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RU2008139671A - METHOD FOR PRODUCING 1-DICHLOROMETHYLISOCHINOLINE - Google Patents

METHOD FOR PRODUCING 1-DICHLOROMETHYLISOCHINOLINE Download PDF

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Publication number
RU2008139671A
RU2008139671A RU2008139671/04A RU2008139671A RU2008139671A RU 2008139671 A RU2008139671 A RU 2008139671A RU 2008139671/04 A RU2008139671/04 A RU 2008139671/04A RU 2008139671 A RU2008139671 A RU 2008139671A RU 2008139671 A RU2008139671 A RU 2008139671A
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Prior art keywords
catalyst
dichloromethylisochinoline
producing
ccl4
iron
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RU2008139671/04A
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Russian (ru)
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RU2402535C2 (en
Inventor
Усеин Меметович Джемилев (RU)
Усеин Меметович Джемилев
Равил Исмагилович Хуснутдинов (RU)
Равил Исмагилович Хуснутдинов
Альфия Руслановна Байгузина (RU)
Альфия Руслановна Байгузина
Ринат Рифхатович Мукминов (RU)
Ринат Рифхатович Мукминов
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Институт нефтехимии и катализа РАН (RU)
Институт нефтехимии и катализа РАН
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Priority to RU2008139671/04A priority Critical patent/RU2402535C2/en
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  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
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Abstract

Способ получения 1-дихлорметилизохинолина формулы ! ! характеризующийся тем, что изохинолин подвергают взаимодействию с CCl4 и МеОН в присутствии катализатора на основе соединений железа, предпочтительно ацетилацетоната железа (III) (Fe(асас)3) или ферроцена (Fe[C5H5]2) при температуре 145-155°С в течение 4-6 ч при мольном соотношении [катализатор]:[C9H7N]:[CCl4]:[метанол]=1-5:100:700-1000:800-1100. The method of obtaining 1-dichloromethylisoquinoline of the formula! ! characterized in that isoquinoline is reacted with CCl4 and MeOH in the presence of a catalyst based on iron compounds, preferably iron (III) acetylacetonate (Fe (acac) 3) or ferrocene (Fe [C5H5] 2) at a temperature of 145-155 ° C for 4-6 hours at a molar ratio [catalyst]: [C9H7N]: [CCl4]: [methanol] = 1-5: 100: 700-1000: 800-1100.

Claims (1)

Способ получения 1-дихлорметилизохинолина формулыThe method of obtaining 1-dichloromethylisoquinoline of the formula
Figure 00000001
Figure 00000001
 характеризующийся тем, что изохинолин подвергают взаимодействию с CCl4 и МеОН в присутствии катализатора на основе соединений железа, предпочтительно ацетилацетоната железа (III) (Fe(асас)3) или ферроцена (Fe[C5H5]2) при температуре 145-155°С в течение 4-6 ч при мольном соотношении [катализатор]:[C9H7N]:[CCl4]:[метанол]=1-5:100:700-1000:800-1100. characterized in that isoquinoline is reacted with CCl 4 and MeOH in the presence of a catalyst based on iron compounds, preferably iron (III) acetylacetonate (Fe (acac) 3 ) or ferrocene (Fe [C 5 H 5 ] 2 ) at a temperature of 145-155 ° C for 4-6 hours at a molar ratio of [catalyst]: [C 9 H 7 N]: [CCl 4 ]: [methanol] = 1-5: 100: 700-1000: 800-1100.
RU2008139671/04A 2008-10-06 2008-10-06 1-dichloromethylisoquinoline synthesis method RU2402535C2 (en)

Priority Applications (1)

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RU2008139671/04A RU2402535C2 (en) 2008-10-06 2008-10-06 1-dichloromethylisoquinoline synthesis method

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RU2008139671/04A RU2402535C2 (en) 2008-10-06 2008-10-06 1-dichloromethylisoquinoline synthesis method

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RU2008139671A true RU2008139671A (en) 2010-04-20
RU2402535C2 RU2402535C2 (en) 2010-10-27

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Effective date: 20101007