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PE20060285A1 - Piridonas sustituidas como inhibidores de pol(adp-ribosa)-polimerasa (parp) - Google Patents

Piridonas sustituidas como inhibidores de pol(adp-ribosa)-polimerasa (parp)

Info

Publication number
PE20060285A1
PE20060285A1 PE2005000326A PE2005000326A PE20060285A1 PE 20060285 A1 PE20060285 A1 PE 20060285A1 PE 2005000326 A PE2005000326 A PE 2005000326A PE 2005000326 A PE2005000326 A PE 2005000326A PE 20060285 A1 PE20060285 A1 PE 20060285A1
Authority
PE
Peru
Prior art keywords
alkyl
benzonitrile
pyridin
dihydro
oxo
Prior art date
Application number
PE2005000326A
Other languages
English (en)
Inventor
Philip Marvin Weintraub
Paul EASTWOOD
David William Stefany
Neil David Moorcroft
Ziqi John Jiang
Stefan Peukert
Uwe Schwahn
Hartmut Rutten
Sungtaek Lim
Kwon Yon Musick
Shujaath Mehdi
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34964825&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20060285(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Publication of PE20060285A1 publication Critical patent/PE20060285A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
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    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

REFERIDA A UN COMPUESTO DE FORMULA I DONDE R ES H O ALQUILO C1-C6; R1 ES ALQUILO C1-C4, ALQUENILO C1-C4, ENTRE OTROS; R2 ES Ar-Y, EN EL QUE Ar ES ARILO, ARILOILO, ENTRE OTROS; Y ES H, -SO2NR5R6, -C(O)R9, ENTRE OTROS; R3 ES H, ALQUILOC1-C4, ALQUENILO C1-C4, ENTRE OTROS; R4 ES ALQUILOC1-C6, ALQUENILO C1-C6, CICLOALQUILO C3-C8, ENTRE OTROS; R3 Y R4 TOMADOS CONJUNTAMENTE CON LOS ATOMOS DE CARBONO A LOS CUALES ESTAN UNIDOS FORMAN UN ANILLO CICLOALQUILO C4-C8 O UN ANILLO BENCENO; R5, R6, R7 Y R8 SON H, ALQUILO C1-C10, CICLOALQUILO C3-C8, ENTRE OTROS; R9 ES H, ALQUILO C1-C6, FENILO, ENTRE OTROS; R11 ES OH, ALCOXI C1-C3, -O-FENILO, ENTRE OTROS; n ES UN NUMERO ENTERO DESDE 1 A 4. TAMBIEN ESTA REFERIDA A COMPOSICIONES QUE COMPRENDEN ESTOS COMPUESTOS CUYOS PREFERIDOS SON 3-(5-ETIL-2-METIL-6-OXO-1,6-DIHIDRO-PIRIDIN-3-IL)BENZONITRILO, 3-(2,5-DIMETIL-6-OXO-1,6-DIHIDRO-PIRIDIN-3-IL)BENZONITRILO, 3-(5-CICLOPROPIL-2-METIL-6-OXO-1,6-DIHIDRO-PIRIDIN-3-IL)BENZONITRILO, ENTRE OTROS. DICHOS COMPUESTOS SON INHIBIDORES DE LA POLI(ADENOSINA 5'-DIFOSFATO RIBOSA)-POLIMERASA (PARP) Y SON UTILES PARA EL TRATAMIENTO Y/O PREVENCION DE UNA DIVERSIDAD DE ENFERMEDADES, INCLUYENDO ENFERMEDADES ASOCIADAS CON EL SISTEMA NERVIOSO CENTRAL Y TRASTORNOS CARDIOVASCULARES
PE2005000326A 2004-03-30 2005-03-22 Piridonas sustituidas como inhibidores de pol(adp-ribosa)-polimerasa (parp) PE20060285A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US55745904P 2004-03-30 2004-03-30

Publications (1)

Publication Number Publication Date
PE20060285A1 true PE20060285A1 (es) 2006-05-08

Family

ID=34964825

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2005000326A PE20060285A1 (es) 2004-03-30 2005-03-22 Piridonas sustituidas como inhibidores de pol(adp-ribosa)-polimerasa (parp)

Country Status (15)

Country Link
US (2) US8173682B2 (es)
EP (1) EP1732896B1 (es)
JP (1) JP4913724B2 (es)
KR (1) KR20070010157A (es)
CN (1) CN1960975A (es)
AR (1) AR048346A1 (es)
AU (1) AU2005230901A1 (es)
BR (1) BRPI0509391A (es)
CA (1) CA2561280A1 (es)
IL (1) IL178058A0 (es)
MX (1) MXPA06011223A (es)
PE (1) PE20060285A1 (es)
TW (1) TW200604174A (es)
UY (1) UY28833A1 (es)
WO (1) WO2005097750A1 (es)

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