PT1115704E - Novas indolinonas substituidas com accao inibidora sobre varias quinases e complexos ciclina/cdk - Google Patents
Novas indolinonas substituidas com accao inibidora sobre varias quinases e complexos ciclina/cdkInfo
- Publication number
- PT1115704E PT1115704E PT99947404T PT99947404T PT1115704E PT 1115704 E PT1115704 E PT 1115704E PT 99947404 T PT99947404 T PT 99947404T PT 99947404 T PT99947404 T PT 99947404T PT 1115704 E PT1115704 E PT 1115704E
- Authority
- PT
- Portugal
- Prior art keywords
- indolinons
- cycline
- replaced
- new
- several kinds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19844003A DE19844003A1 (de) | 1998-09-25 | 1998-09-25 | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
| DE19937496A DE19937496A1 (de) | 1999-08-07 | 1999-08-07 | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1115704E true PT1115704E (pt) | 2003-11-28 |
Family
ID=26049076
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT99947404T PT1115704E (pt) | 1998-09-25 | 1999-09-22 | Novas indolinonas substituidas com accao inibidora sobre varias quinases e complexos ciclina/cdk |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US6855710B2 (pt) |
| EP (1) | EP1115704B1 (pt) |
| JP (1) | JP2002525356A (pt) |
| KR (1) | KR20010085841A (pt) |
| CN (1) | CN1319090A (pt) |
| AT (1) | ATE243195T1 (pt) |
| AU (1) | AU763361B2 (pt) |
| BG (1) | BG105327A (pt) |
| BR (1) | BR9914065A (pt) |
| CA (1) | CA2342622A1 (pt) |
| DE (1) | DE59906030D1 (pt) |
| DK (1) | DK1115704T3 (pt) |
| EA (1) | EA200100320A1 (pt) |
| EE (1) | EE200100184A (pt) |
| ES (1) | ES2196860T3 (pt) |
| HR (1) | HRP20010216A2 (pt) |
| HU (1) | HUP0104973A3 (pt) |
| ID (1) | ID27757A (pt) |
| IL (1) | IL141622A0 (pt) |
| NO (1) | NO20011477L (pt) |
| NZ (1) | NZ510845A (pt) |
| PL (1) | PL346898A1 (pt) |
| PT (1) | PT1115704E (pt) |
| SI (1) | SI1115704T1 (pt) |
| SK (1) | SK4032001A3 (pt) |
| TR (1) | TR200100854T2 (pt) |
| WO (1) | WO2000018734A1 (pt) |
| YU (1) | YU21301A (pt) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9904933D0 (en) | 1999-03-04 | 1999-04-28 | Glaxo Group Ltd | Compounds |
| AU2002341881B2 (en) * | 2001-09-27 | 2008-05-08 | Allergan, Inc. | 3-(arylamino)methylene-1, 3-dihydro-2h-indol-2-ones as kinase inhibitors |
| US20030187026A1 (en) | 2001-12-13 | 2003-10-02 | Qun Li | Kinase inhibitors |
| US6797825B2 (en) | 2001-12-13 | 2004-09-28 | Abbott Laboratories | Protein kinase inhibitors |
| PL373043A1 (en) | 2002-03-26 | 2005-08-08 | Boehringer Ingelheim Pharmaceuticals, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
| US7169936B2 (en) | 2002-07-23 | 2007-01-30 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Indolinone derivatives substituted in the 6-position, their preparation and their use as medicaments |
| PE20040701A1 (es) * | 2002-07-23 | 2004-11-30 | Boehringer Ingelheim Pharma | Derivados de indolinona sustituidos en posicion 6 y su preparacion como medicamentos |
| DE10233366A1 (de) * | 2002-07-23 | 2004-02-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | In 6-Stellung substituierte Indolinonderivate, ihre Herstellung und ihre Verwendung als Arzneimittel |
| US7514468B2 (en) | 2002-07-23 | 2009-04-07 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions |
| DE10237423A1 (de) | 2002-08-16 | 2004-02-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verwendung von LCK-Inhibitoren für die Behandlung von immunologischen Erkrankungen |
| US20040204458A1 (en) | 2002-08-16 | 2004-10-14 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Use of Lck inhibitors for treatment of immunologic diseases |
| CA2496580A1 (en) * | 2002-08-29 | 2004-03-11 | Boehringer Ingelheim Pharmaceuticals, Inc. | 3-(sulfonamidoethyl)-indole derivaties for use as glucocorticoid mimetics in the treatment of inflammatory, allergic and proliferative diseases |
| US7148249B2 (en) * | 2002-09-12 | 2006-12-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Indolinones substituted by heterocycles, the preparation thereof and their use as medicaments |
| JP4879492B2 (ja) * | 2002-11-27 | 2012-02-22 | アラーガン、インコーポレイテッド | 疾患の治療のためのキナーゼ阻害剤 |
| US20050043233A1 (en) | 2003-04-29 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
| UY28526A1 (es) | 2003-09-24 | 2005-04-29 | Boehringer Ingelheim Pharma | Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos |
| ATE414701T1 (de) * | 2003-10-03 | 2008-12-15 | Boehringer Ingelheim Pharma | Fluoreszenzsonden zur verwendung bei einem bindungsassay auf proteinkinaseinhibitoren |
| BRPI0508579A (pt) | 2004-03-11 | 2007-08-14 | Actelion Pharmaceuticals Ltd | composto, composição farmacêutica, e, uso de um composto |
| US7795272B2 (en) | 2004-03-13 | 2010-09-14 | Boehringer Ingelheim Pharmaceutical, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof |
| PE20061155A1 (es) * | 2004-12-24 | 2006-12-16 | Boehringer Ingelheim Int | Derivados de indolinona como agentes para el tratamiento o la prevencion de enfermedades fibroticas |
| PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
| US7635711B2 (en) | 2004-12-27 | 2009-12-22 | Boehringer-Ingelheim Pharmaceuticals, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
| EP1877376A1 (de) | 2005-04-28 | 2008-01-16 | Boehringer Ingelheim International GmbH | Neue verbindungen zur behandlung von entzündlichen erkrankungen |
| MX2009005264A (es) | 2006-12-06 | 2009-05-28 | Boehringer Ingelheim Int | Mimeticos de glucocorticoides, metodos para su fabricacion, composiciones farmaceuticas y usos de los mismos. |
| EP2099489B1 (en) * | 2006-12-11 | 2014-05-21 | Genentech, Inc. | Compositions and methods for treating a neoplasm |
| CN101273991B (zh) * | 2007-03-28 | 2010-05-26 | 广东同德药业有限公司 | 四氢吲哚酮/四氢吲唑酮/四氢咔唑衍生物及其盐在制备抗病毒药物中的应用 |
| TWI432424B (zh) * | 2007-12-03 | 2014-04-01 | Boehringer Ingelheim Int | 製造吲哚啉酮衍生物之方法 |
| UY31506A1 (es) * | 2007-12-03 | 2009-08-03 | Derivados de indolinona y procedimiento para su preparacion | |
| JP2011510032A (ja) * | 2008-01-25 | 2011-03-31 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ６−フルオロ−１，２−ジヒドロ−２−オキソ−３ｈ−インドール−３−イリデン誘導体の塩形態、それらの製造方法及びそれらを含有する医薬組成物 |
| CA2726449A1 (en) | 2008-06-06 | 2009-12-10 | Boehringer Ingelheim International Gmbh | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
| EP2324012A1 (en) | 2008-07-29 | 2011-05-25 | Boehringer Ingelheim International GmbH | New compounds |
| WO2013137371A1 (ja) * | 2012-03-15 | 2013-09-19 | 興和株式会社 | 新規ピリミジン化合物及びそれらを含有する医薬 |
| CN103664737A (zh) * | 2012-09-25 | 2014-03-26 | 杨子娇 | 一类治疗房角狭窄的化合物及其用途 |
| CN111683976B (zh) | 2018-02-05 | 2022-11-18 | 生物辐射实验室股份有限公司 | 具有阴离子交换-疏水混合模式配体的色谱树脂 |
| CN114957084B (zh) * | 2022-01-21 | 2023-05-09 | 九江学院 | 一种吲哚酮类化合物及其制备方法和应用 |
| WO2025155711A1 (en) * | 2024-01-17 | 2025-07-24 | The Board Of Trustees Of The Leland Stanford Junior University | Lrrk2 inhibitors and compositions and uses thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9501567D0 (en) * | 1995-01-26 | 1995-03-15 | Pharmacia Spa | Hydrosoluble 3-arylidene-2-oxindole derivatives as tyrosine kinase inhibitors |
| US5880141A (en) * | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
-
1999
- 1999-09-22 DK DK99947404T patent/DK1115704T3/da active
- 1999-09-22 KR KR1020017003773A patent/KR20010085841A/ko not_active Withdrawn
- 1999-09-22 AU AU60863/99A patent/AU763361B2/en not_active Ceased
- 1999-09-22 DE DE59906030T patent/DE59906030D1/de not_active Expired - Fee Related
- 1999-09-22 SK SK403-2001A patent/SK4032001A3/sk unknown
- 1999-09-22 TR TR2001/00854T patent/TR200100854T2/xx unknown
- 1999-09-22 CN CN99811297A patent/CN1319090A/zh active Pending
- 1999-09-22 WO PCT/EP1999/007040 patent/WO2000018734A1/de not_active Ceased
- 1999-09-22 HU HU0104973A patent/HUP0104973A3/hu unknown
- 1999-09-22 IL IL14162299A patent/IL141622A0/xx unknown
- 1999-09-22 ID IDW20010688A patent/ID27757A/id unknown
- 1999-09-22 PT PT99947404T patent/PT1115704E/pt unknown
- 1999-09-22 EE EEP200100184A patent/EE200100184A/xx unknown
- 1999-09-22 CA CA002342622A patent/CA2342622A1/en not_active Abandoned
- 1999-09-22 HR HR20010216A patent/HRP20010216A2/hr not_active Application Discontinuation
- 1999-09-22 NZ NZ510845A patent/NZ510845A/en unknown
- 1999-09-22 PL PL99346898A patent/PL346898A1/xx not_active Application Discontinuation
- 1999-09-22 YU YU21301A patent/YU21301A/sh unknown
- 1999-09-22 BR BR9914065-9A patent/BR9914065A/pt unknown
- 1999-09-22 EA EA200100320A patent/EA200100320A1/ru unknown
- 1999-09-22 ES ES99947404T patent/ES2196860T3/es not_active Expired - Lifetime
- 1999-09-22 AT AT99947404T patent/ATE243195T1/de not_active IP Right Cessation
- 1999-09-22 EP EP99947404A patent/EP1115704B1/de not_active Expired - Lifetime
- 1999-09-22 JP JP2000572194A patent/JP2002525356A/ja active Pending
- 1999-09-22 SI SI9930391T patent/SI1115704T1/xx unknown
-
2001
- 2001-03-09 BG BG105327A patent/BG105327A/xx unknown
- 2001-03-22 NO NO20011477A patent/NO20011477L/no not_active Application Discontinuation
-
2003
- 2003-09-19 US US10/666,643 patent/US6855710B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US20040058978A1 (en) | 2004-03-25 |
| HUP0104973A2 (hu) | 2002-04-29 |
| YU21301A (sh) | 2003-04-30 |
| EP1115704A1 (de) | 2001-07-18 |
| IL141622A0 (en) | 2002-03-10 |
| HUP0104973A3 (en) | 2002-06-28 |
| WO2000018734A1 (de) | 2000-04-06 |
| DE59906030D1 (de) | 2003-07-24 |
| JP2002525356A (ja) | 2002-08-13 |
| BG105327A (bg) | 2001-12-29 |
| TR200100854T2 (tr) | 2001-12-21 |
| NZ510845A (en) | 2003-10-31 |
| ES2196860T3 (es) | 2003-12-16 |
| CA2342622A1 (en) | 2000-04-06 |
| EA200100320A1 (ru) | 2001-10-22 |
| NO20011477D0 (no) | 2001-03-22 |
| NO20011477L (no) | 2001-03-22 |
| KR20010085841A (ko) | 2001-09-07 |
| DK1115704T3 (da) | 2003-09-29 |
| AU763361B2 (en) | 2003-07-17 |
| ATE243195T1 (de) | 2003-07-15 |
| AU6086399A (en) | 2000-04-17 |
| EE200100184A (et) | 2002-08-15 |
| SI1115704T1 (sl) | 2003-12-31 |
| SK4032001A3 (en) | 2001-11-06 |
| BR9914065A (pt) | 2001-06-19 |
| US6855710B2 (en) | 2005-02-15 |
| ID27757A (id) | 2001-04-26 |
| HRP20010216A2 (en) | 2002-04-30 |
| CN1319090A (zh) | 2001-10-24 |
| EP1115704B1 (de) | 2003-06-18 |
| PL346898A1 (en) | 2002-03-11 |
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