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PE20180329A1 - Metodos para diagnosticar y tratar el cancer - Google Patents

Metodos para diagnosticar y tratar el cancer

Info

Publication number
PE20180329A1
PE20180329A1 PE2017002516A PE2017002516A PE20180329A1 PE 20180329 A1 PE20180329 A1 PE 20180329A1 PE 2017002516 A PE2017002516 A PE 2017002516A PE 2017002516 A PE2017002516 A PE 2017002516A PE 20180329 A1 PE20180329 A1 PE 20180329A1
Authority
PE
Peru
Prior art keywords
methods
subject
cancer
ntrk2
ntrk1
Prior art date
Application number
PE2017002516A
Other languages
English (en)
Inventor
Brian Tuch
Josh Bilenker
Original Assignee
Loxo Oncology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Loxo Oncology Inc filed Critical Loxo Oncology Inc
Publication of PE20180329A1 publication Critical patent/PE20180329A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G01N33/575—
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)

Abstract

Esta referido una serie de mutaciones puntuales diferentes en los genes: receptor de tirosina cinasa neurotrofico de tipo: NTRK1, NTRK2 y NTRK3 en muestras de biopsia de sujetos que tenian una serie de diferentes canceres. Tambien se proporcionan metodos para tratar a un sujeto que tenga cancer, metodos para seleccionar un tratamiento que incluya una cantidad terapeuticamente eficaz de un inhibidor de cinasa relacionada con tropomiosina (Trk) para un sujeto, metodos para determinar la probabilidad de que un sujeto que tiene un cancer tendra una respuesta positiva al tratamiento con un inhibidor de Trk, metodos para predecir la eficacia de un inhibidor de Trk en un sujeto que tiene un cancer, metodos para determinar el riesgo de que un sujeto desarrolle un cancer y metodos para ayudar en el diagnostico del cancer que estan basados en la identificacion de un sujeto que tiene una celula que tiene al menos una de las mutaciones puntuales en los genes NTRK1, NTRK2 y/o NTRK3 o en la determinacion de que el sujeto tiene una celula que tiene al menos una de las mutaciones puntuales en NTRK1, NTRK2 y/o NTRK3. Tambien se proporcionan kits que permiten la deteccion de al menos una de las mutaciones puntuales en NTRK1, NTRK2 y/o NTRK3. En donde el cancer se selecciona entre adenocarcinoma, carcinoma cortical de glandulas suprarrenales, entre otros.
PE2017002516A 2015-06-01 2016-06-01 Metodos para diagnosticar y tratar el cancer PE20180329A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562169443P 2015-06-01 2015-06-01

Publications (1)

Publication Number Publication Date
PE20180329A1 true PE20180329A1 (es) 2018-02-13

Family

ID=56194562

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2017002516A PE20180329A1 (es) 2015-06-01 2016-06-01 Metodos para diagnosticar y tratar el cancer

Country Status (19)

Country Link
US (2) US20180140604A1 (es)
EP (2) EP3722441A1 (es)
JP (1) JP2018526324A (es)
KR (1) KR20180021745A (es)
CN (1) CN107849615A (es)
AU (1) AU2016270803A1 (es)
BR (1) BR112017025773A2 (es)
CA (1) CA2988423A1 (es)
CL (1) CL2017003069A1 (es)
EA (1) EA201792679A1 (es)
HK (1) HK1253093A1 (es)
IL (1) IL256025A (es)
MA (2) MA44936A1 (es)
MX (1) MX2017015461A (es)
PE (1) PE20180329A1 (es)
PH (1) PH12017502200A1 (es)
SV (1) SV2017005577A (es)
TN (1) TN2017000502A1 (es)
WO (1) WO2016196671A1 (es)

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Also Published As

Publication number Publication date
MA44936A1 (fr) 2021-09-30
CN107849615A (zh) 2018-03-27
SV2017005577A (es) 2018-04-17
AU2016270803A1 (en) 2018-01-04
CL2017003069A1 (es) 2018-06-01
US20180140604A1 (en) 2018-05-24
MA41667A1 (fr) 2018-08-31
TN2017000502A1 (en) 2019-04-12
CA2988423A1 (en) 2016-12-08
MX2017015461A (es) 2018-08-15
US20220088021A1 (en) 2022-03-24
EP3722441A1 (en) 2020-10-14
JP2018526324A (ja) 2018-09-13
EP3303631A1 (en) 2018-04-11
EA201792679A1 (ru) 2018-06-29
HK1253093A1 (zh) 2019-06-06
KR20180021745A (ko) 2018-03-05
WO2016196671A1 (en) 2016-12-08
BR112017025773A2 (en) 2018-08-14
IL256025A (en) 2018-01-31
PH12017502200A1 (en) 2018-06-11

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