RU2008115050A - METHOD FOR OBTAINING A STAFLOCOCCUS ANATOXIN-VACCINE - Google Patents
METHOD FOR OBTAINING A STAFLOCOCCUS ANATOXIN-VACCINE Download PDFInfo
- Publication number
- RU2008115050A RU2008115050A RU2008115050/13A RU2008115050A RU2008115050A RU 2008115050 A RU2008115050 A RU 2008115050A RU 2008115050/13 A RU2008115050/13 A RU 2008115050/13A RU 2008115050 A RU2008115050 A RU 2008115050A RU 2008115050 A RU2008115050 A RU 2008115050A
- Authority
- RU
- Russia
- Prior art keywords
- solution
- days
- detoxification
- staphylococcal
- vaccine
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 3
- 229960005486 vaccine Drugs 0.000 title 1
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims abstract 4
- 238000001784 detoxification Methods 0.000 claims abstract 4
- 239000003053 toxin Substances 0.000 claims abstract 4
- 231100000765 toxin Toxicity 0.000 claims abstract 4
- 108700012359 toxins Proteins 0.000 claims abstract 4
- UPCOSYBELNEQAU-UHFFFAOYSA-L (2-decoxy-2-oxoethyl)-[2-[(2-decoxy-2-oxoethyl)-dimethylazaniumyl]ethyl]-dimethylazanium;dichloride Chemical compound [Cl-].[Cl-].CCCCCCCCCCOC(=O)C[N+](C)(C)CC[N+](C)(C)CC(=O)OCCCCCCCCCC UPCOSYBELNEQAU-UHFFFAOYSA-L 0.000 claims abstract 2
- 241000295644 Staphylococcaceae Species 0.000 claims abstract 2
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims abstract 2
- 238000010908 decantation Methods 0.000 claims abstract 2
- 244000005700 microbiome Species 0.000 claims abstract 2
- 238000001179 sorption measurement Methods 0.000 claims abstract 2
- 230000001954 sterilising effect Effects 0.000 claims abstract 2
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract 2
- 239000006228 supernatant Substances 0.000 claims abstract 2
- 239000000725 suspension Substances 0.000 claims abstract 2
- 229940031572 toxoid vaccine Drugs 0.000 claims abstract 2
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Способ получения стафилококковой анатоксин-вакцины, включающий детоксикацию экзо-, эндо и суперэнтеротоксинов в суспензии с автоклавированными стафилококками раствором формалина, сорбцию на гидроксиде алюминия, стерилизацию, отличающийся тем, что детоксикацию стафилококковых токсинов проводят двумя детоксикаторами - первоначально 0,2%-ным раствором формалина в течение 7-9 суток при 40-45°С, а затем 0,6±0,1%-ным раствором этония в течение 7-9 суток при 40-45°С, при этом концентрацию инактивированных токсинов с микроорганизмами увеличивают вдвое путем декантации 50±5% надосадочной жидкости.A method of producing a staphylococcal toxoid vaccine, including detoxification of exo, endo and superenterotoxins in suspension with autoclaved staphylococci with formalin solution, sorption on aluminum hydroxide, sterilization, characterized in that the detoxification of staphylococcal toxins is carried out with two detoxifiers - initially a 0.2% solution for 7-9 days at 40-45 ° С, and then with a 0.6 ± 0.1% ethonium solution for 7-9 days at 40-45 ° С, while the concentration of inactivated toxins with microorganisms is doubled by after decantation, 50 ± 5% of the supernatant.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2008115050/13A RU2377013C1 (en) | 2008-04-16 | 2008-04-16 | Method for production of staphylococcic anatoxin-vaccine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2008115050/13A RU2377013C1 (en) | 2008-04-16 | 2008-04-16 | Method for production of staphylococcic anatoxin-vaccine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2008115050A true RU2008115050A (en) | 2009-10-27 |
| RU2377013C1 RU2377013C1 (en) | 2009-12-27 |
Family
ID=41352491
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2008115050/13A RU2377013C1 (en) | 2008-04-16 | 2008-04-16 | Method for production of staphylococcic anatoxin-vaccine |
Country Status (1)
| Country | Link |
|---|---|
| RU (1) | RU2377013C1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2425668C1 (en) * | 2010-03-22 | 2011-08-10 | Федеральное государственное образовательное учреждение высшего профессионального образования "Курская государственная сельскохозяйственная академия имени профессора И.И. Иванова" Министерства сельского хозяйства Российской Федерации | Method of increasing antibiotics efficiency |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE33922B1 (en) * | 1968-07-03 | 1974-12-11 | Driscoll B O | Improvements in and relating to vaccines |
| RU2139091C1 (en) * | 1999-01-26 | 1999-10-10 | Закрытое акционерное общество "АгроБизнесЦентр" | Method of staphylococcus anatoxin-vaccine preparing |
| RU2229893C2 (en) * | 2001-06-29 | 2004-06-10 | Закрытое акционерное общество "АгроБизнесЦентр" "AgroBusinessCentre" | Method for preparing staphylococcus anatoxin-vaccine |
-
2008
- 2008-04-16 RU RU2008115050/13A patent/RU2377013C1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2377013C1 (en) | 2009-12-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20110417 |