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MX2019005683A - Metodos para detectar mutaciones de adn mediante el uso de extraccion con puntas mitra. - Google Patents

Metodos para detectar mutaciones de adn mediante el uso de extraccion con puntas mitra.

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Publication number
MX2019005683A
MX2019005683A MX2019005683A MX2019005683A MX2019005683A MX 2019005683 A MX2019005683 A MX 2019005683A MX 2019005683 A MX2019005683 A MX 2019005683A MX 2019005683 A MX2019005683 A MX 2019005683A MX 2019005683 A MX2019005683 A MX 2019005683A
Authority
MX
Mexico
Prior art keywords
methods
cancer
detecting dna
dna mutations
mitra
Prior art date
Application number
MX2019005683A
Other languages
English (en)
Inventor
J Clarke Nigel
SANDERS Heather
Original Assignee
Quest Diagnostics Invest Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quest Diagnostics Invest Llc filed Critical Quest Diagnostics Invest Llc
Publication of MX2019005683A publication Critical patent/MX2019005683A/es

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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1058—Directional evolution of libraries, e.g. evolution of libraries is achieved by mutagenesis and screening or selection of mixed population of organisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/4875—Details of handling test elements, e.g. dispensing or storage, not specific to a particular test method
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Ecology (AREA)
  • Cell Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Optics & Photonics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

La presente divulgación proporciona métodos rápidos y no invasivos para determinar si un paciente que presenta síntomas de cáncer, o está en riesgo de cánceres hereditarios tales como cáncer de mama, cáncer de ovario, cáncer de colon o cáncer de piel, podría beneficiarse del tratamiento con uno o más agentes terapéuticos. Estos métodos se basan en detectar mutaciones relacionadas a cánceres hereditarios en muestras de fluidos biológicos secos de pequeño volumen, las cuales son recolectadas utilizando un dispositivo volumétrico absortivo de micromuestreo (por ejemplo, puntas MITRA). Los kits para usarse en la práctica de los métodos también son proporcionados.
MX2019005683A 2016-11-15 2017-11-13 Metodos para detectar mutaciones de adn mediante el uso de extraccion con puntas mitra. MX2019005683A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662422334P 2016-11-15 2016-11-15
PCT/US2017/061316 WO2018093724A1 (en) 2016-11-15 2017-11-13 Methods for detecting dna mutations using mitra tip extraction

Publications (1)

Publication Number Publication Date
MX2019005683A true MX2019005683A (es) 2019-10-30

Family

ID=62106700

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019005683A MX2019005683A (es) 2016-11-15 2017-11-13 Metodos para detectar mutaciones de adn mediante el uso de extraccion con puntas mitra.

Country Status (8)

Country Link
US (3) US11441188B2 (es)
EP (1) EP3541826B1 (es)
JP (2) JP2020501602A (es)
CN (1) CN110167951A (es)
BR (1) BR112019009794A2 (es)
CA (1) CA3044035A1 (es)
MX (1) MX2019005683A (es)
WO (1) WO2018093724A1 (es)

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BRPI0913578A2 (pt) 2008-05-14 2017-06-06 Dermtech Int diagnose de melanoma e lentigo solar por análise de ácido nucléico
WO2022221326A1 (en) * 2021-04-13 2022-10-20 Dermtech, Inc. Gene classifiers and uses thereof
ES2928773T3 (es) 2017-01-17 2022-11-22 Heparegenix Gmbh Inhibidores de proteína cinasas para fomentar la regeneración hepática o reducir o prevenir la muerte de hepatocitos
US11976332B2 (en) 2018-02-14 2024-05-07 Dermtech, Inc. Gene classifiers and uses thereof in non-melanoma skin cancers
US10656059B2 (en) 2018-03-07 2020-05-19 Alcala Pharmaceutical, Inc. Method for qualitative and quantitative multiplexing of drug analytes from biological samples
CN109402113A (zh) * 2018-11-26 2019-03-01 广东腾飞基因科技股份有限公司 基于聚苯乙烯磁珠的干血片基因组提取试剂盒及提取方法
CN109504772A (zh) * 2018-11-29 2019-03-22 张丽英 一种基于数字pcr平台pole基因突变的检测方法
US11162921B2 (en) 2019-04-01 2021-11-02 Alcala Pharmaceutical, Inc. Method for extracting pharmacogenetic DNA from biological fluid retained in a solid resin collection device
CA3153646A1 (en) * 2019-07-19 2021-01-28 Quest Diagnostics Investments Llc Methods for detecting hereditary cancers
EP3869207A1 (en) * 2020-02-24 2021-08-25 Biotage AB Large volume separation system

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EP1910562B1 (en) 2005-06-23 2010-12-08 Keygene N.V. Strategies for high throughput identification and detection of polymorphisms
WO2010054004A2 (en) * 2008-11-04 2010-05-14 Blood Cell Storage, Inc. Nucleic acid extraction on curved glass surfaces
US20120192298A1 (en) * 2009-07-24 2012-07-26 Sigma Aldrich Co. Llc Method for genome editing
WO2011155833A2 (en) 2010-06-09 2011-12-15 Keygene N.V. Combinatorial sequence barcodes for high throughput screening
SG186876A1 (en) 2010-06-30 2013-02-28 Bgi Shenzhen Co Ltd New pcr sequencing method and use thereof in hla genotyping
US20130116597A1 (en) * 2011-11-04 2013-05-09 Phenomenex, Inc. Method and apparatus for acquiring blood for testing
US10590472B2 (en) 2014-09-05 2020-03-17 Zhi Zheng Methods of detecting nucleic acids and applications thereof
WO2016134324A1 (en) 2015-02-20 2016-08-25 Neoteryx, Llc Method and apparatus for acquiring blood for testing
US20160281166A1 (en) * 2015-03-23 2016-09-29 Parabase Genomics, Inc. Methods and systems for screening diseases in subjects
EP3359950B1 (en) 2015-10-05 2020-02-12 Universiteit Gent Dried blood sample analysis
WO2017161201A1 (en) 2016-03-16 2017-09-21 Cynvenio Biosystems Inc. Cancer detection assay and related compositions, methods and systems
US20180089373A1 (en) * 2016-09-23 2018-03-29 Driver, Inc. Integrated systems and methods for automated processing and analysis of biological samples, clinical information processing and clinical trial matching

Also Published As

Publication number Publication date
EP3541826A4 (en) 2020-08-26
US11441188B2 (en) 2022-09-13
JP2020501602A (ja) 2020-01-23
BR112019009794A2 (pt) 2019-08-06
EP3541826A1 (en) 2019-09-25
US11441192B2 (en) 2022-09-13
JP2022191311A (ja) 2022-12-27
US20230078942A1 (en) 2023-03-16
US20180135135A1 (en) 2018-05-17
CA3044035A1 (en) 2018-05-24
CN110167951A (zh) 2019-08-23
WO2018093724A1 (en) 2018-05-24
US20190284639A1 (en) 2019-09-19
EP3541826B1 (en) 2023-09-27

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