RU2017104529A - Композиции neisseria meningitidis и способы их применения - Google Patents
Композиции neisseria meningitidis и способы их применения Download PDFInfo
- Publication number
- RU2017104529A RU2017104529A RU2017104529A RU2017104529A RU2017104529A RU 2017104529 A RU2017104529 A RU 2017104529A RU 2017104529 A RU2017104529 A RU 2017104529A RU 2017104529 A RU2017104529 A RU 2017104529A RU 2017104529 A RU2017104529 A RU 2017104529A
- Authority
- RU
- Russia
- Prior art keywords
- polypeptide
- acid sequence
- neisseria meningitidis
- mammal
- seq
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims 4
- 241000588650 Neisseria meningitidis Species 0.000 title claims 3
- 229920001184 polypeptide Polymers 0.000 claims 15
- 102000004196 processed proteins & peptides Human genes 0.000 claims 15
- 108090000765 processed proteins & peptides Proteins 0.000 claims 15
- 241000124008 Mammalia Species 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 230000002163 immunogen Effects 0.000 claims 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 150000007523 nucleic acids Chemical group 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1217—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Neisseriaceae (F)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
- C12N15/1031—Mutagenizing nucleic acids mutagenesis by gene assembly, e.g. assembly by oligonucleotide extension PCR
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6018—Lipids, e.g. in lipopeptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/36—Neisseria
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (10)
1. Выделенный полипептид, включающий аминокислотную последовательность, представленную в SEQ ID NO: 76.
2. Полипептид по п. 1, отличающийся тем, что полипептид является липидированным.
3. Полипептид по п. 1, отличающийся тем, что полипептид является нелипидированным.
4. Полипептид по п. 1, отличающийся тем, что полипептид является непирувилированным.
5. Полипептид по п. 1, отличающийся тем, что полипептид является нелипидированным и непирувилированным.
6. Полипептид по п. 1, отличающийся тем, что полипептид является иммуногенным.
7. Иммуногенная композиция, включающая полипептид по какому-либо из пп. 1-6.
8. Выделенная последовательность нуклеиновой кислоты, кодирующая выделенный полипептид, состоящий из аминокислотной последовательности, представленной в SEQ ID NO: 76.
9. Способ вызывания иммунной реакции против Neisseria meningitidis у млекопитающего, включающий введение млекопитающему эффективного количества иммуногенной композиции, включающей выделенный полипептид, состоящий из аминокислотной последовательности, представленной в SEQ ID NO: 76.
10. Способ вызывания выработки бактериального антитела против Neisseria meningitidis у млекопитающего, включающий введение млекопитающему эффективного количества иммуногенной композиции, включающей выделенный полипептид, состоящий из аминокислотной последовательности, представленной в SEQ ID NO: 76.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261609257P | 2012-03-09 | 2012-03-09 | |
| US61/609,257 | 2012-03-09 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014136401A Division RU2665841C2 (ru) | 2012-03-09 | 2013-03-06 | Композиции neisseria meningitidis и способы их применения |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2017104529A true RU2017104529A (ru) | 2018-08-16 |
| RU2017104529A3 RU2017104529A3 (ru) | 2020-07-02 |
| RU2739504C2 RU2739504C2 (ru) | 2020-12-25 |
Family
ID=48182966
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014136401A RU2665841C2 (ru) | 2012-03-09 | 2013-03-06 | Композиции neisseria meningitidis и способы их применения |
| RU2017104529A RU2739504C2 (ru) | 2012-03-09 | 2017-02-13 | Композиции neisseria meningitidis и способы их применения |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014136401A RU2665841C2 (ru) | 2012-03-09 | 2013-03-06 | Композиции neisseria meningitidis и способы их применения |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US8986710B2 (ru) |
| EP (3) | EP4043029A1 (ru) |
| JP (2) | JP5925342B2 (ru) |
| KR (5) | KR101716557B1 (ru) |
| CN (3) | CN105693830B (ru) |
| AR (3) | AR090294A1 (ru) |
| AU (5) | AU2013229063B2 (ru) |
| BR (2) | BR122016004924A2 (ru) |
| CA (4) | CA3195971A1 (ru) |
| CO (1) | CO7061042A2 (ru) |
| IL (4) | IL234555B (ru) |
| MX (3) | MX2018011291A (ru) |
| MY (2) | MY198910A (ru) |
| NZ (2) | NZ718108A (ru) |
| PE (2) | PE20142115A1 (ru) |
| PH (2) | PH12014501887B1 (ru) |
| RU (2) | RU2665841C2 (ru) |
| SG (3) | SG10201911003QA (ru) |
| TW (5) | TWI627181B (ru) |
| WO (1) | WO2013132452A2 (ru) |
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| MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
| ES2994878T3 (en) | 2010-08-23 | 2025-02-03 | Wyeth Llc | Stable formulations of neisseria meningitidis rlp2086 antigens |
| KR101584871B1 (ko) | 2010-09-10 | 2016-01-22 | 와이어쓰 엘엘씨 | 네이세리아 메닝기티디스 orf2086 항원의 비-지질화된 변이체 |
| SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
| BR122016004924A2 (pt) * | 2012-03-09 | 2019-07-30 | Pfizer Inc. | Polipeptídeo isolado e composições imunogênicas compreendendo os mesmos |
| EP2964665B1 (en) | 2013-03-08 | 2018-08-01 | Pfizer Inc | Immunogenic fusion polypeptides |
| CA2923129C (en) | 2013-09-08 | 2020-06-09 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| RS61246B1 (sr) | 2014-02-28 | 2021-01-29 | Glaxosmithkline Biologicals Sa | Modifikovani meningokokni fhbp polipeptidi |
| CN106715464B (zh) * | 2014-07-23 | 2021-03-16 | 奥克兰儿童医院及研究中心 | 因子h结合蛋白变体及其使用方法 |
| WO2016132294A1 (en) | 2015-02-19 | 2016-08-25 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| AU2016304853C1 (en) * | 2015-08-11 | 2023-03-16 | Orbis Health Solutions Llc | Bacterial and viral vaccine strategy |
| US20180228885A1 (en) * | 2016-03-04 | 2018-08-16 | Orbis Health Solutions Llc | Bacterial and viral vaccine strategy |
| GB201614687D0 (en) * | 2016-08-31 | 2016-10-12 | Univ Oxford Innovation Ltd | fHbp scaffold |
| EP4309670A3 (en) | 2016-09-02 | 2024-07-17 | Sanofi Pasteur, Inc. | Neisseria meningitidis vaccine |
| US10738338B2 (en) | 2016-10-18 | 2020-08-11 | The Research Foundation for the State University | Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate |
| EP3538668B8 (en) | 2016-11-10 | 2025-04-23 | Talis Biomedical Corporation | Polynucleotides for the amplification and detection of chlamydia trachomatis |
| US10183070B2 (en) * | 2017-01-31 | 2019-01-22 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| CA3129425A1 (en) | 2019-02-11 | 2020-08-20 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| WO2021059181A1 (en) | 2019-09-27 | 2021-04-01 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| US11047007B1 (en) | 2020-03-23 | 2021-06-29 | Talis Biomedical Corporation | Polynucleotides for amplification and detection of SARS-CoV-2 |
| TW202245836A (zh) | 2021-02-19 | 2022-12-01 | 美商賽諾菲巴斯德公司 | 重組ｂ型腦膜炎球菌疫苗 |
| TW202423477A (zh) | 2022-08-03 | 2024-06-16 | 美商賽諾菲巴斯德公司 | 針對腦膜炎奈瑟氏菌b的含佐劑免疫原性組成物 |
| KR102706383B1 (ko) | 2023-05-18 | 2024-09-11 | 지에스칼텍스 주식회사 | 주유소 배관 설치 구조물 |
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| EP2964665B1 (en) | 2013-03-08 | 2018-08-01 | Pfizer Inc | Immunogenic fusion polypeptides |
| PE20160155A1 (es) * | 2013-05-22 | 2016-04-01 | Pearl Therapeutics Inc | Composiciones, metodos y sistemas para el suministro por via respiratoria de tres o mas agentes activos |
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