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PE20191847A1 - Receptores de antigenos quimericos que se dirigen a flt3 - Google Patents

Receptores de antigenos quimericos que se dirigen a flt3

Info

Publication number
PE20191847A1
PE20191847A1 PE2019002489A PE2019002489A PE20191847A1 PE 20191847 A1 PE20191847 A1 PE 20191847A1 PE 2019002489 A PE2019002489 A PE 2019002489A PE 2019002489 A PE2019002489 A PE 2019002489A PE 20191847 A1 PE20191847 A1 PE 20191847A1
Authority
PE
Peru
Prior art keywords
flt3
cars
antigen receptors
antibodies
immune cells
Prior art date
Application number
PE2019002489A
Other languages
English (en)
Inventor
Barbra Johnson Sasu
Danielle Elizabeth Dettling
Cesar Adolfo Sommer
Yik Andy Yeung
Moustafa Marc Hamze
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PE20191847A1 publication Critical patent/PE20191847A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001154—Enzymes
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    • A—HUMAN NECESSITIES
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K—PEPTIDES
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
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    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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    • A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
    • A—HUMAN NECESSITIES
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    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A—HUMAN NECESSITIES
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    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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    • C12N2510/00—Genetically modified cells

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Abstract

Se proporcionan en la presente anticuerpos que se unen especificamente a la tirosina cinasa 3 similar a Fms (FLT3), receptores de antigenos quimericos (CAR) que se unen especificamente a FLT3 y celulas inmunitarias modificadas que expresan dichos CAR (por ejemplo, linfocitos T con CAR especificos para FLT3). La invencion tambien proporciona la confeccion de estos anticuerpos, CAR y celulas inmunitarias modificadas. La invencion tambien proporciona el uso de dichos anticuerpos, CAR y celulas inmunitarias modificadas, por ejemplo, para el tratamiento de una afeccion asociada con celulas malignas que expresan FLT3 (por ejemplo, cancer)
PE2019002489A 2017-06-02 2018-05-31 Receptores de antigenos quimericos que se dirigen a flt3 PE20191847A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762514574P 2017-06-02 2017-06-02
US201762514634P 2017-06-02 2017-06-02
US201862660908P 2018-04-20 2018-04-20
PCT/US2018/035492 WO2018222935A1 (en) 2017-06-02 2018-05-31 Chimeric antigen receptors targeting flt3

Publications (1)

Publication Number Publication Date
PE20191847A1 true PE20191847A1 (es) 2019-12-31

Family

ID=64456324

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2019002489A PE20191847A1 (es) 2017-06-02 2018-05-31 Receptores de antigenos quimericos que se dirigen a flt3
PE2024001273A PE20241587A1 (es) 2017-06-02 2018-05-31 Receptores de antigenos quimericos que se dirigen a flt3

Family Applications After (1)

Application Number Title Priority Date Filing Date
PE2024001273A PE20241587A1 (es) 2017-06-02 2018-05-31 Receptores de antigenos quimericos que se dirigen a flt3

Country Status (17)

Country Link
US (1) US12296012B2 (es)
EP (1) EP3630837A1 (es)
JP (2) JP7317718B2 (es)
KR (1) KR102725603B1 (es)
CN (2) CN119899277A (es)
AU (1) AU2018278321B2 (es)
BR (1) BR112019024604A2 (es)
CA (1) CA3062328A1 (es)
CO (1) CO2019013654A2 (es)
IL (1) IL270896A (es)
MX (1) MX2019013923A (es)
MY (1) MY201327A (es)
PE (2) PE20191847A1 (es)
PH (1) PH12019502637A1 (es)
SG (1) SG10202108528QA (es)
TW (2) TWI778068B (es)
WO (1) WO2018222935A1 (es)

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TWI790120B (zh) 2017-06-02 2023-01-11 美商輝瑞大藥廠 對flt3具特異性之抗體及其用途
JP7560356B2 (ja) * 2017-08-01 2024-10-02 ユリウス－マクシミリアン－ウニヴェルシテート・ヴュルツブルク 急性骨髄性白血病を治療するためのｆｌｔ３ ｃａｒ－ｔ細胞及びｆｌｔ３阻害剤の使用
MX2021007339A (es) 2018-12-18 2021-07-15 Boehringer Ingelheim Io Canada Inc Anticuerpos agonistas de flt3 y usos de estos.
CN109694875B (zh) * 2018-12-27 2022-04-29 山东兴瑞生物科技有限公司 抗CII嵌合抗原受体编码基因、慢病毒质粒、Treg免疫细胞及其应用
JP2022526194A (ja) * 2019-04-10 2022-05-23 エレベートバイオ テクノロジーズ，インコーポレイテッド Ｆｌｔ３特異的キメラ抗原受容体およびその使用方法
KR20220016083A (ko) 2019-04-30 2022-02-08 센티 바이오사이언시스, 인코포레이티드 키메라 수용체 및 이의 사용 방법
PE20221256A1 (es) * 2019-10-15 2022-08-16 Dragonfly Therapeutics Inc Anticuerpos dirigidos a flt3 y uso de los mismos
KR102371151B1 (ko) * 2020-03-13 2022-03-07 주식회사 큐로셀 항-bcma 결합 영역, 이를 포함하는 융합단백질, 및 이를 포함하는 조성물
MX2022012919A (es) * 2020-04-14 2022-11-16 Servier Lab Anticuerpos anti-flt3 y composiciones.
EP4135851A1 (en) * 2020-04-17 2023-02-22 City of Hope Flt3-targeted chimeric antigen receptor modified cells for treatment of flt3-positive malignancies
MX2023007384A (es) 2020-12-21 2023-07-05 Allogene Therapeutics Inc Car con puerta cd45 activado por proteasa.
MX2023008809A (es) 2021-01-29 2023-08-04 Allogene Therapeutics Inc ATENUACIÓN O INACTIVACIÓN DE UNO O MÁS DE TAP2, NLRC5, ß2M, TRAC, RFX5, RFXAP Y RFXANK PARA MITIGAR EL RECONOCIMIENTO DE CÉLULAS T DE PRODUCTOS CELULARES ALOGÉNICOS.
CA3232234A1 (en) * 2021-09-20 2023-03-23 The Regents Of The University Of California Novel wnt agonist antibodies and therapeutic uses thereof
CN116410315A (zh) * 2021-12-31 2023-07-11 博生吉医药科技(苏州)有限公司 一种新型靶向人flt3的嵌合抗原受体修饰的t细胞的构建及应用
WO2023165514A1 (zh) * 2022-03-01 2023-09-07 江苏恒瑞医药股份有限公司 特异性结合flt3和cd3的抗原结合分子及其医药用途
CN119654406A (zh) 2022-07-29 2025-03-18 艾洛基治疗公司 具有降低的基因表达以减轻免疫细胞识别的经工程化的细胞
WO2025096560A1 (en) 2023-10-30 2025-05-08 Allogene Therapeutics, Inc. Engineered cells
CN120040594B (zh) * 2025-02-21 2025-09-23 四川大学 一种靶向flt3基因编辑通用型car-t细胞的制备方法和应用

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