RU2012153963A - Лечение рака груди с помощью соединения 4-иод-3-нитробензамид в комбинации с противоопухолевыми средствами - Google Patents
Лечение рака груди с помощью соединения 4-иод-3-нитробензамид в комбинации с противоопухолевыми средствами Download PDFInfo
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- 206010006187 Breast cancer Diseases 0.000 title claims abstract 15
- 208000026310 Breast neoplasm Diseases 0.000 title claims abstract 15
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- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 claims abstract 9
- 229960004768 irinotecan Drugs 0.000 claims abstract 9
- 150000003839 salts Chemical class 0.000 claims abstract 8
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- 238000000034 method Methods 0.000 claims 11
- 206010073095 invasive ductal breast carcinoma Diseases 0.000 claims 2
- 208000037819 metastatic cancer Diseases 0.000 claims 2
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- 230000005855 radiation Effects 0.000 claims 2
- 239000012661 PARP inhibitor Substances 0.000 claims 1
- 229940121906 Poly ADP ribose polymerase inhibitor Drugs 0.000 claims 1
- 102100025803 Progesterone receptor Human genes 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 108090000468 progesterone receptors Proteins 0.000 claims 1
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Abstract
1. Применение (i) 4-иод-3-нитробензамида или его метаболита, или его фармацевтически приемлемой соли и (ii) иринотекана для получения лекарственного средства для лечения рака молочной железы, который является отрицательным по отношению к рецептору эстрогена (ER), рецептору прогестерона (PR) и эпидермальному фактору роста человека 2 (HER2), причем лекарственное средство приготовлено для раздельного, последовательного или одновременного введения (i) и (ii).2. Применение по п.1, в котором лекарственное средство приготовлено для предоставления эффективного количества (i) и (ii) для обеспечения по меньшей мере одного терапевтического эффекта, выбранного из группы, состоящей из уменьшения размеров опухоли молочной железы, сокращения метастазов, полной ремиссии, частичной ремиссии, стабильного течения болезни или полного патологического ответа.3. Применение по п.2, в котором терапевтический эффект приводит к сопоставимому уровню клинического ответа (CBR = CR (полная ремиссия) + PR (частичная ремиссия) + SD (стабильное течение болезни) ≥ 6 месяцев), который достигается по сравнению с лечением указанным иринотеканом, который вводили без 4-иод-3-нитробензамида.4. Применение по п.3, в котором улучшение уровня клинического ответа составляет по меньшей мере примерно 60% или выше.5. Применение по любому из пп. 1-4, в котором рак молочной железы диагностирован на I стадии, II стадии или III стадии.6. Применение по п.1, в котором лекарственное средство приготовлено для предоставления пациенту хирургии, лучевой терапии, химиотерапии, генной терапии, терапии ДНК, вирусной терапии, терапии РНК, терапии ДНК, адъювантной терапии, неоадъювантной терапии, иммунотера�
Claims (23)
1. Применение (i) 4-иод-3-нитробензамида или его метаболита, или его фармацевтически приемлемой соли и (ii) иринотекана для получения лекарственного средства для лечения рака молочной железы, который является отрицательным по отношению к рецептору эстрогена (ER), рецептору прогестерона (PR) и эпидермальному фактору роста человека 2 (HER2), причем лекарственное средство приготовлено для раздельного, последовательного или одновременного введения (i) и (ii).
2. Применение по п.1, в котором лекарственное средство приготовлено для предоставления эффективного количества (i) и (ii) для обеспечения по меньшей мере одного терапевтического эффекта, выбранного из группы, состоящей из уменьшения размеров опухоли молочной железы, сокращения метастазов, полной ремиссии, частичной ремиссии, стабильного течения болезни или полного патологического ответа.
3. Применение по п.2, в котором терапевтический эффект приводит к сопоставимому уровню клинического ответа (CBR = CR (полная ремиссия) + PR (частичная ремиссия) + SD (стабильное течение болезни) ≥ 6 месяцев), который достигается по сравнению с лечением указанным иринотеканом, который вводили без 4-иод-3-нитробензамида.
4. Применение по п.3, в котором улучшение уровня клинического ответа составляет по меньшей мере примерно 60% или выше.
5. Применение по любому из пп. 1-4, в котором рак молочной железы диагностирован на I стадии, II стадии или III стадии.
6. Применение по п.1, в котором лекарственное средство приготовлено для предоставления пациенту хирургии, лучевой терапии, химиотерапии, генной терапии, терапии ДНК, вирусной терапии, терапии РНК, терапии ДНК, адъювантной терапии, неоадъювантной терапии, иммунотерапии, нанотерапии или их сочетания.
7. Применение по п. 1, в котором лекарственное средство приготовлено для предоставления пациенту подвергающемуся гамма-облучению.
8. Применение по п.1, в котором указанный рак молочной железы представляет собой инфильтрующую протоковую карциному.
9. Применение по любому из пп. 1-4 и 7-10, в котором рак молочной железы представляет собой метастатический рак.
10. Применение по п.1, в котором вводится эффективное количество 4-иод-3-нитробензамида или его фармацевтически приемлемой соли.
11. Применение по п.1, в котором 4-иод-3-нитробензамид или его метаболит, или его фармацевтически приемлемая соль и иринотекан представлены в различных лекарственных формах и вводятся последовательно.
12. Применение по п.1, в котором 4-иод-3-нитробензамид или его метаболит, или его фармацевтически приемлемая соль и иринотекан вводятся одновременно.
13. Способ лечения рака молочной железы, который является отрицательным по отношению к рецептору эстрогена (ER), рецептору прогестерона (PR) и эпидермальному фактору роста человека 2 (HER2) у пациента, предусматривающий введение пациенту имеющему рак молочной железы, который является отрицательным по отношению к ER, PR и HER2, эффективного количества 4-иод-3-нитробензамида или его метаболита, или его фармацевтически приемлемой соли и иринотекана.
14. Способ по п.13, в котором эффективное количество обеспечивает по меньшей мере один терапевтический эффект, выбранный из группы, состоящей из уменьшения размеров опухоли молочной железы, сокращения метастазов, полной ремиссии, частичной ремиссии, стабильного течения болезни или полного патологического ответа.
15. Способ по п.13, в котором сопоставимый уровень клинического ответа (CBR = CR (полная ремиссия) + PR (частичная ремиссия) + SD (стабильное течение болезни) ≥ 6 месяцев) достигается по сравнению с лечением указанным иринотеканом, который вводили без 4-иод-3-нитробензамида.
16. Способ по п.15, в котором улучшение уровня клинического ответа составляет по меньшей мере примерно 60% или выше.
17. Способ по п.13, в котором рак молочной железы диагностирован на I стадии, II стадии или III стадии.
18. Способ по п.13, дополнительно включающий хирургию, лучевую терапию, химиотерапию, генную терапию, терапию ДНК, вирусную терапию, терапию РНК, терапию ДНК, адъювантную терапию, неоадъювантную терапию, иммунотерапию, нанотерапию или их сочетание.
19. Способ по п. 13, дополнительно включающий введение пациенту ингибитора PARP в сочетании с гамма-облучением.
20. Способ по п.13, в котором указанный рак молочной железы представляет собой инфильтрующую протоковую карциному.
21. Способ по п.13, в котором указанный рак молочной железы представляет собой метастатический рак.
22. Способ по п.13, в котором вводится эффективное количество 4-иод-3-нитробензамида или его фармацевтически приемлемой соли.
23. Способ по п.13, в котором иринотекан вводится до, вместе или после введения 4-иод-3-нитробензамид или его метаболит, или его фармацевтически приемлемой соли.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98733307P | 2007-11-12 | 2007-11-12 | |
| US60/987,333 | 2007-11-12 | ||
| US1236407P | 2007-12-07 | 2007-12-07 | |
| US61/012,364 | 2007-12-07 | ||
| US5852808P | 2008-06-03 | 2008-06-03 | |
| US61/058,528 | 2008-06-03 |
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| RU2010123884/14A Division RU2480211C2 (ru) | 2007-11-12 | 2008-11-11 | Лечение рака молочной железы с помощью соединения 4-иод-3-нитробензамид в комбинации с противоопухолевыми средствами |
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| RU2012153963/14A RU2012153963A (ru) | 2007-11-12 | 2012-12-13 | Лечение рака груди с помощью соединения 4-иод-3-нитробензамид в комбинации с противоопухолевыми средствами |
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