RU2018107055A - Фармацевтическая композиция с улучшенной устойчивостью при хранении и способ ее получения - Google Patents
Фармацевтическая композиция с улучшенной устойчивостью при хранении и способ ее получения Download PDFInfo
- Publication number
- RU2018107055A RU2018107055A RU2018107055A RU2018107055A RU2018107055A RU 2018107055 A RU2018107055 A RU 2018107055A RU 2018107055 A RU2018107055 A RU 2018107055A RU 2018107055 A RU2018107055 A RU 2018107055A RU 2018107055 A RU2018107055 A RU 2018107055A
- Authority
- RU
- Russia
- Prior art keywords
- pharmaceutical composition
- composition according
- formula
- mass parts
- amount
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims 13
- 238000004519 manufacturing process Methods 0.000 title 1
- 229940079593 drug Drugs 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 5
- 230000002209 hydrophobic effect Effects 0.000 claims 4
- 239000012535 impurity Substances 0.000 claims 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 229920000469 amphiphilic block copolymer Polymers 0.000 claims 2
- 229920000747 poly(lactic acid) Polymers 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Polymers OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 1
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 1
- 229930012538 Paclitaxel Natural products 0.000 claims 1
- 229920002732 Polyanhydride Polymers 0.000 claims 1
- 229920000954 Polyglycolide Polymers 0.000 claims 1
- 229920001710 Polyorthoester Polymers 0.000 claims 1
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 1
- 229920001400 block copolymer Polymers 0.000 claims 1
- 229960003668 docetaxel Drugs 0.000 claims 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
- 229960001592 paclitaxel Drugs 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 239000002745 poly(ortho ester) Substances 0.000 claims 1
- 229920002401 polyacrylamide Polymers 0.000 claims 1
- 229920001610 polycaprolactone Polymers 0.000 claims 1
- 239000004632 polycaprolactone Substances 0.000 claims 1
- 229920000515 polycarbonate Polymers 0.000 claims 1
- 239000004417 polycarbonate Substances 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 230000008022 sublimation Effects 0.000 claims 1
- 238000000859 sublimation Methods 0.000 claims 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2015-0106629 | 2015-07-28 | ||
| KR20150106629 | 2015-07-28 | ||
| PCT/KR2016/008270 WO2017018820A1 (fr) | 2015-07-28 | 2016-07-28 | Composition pharmaceutique à stabilité au stockage améliorée, et son procédé de préparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2018107055A true RU2018107055A (ru) | 2019-08-28 |
| RU2018107055A3 RU2018107055A3 (fr) | 2019-08-28 |
Family
ID=57884713
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018107055A RU2018107055A (ru) | 2015-07-28 | 2016-07-28 | Фармацевтическая композиция с улучшенной устойчивостью при хранении и способ ее получения |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP3328437A4 (fr) |
| JP (1) | JP2018521105A (fr) |
| KR (1) | KR101787453B1 (fr) |
| CN (1) | CN107466231A (fr) |
| AU (1) | AU2016299548A1 (fr) |
| BR (1) | BR112018001737A2 (fr) |
| CA (1) | CA2993928A1 (fr) |
| HK (1) | HK1249441A1 (fr) |
| IL (1) | IL257187A (fr) |
| MX (1) | MX2018001223A (fr) |
| RU (1) | RU2018107055A (fr) |
| WO (1) | WO2017018820A1 (fr) |
| ZA (1) | ZA201801187B (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101787447B1 (ko) * | 2015-07-28 | 2017-10-19 | 주식회사 삼양바이오팜 | 보관 안정성이 향상된 약학 조성물 및 그의 제조 방법 |
| KR101787451B1 (ko) * | 2015-07-28 | 2017-10-19 | 주식회사 삼양바이오팜 | 보관 안정성이 향상된 약학 조성물 및 그의 제조 방법 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6020507A (en) | 1998-03-02 | 2000-02-01 | Bristol-Myers Squibb Company | Synthesis of paclitaxel from baccatin III by protection of the 7-hydroxyl of baccatin III using a strong base and an electrophile |
| AU2001258872C1 (en) * | 2000-05-12 | 2005-05-26 | Samyang Biopharmaceuticals Corporation | Method for the preparation of polymeric micelle via phase separation of block copolymer |
| US7217770B2 (en) * | 2000-05-17 | 2007-05-15 | Samyang Corporation | Stable polymeric micelle-type drug composition and method for the preparation thereof |
| CA2463172C (fr) * | 2001-10-18 | 2009-08-18 | Samyang Corporation | Composition de micelle polymere a la stabilite amelioree |
| WO2005037840A1 (fr) | 2003-10-16 | 2005-04-28 | Mayne Pharma (Usa), Inc. | Methode pour inverser le groupe hydroxyle c2' d'esters de taxane |
| EP2229417B1 (fr) * | 2007-12-31 | 2014-07-30 | Samyang Biopharmaceuticals Corporation | Procédé de préparation de copolymère amphiphile de haute pureté comprenant un bloc hydrophobe issu d'un alpha-hydroxy acide |
| KR101024742B1 (ko) * | 2007-12-31 | 2011-03-24 | 주식회사 삼양사 | 탁산 함유 양친성 블록 공중합체 미셀 조성물 및 그 제조방법 |
| US9801818B2 (en) * | 2007-12-31 | 2017-10-31 | Samyang Biopharmaceuticals Corporation | Method for stabilizing amphiphilic block copolymer micelle composition containing poorly water-soluble drug |
| EP2201935B1 (fr) * | 2008-12-26 | 2020-07-08 | Samyang Biopharmaceuticals Corporation | Composition de micelles polymères contenant un médicament faiblement soluble et son procédé de préparation |
-
2016
- 2016-07-27 KR KR1020160095415A patent/KR101787453B1/ko active Active
- 2016-07-28 WO PCT/KR2016/008270 patent/WO2017018820A1/fr not_active Ceased
- 2016-07-28 BR BR112018001737A patent/BR112018001737A2/pt not_active Application Discontinuation
- 2016-07-28 MX MX2018001223A patent/MX2018001223A/es unknown
- 2016-07-28 CA CA2993928A patent/CA2993928A1/fr not_active Abandoned
- 2016-07-28 CN CN201680001947.1A patent/CN107466231A/zh active Pending
- 2016-07-28 JP JP2018504263A patent/JP2018521105A/ja active Pending
- 2016-07-28 AU AU2016299548A patent/AU2016299548A1/en not_active Abandoned
- 2016-07-28 EP EP16830853.4A patent/EP3328437A4/fr not_active Withdrawn
- 2016-07-28 RU RU2018107055A patent/RU2018107055A/ru unknown
- 2016-07-28 HK HK18109126.8A patent/HK1249441A1/zh unknown
-
2018
- 2018-01-28 IL IL257187A patent/IL257187A/en unknown
- 2018-02-21 ZA ZA2018/01187A patent/ZA201801187B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2016299548A1 (en) | 2018-02-22 |
| HK1249441A1 (zh) | 2018-11-02 |
| EP3328437A1 (fr) | 2018-06-06 |
| IL257187A (en) | 2018-03-29 |
| ZA201801187B (en) | 2018-12-19 |
| BR112018001737A2 (pt) | 2018-09-11 |
| RU2018107055A3 (fr) | 2019-08-28 |
| CN107466231A (zh) | 2017-12-12 |
| CA2993928A1 (fr) | 2017-02-02 |
| KR101787453B1 (ko) | 2017-10-19 |
| JP2018521105A (ja) | 2018-08-02 |
| MX2018001223A (es) | 2018-11-09 |
| KR20170015200A (ko) | 2017-02-08 |
| EP3328437A4 (fr) | 2019-03-20 |
| WO2017018820A1 (fr) | 2017-02-02 |
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