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MX2023008809A - ATENUACIÓN O INACTIVACIÓN DE UNO O MÁS DE TAP2, NLRC5, ß2M, TRAC, RFX5, RFXAP Y RFXANK PARA MITIGAR EL RECONOCIMIENTO DE CÉLULAS T DE PRODUCTOS CELULARES ALOGÉNICOS. - Google Patents

ATENUACIÓN O INACTIVACIÓN DE UNO O MÁS DE TAP2, NLRC5, ß2M, TRAC, RFX5, RFXAP Y RFXANK PARA MITIGAR EL RECONOCIMIENTO DE CÉLULAS T DE PRODUCTOS CELULARES ALOGÉNICOS.

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Publication number
MX2023008809A
MX2023008809A MX2023008809A MX2023008809A MX2023008809A MX 2023008809 A MX2023008809 A MX 2023008809A MX 2023008809 A MX2023008809 A MX 2023008809A MX 2023008809 A MX2023008809 A MX 2023008809A MX 2023008809 A MX2023008809 A MX 2023008809A
Authority
MX
Mexico
Prior art keywords
cells
nlrc5
rfxank
rfxap
rfx5
Prior art date
Application number
MX2023008809A
Other languages
English (en)
Inventor
Blarcom Thomas John Van
Cesar Adolfo Sommer
Michael Thomas Bethune
Eric Hans Gschweng
YI Michael C
Original Assignee
Allogene Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allogene Therapeutics Inc filed Critical Allogene Therapeutics Inc
Publication of MX2023008809A publication Critical patent/MX2023008809A/es

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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K40/32—T-cell receptors [TCR]
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
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    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
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Abstract

En la presente descripción se proporcionan células inmunitarias genomanipuladas y poblaciones de estas para su administración a pacientes para tratar el cáncer (p. ej., tumores sólidos o tumores líquidos) y otras afecciones. Las células se genomanipulan para expresar funcionalmente un nivel reducido de uno o más de RFX5, NLRC5, TAP2, ß2m, TRAC, RFXAP, CIITA y RFXANK. Las células opcionalmente se genomanipulan de manera adicional para expresar una o más de una proteína adicional tal como una proteína de unión a antígenos (p. ej., un receptor quimérico para el antígeno (CAR) o receptor de células T) para dirigirse a células tumorales u otras células dañadas en el paciente y/o para expresar otros genes a un nivel reducido. También se proporcionan métodos para fabricar y usar las células genomanipuladas, composiciones y kits que las comprenden, y métodos para tratar mediante la administración de las células y las composiciones.
MX2023008809A 2021-01-29 2022-01-28 ATENUACIÓN O INACTIVACIÓN DE UNO O MÁS DE TAP2, NLRC5, ß2M, TRAC, RFX5, RFXAP Y RFXANK PARA MITIGAR EL RECONOCIMIENTO DE CÉLULAS T DE PRODUCTOS CELULARES ALOGÉNICOS. MX2023008809A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202163143748P 2021-01-29 2021-01-29
US202163176818P 2021-04-19 2021-04-19
US202263267041P 2022-01-21 2022-01-21
PCT/US2022/014393 WO2022165233A1 (en) 2021-01-29 2022-01-28 KNOCKDOWN OR KNOCKOUT OF ONE OR MORE OF TAP2, NLRC5, β2m, TRAC, RFX5, RFXAP AND RFXANK TO MITIGATE T CELL RECOGNITION OF ALLOGENEIC CELL PRODUCTS

Publications (1)

Publication Number Publication Date
MX2023008809A true MX2023008809A (es) 2023-08-04

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MX2023008809A MX2023008809A (es) 2021-01-29 2022-01-28 ATENUACIÓN O INACTIVACIÓN DE UNO O MÁS DE TAP2, NLRC5, ß2M, TRAC, RFX5, RFXAP Y RFXANK PARA MITIGAR EL RECONOCIMIENTO DE CÉLULAS T DE PRODUCTOS CELULARES ALOGÉNICOS.

Country Status (9)

Country Link
US (1) US20220251505A1 (es)
EP (1) EP4284918A1 (es)
JP (1) JP2024505075A (es)
KR (1) KR20230142470A (es)
AU (1) AU2022212130A1 (es)
CA (1) CA3204417A1 (es)
IL (1) IL303853A (es)
MX (1) MX2023008809A (es)
WO (1) WO2022165233A1 (es)

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