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CO2017010502A2 - Receptores del antígeno quimérico dirigidos al antígeno de maduración de células b - Google Patents

Receptores del antígeno quimérico dirigidos al antígeno de maduración de células b

Info

Publication number
CO2017010502A2
CO2017010502A2 CONC2017/0010502A CO2017010502A CO2017010502A2 CO 2017010502 A2 CO2017010502 A2 CO 2017010502A2 CO 2017010502 A CO2017010502 A CO 2017010502A CO 2017010502 A2 CO2017010502 A2 CO 2017010502A2
Authority
CO
Colombia
Prior art keywords
cars
cell maturation
antigen
immune cells
receptors targeting
Prior art date
Application number
CONC2017/0010502A
Other languages
English (en)
Inventor
Tracy Chia-Chien Kuo
Riggers Javier Fernando Chaparro
Barbra Johnson Sasu
Roman Galetto
Bijan Andre Boldajipour
Cesar Adolfo Sommer
Blarcom Thomas John Van
Thomas Charles Pertel
Arvind Rajpal
Philippe Duchateau
Alexandre Juillerat
Julien Valton
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CO2017010502A2 publication Critical patent/CO2017010502A2/es

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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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Abstract

La invención provee CARs (CARs) que específicamente unen a BCMA (antígeno de maduración de célula B). La invención además se refiere a células inmunes manipuladas que comprenden dichos CARs, ácidos nucleicos que codifican CAR, y métodos de hacer dichos CARs, células inmunes manipuladas, y ácidos nucleicos. La invención además se refiere a métodos terapéuticos para uso de estos CARs y células inmunes manipuladas para el tratamiento de una condición asociada con células malignas que expresan BCMA (por ejemplo, cáncer).
CONC2017/0010502A 2015-04-13 2017-10-13 Receptores del antígeno quimérico dirigidos al antígeno de maduración de células b CO2017010502A2 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562146825P 2015-04-13 2015-04-13
US201662286473P 2016-01-25 2016-01-25
US201662301177P 2016-02-29 2016-02-29
PCT/IB2016/051808 WO2016166630A1 (en) 2015-04-13 2016-03-30 Chimeric antigen receptors targeting b-cell maturation antigen

Publications (1)

Publication Number Publication Date
CO2017010502A2 true CO2017010502A2 (es) 2018-01-05

Family

ID=55650627

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2017/0010502A CO2017010502A2 (es) 2015-04-13 2017-10-13 Receptores del antígeno quimérico dirigidos al antígeno de maduración de células b

Country Status (20)

Country Link
US (3) US10294304B2 (es)
EP (2) EP3757128B1 (es)
JP (2) JP6921001B2 (es)
KR (3) KR102349475B1 (es)
CN (2) CN107980046B (es)
AU (3) AU2016248947B2 (es)
CA (1) CA2925589A1 (es)
CO (1) CO2017010502A2 (es)
DK (1) DK3283520T3 (es)
ES (2) ES2807591T3 (es)
IL (2) IL297223B2 (es)
MX (2) MX377809B (es)
MY (1) MY188432A (es)
PE (1) PE20171653A1 (es)
PH (1) PH12017501728A1 (es)
RU (1) RU2706582C2 (es)
SG (2) SG10201912666PA (es)
TW (2) TWI700298B (es)
WO (1) WO2016166630A1 (es)
ZA (1) ZA201706384B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11505590B2 (en) 2016-04-08 2022-11-22 Immunocore Limited T cell receptors

Families Citing this family (103)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015158671A1 (en) * 2014-04-14 2015-10-22 Cellectis Bcma (cd269) specific chimeric antigen receptors for cancer immunotherapy
JP7054622B2 (ja) 2014-07-21 2022-04-14 ノバルティス アーゲー ヒト化抗ｂｃｍａキメラ抗原受容体を使用した癌の処置
EP3230441A4 (en) 2014-12-12 2018-10-03 Voyager Therapeutics, Inc. Compositions and methods for the production of scaav
JP6779909B2 (ja) 2015-01-26 2020-11-04 セレクティスＣｅｌｌｅｃｔｉｓ がん免疫治療のための抗ＣＬＬ１特異的単鎖キメラ抗原受容体（ｓｃＣＡＲ）
SI3988117T1 (sl) 2015-04-13 2025-03-31 Pfizer Inc. Terapevtska protitelesa in njihova uporaba
US10294304B2 (en) 2015-04-13 2019-05-21 Pfizer Inc. Chimeric antigen receptors targeting B-cell maturation antigen
TWI761831B (zh) 2016-04-01 2022-04-21 美商凱特製藥公司 嵌合抗原受體（ｃａｒ）和ｔ細胞受體（ｔｃｒ）及彼等之用途
PL3436030T3 (pl) 2016-04-01 2022-12-19 Kite Pharma, Inc. Receptory chimeryczne i sposoby ich zastosowania
CA3019149A1 (en) 2016-04-01 2017-10-05 Kite Pharma, Inc. Chimeric antigen and t cell receptors and methods of use
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
US11219646B2 (en) * 2016-09-30 2022-01-11 Baylor College Of Medicine Chimeric antigen receptor therapy with reduced cytotoxicity for viral disease
KR20250072712A (ko) 2016-12-02 2025-05-26 앤젤레스 테라퓨틱스, 인코포레이티드 합성 면역 수용체 및 이의 사용 방법
WO2018112334A1 (en) 2016-12-16 2018-06-21 Bluefin Biomedicine, Inc. Anti-cub domain-containing protein 1 (cdcp1) antibodies, antibody drug conjugates, and methods of use thereof
EP3824906A1 (en) 2016-12-21 2021-05-26 Amgen Inc. Anti-tnf alpha antibody formulations
WO2018144535A1 (en) 2017-01-31 2018-08-09 Novartis Ag Treatment of cancer using chimeric t cell receptor proteins having multiple specificities
WO2018201051A1 (en) 2017-04-28 2018-11-01 Novartis Ag Bcma-targeting agent, and combination therapy with a gamma secretase inhibitor
US20200055948A1 (en) 2017-04-28 2020-02-20 Novartis Ag Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor
TWI790120B (zh) 2017-06-02 2023-01-11 美商輝瑞大藥廠 對flt3具特異性之抗體及其用途
WO2018222935A1 (en) * 2017-06-02 2018-12-06 Pfizer Inc. Chimeric antigen receptors targeting flt3
CN111629749A (zh) 2017-10-18 2020-09-04 诺华股份有限公司 用于选择性蛋白质降解的组合物和方法
WO2019090003A1 (en) 2017-11-01 2019-05-09 Juno Therapeutics, Inc. Chimeric antigen receptors specific for b-cell maturation antigen (bcma)
US11851679B2 (en) 2017-11-01 2023-12-26 Juno Therapeutics, Inc. Method of assessing activity of recombinant antigen receptors
KR20200099137A (ko) 2017-11-06 2020-08-21 주노 쎄러퓨티크스 인코퍼레이티드 세포 요법 및 감마 세크레타제 억제제의 조합
MX2020004948A (es) 2017-11-15 2020-11-11 Novartis Ag Receptor de antígeno quimérico que selecciona como diana bcma, receptor de antígeno quimérico que selecciona como diana cd19 y terapias de combinación.
WO2019108900A1 (en) 2017-11-30 2019-06-06 Novartis Ag Bcma-targeting chimeric antigen receptor, and uses thereof
CN109971715A (zh) * 2017-12-28 2019-07-05 深圳华大生命科学研究院 一种扩增特异性car-t细胞的培养方法
EP3737408A1 (en) 2018-01-08 2020-11-18 Novartis AG Immune-enhancing rnas for combination with chimeric antigen receptor therapy
AU2019215031B2 (en) 2018-01-31 2025-10-09 Novartis Ag Combination therapy using a chimeric antigen receptor
TWI728308B (zh) * 2018-02-01 2021-05-21 大陸商南京馴鹿醫療技術有限公司 一種結合ｂｃｍａ的嵌合抗原受體（ｃａｒ）及其應用
US11266690B2 (en) * 2018-02-01 2022-03-08 Nanjing Iaso Biotherapeutics Co., Ltd. Chimeric antigen receptor (CAR) binding to BCMA, and uses thereof
WO2019152705A1 (en) 2018-02-01 2019-08-08 Pfizer Inc. Antibodies specific for cd70 and their uses
KR102780406B1 (ko) * 2018-02-01 2025-03-17 화이자 인코포레이티드 Cd70을 표적으로 하는 키메라 항원 수용체
US20200399383A1 (en) 2018-02-13 2020-12-24 Novartis Ag Chimeric antigen receptor therapy in combination with il-15r and il15
WO2019165145A1 (en) 2018-02-21 2019-08-29 Iuve, Inc. Method for measuring systemic chronic inflammaging
SG11202007495SA (en) * 2018-02-21 2020-09-29 Celgene Corp Bcma-binding antibodies and uses thereof
JP7526101B2 (ja) 2018-03-02 2024-07-31 アロジーン セラピューティクス，インコーポレイテッド 誘導性キメラサイトカイン受容体
IT201800003464A1 (it) 2018-03-13 2019-09-13 Ospedale Pediatrico Bambino Gesu Cellule T CAR-CD30 per il trattamento di tumori CD30+
CN116514995A (zh) * 2018-04-12 2023-08-01 上海赛比曼生物科技有限公司 靶向bcma的嵌合抗原受体及其制法和应用
IL317554A (en) 2018-06-01 2025-02-01 Novartis Ag Anti-BCMA binding molecules and their uses
CN112203725A (zh) * 2018-06-13 2021-01-08 诺华股份有限公司 Bcma嵌合抗原受体及其用途
TWI838389B (zh) 2018-07-19 2024-04-11 美商再生元醫藥公司 雙特異性抗-BCMAｘ抗-CD3抗體及其用途
KR102901020B1 (ko) * 2018-07-19 2025-12-19 리제너론 파아마슈티컬스, 인크. Bcma 특이성을 갖는 키메라 항원 수용체 및 이의 용도
CA3107515A1 (en) * 2018-07-24 2020-01-30 Carsgen Therapeutics Co., Ltd. Method for tumor treatment with immune effector cells
CN110850067B (zh) * 2018-08-21 2023-08-15 上海恒润达生生物科技股份有限公司 嵌合抗原受体亲和力检测方法
SI3844267T1 (sl) 2018-08-31 2025-10-30 Novartis Ag Postopki izdelave celic, ki izražajo receptorje himernega antigena
US20210171909A1 (en) 2018-08-31 2021-06-10 Novartis Ag Methods of making chimeric antigen receptor?expressing cells
NZ773507A (en) 2018-09-27 2025-09-26 Autolus Ltd Chimeric antigen receptor
CN113614108A (zh) 2018-11-01 2021-11-05 朱诺治疗学股份有限公司 G蛋白偶合受体c类5族成员d(gprc5d)特异性嵌合抗原受体
SG11202104188VA (en) 2018-11-01 2021-05-28 Juno Therapeutics Inc Methods for treatment using chimeric antigen receptors specific for b-cell maturation antigen
WO2020112796A1 (en) * 2018-12-01 2020-06-04 Allogene Therapeutics, Inc. Chimeric antigen receptors targeting b-cell maturation antigen and methods of use thereof
CN111454358A (zh) * 2019-01-18 2020-07-28 四川科伦博泰生物医药股份有限公司 一种嵌合抗原受体及其应用
KR20210134339A (ko) 2019-02-25 2021-11-09 노파르티스 아게 바이러스 전달을 위한 메조다공성 실리카 입자 조성물
AU2020232597B2 (en) 2019-03-01 2025-08-07 Allogene Therapeutics, Inc. Constitutively active chimeric cytokine receptors
KR20210136042A (ko) 2019-03-01 2021-11-16 알로젠 테라퓨틱스 인코포레이티드 Pd-1 엑토도메인을 보유하는 키메라 사이토카인 수용체
AU2020240132A1 (en) 2019-03-21 2021-09-16 Regeneron Pharmaceuticals, Inc. Combination of IL-4/IL-13 pathway inhibitors and plasma cell ablation for treating allergy
EP3942025A1 (en) 2019-03-21 2022-01-26 Novartis AG Car-t cell therapies with enhanced efficacy
WO2020210678A1 (en) 2019-04-12 2020-10-15 Novartis Ag Methods of making chimeric antigen receptor-expressing cells
EP3959320A1 (en) 2019-04-24 2022-03-02 Novartis AG Compositions and methods for selective protein degradation
US20230174627A1 (en) * 2019-05-14 2023-06-08 Jeffrey W. FROUDE Antibodies to sudan and ebola virus
WO2020236964A1 (en) * 2019-05-20 2020-11-26 The Trustees Of The University Of Pennsylvania Engineered expression of cell surface and secreted sialidase by car t cells for increased efficacy in solid tumors
CN121293351A (zh) 2019-05-21 2026-01-09 诺华股份有限公司 Cd19结合分子及其用途
AU2020283027A1 (en) 2019-05-30 2021-12-23 Lentigen Technology, Inc. Compositions and methods for treating cancer with anti-BCMA immunotherapy
SE544015C2 (en) * 2019-06-18 2021-11-02 Tx Medic Ab Allogenic car-t cell therapy
WO2021026362A1 (en) 2019-08-07 2021-02-11 Edifice Health, Inc. Treatment of prevention of cardiovascular disease
JP2022544592A (ja) 2019-08-16 2022-10-19 ヤンセン バイオテツク，インコーポレーテツド 改善された機能を有する治療用免疫細胞及びその作製方法
BR112022003553A2 (pt) 2019-08-30 2022-05-24 Allogene Therapeutics Inc Receptores de citocina quiméricos compreendendo domínios de ligação a tgf beta
US20220370500A1 (en) * 2019-09-18 2022-11-24 Board Of Regents, The University Of Texas System A method of engineering natural killer-cells to target bcma-positive tumors
JP2023501871A (ja) * 2019-09-20 2023-01-20 上海吉倍生物技術有限公司 Ｂｃｍａ標的化抗体及びキメラ抗原受容体
EP4041397A1 (en) * 2019-10-01 2022-08-17 Epsilogen Ltd Hybrid antibody
WO2021090062A1 (en) * 2019-11-07 2021-05-14 Eisai R&D Management Co., Ltd. Anti-mesothelin eribulin antibody-drug conjugates and methods of use
MX2022006391A (es) 2019-11-26 2022-06-24 Novartis Ag Receptores de antigeno quimerico que se unen a bcma y cd19 y usos de los mismos.
WO2021146604A1 (en) 2020-01-16 2021-07-22 Allogene Therapeutics, Inc. Combination therapies of chimeric antigen receptors targeting b-cell maturation antigen and gamma secretase inhibitors
PH12022552033A1 (en) * 2020-02-24 2023-11-20 Allogene Therapeutics Inc Bcma car-t cells with enhanced activities
BR112022016633A2 (pt) 2020-02-27 2022-12-13 Novartis Ag Métodos para produzir células que expressam receptor de antígeno quimérico
PH12022552283A1 (en) 2020-02-27 2024-01-22 Novartis Ag Methods of making chimeric antigen receptor-expressing cells
GB202005216D0 (en) * 2020-04-08 2020-05-20 Autolus Ltd Cell
WO2021211382A1 (en) * 2020-04-13 2021-10-21 Edifice Health, Inc. Compounds and methods for modifying iage
GB202007842D0 (en) * 2020-05-26 2020-07-08 Quell Therapeutics Ltd Polypeptide useful in adoptive cell therapy
CA3185455A1 (en) 2020-06-11 2021-12-16 Novartis Ag Zbtb32 inhibitors and uses thereof
KR102316091B1 (ko) * 2020-06-17 2021-10-25 국립암센터 Bcma를 표적으로 하는 키메라 항원 수용체 및 이의 용도
EP4202047A4 (en) * 2020-08-20 2024-09-18 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. UNIQUE VARIABLE STRUCTURAL DOMAIN FOR BCMA BINDING AND ANTIGEN BINDING MOLECULE
IL300489A (en) 2020-08-21 2023-04-01 Novartis Ag Compositions and methods for in vivo production of CAR expressing cells
CN114106176B (zh) * 2020-09-01 2024-04-09 深圳市菲鹏生物治疗股份有限公司 Cd22抗体及其应用
TW202241935A (zh) 2020-12-18 2022-11-01 美商世紀治療股份有限公司 具有可調適受體專一性之嵌合抗原受體系統
EP4263590A1 (en) 2020-12-21 2023-10-25 Allogene Therapeutics, Inc. Protease-activating cd45-gate car
USD939199S1 (en) 2021-01-29 2021-12-28 O2 Partners, Llc Shoe insole
US20240384293A1 (en) 2021-04-27 2024-11-21 Novartis Ag Viral vector production system
CN117858901A (zh) 2021-08-20 2024-04-09 诺华股份有限公司 制备表达嵌合抗原受体的细胞的方法
EP4396159A1 (en) 2021-09-01 2024-07-10 Springworks Therapeutics, Inc. Synthesis of nirogacestat
US20230407252A1 (en) 2022-04-28 2023-12-21 Allogene Therapeutics, Inc. Methods for donor cell analysis
CN120051298A (zh) 2022-08-05 2025-05-27 朱诺治疗学股份有限公司 Gprc5d和bcma特异性嵌合抗原受体
US20240101710A1 (en) * 2022-09-19 2024-03-28 Allogene Therapeutics, Inc. B-cell maturation antigen (bcma) anti-idiotypic antibodies
EP4608983A1 (en) 2022-10-26 2025-09-03 Novartis AG Lentiviral formulations
US12173081B2 (en) 2023-03-21 2024-12-24 Biograph 55, Inc. CD19/CD38 multispecific antibodies
EP4626447A1 (en) 2023-03-31 2025-10-08 AbelZeta Inc. Bispecific chimeric antigen receptors targeting cd20 and bcma
WO2025076113A1 (en) 2023-10-05 2025-04-10 Capstan Therapeutics, Inc. Ionizable cationic lipids with conserved spacing and lipid nanoparticles
WO2025076127A1 (en) 2023-10-05 2025-04-10 Capstan Therapeutics, Inc. Constrained ionizable cationic lipids and lipid nanoparticles
WO2025160324A2 (en) 2024-01-26 2025-07-31 Regeneron Pharmaceuticals, Inc. Methods and compositions for using plasma cell depleting agents and/or b cell depleting agents to suppress host anti-aav antibody response and enable aav transduction and re-dosing
WO2025160340A2 (en) 2024-01-26 2025-07-31 Regeneron Pharmaceuticals, Inc. Combination immunosuppression for inhibiting an immune response and enabling immunogen administration and re-administration
WO2025184567A1 (en) 2024-03-01 2025-09-04 Regeneron Pharmaceuticals, Inc. Methods and compositions for re-dosing aav using anti-cd40 antagonistic antibody to suppress host anti-aav antibody response
WO2025217454A2 (en) 2024-04-11 2025-10-16 Capstan Therapeutics, Inc. Ionizable cationic lipids and lipid nanoparticles
WO2025217452A1 (en) 2024-04-11 2025-10-16 Capstan Therapeutics, Inc. Constrained ionizable cationic lipids and lipid nanoparticles

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR901228A (fr) 1943-01-16 1945-07-20 Deutsche Edelstahlwerke Ag Système d'aimant à entrefer annulaire
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4754065A (en) 1984-12-18 1988-06-28 Cetus Corporation Precursor to nucleic acid probe
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
GB8601597D0 (en) 1986-01-23 1986-02-26 Wilson R H Nucleotide sequences
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
GB8611832D0 (en) 1986-05-15 1986-06-25 Holland I B Polypeptide
US5037743A (en) 1988-08-05 1991-08-06 Zymogenetics, Inc. BAR1 secretion signal
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5858358A (en) 1992-04-07 1999-01-12 The United States Of America As Represented By The Secretary Of The Navy Methods for selectively stimulating proliferation of T cells
US6352694B1 (en) 1994-06-03 2002-03-05 Genetics Institute, Inc. Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells
US6905680B2 (en) 1988-11-23 2005-06-14 Genetics Institute, Inc. Methods of treating HIV infected subjects
US6534055B1 (en) 1988-11-23 2003-03-18 Genetics Institute, Inc. Methods for selectively stimulating proliferation of T cells
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
DE69133476T2 (de) 1990-08-29 2006-01-05 GenPharm International, Inc., Palo Alto Transgene Mäuse fähig zur Produktion heterologer Antikörper
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
CA2405246A1 (en) 1990-12-03 1992-06-11 Genentech, Inc. Enrichment method for variant proteins with alterred binding properties
US7175843B2 (en) 1994-06-03 2007-02-13 Genetics Institute, Llc Methods for selectively stimulating proliferation of T cells
US7067318B2 (en) 1995-06-07 2006-06-27 The Regents Of The University Of Michigan Methods for transfecting T cells
US6692964B1 (en) 1995-05-04 2004-02-17 The United States Of America As Represented By The Secretary Of The Navy Methods for transfecting T cells
GB9809951D0 (en) 1998-05-08 1998-07-08 Univ Cambridge Tech Binding molecules
KR20090016772A (ko) 1999-08-17 2009-02-17 바이오겐 아이덱 엠에이 인코포레이티드 Ｂａｆｆ 수용체(ｂｃｍａ), 면역조절제
KR20030032922A (ko) 2000-02-24 2003-04-26 싸이트 테라피스 인코포레이티드 세포의 동시 자극 및 농축
US7572631B2 (en) 2000-02-24 2009-08-11 Invitrogen Corporation Activation and expansion of T cells
US6867041B2 (en) 2000-02-24 2005-03-15 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
US6797514B2 (en) 2000-02-24 2004-09-28 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
AU2002238052A1 (en) * 2001-02-20 2002-09-04 Zymogenetics, Inc. Antibodies that bind both bcma and taci
US20080267965A1 (en) 2002-02-21 2008-10-30 Kalled Susan L Use of Bcma as an Immunoregulatory Agent
ES2478242T3 (es) * 2007-03-22 2014-07-21 Genentech, Inc. Anticuerpos anti IgE apoptóticos que se unen con el IgE unido a membrana
DK2406284T5 (en) 2009-03-10 2017-06-12 Biogen Ma Inc ANTI-BCMA ANTIBODIES
US20120189618A1 (en) * 2010-07-16 2012-07-26 Boehringer Ingelheim International Gmbh Superior efficacy of cd37 antibodies in cll blood samples
WO2012058458A2 (en) 2010-10-27 2012-05-03 Cellectis Sa Method for increasing the efficiency of double-strand break-induced mutagenesis
US20130273055A1 (en) 2010-11-16 2013-10-17 Eric Borges Agents and methods for treating diseases that correlate with bcma expression
AU2012264890C1 (en) * 2011-05-27 2016-03-10 Glaxo Group Limited BCMA (CD269/TNFRSF17) -binding proteins
UA112434C2 (uk) 2011-05-27 2016-09-12 Ґлаксо Ґруп Лімітед Антигензв'язувальний білок, який специфічно зв'язується з всма
TWI679212B (zh) 2011-11-15 2019-12-11 美商安進股份有限公司 針對ｂｃｍａ之e3以及ｃｄ３的結合分子
EP3689383B1 (en) * 2012-04-11 2025-12-31 The United States Of America, As Represented By The Secretary, Department of Health and Human Services Chimeric antigen receptors targeting a B lymphocyte maturation antigen
GB201206559D0 (en) * 2012-04-13 2012-05-30 Ucl Business Plc Polypeptide
UA119227C2 (uk) 2012-04-20 2019-05-27 Аптево Рісьорч Енд Девелопмент Ллс Поліпептид, що зв'язується з cd3
US20150017136A1 (en) 2013-07-15 2015-01-15 Cellectis Methods for engineering allogeneic and highly active t cell for immunotherapy
DK2893004T3 (en) 2012-09-04 2019-02-04 Cellectis MULTI-CHAIN CHEMICAL ANTIGEN RECEPTOR AND APPLICATIONS THEREOF
AU2013340799B2 (en) * 2012-11-01 2018-08-09 Max-Delbruck-Centrum Fur Molekulare Medizin (Mdc) An antibody that binds CD269 (BCMA) suitable for use in the treatment of plasma cell diseases such as multiple myeloma and autoimmune diseases
TW201425336A (zh) 2012-12-07 2014-07-01 Amgen Inc Ｂｃｍａ抗原結合蛋白質
US9243058B2 (en) 2012-12-07 2016-01-26 Amgen, Inc. BCMA antigen binding proteins
CN110981964B (zh) 2013-01-14 2023-09-15 Xencor股份有限公司 新型异二聚体蛋白
DK2953972T3 (da) 2013-02-05 2020-10-12 Engmab Sarl Fremgangsmåde til udvælgelse af antistoffer mod bcma
EP2762497A1 (en) 2013-02-05 2014-08-06 EngMab AG Bispecific antibodies against CD3epsilon and BCMA
EP3831840A1 (en) * 2013-03-15 2021-06-09 Celgene Corporation Modified t lymphocytes
AR095374A1 (es) 2013-03-15 2015-10-14 Amgen Res Munich Gmbh Moléculas de unión para bcma y cd3
CN105452287A (zh) 2013-04-17 2016-03-30 贝勒医学院 免疫抑制性TGF-β信号转换器
SG10201708896WA (en) 2013-05-13 2017-11-29 Cellectis Cd19 specific chimeric antigen receptor and uses thereof
MX2015015638A (es) * 2013-05-13 2016-10-28 Cellectis Metodos para diseñar celulas t altamente activas para inmunoterapia.
EP3004337B1 (en) 2013-05-29 2017-08-02 Cellectis Methods for engineering t cells for immunotherapy by using rna-guided cas nuclease system
GB201317929D0 (en) 2013-10-10 2013-11-27 Ucl Business Plc Chimeric antigen receptor
GB201317928D0 (en) 2013-10-10 2013-11-27 Ucl Business Plc Molecule
EP3243831A1 (en) 2014-02-27 2017-11-15 Ucl Business Plc Variants of the proliferation-inducing ligand (april)
WO2015158671A1 (en) * 2014-04-14 2015-10-22 Cellectis Bcma (cd269) specific chimeric antigen receptors for cancer immunotherapy
EP3137500A1 (en) 2014-04-30 2017-03-08 Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft Humanized antibodies against cd269 (bcma)
JP7054622B2 (ja) * 2014-07-21 2022-04-14 ノバルティス アーゲー ヒト化抗ｂｃｍａキメラ抗原受容体を使用した癌の処置
RU2747457C2 (ru) 2014-07-24 2021-05-05 Блубёрд Био, Инк. Химерные антигенные рецепторы к bcma
EP3023437A1 (en) 2014-11-20 2016-05-25 EngMab AG Bispecific antibodies against CD3epsilon and BCMA
EP3029068A1 (en) 2014-12-03 2016-06-08 EngMab AG Bispecific antibodies against CD3epsilon and BCMA for use in the treatment of diseases
KR102698738B1 (ko) 2014-12-05 2024-08-28 메모리얼 슬로안 케터링 캔서 센터 B-세포 성숙화 항원을 표적화하는 키메라 항원 수용체 및 그의 용도
HK1245801B (en) 2014-12-12 2020-05-15 2Seventy Bio, Inc. Bcma chimeric antigen receptors
JP6779909B2 (ja) 2015-01-26 2020-11-04 セレクティスＣｅｌｌｅｃｔｉｓ がん免疫治療のための抗ＣＬＬ１特異的単鎖キメラ抗原受容体（ｓｃＣＡＲ）
US10294304B2 (en) 2015-04-13 2019-05-21 Pfizer Inc. Chimeric antigen receptors targeting B-cell maturation antigen
SI3988117T1 (sl) * 2015-04-13 2025-03-31 Pfizer Inc. Terapevtska protitelesa in njihova uporaba
WO2020112796A1 (en) * 2018-12-01 2020-06-04 Allogene Therapeutics, Inc. Chimeric antigen receptors targeting b-cell maturation antigen and methods of use thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11505590B2 (en) 2016-04-08 2022-11-22 Immunocore Limited T cell receptors

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