Foundation Gallium-containing compounds for the treatment of infections caused by intracellular pathogens and pathogens causing chronic pulmonary infection
US6602293B1 (en) 1996-11-01 2003-08-05 The Johns Hopkins University Polymeric composite orthopedic implant
DE19652608C1 (de) 1996-12-18 1998-08-27 Eska Implants Gmbh & Co Prophylaxe-Implantat gegen Frakturen osteoporotisch befallener Knochensegmente
WO1998030102A1 (en) 1997-01-09 1998-07-16 Emory University Non-iron metalloporphyrins and methods of use
US6013591A (en) 1997-01-16 2000-01-11 Massachusetts Institute Of Technology Nanocrystalline apatites and composites, prostheses incorporating them, and method for their production
EP0914072B1 (en) 1997-03-04 2004-05-19 Technology Finance Corporation (Proprietary) Limited An artefact suitable for use as a bone implant
US6071982A (en) 1997-04-18 2000-06-06 Cambridge Scientific, Inc. Bioerodible polymeric semi-interpenetrating network alloys for surgical plates and bone cements, and method for making same
SE9701647D0 (sv) 1997-04-30 1997-04-30 Nobel Biocare Ab Calcium-phonsphate coated implant element
FR2768046B1 (fr) 1997-09-08 1999-12-17 Tornier Sa Cotyle a bouchons
SE513556C2 (sv) 1997-11-11 2000-10-02 Nobel Biocare Ab Implantatelement med tunt ytskickt applicerat genom het isostatisk pressning
US5958430A (en) 1998-02-20 1999-09-28 Battelle Memorial Institute Thin film composition with biological substance and method of making
US6139585A (en) 1998-03-11 2000-10-31 Depuy Orthopaedics, Inc. Bioactive ceramic coating and method
US6736849B2 (en) 1998-03-11 2004-05-18 Depuy Products, Inc. Surface-mineralized spinal implants
JP4254057B2 (ja) 1998-05-08 2009-04-15 日油株式会社 ハイドロキシアパタイトの製造方法及び複合体の製造方法
US6261322B1 (en) 1998-05-14 2001-07-17 Hayes Medical, Inc. Implant with composite coating
JPH11323570A (ja) * 1998-05-15 1999-11-26 Mitsubishi Materials Corp ハイドロキシアパタイト皮膜の形成方法
AU766735B2 (en) 1998-09-15 2003-10-23 Isotis N.V. Osteoinduction
AU772751B2 (en) * 1998-09-15 2004-05-06 Isotis N.V. Method for coating medical implants
JP2000210313A (ja) 1999-01-20 2000-08-02 Kobe Steel Ltd 生体親和性に優れた骨代替材料
ES2320722T3 (es) 1999-04-07 2009-05-28 SMITH & NEPHEW ORTHOPAEDICS AG Vastago en forma de hoja de una protesis de cadera para el anclaje en el femur.
ES2226829T3 (es) 1999-04-15 2005-04-01 Franz Sutter Protesis de cabeza de articulacion y conjunto de piezas para su construccion.
SK284754B6 (sk) 1999-05-13 2005-11-03 Marcel �It�Ansk� Necementovaná totálna náhrada ľudského bedrového zhybu
US6364884B1 (en) 1999-07-23 2002-04-02 Ethicon, Inc. Method of securing a graft using a graft fixation device
US6402766B2 (en) 1999-07-23 2002-06-11 Ethicon, Inc. Graft fixation device combination
US6436110B2 (en) 1999-07-23 2002-08-20 Ethicon, Inc. Method of securing a graft using a graft fixation device
US6497707B1 (en) 1999-07-23 2002-12-24 Ethicon, Inc. Graft fixation device combination
US6488716B1 (en) 1999-07-30 2002-12-03 Guofu Huang Anatomic femoral prosthesis for total hip arthroplasty
GB9919810D0 (en) 1999-08-20 1999-10-27 Walker Peter S Conservative hip replacement
JP4172883B2 (ja) 1999-09-08 2008-10-29 Ｈｏｙａ株式会社 薬物徐放用担体および薬物徐放用担体の製造方法
FR2798841B1 (fr) 1999-09-28 2002-03-01 Depuy France Implant acetabulaire pour prothese de hanche
FR2800597B1 (fr) 1999-11-09 2002-08-30 Amplitude Cotyle de prothese de hanche a double mobilite
RU2194536C2 (ru) * 1999-11-17 2002-12-20 Институт физики прочности и материаловедения СО РАН Способ формирования биоактивного покрытия на имплантат
US6592624B1 (en) 1999-11-24 2003-07-15 Depuy Acromed, Inc. Prosthetic implant element
US7115143B1 (en) 1999-12-08 2006-10-03 Sdgi Holdings, Inc. Orthopedic implant surface configuration
DE50010191D1 (de) 1999-12-21 2005-06-02 Ceramtec Ag Hydroxylapatitbeschichtung von aluminiumoxid-keramiken
EP1645248B8 (en) 2000-02-04 2010-06-16 Warsaw Orthopedic, Inc. Expandable interbody spinal fusion implant having pivotally attached blocker
US6319286B1 (en) 2000-03-13 2001-11-20 Exactech, Inc Modular hip prosthesis
GB2360457A (en) 2000-03-21 2001-09-26 Biomet Merck Ltd Knee prosthesis with keel
US6679917B2 (en) 2000-05-01 2004-01-20 Arthrosurface, Incorporated System and method for joint resurface repair
US6520964B2 (en) 2000-05-01 2003-02-18 Std Manufacturing, Inc. System and method for joint resurface repair
DE10021697A1 (de) 2000-05-04 2001-12-06 Plus Endoprothetik Ag Rotkreuz Endoprothesenschaft und Verfahren zu seiner Herstellung
GB0015479D0 (en) 2000-06-23 2000-08-16 Univ London Transcutaneous Prosthesis
US20030021825A1 (en) * 2000-06-28 2003-01-30 Pathak Chandrashekhar P. Cleaning of medical devices with supercritical fluids
US7226480B2 (en) 2000-08-15 2007-06-05 Depuy Spine, Inc. Disc prosthesis
FR2818118B1 (fr) 2000-12-14 2003-06-06 Sulzer Orthopedie S A Cupule cotyloidienne pour prothese de la hanche
GB2370041C (en) 2000-12-15 2007-01-25 Stanmore Implants Worldwide A modular system for formation of a prosthesis
US20020134667A1 (en) 2001-01-16 2002-09-26 Driskell Thomas D. Bioactive device having surface with alloyed layer of calcium phosphate compounds and method of making
AU2002252879B2 (en) 2001-04-23 2007-08-02 Smith & Nephew (Overseas) Limited Use of metals to treat mucosal membranes
ES2424614T3 (es) 2001-05-01 2013-10-07 Amedica Corporation Injerto óseo radiolúcido
PT1264606E (pt) 2001-06-06 2008-09-29 Biomet Orthopaedics Switzerland Gmbh Material metálico revestido de apatite, processo para a sua preparação bem como utilização
JP4685277B2 (ja) 2001-06-20 2011-05-18 独立行政法人物質・材料研究機構 生体組織基体の被覆方法
CA2451554A1 (en) 2001-06-22 2003-01-03 Basf Aktiengesellschaft Rod shaped apatite crystals with a specific length-to-width ratio
GB0116725D0 (en) 2001-07-09 2001-08-29 Europ Economic Community Biomedical titanium implants
US7241315B2 (en) 2001-07-23 2007-07-10 Robert Evans Femoral head resurfacing apparatus and methods
GB0124847D0 (en) 2001-10-16 2001-12-05 Finsbury Dev Ltd Prosthesis
US6596338B2 (en) 2001-10-24 2003-07-22 Howmedica Osteonics Corp. Antibiotic calcium phosphate coating
US6709462B2 (en) 2002-01-11 2004-03-23 Mayo Foundation For Medical Education And Research Acetabular shell with screw access channels
WO2003061579A2 (en) 2002-01-18 2003-07-31 Emory University Phthalocyanine and porphyrazine pharmaceutical compositions
US6908486B2 (en) 2002-01-25 2005-06-21 Mayo Foundation For Medical Education And Research Modular acetabular anti-protrusio cage and porous ingrowth cup combination
US7132015B2 (en) 2002-02-20 2006-11-07 University Of Southern California Materials for dental and biomedical application
FR2836681B1 (fr) 2002-03-04 2004-06-18 Centre Nat Rech Scient Compose phosphocalcique modifie, composition injectable le contenant
US20040024471A1 (en) 2002-06-27 2004-02-05 Ferree Bret A. Bone cell covered arthroplasty devices
KR100465985B1 (ko) 2002-07-30 2005-01-15 재단법인서울대학교산학협력재단 인공골용 생체활성 복합 세라믹스 조성물 및 그의 제조방법
CA2498743A1 (en) 2002-09-13 2004-03-25 The University Of British Columbia Calcium phosphate coated implantable medical devices and processes for making same
US20040053197A1 (en) 2002-09-16 2004-03-18 Zoran Minevski Biocompatible implants
GB2396561A (en) 2002-12-27 2004-06-30 Biomet Merck Ltd Hip prosthesis with ceramic bearing
US7087086B2 (en) 2003-01-31 2006-08-08 Depuy Products, Inc. Biological agent-containing ceramic coating and method
US6905723B2 (en) 2003-05-30 2005-06-14 Depuy Products, Inc. Strontium-substituted apatite coating
US7067169B2 (en) 2003-06-04 2006-06-27 Chemat Technology Inc. Coated implants and methods of coating
JP2005021208A (ja) 2003-06-30 2005-01-27 National Institute Of Advanced Industrial & Technology タンパク担持アルカリ処理チタン、その製造方法及びそれを用いたタンパク担時生体材料及び組織工学スキャフォールド
FR2858209B1 (fr) 2003-07-30 2006-06-02 Depuy France Implant acetabulaire et procede de fabrication de cet implant
DK1527758T3 (da) 2003-10-31 2007-05-21 Orthofix Srl Ledprotese til metacarpus-phalangeal eller interphalangeal anvendelse
US20050100578A1 (en) 2003-11-06 2005-05-12 Schmid Steven R. Bone and tissue scaffolding and method for producing same
EP1694341A1 (en) 2003-12-17 2006-08-30 Titan Pharmaceuticals, Inc. Use of gallium to treat inflammatory arthritis
US8414547B2 (en) 2004-04-29 2013-04-09 C. R. Bard, Inc. Modulating agents for antimicrobial coatings
US7892290B2 (en) 2004-05-28 2011-02-22 Smith & Nephew, Inc. Fluted sleeve hip prosthesis for modular stem
SE527610C2 (sv) 2004-06-15 2006-04-25 Promimic Ab Förfarande för framställning av syntetiskt, kristallint kalciumfosfat i nanostorlek
FR2872432B1 (fr) 2004-07-02 2006-09-22 Coating Ind Sa Procede de revetement d'au moins une partie de la surface d'une prothese medicale par un ou plusieurs agent(s) antibacteriens
US7622191B2 (en) 2004-07-19 2009-11-24 University Of South Florida Titania-based coating for capillary microextraction
DE102004052409B3 (de) 2004-10-25 2006-05-18 Eska Implants Gmbh & Co. Subkutanes, intramuskuläres Lager für ein starres transkutanes Implantat
JP4595084B2 (ja) 2004-11-08 2010-12-08 独立行政法人産業技術総合研究所 結晶配向性を有するアパタイトを被覆したアパタイト複合体
FR2877563B1 (fr) 2004-11-08 2007-11-30 Centre Nat Rech Scient Cnrse Prothese acetabulaire destinee a etre fixee sans ciment
US7155143B2 (en) 2004-11-10 2006-12-26 Xerox Corporation Silencer for an imaging device photoreceptor
US8329202B2 (en) 2004-11-12 2012-12-11 Depuy Products, Inc. System and method for attaching soft tissue to an implant
EP1846325A4 (en) 2005-01-04 2010-04-21 Univ Rutgers HYDROXYAPATITE WITH CONTROLLABLE SIZE AND MORPHOLOGY
WO2011053598A1 (en) 2009-10-26 2011-05-05 Rutgers, The State University Of New Jersey Hydroxyapatite with controllable size and morphology
US8535751B2 (en) 2005-01-24 2013-09-17 Tantaline A/S Method for coating an object
US8323348B2 (en) 2005-02-22 2012-12-04 Taiyen Biotech Co., Ltd. Bone implants
US8491936B2 (en) * 2005-03-16 2013-07-23 North Carolina State University Functionally graded biocompatible coating and coated implant
US8292967B2 (en) 2005-04-21 2012-10-23 Biomet Manufacturing Corp. Method and apparatus for use of porous implants
DE102005026566A1 (de) 2005-06-08 2007-02-22 Implantcast Gmbh Zementfreie Tibiakomponente für eine Sprunggelenkprothese sowie mit einer solchen gebildete Sprunggelenkprothese
DE102005037141A1 (de) 2005-08-06 2007-02-08 Syntan Gbr(vertretungsberechtigter Gesellschafter Hr. Dr. Dieter Girlich, 01309 Dresden) Spongiös-metallisches Implantat und Verfahren zu seiner Herstellung
US20070055380A1 (en) 2005-09-08 2007-03-08 Biomet Manufacturing Corp Method and apparatus for a glenoid prosthesis
CN101484178A (zh) 2005-11-01 2009-07-15 赛德罗米克斯有限责任公司 使用镓化合物的口部和表面微生物的生长控制
US8002842B2 (en) 2005-11-07 2011-08-23 Biomet Manufacturing Corp. Method and apparatus for reducing rim loading of an acetabular shell
JP4895588B2 (ja) 2005-11-30 2012-03-14 株式会社ビー・アイ・テック セメントレス型人工股関節用ステム
US20100040668A1 (en) 2006-01-12 2010-02-18 Rutgers, The State University Of New Jersey Biomimetic Hydroxyapatite Composite Materials and Methods for the Preparation Thereof
GB0601687D0 (en) 2006-01-27 2006-03-08 Smith & Nephew Antimicrobial materials
EP1978976A2 (en) 2006-01-30 2008-10-15 Titan Pharmaceuticals, Inc. Use of gallium to treat biofilm-associated infectons
US20110020419A1 (en) 2006-02-17 2011-01-27 Huipin Yuan Osteoinductive calcium phosphates
WO2007124511A2 (en) 2006-04-25 2007-11-01 Washington State University Resorbable ceramics with controlled strength loss rates
US7767250B2 (en) 2006-06-15 2010-08-03 National Research Council Of Canada Bioceramic coating of a metal-containing substrate
WO2007148682A1 (ja) 2006-06-19 2007-12-27 Kyoto University 生体活性複合材料の製造方法
US10004604B2 (en) 2006-09-08 2018-06-26 Kyocera Corporation Bioimplant for artifical joint with evanescent coating film
JP5162749B2 (ja) 2006-09-14 2013-03-13 国立大学法人 岡山大学 アパタイト複合体及びその製造方法
US20080097618A1 (en) 2006-10-18 2008-04-24 Kevin Charles Baker Deposition of calcium-phosphate (CaP) and calcium-phosphate with bone morphogenic protein (CaP+BMP) coatings on metallic and polymeric surfaces
KR20090089838A (ko) 2006-12-01 2009-08-24 데이진 화이바 가부시키가이샤 고분자 성형물에 대한 기능 부여 방법 및 그 장치
EP2018864A1 (en) 2007-07-23 2009-01-28 Biomet Deutschland GmbH Pharmaceutical composition, substrate comprising a pharmaceutical composition, and use of a pharmaceutical composition
EP2200669B1 (en) 2007-08-20 2011-12-28 Smith & Nephew, PLC Method of forming a bioactive implant material
ES2315194B1 (es) * 2007-09-10 2010-02-26 Francisco J. GARCIA SABAN Procedimiento para obtener una nueva superficie de un implante metalico a base de titanio destinado a ser insertado en tejido oseo.
CN101411892B (zh) * 2007-10-19 2013-01-16 中国科学院金属研究所 镁合金表面羟基磷灰石/聚乳酸复合生物涂层的制备方法
SE531779C2 (sv) 2007-11-26 2009-08-04 Promimic Ab Framställning av kalciumfosfatpartiklar i nanostorlek som pulver eller beläggning via bifunktionella prekursorer
US8821911B2 (en) 2008-02-29 2014-09-02 Smith & Nephew, Inc. Coating and coating method
JP2011512957A (ja) 2008-02-29 2011-04-28 スミス アンド ネフュー インコーポレーテッド 生物医学的応用のための勾配コーティング
US8043375B2 (en) 2008-03-06 2011-10-25 MoiRai Orthopaedic, LLC Cartilage implants
US20130273135A1 (en) 2008-03-25 2013-10-17 University Of Utah Research Foundation Controlled Release Combination Biomaterials
FR2929104B1 (fr) 2008-03-28 2012-09-07 T O Element cotyloidien de prothese de hanche, et prothese totale de hanche le comportant.
TR200803782A2 (tr) 2008-05-27 2009-06-22 Pasi̇nli̇ Ahmet Modifiye edilmiş biyomimetik teknik kullanılarak kalsiyum fosfat esaslı kaplamaların yeni bir yaklaşımla sentezlenmesi.
CN101491693A (zh) * 2008-09-23 2009-07-29 西北有色金属研究院 羟基磷灰石/二氧化钛复合生物活性涂层的制备方法
US8187304B2 (en) 2008-11-10 2012-05-29 Malek Michel H Facet fusion system
FR2940759B1 (fr) 2009-01-08 2011-10-07 Memometal Technologies Tige d'ancrage intra medullaire pour tete d'implant orthopedique
EP2228080A1 (en) 2009-03-03 2010-09-15 Graftys Galliated calcium phosphate biomaterials
US8894958B2 (en) 2009-03-03 2014-11-25 Centre National De La Recherche Scientifique (C.N.R.S.) Galliated calcium phosphate biomaterials
US8623311B2 (en) 2009-03-03 2014-01-07 Graftys Gallium-doped phosphocalcic compounds
EP2228079A1 (en) 2009-03-03 2010-09-15 Graftys Gallium-doped phosphocalcic compounds
US8071156B2 (en) 2009-03-04 2011-12-06 Boston Scientific Scimed, Inc. Endoprostheses
US8556972B2 (en) 2009-04-02 2013-10-15 Sevika Holding AG Monolithic orthopedic implant with an articular finished surface
US8696759B2 (en) 2009-04-15 2014-04-15 DePuy Synthes Products, LLC Methods and devices for implants with calcium phosphate
US9539233B2 (en) 2009-05-04 2017-01-10 Aridis Pharmaceuticals Inc. Gallium formulation for the treatment and prevention of infectious diseases
KR101091589B1 (ko) 2009-06-18 2011-12-13 오스템임플란트 주식회사 망상 또는 섬 형상의 저결정 수산화아파타이트로 코팅된 임플란트 및 이의 코팅 방법
WO2011035434A1 (en) 2009-09-23 2011-03-31 The University Of British Columbia Gallium complex anti microbial compounds, compositions, uses and methods
US20110076396A1 (en) 2009-09-28 2011-03-31 Limin Guan Method of forming a calcium phosphate coating within a porous material
RU2423150C1 (ru) * 2009-11-23 2011-07-10 Государственное образовательное учреждение высшего профессионального образования "Томский политехнический университет" Кальций-фосфатное биологически активное покрытие на имплантате и способ его нанесения
CA2782789A1 (en) 2009-12-09 2011-06-16 Kci Licensing, Inc. Inhibiting bacterial infection and biofilm formation
CN101757689A (zh) 2010-01-19 2010-06-30 上海理工大学 一种具有TiO2-HA表面涂层的钛或钛合金及其制备方法
US8303879B2 (en) 2010-02-01 2012-11-06 Sb Technologies, Llc Composite interbody device and method of manufacture
EP2389901B8 (en) 2010-05-24 2013-05-15 Episurf IP Management AB An implant for cartilage repair
WO2012003432A2 (en) 2010-07-01 2012-01-05 Patty-Fu Giles Controlled-release antibiotic nanoparticles for implants and bone grafts
US8998987B2 (en) 2010-11-11 2015-04-07 Zimmer, Inc. Orthopedic implant with porous polymer bone contacting surface
US20120245135A1 (en) 2011-03-24 2012-09-27 Genta Incorporated Gallium Complexes, Pharmaceutical Compositions And Methods Of Use
US8579990B2 (en) 2011-03-30 2013-11-12 Ethicon, Inc. Tissue repair devices of rapid therapeutic absorbency
EP2522373A1 (en) 2011-05-11 2012-11-14 Dentsply IH AB Biocompatible component
FR2982620B1 (fr) 2011-11-10 2014-09-05 Centre Nat Rech Scient Materiaux metalliques presentant une couche superficielle de phosphate de calcium, et procedes pour le preparer
FR2982507B1 (fr) * 2011-11-14 2016-05-20 Obl Procede de traitement de surface des implants osseux en titane utilisant successivement un bain d'hydroxyde de sodium et une anodisation
RU2476243C1 (ru) * 2012-01-11 2013-02-27 Федеральное государственное бюджетное учреждение науки Институт физики прочности и материаловедения Сибирского отделения Российской академии наук (ИФПМ СО РАН) Способ получения кальцийфосфатного покрытия на имплантате из биоинертного материала (варианты)
US8663329B2 (en) 2012-01-28 2014-03-04 Mark J Ernst Expandable implant for mammalian bony segment stabilization
US9108860B2 (en) 2012-02-10 2015-08-18 Ahmet Cuneyt Tas Synthesis of amorphous calcium phosphate or poorly crystalline calcium phosphate powders by using Ca metal
EP2830672A1 (en) 2012-03-30 2015-02-04 Dentsply IH AB A medical device having a surface comprising antimicrobial metal
EP2662051A1 (en) 2012-05-11 2013-11-13 Dentsply IH AB Medical device having a surface comprising nanoparticles
DE102012210804B4 (de) 2012-06-26 2014-07-10 Innovent E.V. Verfahren zur Erzeugung einer bakteriziden Schicht auf einem Grundkörper aus Titan oder einer Titanbasislegierung
WO2014027612A1 (ja) 2012-08-16 2014-02-20 学校法人中部大学 骨修復材料及びその製造方法
RU134039U1 (ru) * 2013-04-30 2013-11-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Саратовский государственный технический университет имени Гагарина Ю.А." (СГТУ имени Гагарина Ю.А.) Имплантат с биоактивной остеостимулирующей поверхностью
RU2566060C1 (ru) 2014-04-16 2015-10-20 Общество с ограниченной ответственностью "КОНМЕТ" Биоактивное покрытие титанового имплантата, вводимого в костную ткань человека
CN104857563A (zh) * 2015-05-25 2015-08-26 苏州奥芮济医疗科技有限公司 一种含Ag氟羟基磷灰石涂层及其制备方法和应用
JP2018115757A (ja) 2017-01-20 2018-07-26 トヨタ自動車株式会社 車両用駆動力配分装置
US10537661B2 (en) 2017-03-28 2020-01-21 DePuy Synthes Products, Inc. Orthopedic implant having a crystalline calcium phosphate coating and methods for making the same
US10537658B2 (en) 2017-03-28 2020-01-21 DePuy Synthes Products, Inc. Orthopedic implant having a crystalline gallium-containing hydroxyapatite coating and methods for making the same

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US20210299328A1 (en) 2021-09-30
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