CL2016000816A1 - Forma de dosificación que comprende al compuesto (s)-3-(4-((4-morfolinometil)bencil)oxi)-1-oxoisoindolin-2-il)piperidin-2,6-diona, una cantidad de 90 hasta 99,9 por ciento en peso del peso total de una mezcla de almidón y lactosa como portador o excipiente, y acido esteárico como lubricante; su uso en el tratamiento de cáncer y enfermedades autoinmunes, entre otras. - Google Patents
Forma de dosificación que comprende al compuesto (s)-3-(4-((4-morfolinometil)bencil)oxi)-1-oxoisoindolin-2-il)piperidin-2,6-diona, una cantidad de 90 hasta 99,9 por ciento en peso del peso total de una mezcla de almidón y lactosa como portador o excipiente, y acido esteárico como lubricante; su uso en el tratamiento de cáncer y enfermedades autoinmunes, entre otras.Info
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- CL2016000816A1 CL2016000816A1 CL2016000816A CL2016000816A CL2016000816A1 CL 2016000816 A1 CL2016000816 A1 CL 2016000816A1 CL 2016000816 A CL2016000816 A CL 2016000816A CL 2016000816 A CL2016000816 A CL 2016000816A CL 2016000816 A1 CL2016000816 A1 CL 2016000816A1
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- excipient
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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Abstract
El objetivo buscado a través de la presente solicitud es la necesidad de proporcionar una forma de dosificación que comprenda al compuesto (S)-3-(4-((4-morfolinometil)bencil)oxi)-1-oxoisoindolin-2-il)piperidin-2,6-diona o CC-220 (compuesto A) que tenga propiedades físicas de estabilidad mejoradas, solucionando el problema de inestabilidad debido a que el compuesto A es propenso a la hidrolisis . Como solución proponen una forma de dosificación oral en forma de cápsula que comprende: i. el compuesto A o un profarmaco farmacéuticamente aceptable, sal, solvato, hidrato, clarato, estereoisómero, tautomero, o mezclas racémicas de los mismos, en una cantidad de 0,1 hasta 3 por ciento en peso del peso total de la forma de dosificación; ii. un portador o excipiente a una cantidad de 90 hasta 99,9 por ciento en peso del peso total de la forma de dosificación oral, en donde el portador o excipiente es una mezcla de almidón y lactosa; y iii. un lubricante, donde dicho lubricante es ácido esteárico. Y el uso de dicha forma de dosificación en el tratamiento de cáncer y enfermedades autoinmunes, entre otras.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361888419P | 2013-10-08 | 2013-10-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2016000816A1 true CL2016000816A1 (es) | 2017-03-10 |
Family
ID=51743584
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2016000816A CL2016000816A1 (es) | 2013-10-08 | 2016-04-08 | Forma de dosificación que comprende al compuesto (s)-3-(4-((4-morfolinometil)bencil)oxi)-1-oxoisoindolin-2-il)piperidin-2,6-diona, una cantidad de 90 hasta 99,9 por ciento en peso del peso total de una mezcla de almidón y lactosa como portador o excipiente, y acido esteárico como lubricante; su uso en el tratamiento de cáncer y enfermedades autoinmunes, entre otras. |
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| BR (1) | BR112016007729B1 (es) |
| CA (1) | CA2921436C (es) |
| CL (1) | CL2016000816A1 (es) |
| CR (1) | CR20160131A (es) |
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| IL (1) | IL244494B (es) |
| LT (1) | LT3054927T (es) |
| MX (1) | MX2016004342A (es) |
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| PE (1) | PE20160550A1 (es) |
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| SG (1) | SG11201600996UA (es) |
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| JP2013519675A (ja) | 2010-02-11 | 2013-05-30 | セルジーン コーポレイション | アリールメトキシイソインドリン誘導体、それを含む組成物、及びその使用方法 |
| US20150038511A1 (en) | 2012-08-09 | 2015-02-05 | Celgene Corporation | Treatment of immune-related and inflammatory diseases |
| ES2800026T3 (es) | 2012-08-09 | 2020-12-23 | Celgene Corp | Tratamiento de enfermedades inmunitarias e inflamatorias |
| WO2014116573A1 (en) | 2013-01-22 | 2014-07-31 | Celgene Corporation | Processes for the preparation of isotopologues of 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione and pharmaceutically acceptable salts thereof |
| TWI794885B (zh) * | 2014-05-19 | 2023-03-01 | 美商西建公司 | 全身紅斑性狼瘡之治療 |
| ITUB20160650A1 (it) * | 2016-02-11 | 2017-08-11 | Dipharma S A | Formulazioni farmaceutiche solide stabili contenenti 2-(2-nitro-4-trifluorometilbenzoil)-1,3-cicloesandione |
| CN112839658B (zh) * | 2018-10-01 | 2024-10-29 | 细胞基因公司 | 用于治疗癌症的组合疗法 |
| MX2021005366A (es) | 2018-11-08 | 2021-09-10 | Juno Therapeutics Inc | Metodos y combinaciones para el tratamiento y modulacion de celulas t. |
| EA202191904A1 (ru) * | 2019-01-09 | 2021-10-04 | Селджин Корпорейшн | Фармацевтические композиции, содержащие (s)-4-(4-(4-(((2-(2,6-диоксопиперидин-3-ил)-1-оксоизоиндолин-4-ил)окси)метил)бензил)пиперазин-1-ил)-3-фторбензонитрил и способы их применения |
| AU2020379043A1 (en) | 2019-11-07 | 2022-06-02 | Juno Therapeutics, Inc. | Combination of a T cell therapy and (S)-3-[4-(4-morpholin-4-ylmethyl-benzyloxy)-1-oxo-1,3-dihydro-isoindol-2-yl]-piperidine-2,6-dione |
| EP4069245A1 (en) * | 2019-12-02 | 2022-10-12 | Celgene Corporation | Therapy for the treatment of cancer |
| CN115916191A (zh) * | 2020-06-25 | 2023-04-04 | 新基公司 | 用组合疗法治疗癌症的方法 |
| CA3181682A1 (en) * | 2020-07-17 | 2022-01-20 | Anil Kapur | Subcutaneous telomerase inhibitor compositions and methods for using same |
| WO2024064646A1 (en) | 2022-09-20 | 2024-03-28 | Celgene Corporation | Salts and solid forms of (s)- or racemic 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione and methods of using the same |
| WO2025076472A1 (en) | 2023-10-06 | 2025-04-10 | Juno Therapeutics, Inc. | Combination therapies with a cell therapy expressing a gprc5d-targeting car and related methods and uses |
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| BRPI0518282A2 (pt) | 2004-11-23 | 2008-11-11 | Celgene Corp | uso de uma quantidade terapeuticamente ou profilaticamente efetiva de um composto imunomodulatàrio |
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| ATE502634T1 (de) | 2006-09-15 | 2011-04-15 | Celgene Corp | N-methylaminomethyl-isoindol-verbindungen und diese enthaltende zusammensetzungen und diese verwendende verfahren |
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| JP2013519675A (ja) * | 2010-02-11 | 2013-05-30 | セルジーン コーポレイション | アリールメトキシイソインドリン誘導体、それを含む組成物、及びその使用方法 |
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