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PE20231854A1 - Anticuerpo monoclonal o fragmento de union al antigeno del mismo que se une especificamente al gd2 (gangliosido gd2), y uso del mismo - Google Patents

Anticuerpo monoclonal o fragmento de union al antigeno del mismo que se une especificamente al gd2 (gangliosido gd2), y uso del mismo

Info

Publication number
PE20231854A1
PE20231854A1 PE2023002713A PE2023002713A PE20231854A1 PE 20231854 A1 PE20231854 A1 PE 20231854A1 PE 2023002713 A PE2023002713 A PE 2023002713A PE 2023002713 A PE2023002713 A PE 2023002713A PE 20231854 A1 PE20231854 A1 PE 20231854A1
Authority
PE
Peru
Prior art keywords
seq
amino acid
acid sequence
group
sequence selected
Prior art date
Application number
PE2023002713A
Other languages
English (en)
Inventor
Sergei Andreevich Ageev
Yulia Sergeevna Chernykh
Diana Aleksandrovna Kondinskaia
Valeriia Evgenevna Shigina
Dina Khaidarovna Sakharova
Mariia Anatolevna Grefenshtein
Alina Konstantinovna Stolyarova
Valery Vladimirovich Solovyev
Pavel Adreevich Iakovlev
Dmitry Valentinovich Morozov
Original Assignee
Biocad Joint Stock Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from RU2021107773A external-priority patent/RU2796937C2/ru
Application filed by Biocad Joint Stock Co filed Critical Biocad Joint Stock Co
Publication of PE20231854A1 publication Critical patent/PE20231854A1/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C07K16/3084Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated gangliosides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/40Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41Glycosylation, sialylation, or fucosylation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732Antibody-dependent cellular cytotoxicity [ADCC]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734Complement-dependent cytotoxicity [CDC]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Referida a un anticuerpo monoclonal aislado o un fragmento de union al antigeno del mismo que se une especificamente al GD2 (gangliosido GD2), que comprende: (a) un dominio variable de la cadena pesada que comprende: CDR1 con una secuencia aminoacida seleccionada del grupo de la SEQ ID NO: 1 o SEQ ID NO: 2, CDR2 con la secuencia aminoacida de la SEQ ID NO: 3, CDR3 con una secuencia aminoacida seleccionada del grupo de la SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6 o SEQ ID NO: 7; y (b) un dominio variable de la cadena ligera que comprende: (i) CDR1 con una secuencia aminoacida seleccionada del grupo de la SEQ ID NO: 8 o SEQ ID NO: 9, (ii) CDR2 con una secuencia aminoacida seleccionada del grupo de la SEQ ID NO: 10 o SEQ ID NO: 11, (iii) CDR3 con una secuencia aminoacida seleccionada del grupo de la SEQ ID NO: 12 o SEQ ID NO: 13. La invencion se refiere ademas a acidos nucleicos que codifican dicho anticuerpo, vectores de expresion, celulas huesped y metodos para producirlos, metodos para producir los anticuerpos segun la invencion, composiciones farmaceuticas que comprenden el anticuerpo segun la invencion, composiciones farmaceuticas que comprenden el anticuerpo segun la invencion y otros compuestos terapeuticamente activos.
PE2023002713A 2021-03-24 2022-03-24 Anticuerpo monoclonal o fragmento de union al antigeno del mismo que se une especificamente al gd2 (gangliosido gd2), y uso del mismo PE20231854A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2021107773A RU2796937C2 (ru) 2021-03-24 Моноклональное антитело или его антигенсвязывающий фрагмент, которое специфически связывается с gd2 (ганглиозид gd2), и его применение
PCT/RU2022/050096 WO2022203552A1 (en) 2021-03-24 2022-03-24 Monoclonal antibody that specifically binds to gd2

Publications (1)

Publication Number Publication Date
PE20231854A1 true PE20231854A1 (es) 2023-11-21

Family

ID=83395963

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2023002713A PE20231854A1 (es) 2021-03-24 2022-03-24 Anticuerpo monoclonal o fragmento de union al antigeno del mismo que se une especificamente al gd2 (gangliosido gd2), y uso del mismo

Country Status (12)

Country Link
CN (1) CN117677695A (es)
AR (1) AR125219A1 (es)
CL (1) CL2023002843A1 (es)
CO (1) CO2023012549A2 (es)
CR (1) CR20230456A (es)
EC (1) ECSP23072412A (es)
MA (1) MA62715B1 (es)
MX (1) MX2023011246A (es)
PE (1) PE20231854A1 (es)
TW (1) TW202304989A (es)
UY (1) UY39687A (es)
WO (1) WO2022203552A1 (es)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL1706428T3 (pl) * 2004-01-22 2010-02-26 Merck Patent Gmbh Przeciwciała przeciwnowotworowe o zredukowanym wiązaniu dopełniacza
CA2801210C (en) * 2010-06-19 2020-07-21 Memorial Sloan-Kettering Cancer Center Anti-gd2 antibodies
CA2903576C (en) * 2013-03-15 2021-06-08 Nai-Kong V. Cheung High affinity anti-gd2 antibodies

Also Published As

Publication number Publication date
MA62715A1 (fr) 2024-07-31
CL2023002843A1 (es) 2024-03-22
UY39687A (es) 2022-08-31
MA62715B1 (fr) 2025-01-31
AR125219A1 (es) 2023-06-28
TW202304989A (zh) 2023-02-01
WO2022203552A1 (en) 2022-09-29
CN117677695A (zh) 2024-03-08
MX2023011246A (es) 2023-10-30
CR20230456A (es) 2023-12-13
CO2023012549A2 (es) 2023-10-09
ECSP23072412A (es) 2023-10-31

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