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PE20240224A1 - Anticuerpo biespecifico anti-tspan8/anti-cd3 y anticuerpo anti-tspan8 - Google Patents

Anticuerpo biespecifico anti-tspan8/anti-cd3 y anticuerpo anti-tspan8

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Publication number
PE20240224A1
PE20240224A1 PE2023001609A PE2023001609A PE20240224A1 PE 20240224 A1 PE20240224 A1 PE 20240224A1 PE 2023001609 A PE2023001609 A PE 2023001609A PE 2023001609 A PE2023001609 A PE 2023001609A PE 20240224 A1 PE20240224 A1 PE 20240224A1
Authority
PE
Peru
Prior art keywords
tspan8
antibody
seq
positions
region
Prior art date
Application number
PE2023001609A
Other languages
English (en)
Inventor
Yoshiyuki Tenda
Masatoshi Yuri
Daisuke Yamajuku
Takeshi Tsutsumi
Yuko Kusuzaki
Hiroki Sasaki
Fumiko Chiwaki
Masayuki Komatsu
Original Assignee
Astellas Pharma Inc
Nat Cancer Ct
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc, Nat Cancer Ct filed Critical Astellas Pharma Inc
Publication of PE20240224A1 publication Critical patent/PE20240224A1/es

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Abstract

La presente invencion se refiere a un anticuerpo biespecifico que se une a TSPAN8 (tetraspanina-8) y CD3 (grupo de diferenciacion 3) que comprende: a) una region de Fab de un anticuerpo anti-TSPAN8 que consiste en un fragmento de cadena pesada que comprende una region variable de la cadena pesada y una cadena liviana que comprende una region variable de la cadena liviana del anticuerpo anti-TSPAN8; (b) una region anti-CD3-scFv que comprende una region variable de la cadena pesada y una region variable de la cadena liviana de un anticuerpo anti-CD3; y (c) una region Fc que consiste en un primer polipeptido de Fc ligado al fragmento de cadena pesada de la region Fab (a) y un segundo polipeptido de Fc ligado a la region anti-CD3-scFv (b). Donde la region variable de la cadena pesada del anticuerpo anti-TSPAN8 comprende una CDR1 que consiste en una secuencia de aminoacidos de las posiciones de aminoacidos 31 a 35 de la SEQ ID NO: 6, una CDR2 de posiciones de 50 a 66 de la SEQ ID NO: 6 y una CDR3 de posiciones 99 a 110 de la SEQ ID NO: 6, y la region variable de la cadena liviana comprende una CDR1 que consiste en una secuencia de aminoacidos de las posiciones de aminoacidos 24 a 34 de la SEQ ID NO: 8, una CDR2 de posiciones 50 a 56 de la SEQ ID NO: 8, y una CDR3 de posiciones 89 a 96 de la SEQ ID NO: 8. Tambien se refiere a un polinucleotido que codifica el citado anticuerpo biespecifico, un vector de expresion que comprende el citado polinucleotido, una celula huesped transformada con el citado vector de expresion, un metodo para producir el anticuerpo biespecifico y una composicion farmaceutica que lo comprende. Dicho anticuerpo biespecifico exhibio actividad citotoxica contra una celula cancerosa que expresa TSPAN8 en la superficie celular
PE2023001609A 2020-11-16 2021-11-15 Anticuerpo biespecifico anti-tspan8/anti-cd3 y anticuerpo anti-tspan8 PE20240224A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2020189988 2020-11-16
PCT/JP2021/041839 WO2022102768A1 (ja) 2020-11-16 2021-11-15 抗ｔｓｐａｎ８－抗ｃｄ３二重特異性抗体及び抗ｔｓｐａｎ８抗体

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PE20240224A1 true PE20240224A1 (es) 2024-02-16

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CR20230244A (es) * 2020-11-16 2023-07-12 Astellas Pharma Inc Anticuerpo biespecífico anti-tspan8/anti-cd3 y anticuerpo anti-tspan8
JP2025087939A (ja) * 2022-04-13 2025-06-11 アステラス製薬株式会社 がん治療におけるｐｄ－１シグナル阻害剤との組み合わせによる抗ｔｓｐａｎ８－抗ｃｄ３二重特異性抗体の使用
AU2023268258A1 (en) 2022-05-12 2024-11-28 Astellas Pharma Inc. Anti-taa/anti-cd3 multispecific antibody

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CA3200860A1 (en) 2022-05-19
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US20230348587A1 (en) 2023-11-02
CL2023001392A1 (es) 2023-10-13
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