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RU2001132111A - Композиции, подавляющие развитие кровеносных сосудов и способы их использования - Google Patents

Композиции, подавляющие развитие кровеносных сосудов и способы их использования Download PDF

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Publication number
RU2001132111A
RU2001132111A RU2001132111/14A RU2001132111A RU2001132111A RU 2001132111 A RU2001132111 A RU 2001132111A RU 2001132111/14 A RU2001132111/14 A RU 2001132111/14A RU 2001132111 A RU2001132111 A RU 2001132111A RU 2001132111 A RU2001132111 A RU 2001132111A
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Russia
Prior art keywords
stent
composition according
obstruction
blood vessels
coated
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RU2001132111/14A
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English (en)
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RU2304433C2 (ru
Inventor
Элен М. БАРТ (CA)
Элен М. БАРТ
Уиль м Л. ХАНТЕР (CA)
Уильям Л. ХАНТЕР
Линдсэй С. МЭЧЭН (CA)
Линдсэй С. МЭЧЭН
А. Лэрри АРСЕНО (CA)
А. Лэрри АРСЕНО
Джон К. ДЖЕКСОН (CA)
Джон К. ДЖЕКСОН
Original Assignee
Энджиоджинезис Текнолоджиз, Инк. (Ca)
Энджиоджинезис Текнолоджиз, Инк.
Дзе Юниверсити Оф Бритиш Колумбия (Ca)
Дзе Юниверсити оф Бритиш Колумбия
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Application filed by Энджиоджинезис Текнолоджиз, Инк. (Ca), Энджиоджинезис Текнолоджиз, Инк., Дзе Юниверсити Оф Бритиш Колумбия (Ca), Дзе Юниверсити оф Бритиш Колумбия filed Critical Энджиоджинезис Текнолоджиз, Инк. (Ca)
Publication of RU2001132111A publication Critical patent/RU2001132111A/ru
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Claims (39)

1. Композиция, включающая (a) фактор, подавляющий развитие кровеносных сосудов; и (b) полимерный носитель.
2. Композиция по п.1, в которой указанным фактором, подавляющим развитие кровеносных сосудов, является антиинвазивный фактор.
3. Композиция по п.1, в которой указанным фактором, подавляющим развитие кровеносных сосудов, является ретеновая кислота и ее производные.
4. Композиция по п.1, в которой указанный фактор, подавляющий развитие кровеносных сосудов, выбирают из группы, включающей сурамин, тканевый ингибитор металлопротеиназы-1, тканевый ингибитор металлопротеиназы-2, ингибитор-1 плазминогенового активатора, ингибитор-2 плазминогенового активатора.
5. Композиция, включающая: (а) таксол, и (b) полимерный носитель.
6. Композиция по любому из пп.1-5, которая приготавливается в виде микросфер со средним размером от 0,1 до 200 мкм.
7. Композиция по любому из пп.1-5, которая приготавливается в виде пленки со средним толщиной от 100 мкм до 2 мм.
8. Композиция по любому из пп.1-5, которая представляет собой жидкость при температуре выше 45°С и которая представляет собой твердое вещество или полутвердое вещество при температуре 37°С.
9. Композиция по любому из пп.1-5, в которой указанным полимерным носителем является (полиэтилен-винилацетат), сшитый 40%-тами винилацетата.
10. Композиция по любому из пп.1-5, в которой указанным полимерным носителем является сополимер молочной и гликолевой кислот.
11. Композиция по любому из пп.1-5, в которой указанным полимерным носителем является поликапролактон.
12. Композиция по любому из пп.1-5, в которой указанным полимерным носителем является полимолочная кислота.
13. Композиция по любому из пп.1-5, в которой указанным полимерным носителем является сополимер поли(этилен-винилацетата), сшитого 40%-тами винилацетата, и полимолочной кислоты.
14. Композиция по любому из пп.1-5, в которой указанным полимерным носителем является сополимер полимолочной кислоты и поликапролактона.
15. Способ эмболизации кровеносного сосуда, заключающийся в доставке в указанный сосуд терапевтически эффективного количества композиции по любому из пп.1-14, так что указанный кровеносный сосуд эффективно закупоривается.
16. Способ по п.15, где указанный кровеносный сосуд питает опухоль.
17. Стент, имеющий в общем случае трубчатую структуру, поверхность которой покрыта композицией по любому из пп.1-14.
18. Способ расширения просвета расположенного внутри тела канала, заключающийся в размещении в канале стента, при этом стент имеет в общем случае трубчатую структуру, поверхность которой покрыта композицией по любому из пп.1-14, так что указанный канал расширяется.
19. Способ устранения непроходимости сосудов, заключающийся в размещении сосудистого стента в канал сосуда, при этом стент имеет в общем случае трубчатую структуру, поверхность которой покрыта композицией по любому из пп.1-14, так что указанная непроходимость сосуда устраняется.
20. Способ устранения непроходимости желчных протоков, заключающийся в размещении стента в желчном протоке, при этом стент имеет в общем случае трубчатую структуру, поверхность которой покрыта композицией по любому из пп.1-14, так что указанная непроходимость желчного протока устраняется.
21. Способ устранения непроходимости мочеиспускательного канала, заключающийся в размещении уретрального стента в мочеиспускательном канале, при этом стент имеет в общем случае трубчатую структуру, поверхность которой покрыта композицией по любому из пп.1-14, так что указанная непроходимость мочеиспускательного канала устраняется.
22. Способ устранения непроходимости пищевода, заключающийся в размещении стента в пищеводе, при этом стент имеет в общем случае трубчатую структуру, поверхность которой покрыта композицией по любому из пп.1-14, так что указанная непроходимость пищевода устраняется.
23. Способ устранения трахеально-бронхиальной непроходимости, заключающийся в размещении трахеально-бронхиального стента в трахее или бронхе, при этом стент имеет в общем случае трубчатую структуру, поверхность которой покрыта композицией по любому из пп.1-14, так что указанная трахеальнобронхиальная непроходимость устраняется.
24. Способ лечения места иссечения опухоли, заключающийся в нанесении композиции по любому из пп.1-14 на границы иссечения опухоли после, операции, так что подавляется местный рецидив рака и образование в указанном месте новых кровеносных сосудов.
25. Способ по п.24, где указанной композицией, подавляющей развитие кровеносных сосудов является термопаста.
26. Способ по п.24, в котором стадия нанесения включает разбрызгивание композиции наносфер, включающих составы, подавляющие развитие кровеносных сосудов, на границы иссечения опухоли.
27. Способ лечения реваскуляризации роговицы, заключающийся в нанесении на роговицу терапевтически эффективного количества композиции по любому из пп.1-14, так что образование кровеносных сосудов подавляется.
28. Способ по п.27, в котором указанная композиция также содержит кортикостероид для местного назначения.
29. Способ подавления развития кровеносных сосудов у пациентов с неонкогенными заболеваниями, определяемыми развитием кровеносных сосудов, который заключается в назначении терапевтически эффективного количества композиции, содержащей таксол, пациенту, страдающему от неонкогенного заболевания, определяемого развитием кровеносных сосудов, такого как образование новых кровеносных сосудов.
30. Способ эмболизации кровеносного сосуда при неонкогенных заболеваний, определяемых развитием кровеносных сосудов, который заключается в доставке в указанный сосуд терапевтически эффективного количества композиции, содержащей таксол, так что указанный кровеносный сосуд эффективно закупоривается.
31. Способ расширения просвета расположенного внутри тела канала, заключающийся в размещении в канале стента, при этом стент имеет в общем случае трубчатую структуру, поверхность которой покрыта композицией, содержащей таксол, так что указанных проход расширяется.
32. Способ устранения непроходимости сосудов, заключающийся в размещении сосудистого стента в канал сосуда, при этом стент имеет в общем случае трубчатую структуру, поверхность которой покрыта композицией, содержащей таксол, так что указанная непроходимости сосуда устраняется.
33. Способ устранения непроходимости желчных протоков, заключающийся в размещении стента в желчном протоке, при этом стент имеет в общем случае трубчатую структуру, поверхность которой покрыта композицией, содержащей таксол, так что указанная непроходимость желчного протока устраняется.
34. Способ устранения непроходимости мочеиспускательного канала, заключающийся в размещении уретрального стента в мочеиспускательном канале, при этом стент имеет в общем случае трубчатую структуру, поверхность которой покрыта композицией, содержащей таксол, так что указанная непроходимость мочеиспускательного канала устраняется.
35. Способ устранения непроходимости пищевода, заключающийся в размещении стента в пищеводе, при этом стент имеет в общем случае трубчатую структуру, поверхность которой покрыта композицией, содержащей таксол, так что указанная непроходимость пищевода устраняется.
36. Способ устранения трахеально-бронхиальной непроходимости, заключающийся в размещении трахеально-бронхиального стента в трахее или бронхе, при этом стент имеет в общем случае трубчатую структуру, поверхность которой покрыта композицией, содержащей таксол, так что указанная трахеально-бронхиальная непроходимость устраняется.
37. Способ лечения места иссечения опухоли, заключающийся в нанесении композиции, содержащей таксол, на границы иссечения опухоли после операции, так что подавляется местный рецидив рака и образование в указанном месте новых кровеносных сосудов.
38. Способ лечения реваскуляризации роговицы, заключающийся в нанесении на роговицу терапевтически эффективного количества композиции, содержащей таксол, так что образование кровеносных сосудов подавляется.
39. Фармацевтическое средство, включающее (a) таксол в контейнере и (b) размещенное на контейнере извещение, форма которого определяется правительственным учреждением, регулирующим производство, использованием и продажу фармацевтических препаратов, при этом в извещении должно быть указано, что указанный таксол разрешен указанным правительственным учреждением к использованию при лечении неонкогенных заболеваний человека и животных, определяемых развитием кровеносных сосудов.
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US20110071612A1 (en) 2011-03-24
CN101185759B (zh) 2011-05-25
DE69435002T2 (de) 2008-03-20
US20020119202A1 (en) 2002-08-29
US6506411B2 (en) 2003-01-14
KR100389223B1 (ko) 2003-10-08
US6544544B2 (en) 2003-04-08
ES2267638T3 (es) 2007-03-16
ES2290074T3 (es) 2008-02-16
JP2006328086A (ja) 2006-12-07
JP4476536B2 (ja) 2010-06-09
US20090036517A1 (en) 2009-02-05
RU2180844C2 (ru) 2002-03-27
ATE537858T1 (de) 2012-01-15
EP1652539B8 (en) 2011-06-15
DE69435002D1 (de) 2007-08-30
JP2007084572A (ja) 2007-04-05
CA2167268A1 (en) 1995-02-02
DE69435342D1 (de) 2011-05-05
EP1159974B1 (en) 2007-07-18
EP1695698B1 (en) 2011-03-23
US20050123605A1 (en) 2005-06-09
EP1695698A1 (en) 2006-08-30
RU2007111679A (ru) 2008-10-10
KR20110049898A (ko) 2011-05-12
ES2321241T3 (es) 2009-06-03
HK1042054B (en) 2008-11-14
US20060240113A1 (en) 2006-10-26
EP2226085B1 (en) 2013-11-27
US20030003094A1 (en) 2003-01-02
US20040076672A1 (en) 2004-04-22
CN1704121A (zh) 2005-12-07
EP1695697A1 (en) 2006-08-30
DE69435139D1 (de) 2008-10-23
EP1155690A2 (en) 2001-11-21
US20110066251A1 (en) 2011-03-17
CN100998565A (zh) 2007-07-18
EP1695697A3 (en) 2007-12-26
CN100998869A (zh) 2007-07-18
US20100240742A1 (en) 2010-09-23
DE69403966T2 (de) 1998-02-05
DE69434048T2 (de) 2005-10-06
EP1155691A3 (en) 2002-05-29
JPH09503488A (ja) 1997-04-08
CN101007173A (zh) 2007-08-01
EP1155690B1 (en) 2004-09-29
EP1155689A3 (en) 2001-11-28
EP1155689B1 (en) 2006-09-20
KR101222904B1 (ko) 2013-01-17
KR100934111B1 (ko) 2009-12-31
EP1652539A1 (en) 2006-05-03
EP1946749A1 (en) 2008-07-23
KR20080043375A (ko) 2008-05-16
EP0797988A3 (en) 2000-11-22
CA2472373A1 (en) 1995-02-02
LU92423I2 (en) 2015-01-20
AU7119294A (en) 1995-02-20
ATE339975T1 (de) 2006-10-15
NZ268326A (en) 1997-12-19
EP1632259A3 (en) 2006-08-09
HK1042054A1 (en) 2002-08-02
NZ511762A (en) 2003-09-26
JP4920353B2 (ja) 2012-04-18
NO20073066L (no) 1996-03-18
EP0706376B1 (en) 1997-06-25
EP1155691B1 (en) 2008-09-17
PT1159974E (pt) 2007-10-31
DE69434856T4 (de) 2009-09-24
KR20090090403A (ko) 2009-08-25
HK1079715A1 (zh) 2006-04-13
EP1652539B1 (en) 2011-03-23
DK1159974T3 (da) 2007-11-26
GR3024833T3 (en) 1998-01-30
NO324275B1 (no) 2007-09-17
CN101185759A (zh) 2008-05-28
DK0797988T3 (da) 2009-05-11
US20050208137A1 (en) 2005-09-22
EP1155690A3 (en) 2001-11-28
JP4597115B2 (ja) 2010-12-15
EP2226085A1 (en) 2010-09-08
NZ523799A (en) 2005-03-24
US20090074830A1 (en) 2009-03-19
US20060121117A1 (en) 2006-06-08
US20110118825A1 (en) 2011-05-19
US20080166387A1 (en) 2008-07-10
ATE277649T1 (de) 2004-10-15
ATE367173T1 (de) 2007-08-15
DE69403966T3 (de) 2008-04-17
EP1155689A2 (en) 2001-11-21
PT1155689E (pt) 2007-01-31
CN1138505C (zh) 2004-02-18
DE69434856T2 (de) 2007-03-01
NO960226L (no) 1996-03-18
CA2472404A1 (en) 1995-02-02
WO1995003036A1 (en) 1995-02-02
US20040062810A1 (en) 2004-04-01
EP0797988A2 (en) 1997-10-01
DK2226085T3 (da) 2014-02-03
CN1130866A (zh) 1996-09-11
JP2002326930A (ja) 2002-11-15
CA2167268C (en) 2004-09-28
EP0797988B1 (en) 2009-01-14
EP1159975A3 (en) 2002-03-27
EP1632259B1 (en) 2011-12-21
RU2304433C2 (ru) 2007-08-20
EP0706376B2 (en) 2007-08-08
ATE420628T1 (de) 2009-01-15
US20130102657A1 (en) 2013-04-25
KR20030097620A (ko) 2003-12-31
ES2449311T3 (es) 2014-03-19
CN1502331A (zh) 2004-06-09
ES2106553T5 (es) 2008-02-16
DE69435185D1 (de) 2009-03-05
CA2468375A1 (en) 1995-02-02
US20070003630A1 (en) 2007-01-04
DE69434048D1 (de) 2004-11-04
DE69403966D1 (de) 1997-07-31
US8221794B2 (en) 2012-07-17
EP1632259A2 (en) 2006-03-08
DK0706376T5 (da) 2006-05-15
DE69435341D1 (de) 2011-05-05
PT2226085E (pt) 2014-03-04
DE69434856D1 (de) 2006-11-02
US7820193B2 (en) 2010-10-26
EP1159975B1 (en) 2008-09-10
CN1704121B (zh) 2010-08-18
JP3423317B2 (ja) 2003-07-07
NZ533467A (en) 2006-02-24
ATE502664T1 (de) 2011-04-15
DE69435141D1 (de) 2008-10-30
ATE407712T1 (de) 2008-09-15
CA2472373C (en) 2009-10-13
NO960226D0 (no) 1996-01-18
PT797988E (pt) 2009-05-19
NZ329193A (en) 2001-08-31
EP1159974A1 (en) 2001-12-05
EP1159975A2 (en) 2001-12-05
US20020164377A1 (en) 2002-11-07
ATE154757T1 (de) 1997-07-15
US20070298123A1 (en) 2007-12-27
US20070003629A1 (en) 2007-01-04
ES2106553T3 (es) 1997-11-01
US20100292314A1 (en) 2010-11-18
US20080020063A1 (en) 2008-01-24
ATE408429T1 (de) 2008-10-15
US20060127445A1 (en) 2006-06-15
LU92422I2 (en) 2015-01-20
EP1155691A2 (en) 2001-11-21
AU693797B2 (en) 1998-07-09
DK0706376T3 (da) 1997-10-13
EP0706376A1 (en) 1996-04-17
DK0706376T4 (da) 2007-12-10
ATE502625T1 (de) 2011-04-15

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