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PE20231187A1 - Anticuerpos anti-par-2 y metodos de uso de los mismos - Google Patents

Anticuerpos anti-par-2 y metodos de uso de los mismos

Info

Publication number
PE20231187A1
PE20231187A1 PE2023000322A PE2023000322A PE20231187A1 PE 20231187 A1 PE20231187 A1 PE 20231187A1 PE 2023000322 A PE2023000322 A PE 2023000322A PE 2023000322 A PE2023000322 A PE 2023000322A PE 20231187 A1 PE20231187 A1 PE 20231187A1
Authority
PE
Peru
Prior art keywords
par
antibody
binding fragment
antigen
seq
Prior art date
Application number
PE2023000322A
Other languages
English (en)
Inventor
Anna Mikaela Bracken
Adam Clarke
Birdget A Cooksey
Anthony Gerard Doyle
Mark Terence Liddament
Matthew Pollard
Lynn Poulton
Anna Maria Matilda Quigley
Julia Rozenfeld
Marta Szabat
Original Assignee
Cephalon Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cephalon Llc filed Critical Cephalon Llc
Publication of PE20231187A1 publication Critical patent/PE20231187A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invencion se refiere a un anticuerpo aislado o fragmento de union a antigeno del mismo que comprende la region determinante de complementariedad (CDR) 1 de la region variable de cadena pesada (VH), VHCDR2, VHCDR3 y la region variable de cadena ligera (VL) secuencias CDR1, CDR y CDR3 de SEQ ID NO: 1 (GFSLX1X2YX4X4X5), 2 (VIWGNX6NX7YYX8), 3 (WX9GX10KDX11PFDY), 4 X12ASQNX13YKX14LD), 5 (X15X16X17X18X19X20T) y 6 (X21QHX22X23GWT), respectivamente. Dicho anticuerpo o fragmento de union a antigeno del mismo tambien comprende una VH de SEQ ID NO: 20 o 21 y una VL de SEQ ID NO: 23, 24, 25, 26 o 27. Tambien se refiere a un polinucleotido aislado, un vector aislado, una celula huesped, un metodo de produccion y a una composicion farmaceutica. El anticuerpo o fragmento de union a antigeno del mismo de la invencion se une especificamente al receptor 2 activado por proteasa humana (PAR-2), en el que el anticuerpo o fragmento de union a antigeno del mismo: (a) bloquea la interaccion entre un ligando de PAR-2 y un dominio extracelular de PAR-2 y/o (b) bloquea la activacion de PAR-2 por un ligando activador de PAR-2, en donde el anticuerpo o fragmento de union de antigeno del mismo no se une a los aminoacidos 59-63 del extremo N-terminal de PAR-2 humano, siendo util en el tratamiento del cancer.
PE2023000322A 2020-08-18 2021-08-18 Anticuerpos anti-par-2 y metodos de uso de los mismos PE20231187A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063067259P 2020-08-18 2020-08-18
PCT/US2021/046552 WO2022040345A1 (en) 2020-08-18 2021-08-18 Anti-par-2 antibodies and methods of use thereof

Publications (1)

Publication Number Publication Date
PE20231187A1 true PE20231187A1 (es) 2023-08-15

Family

ID=77897712

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2023000322A PE20231187A1 (es) 2020-08-18 2021-08-18 Anticuerpos anti-par-2 y metodos de uso de los mismos

Country Status (25)

Country Link
US (2) US11725052B2 (es)
EP (2) EP4200018B1 (es)
JP (1) JP2023538379A (es)
KR (1) KR20230048439A (es)
CN (1) CN116761821B (es)
AU (1) AU2021328375A1 (es)
CA (1) CA3192208A1 (es)
CL (1) CL2023000494A1 (es)
CO (1) CO2023003208A2 (es)
DK (1) DK4200018T3 (es)
ES (1) ES3015472T3 (es)
FI (1) FI4200018T3 (es)
HR (1) HRP20250221T1 (es)
HU (1) HUE070287T2 (es)
IL (1) IL300660A (es)
LT (1) LT4200018T (es)
MX (1) MX2023002001A (es)
PE (1) PE20231187A1 (es)
PL (1) PL4200018T3 (es)
PT (1) PT4200018T (es)
RS (1) RS66573B1 (es)
SI (1) SI4200018T1 (es)
SM (1) SMT202500106T1 (es)
WO (1) WO2022040345A1 (es)
ZA (1) ZA202302158B (es)

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CN113795505A (zh) * 2019-05-03 2021-12-14 詹森生物科技公司 Par2调节及其方法
EP4200018B1 (en) * 2020-08-18 2025-01-01 Cephalon LLC Anti-par-2 antibodies and methods of use thereof
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WO2023215787A1 (en) * 2022-05-04 2023-11-09 Vst Bio Corporation Compositions and methods for selective regulation of vascular permeability
WO2025172573A1 (en) 2024-02-16 2025-08-21 Domain Therapeutics Combinations of par2 inhibitors and immune checkpoint inhibitors for the treatment of cancer
CN120647762B (zh) * 2025-06-16 2026-01-23 首都医科大学附属北京友谊医院 一种抗β1-AR-ECII抗体及其应用

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Also Published As

Publication number Publication date
DK4200018T3 (da) 2025-03-10
TW202227489A (zh) 2022-07-16
EP4454659A2 (en) 2024-10-30
US20220056125A1 (en) 2022-02-24
CA3192208A1 (en) 2022-02-24
JP2023538379A (ja) 2023-09-07
US11725052B2 (en) 2023-08-15
ES3015472T3 (en) 2025-05-05
EP4454659A3 (en) 2025-01-22
HRP20250221T1 (hr) 2025-04-11
SMT202500106T1 (it) 2025-05-12
CL2023000494A1 (es) 2023-08-18
ZA202302158B (en) 2024-06-26
EP4200018A1 (en) 2023-06-28
HUE070287T2 (hu) 2025-05-28
WO2022040345A1 (en) 2022-02-24
AU2021328375A1 (en) 2023-04-13
US20240150457A1 (en) 2024-05-09
PT4200018T (pt) 2025-03-10
CN116761821B (zh) 2024-06-14
CN116761821A (zh) 2023-09-15
MX2023002001A (es) 2023-03-21
LT4200018T (lt) 2025-03-25
US12384841B2 (en) 2025-08-12
KR20230048439A (ko) 2023-04-11
EP4200018B1 (en) 2025-01-01
CO2023003208A2 (es) 2023-03-17
IL300660A (en) 2023-04-01
PL4200018T3 (pl) 2025-06-02
SI4200018T1 (sl) 2025-07-31
RS66573B1 (sr) 2025-03-31
FI4200018T3 (fi) 2025-03-08

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