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BG105327A - Нови заместени индолинони с инхибиращо действие върху различни кинази и комплекси циклин/cdk - Google Patents

Нови заместени индолинони с инхибиращо действие върху различни кинази и комплекси циклин/cdk

Info

Publication number
BG105327A
BG105327A BG105327A BG10532701A BG105327A BG 105327 A BG105327 A BG 105327A BG 105327 A BG105327 A BG 105327A BG 10532701 A BG10532701 A BG 10532701A BG 105327 A BG105327 A BG 105327A
Authority
BG
Bulgaria
Prior art keywords
cyclin
indonalines
cdk
compositions
inhibitor activity
Prior art date
Application number
BG105327A
Other languages
Bulgarian (bg)
English (en)
Inventor
Rainer Walter
Wolfgang Grell
Armin Heckel
Frank Himmelsbach
Wolfgang Eberlein
Gerald Roth
Meel Jacobus Van
Norbert Redemann
Walter Spevak
- GRUNT Ulrike TONTSCH
Rueden Thomas Von
Original Assignee
Boehringer Ingelheim Pharma Gmbh & Co. Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19844003A external-priority patent/DE19844003A1/de
Priority claimed from DE19937496A external-priority patent/DE19937496A1/de
Application filed by Boehringer Ingelheim Pharma Gmbh & Co. Kg filed Critical Boehringer Ingelheim Pharma Gmbh & Co. Kg
Publication of BG105327A publication Critical patent/BG105327A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
BG105327A 1998-09-25 2001-03-09 Нови заместени индолинони с инхибиращо действие върху различни кинази и комплекси циклин/cdk BG105327A (bg)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19844003A DE19844003A1 (de) 1998-09-25 1998-09-25 Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
DE19937496A DE19937496A1 (de) 1999-08-07 1999-08-07 Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
PCT/EP1999/007040 WO2000018734A1 (de) 1998-09-25 1999-09-22 Neue substituierte indolinone mit inhibierender wirkung auf verschiedene kinasen und cyclin/cdk-komplexe

Publications (1)

Publication Number Publication Date
BG105327A true BG105327A (bg) 2001-12-29

Family

ID=26049076

Family Applications (1)

Application Number Title Priority Date Filing Date
BG105327A BG105327A (bg) 1998-09-25 2001-03-09 Нови заместени индолинони с инхибиращо действие върху различни кинази и комплекси циклин/cdk

Country Status (28)

Country Link
US (1) US6855710B2 (xx)
EP (1) EP1115704B1 (xx)
JP (1) JP2002525356A (xx)
KR (1) KR20010085841A (xx)
CN (1) CN1319090A (xx)
AT (1) ATE243195T1 (xx)
AU (1) AU763361B2 (xx)
BG (1) BG105327A (xx)
BR (1) BR9914065A (xx)
CA (1) CA2342622A1 (xx)
DE (1) DE59906030D1 (xx)
DK (1) DK1115704T3 (xx)
EA (1) EA200100320A1 (xx)
EE (1) EE200100184A (xx)
ES (1) ES2196860T3 (xx)
HR (1) HRP20010216A2 (xx)
HU (1) HUP0104973A3 (xx)
ID (1) ID27757A (xx)
IL (1) IL141622A0 (xx)
NO (1) NO20011477L (xx)
NZ (1) NZ510845A (xx)
PL (1) PL346898A1 (xx)
PT (1) PT1115704E (xx)
SI (1) SI1115704T1 (xx)
SK (1) SK4032001A3 (xx)
TR (1) TR200100854T2 (xx)
WO (1) WO2000018734A1 (xx)
YU (1) YU21301A (xx)

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GB9904933D0 (en) 1999-03-04 1999-04-28 Glaxo Group Ltd Compounds
US20030225152A1 (en) * 2001-09-27 2003-12-04 Andrews Steven W. 3-(Arylamino)methylene-1, 3-dihydro-2h-indol-2-ones as kinase inhibitors
US20030187026A1 (en) 2001-12-13 2003-10-02 Qun Li Kinase inhibitors
US6797825B2 (en) 2001-12-13 2004-09-28 Abbott Laboratories Protein kinase inhibitors
KR101022977B1 (ko) 2002-03-26 2011-03-18 베링거 인겔하임 파마슈티칼즈, 인코포레이티드 글루코코르티코이드 모사체, 이의 제조방법, 약제학적조성물 및 이의 용도
US7514468B2 (en) 2002-07-23 2009-04-07 Boehringer Ingelheim Pharma Gmbh & Co. Kg Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions
PE20040701A1 (es) * 2002-07-23 2004-11-30 Boehringer Ingelheim Pharma Derivados de indolinona sustituidos en posicion 6 y su preparacion como medicamentos
US7169936B2 (en) 2002-07-23 2007-01-30 Boehringer Ingelheim Pharma Gmbh & Co. Kg Indolinone derivatives substituted in the 6-position, their preparation and their use as medicaments
DE10233366A1 (de) * 2002-07-23 2004-02-12 Boehringer Ingelheim Pharma Gmbh & Co. Kg In 6-Stellung substituierte Indolinonderivate, ihre Herstellung und ihre Verwendung als Arzneimittel
DE10237423A1 (de) 2002-08-16 2004-02-19 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verwendung von LCK-Inhibitoren für die Behandlung von immunologischen Erkrankungen
US20040204458A1 (en) 2002-08-16 2004-10-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Use of Lck inhibitors for treatment of immunologic diseases
DE60333371D1 (de) * 2002-08-29 2010-08-26 Boehringer Ingelheim Pharma 3-(sulfonamidoethyl)-indol-derivate zur verwendung als glucocorticoid-mimetika bei der behandlung von entzündlichen, allergischen und proliferativen erkrankungen
US7148249B2 (en) * 2002-09-12 2006-12-12 Boehringer Ingelheim Pharma Gmbh & Co. Kg Indolinones substituted by heterocycles, the preparation thereof and their use as medicaments
JP4879492B2 (ja) * 2002-11-27 2012-02-22 アラーガン、インコーポレイテッド 疾患の治療のためのキナーゼ阻害剤
US20050043233A1 (en) 2003-04-29 2005-02-24 Boehringer Ingelheim International Gmbh Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis
UY28526A1 (es) 2003-09-24 2005-04-29 Boehringer Ingelheim Pharma Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos
JP4949845B2 (ja) * 2003-10-03 2012-06-13 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド タンパク質キナーゼインヒビター結合アッセイにおける使用のための蛍光プローブ
WO2005094816A1 (en) 2004-03-11 2005-10-13 Actelion Pharmaceuticals Ltd Indol-1-yl-acetic acid derivatives
US7795272B2 (en) 2004-03-13 2010-09-14 Boehringer Ingelheim Pharmaceutical, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof
PE20060777A1 (es) 2004-12-24 2006-10-06 Boehringer Ingelheim Int Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
PE20061155A1 (es) * 2004-12-24 2006-12-16 Boehringer Ingelheim Int Derivados de indolinona como agentes para el tratamiento o la prevencion de enfermedades fibroticas
US7741361B2 (en) 2004-12-27 2010-06-22 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
MX2007012907A (es) * 2005-04-28 2008-03-14 Boehringer Ingelheim Int Nuevos compuestos para el tratamiento de enfermedades inflamatorias.
JP2010512331A (ja) 2006-12-06 2010-04-22 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング グルココルチコイド模倣薬、それらの製造方法、医薬組成物、及びこれらの使用
WO2008073509A2 (en) * 2006-12-11 2008-06-19 Genentech, Inc. Compositions and methods for treating a neoplasm
CN101273991B (zh) * 2007-03-28 2010-05-26 广东同德药业有限公司 四氢吲哚酮/四氢吲唑酮/四氢咔唑衍生物及其盐在制备抗病毒药物中的应用
PE20091445A1 (es) 2007-12-03 2009-10-19 Boehringer Ingelheim Int Derivados de indolinona y procedimiento para su fabricacion
RU2525114C2 (ru) * 2007-12-03 2014-08-10 Бёрингер Ингельхайм Интернациональ Гмбх Способ получения производного индолинона
AU2009207862A1 (en) * 2008-01-25 2009-07-30 Boehringer Ingelheim International Gmbh Salt forms of a 6-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene derivative, process for their manufacture and pharmaceutical compositions containing same
ATE541846T1 (de) 2008-06-06 2012-02-15 Boehringer Ingelheim Int Glucocorticoidmimetika, verfahren zu deren herstellung, pharmazeutische zusammensetzungen und anwendungen davon
NZ590560A (en) 2008-07-29 2012-12-21 Boehringer Ingelheim Int Indolinone Inhibitors of cell cycle kinases
WO2013137371A1 (ja) * 2012-03-15 2013-09-19 興和株式会社 新規ピリミジン化合物及びそれらを含有する医薬
CN103664737A (zh) * 2012-09-25 2014-03-26 杨子娇 一类治疗房角狭窄的化合物及其用途
US11666888B2 (en) 2018-02-05 2023-06-06 Bio-Rad Laboratories, Inc. Chromatography resin having an anionic exchange-hydrophobic mixed mode ligand
CN114957084B (zh) * 2022-01-21 2023-05-09 九江学院 一种吲哚酮类化合物及其制备方法和应用
WO2025155711A1 (en) * 2024-01-17 2025-07-24 The Board Of Trustees Of The Leland Stanford Junior University Lrrk2 inhibitors and compositions and uses thereof

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Publication number Priority date Publication date Assignee Title
GB9501567D0 (en) * 1995-01-26 1995-03-15 Pharmacia Spa Hydrosoluble 3-arylidene-2-oxindole derivatives as tyrosine kinase inhibitors
US5880141A (en) * 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease

Also Published As

Publication number Publication date
US20040058978A1 (en) 2004-03-25
NZ510845A (en) 2003-10-31
HUP0104973A2 (hu) 2002-04-29
CN1319090A (zh) 2001-10-24
SK4032001A3 (en) 2001-11-06
ATE243195T1 (de) 2003-07-15
KR20010085841A (ko) 2001-09-07
EP1115704A1 (de) 2001-07-18
SI1115704T1 (sl) 2003-12-31
CA2342622A1 (en) 2000-04-06
EP1115704B1 (de) 2003-06-18
NO20011477D0 (no) 2001-03-22
HUP0104973A3 (en) 2002-06-28
AU6086399A (en) 2000-04-17
HRP20010216A2 (en) 2002-04-30
PT1115704E (pt) 2003-11-28
PL346898A1 (en) 2002-03-11
DE59906030D1 (de) 2003-07-24
NO20011477L (no) 2001-03-22
AU763361B2 (en) 2003-07-17
WO2000018734A1 (de) 2000-04-06
ID27757A (id) 2001-04-26
ES2196860T3 (es) 2003-12-16
IL141622A0 (en) 2002-03-10
DK1115704T3 (da) 2003-09-29
TR200100854T2 (tr) 2001-12-21
JP2002525356A (ja) 2002-08-13
US6855710B2 (en) 2005-02-15
EE200100184A (et) 2002-08-15
YU21301A (sh) 2003-04-30
BR9914065A (pt) 2001-06-19
EA200100320A1 (ru) 2001-10-22

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