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RU2008117118A - Стробируемая вольтамперометрия - Google Patents

Стробируемая вольтамперометрия Download PDF

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RU2008117118A
RU2008117118A RU2008117118/28A RU2008117118A RU2008117118A RU 2008117118 A RU2008117118 A RU 2008117118A RU 2008117118/28 A RU2008117118/28 A RU 2008117118/28A RU 2008117118 A RU2008117118 A RU 2008117118A RU 2008117118 A RU2008117118 A RU 2008117118A
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Abstract

1. Вольтамперометрический способ определения концентрации аналита в образце, заключающийся в том, что ! осуществляют приложение импульсной последовательности к образцу, причем импульсная последовательность содержит, по меньшей мере, два рабочих цикла, ! измеряют результирующие токи и ! определяют концентрацию аналита в образце. ! 2. Способ по п.1, отличающийся тем, что на каждом из рабочих циклов осуществляют возбуждение в течении от 0,1 до 1,5 с. ! 3. Способ по п.1, отличающийся тем, что на каждом из рабочих циклов осуществляют релаксацию в течении, по меньшей мере, 1 с. ! 4. Способ по п.1, отличающийся тем, что подают импульсную последовательность, которая включает, по меньшей мере, три рабочих цикла в пределах 90 с или менее. ! 5. Способ по п.1, отличающийся тем, что подают импульсную последовательность, которая включает, по меньшей мере, три рабочих цикла в пределах 5 с или менее. ! 6. Способ по п.1, отличающийся тем, что подают импульсную последовательность, которая содержит терминальный импульс считывания. ! 7. Способ по п.1, отличающийся тем, что импульсную последовательность прикладывают к сенсорной панели, содержащей диффузионный барьерный слой на рабочем электроде. ! 8. Способ по п.1, отличающийся тем, что концентрация аналита, определенная способом, включает меньшую погрешность, вызванную фоновым влиянием медиатора, чем концентрация аналита, определенная другим способом, в котором отсутствует импульсная последовательность, включающая, по меньшей мере, два рабочих цикла. ! 9. Способ по п.1, отличающийся тем, что концентрация аналита, определенная способом, включает меньшую погрешность, связанную с фоновым влиянием медиатора, чем к�

Claims (48)

1. Вольтамперометрический способ определения концентрации аналита в образце, заключающийся в том, что
осуществляют приложение импульсной последовательности к образцу, причем импульсная последовательность содержит, по меньшей мере, два рабочих цикла,
измеряют результирующие токи и
определяют концентрацию аналита в образце.
2. Способ по п.1, отличающийся тем, что на каждом из рабочих циклов осуществляют возбуждение в течении от 0,1 до 1,5 с.
3. Способ по п.1, отличающийся тем, что на каждом из рабочих циклов осуществляют релаксацию в течении, по меньшей мере, 1 с.
4. Способ по п.1, отличающийся тем, что подают импульсную последовательность, которая включает, по меньшей мере, три рабочих цикла в пределах 90 с или менее.
5. Способ по п.1, отличающийся тем, что подают импульсную последовательность, которая включает, по меньшей мере, три рабочих цикла в пределах 5 с или менее.
6. Способ по п.1, отличающийся тем, что подают импульсную последовательность, которая содержит терминальный импульс считывания.
7. Способ по п.1, отличающийся тем, что импульсную последовательность прикладывают к сенсорной панели, содержащей диффузионный барьерный слой на рабочем электроде.
8. Способ по п.1, отличающийся тем, что концентрация аналита, определенная способом, включает меньшую погрешность, вызванную фоновым влиянием медиатора, чем концентрация аналита, определенная другим способом, в котором отсутствует импульсная последовательность, включающая, по меньшей мере, два рабочих цикла.
9. Способ по п.1, отличающийся тем, что концентрация аналита, определенная способом, включает меньшую погрешность, связанную с фоновым влиянием медиатора, чем концентрация аналита, определенная вольтамперометрическим способом, в котором отсутствует импульсная последовательность, включающая, по меньшей мере, два рабочих цикла.
10. Способ по п.1, отличающийся тем, что используют образец, являющийся жидкостью, содержащей биологическую жидкость.
11. Способ по п.1, отличающийся тем, что аналит является глюкозой.
12. Способ по п.1, отличающийся тем, что на рабочих циклах осуществляют возбуждение, для чего используют потенциал, изменяющийся с течением времени.
13. Способ по п.1, отличающийся тем, что на каждом из рабочих циклов осуществляют возбуждение, для чего используют потенциал, изменяющийся линейно с течением времени.
14. Способ по п.13, отличающийся тем, что рабочие циклы включают релаксацию и возбуждение, выбранное из группы, состоящей из линейного, циклического, нециклического и их сочетаний.
15. Способ по п.13, отличающийся тем, что величину тока регистрируют в ходе каждого возбуждения.
16. Способ по п.1, отличающийся тем, что рабочие циклы включают нециклические возбуждения, по существу, не включающие пик обратного окисления или пик обратного восстановления.
17. Способ по п.16, отличающийся тем, что уменьшают концентрацию медиатора в образце, не зависящую от аналита, по отношению к способу, где рабочие циклы включают циклические возбуждения.
18. Способ по п.1, отличающийся тем, что рабочие циклы включают нециклические возбуждения, завершающиеся перед инициацией пика обратного тока.
19. Способ по п.1, отличающийся тем, что рабочие циклы включают нециклические возбуждения, по существу, не включающие пики прямого и обратного окисления и восстановления.
20. Способ по п.1, отличающийся тем, что рабочие циклы включают нециклические возбуждения, по существу, в пределах области ограниченного диффузией тока окислительно-восстановительной пары.
21. Способ по п.1, отличающийся тем, что определяют, по меньшей мере, один контурный профиль.
22. Способ по п.1, отличающийся тем, что применяют к результирующим токам, по меньшей мере, одну обработку данных, выбранную из группы, состоящей из полуинтеграла, полупроизводной и производной.
23. Способ по п.1, отличающийся тем, что дополнительно определяют совокупность калибровочных множеств исходя из токов.
24. Способ по п.23, отличающийся тем, что количество рабочих циклов определяют исходя из совокупности калибровочных множеств.
25. Способ по п.23, отличающийся тем, что определяют концентрацию аналита путем усреднения множественных величин концентраций, полученных исходя из совокупности калибровочных множеств.
26. Способ по п.1, отличающийся тем, что дополнительно определяют, является ли сенсорная панель, содержащая образец, не полностью заполненной образцом.
27. Способ по п.26, отличающийся тем, что определяют, является ли сенсорная панель, содержащая образец, не полностью заполненной, для чего сравнивают, по меньшей мере, одну величину тока с предварительно выбранной величиной.
28. Способ по п.1, отличающийся тем, что дополнительно определяют содержание активного ионизирующего вещества сенсорной панели.
29. Способ по п.28, отличающийся тем, что для определения содержания активного ионизирующего вещества сенсорной панели определяют отношение величин токов прямого и обратного сканирования.
30. Способ по п.29, отличающийся тем, что отношение предварительно коррелируют с известными количествами активного ионизирующего вещества.
31. Способ по п.29, отличающийся тем, что наклон калибровки изменяют в зависимости от содержания активного ионизирующего вещества сенсорной панели.
32. Способ по п.1, отличающийся тем, что отношение времени возбуждения/релаксации для рабочих циклов устанавливают от 0,3 до 0,2.
33. Переносное устройство для определения концентрации аналита в образце, содержащее стробируемое вольтамперометрическое измерительное устройство, адаптированное для подключения сенсорной панели,
причем стробируемое вольтамперометрическое измерительное устройство содержит, по меньшей мере, два контакта устройства, электрически связанных с дисплеем посредством электрической схемы,
сенсорная панель содержит, по меньшей мере, первый и второй контакты сенсорной панели, при этом первый контакт сенсорной панели электрически связан с рабочим электродом, а второй контакт сенсорной панели электрически связан с противоэлектродом через проводники,
первый слой реагента размещен, по меньшей мере, на одном из электродов и содержит оксидоредуктазу и, по меньшей мере, одно вещество окислительно-восстановительной пары.
34. Устройство по п.33, отличающееся тем, что электроды расположены на одной и той же подложке.
35. Устройство по п.33, отличающееся тем, что электроды расположены на разных подложках.
36. Переносное измерительное устройство для определения концентрации аналита в образце, в котором
указанное устройство адаптировано для подключения сенсорной панели, и содержит,
по меньшей мере, два контакта,
по меньшей мере, один дисплей и
электрическую схему, обеспечивающую электрическую связь, по меньшей мере, между двумя контактами и, по меньшей мере, одним дисплеем, и содержащую процессор, электрически связанный с электрическим зарядным устройством, и считываемым компьютером носителем информации,
при этом процессор предназначен для генерации импульсной последовательности от электрического зарядного устройства, по меньшей мере, к двум контактам, причем импульсная последовательность содержит, по меньшей мере, два рабочих цикла,
при этом процессор предназначен для измерения, по меньшей мере, одного профиля тока, по меньшей мере, на двух контактах,
и предназначен также для определения аналита в образце в зависимости, по меньшей мере, от одного профиля тока.
37. Устройство по п.36, отличающееся тем, что каждый рабочий цикл включает возбуждение и релаксацию.
38. Устройство по п.36, отличающееся тем, что процессор предназначен для применения, по меньшей мере, одной обработки данных, выбранной из группы, состоящей из полуинтеграла, полупроизводной и производной, к профилю тока для определения аналита в образце.
39. Способ уменьшения погрешности, вызванной фоновым влиянием медиатора, в определяемой концентрации аналита в образце, заключающийся в том, что
прикладывают стробированную вольтамперометрическую импульсную последовательность к образцу, причем импульсная последовательность содержит, по меньшей мере, два рабочих цикла.
40. Способ определения продолжительности импульсной последовательности, включающей, по меньшей мере, два рабочих цикла, для определения концентрации аналита в образце, заключающийся в том, что
определяют совокупность калибровочных множеств, определяемых исходя из токов, зарегистрированных в ходе, по меньшей мере, двух рабочих циклов, и
определяют продолжительность импульсной последовательности в зависимости от определяемой концентрации аналита в образце.
41. Способ по п.40, отличающийся тем, что импульсная последовательность является стробированной вольтамперометрической импульсной последовательностью.
42. Способ сигнализации пользователю о добавлении дополнительного количества образца на сенсорную панель, заключающийся в том, что
определяют, является ли сенсорная панель не полностью заполненной посредством сравнения, по меньшей мере, одной величины тока, зарегистрированной исходя из импульсной последовательности, включающей, по меньшей мере, два рабочих цикла, с предварительно заданной величиной, и
сигнализируют пользователю о добавлении дополнительного количества образца на сенсорную панель, если панель не полностью заполнена.
43. Способ по п.42, отличающийся тем, что импульсная последовательность является стробированной вольтамперометрической импульсной последовательностью.
44. Способ по п.42, отличающийся тем, что используют сенсорную панель, содержащую два электрода.
45. Способ по п.42, отличающийся тем, что определение осуществляют менее чем за пять секунд.
46. Вольтамперометрический способ для определения концентрации аналита в образце, заключающийся в том, что
прикладывают импульсную последовательность к образцу, причем импульсная последовательность содержит, по меньшей мере, два рабочих цикла, обладающих отношениями времени возбуждения/релаксации от 0,3 до 0,2,
измеряют результирующие токи и
определяют концентрацию аналита в образце.
47. Способ по п.46, отличающийся тем, что концентрация аналита, определенная заявленным способом, является более точной, чем концентрация аналита, определенная другим способом, где отношение времени возбуждения/релаксации для импульса больше 0,3.
48. Электрохимический способ для определения концентрации аналита в образце, где усовершенствование включает приложение к образцу стробированной вольтамперометрической импульсной последовательности, включающей, по меньшей мере, два рабочих цикла.
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