RU2008112753A - METHOD FOR OBTAINING TUBERCULOSIS ANATOXIN - Google Patents
METHOD FOR OBTAINING TUBERCULOSIS ANATOXIN Download PDFInfo
- Publication number
- RU2008112753A RU2008112753A RU2008112753/13A RU2008112753A RU2008112753A RU 2008112753 A RU2008112753 A RU 2008112753A RU 2008112753/13 A RU2008112753/13 A RU 2008112753/13A RU 2008112753 A RU2008112753 A RU 2008112753A RU 2008112753 A RU2008112753 A RU 2008112753A
- Authority
- RU
- Russia
- Prior art keywords
- tuberculous
- allergens
- sorption
- days
- aluminum hydroxide
- Prior art date
Links
- SGNXVBOIDPPRJJ-PSASIEDQSA-N 1-[(1r,6r)-9-azabicyclo[4.2.1]non-4-en-5-yl]ethanone Chemical compound CC(=O)C1=CCC[C@@H]2CC[C@H]1N2 SGNXVBOIDPPRJJ-PSASIEDQSA-N 0.000 title 1
- 239000003948 anatoxin Substances 0.000 title 1
- 201000008827 tuberculosis Diseases 0.000 title 1
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims abstract 8
- 239000013566 allergen Substances 0.000 claims abstract 4
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims abstract 4
- 238000001784 detoxification Methods 0.000 claims abstract 4
- 238000001179 sorption measurement Methods 0.000 claims abstract 4
- UPCOSYBELNEQAU-UHFFFAOYSA-L (2-decoxy-2-oxoethyl)-[2-[(2-decoxy-2-oxoethyl)-dimethylazaniumyl]ethyl]-dimethylazanium;dichloride Chemical compound [Cl-].[Cl-].CCCCCCCCCCOC(=O)C[N+](C)(C)CC[N+](C)(C)CC(=O)OCCCCCCCCCC UPCOSYBELNEQAU-UHFFFAOYSA-L 0.000 claims abstract 2
- 238000010908 decantation Methods 0.000 claims abstract 2
- 239000002158 endotoxin Substances 0.000 claims abstract 2
- 239000002095 exotoxin Substances 0.000 claims abstract 2
- 239000007788 liquid Substances 0.000 claims abstract 2
- 238000004519 manufacturing process Methods 0.000 claims abstract 2
- 239000000047 product Substances 0.000 claims abstract 2
- 230000001954 sterilising effect Effects 0.000 claims abstract 2
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract 2
- 239000006228 supernatant Substances 0.000 claims abstract 2
- 239000003053 toxin Substances 0.000 claims abstract 2
- 231100000765 toxin Toxicity 0.000 claims abstract 2
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
Способ получения туберкулезного анатоксина, включающий детоксикацию туберкулезных экзо- и эндотоксино-аллергенов раствором формалина, сорбцию на гидроксиде алюминия, стерилизацию, отличающийся тем, что детоксикацию 2,5±0,2 мг/мл туберкулезных токсино-аллергенов проводят двумя детоксикаторами - первоначально 0,2% раствором формалина в течение 7-9 сут при 42-45°С, а затем 0,5% раствором этония при 42-45°С в течение 7-9 сут, сорбцией на гидроксиде алюминия (1-3 мг/мл), а увеличение вдвое концентрации биопрепарата обеспечивают декантацией 50±5% надосадочной жидкости.A method for producing tuberculous toxoid, including detoxification of tuberculous exo and endotoxin allergens with formalin solution, sorption on aluminum hydroxide, sterilization, characterized in that detoxification of 2.5 ± 0.2 mg / ml tuberculous toxin allergens is carried out with two detoxifiers - initially 0, 2% formalin solution for 7-9 days at 42-45 ° C, and then a 0.5% ethonium solution at 42-45 ° C for 7-9 days, sorption on aluminum hydroxide (1-3 mg / ml) , and a doubling of the concentration of the biological product is provided by decantation of 50 ± 5% supernatant liquid.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2008112753/13A RU2392002C2 (en) | 2008-04-02 | 2008-04-02 | Tuberculosis anatoxin manufacture method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2008112753/13A RU2392002C2 (en) | 2008-04-02 | 2008-04-02 | Tuberculosis anatoxin manufacture method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2008112753A true RU2008112753A (en) | 2009-10-10 |
| RU2392002C2 RU2392002C2 (en) | 2010-06-20 |
Family
ID=41260410
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2008112753/13A RU2392002C2 (en) | 2008-04-02 | 2008-04-02 | Tuberculosis anatoxin manufacture method |
Country Status (1)
| Country | Link |
|---|---|
| RU (1) | RU2392002C2 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2631607C1 (en) * | 2016-11-22 | 2017-09-25 | Владислав Николаевич Ласкавый | Means for cattle leukemia prevention and method for its application |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5504005A (en) * | 1987-03-02 | 1996-04-02 | Albert Einstein College Of Medicine Of Yeshiva University | Recombinant mycobacterial vaccine |
| RU2139090C1 (en) * | 1999-01-26 | 1999-10-10 | Закрытое акционерное общество "АгроБизнесЦентр" | Method of preparing tuberculosis anatoxin |
| RU2170588C1 (en) * | 2000-02-22 | 2001-07-20 | Предприятие по производству бактерийных препаратов Научно-исследовательского института эпидемиологии и микробиологии им. Н.Ф. Гамалеи РАМН | Method of preparing vaccine bcg-m for sparing primary immunization |
| RU2262950C2 (en) * | 2001-03-23 | 2005-10-27 | Каунсил Оф Сайентифик Энд Индастриал Рисерч | Method for obtaining vaccine for treating tuberculosis and other intracellular infectious diseases and vaccine obtained according to declared method |
-
2008
- 2008-04-02 RU RU2008112753/13A patent/RU2392002C2/en not_active IP Right Cessation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2631607C1 (en) * | 2016-11-22 | 2017-09-25 | Владислав Николаевич Ласкавый | Means for cattle leukemia prevention and method for its application |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2392002C2 (en) | 2010-06-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20110403 |