PE20140865A1 - Inhibidores de la tirosina-quinasa de bruton - Google Patents
Inhibidores de la tirosina-quinasa de brutonInfo
- Publication number
- PE20140865A1 PE20140865A1 PE2014000220A PE2014000220A PE20140865A1 PE 20140865 A1 PE20140865 A1 PE 20140865A1 PE 2014000220 A PE2014000220 A PE 2014000220A PE 2014000220 A PE2014000220 A PE 2014000220A PE 20140865 A1 PE20140865 A1 PE 20140865A1
- Authority
- PE
- Peru
- Prior art keywords
- methyl
- pyridin
- tyrosine kinase
- compounds
- bruton tyrosine
- Prior art date
Links
- 102000001714 Agammaglobulinaemia Tyrosine Kinase Human genes 0.000 title abstract 3
- 108010029445 Agammaglobulinaemia Tyrosine Kinase Proteins 0.000 title abstract 3
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 title 1
- 239000005483 tyrosine kinase inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 208000006673 asthma Diseases 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical group [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE REFIERE A COMPUESTOS HETEROCICLOS DE FORMULA (I) DONDE X ES CH, CH2, N, ENTRE OTROS; R ES H, R1, ENTRE OTROS, EN DONDE R1 ES ARILO, HETEROARILO, CICLOALQUILO, ENTRE OTROS; A, Y, Y1 E Y2 SON CADA UNO CH O N; Y3 ES H O F; Y4 ES Y4a, Y4b, ENTRE OTROS, EN DONDE Y4a ES H O HALOGENO; Y4b ES ALQUILO INFERIOR OPCIONALMENTE SUSTITUIDO CON HALOGENO, HIDROXI, CN, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 6-TERT-BUTIL-8-FLUOR-2-{3-HIDROXIMETIL-4-[1-METIL-5-(1'-METIL-1',2',3',4',5',6'-HEXAHIDRO-[3,4']BIPIRIDINIL-6-ILAMINO)-6-OXO-1,6-DIHIDRO-PIRIDAZIN-3-IL]-PIRIDIN-2-IL}-2H-FTALAZIN-1-ONA; 6-TERT-BUTIL-8-FLUOR-2-(3-HIDROXIMETIL-4-{1-METIL-5-[5-((S)-1-METIL-PIRROLIDIN-2-IL)-PIRIDIN-2-ILAMINO]-6-OXO-1,6-DIHIDRO-PIRIDAZIN-3-IL}-PIRIDIN-2-IL)-2H-FTALAZIN-1-ONA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA TIROSINA QUINASA DE BRUTON (BTK) SIENDO UTILES EN EL TRATAMIENTO DE ARTRITIS REUMATOIDE, ASMA
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161524374P | 2011-08-17 | 2011-08-17 | |
| US201261649991P | 2012-05-22 | 2012-05-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20140865A1 true PE20140865A1 (es) | 2014-07-19 |
Family
ID=46690498
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2014000220A PE20140865A1 (es) | 2011-08-17 | 2012-08-14 | Inhibidores de la tirosina-quinasa de bruton |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US8889682B2 (es) |
| EP (1) | EP2744804B1 (es) |
| JP (1) | JP5823616B2 (es) |
| KR (1) | KR20140052032A (es) |
| CN (1) | CN103748088A (es) |
| AR (1) | AR087543A1 (es) |
| AU (1) | AU2012296888A1 (es) |
| BR (1) | BR112014003582A2 (es) |
| CA (1) | CA2841801A1 (es) |
| CL (1) | CL2014000350A1 (es) |
| CO (1) | CO6842020A2 (es) |
| CR (1) | CR20140027A (es) |
| EA (1) | EA024689B1 (es) |
| EC (1) | ECSP14013212A (es) |
| HK (1) | HK1197060A1 (es) |
| IL (1) | IL230561A0 (es) |
| MA (1) | MA35419B1 (es) |
| MX (1) | MX349372B (es) |
| PE (1) | PE20140865A1 (es) |
| PH (1) | PH12014500128A1 (es) |
| TW (1) | TW201311669A (es) |
| WO (1) | WO2013024078A1 (es) |
| ZA (1) | ZA201400739B (es) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013067277A1 (en) | 2011-11-03 | 2013-05-10 | Genentech, Inc. | Alkylated piperazine compounds as inhibitors of btk activity |
| EP2773632B1 (en) * | 2011-11-03 | 2017-04-12 | F. Hoffmann-La Roche AG | 8-fluorophthalazin-1(2h)-one compounds as inhibitors of btk activity |
| CN104105697B (zh) | 2011-11-03 | 2016-11-09 | 霍夫曼-拉罗奇有限公司 | 二环哌嗪化合物 |
| UA111756C2 (uk) | 2011-11-03 | 2016-06-10 | Ф. Хоффманн-Ля Рош Аг | Сполуки гетероарилпіридону та азапіридону як інгібітори тирозинкінази брутона |
| WO2013157021A1 (en) | 2012-04-20 | 2013-10-24 | Advinus Therapeutics Limited | Bicyclic compounds, compositions and medicinal applications thereof |
| CA2869954C (en) | 2012-04-20 | 2023-01-03 | Advinus Therapeutics Limited | Substituted hetero-bicyclic compounds, compositions and medicinal applications thereof in medical conditions related to modulation of bruton's tyrosine kinase activity |
| EP3550031A1 (en) | 2012-07-24 | 2019-10-09 | Pharmacyclics, LLC | Mutations associated with resistance to inhibitors of bruton's tyrosine kinase (btk) |
| BR112015002590A2 (pt) | 2012-08-10 | 2019-08-06 | Boehringer Ingelheim Int | compostos heteroaromáticos como inibidores de tirosina cinase de bruton (btk) |
| MX2015006162A (es) * | 2012-11-16 | 2015-08-14 | Hoffmann La Roche | Inhibidores de la tirosina-cinasa de bruton. |
| KR20150075115A (ko) * | 2012-11-30 | 2015-07-02 | 에프. 호프만-라 로슈 아게 | 브루톤 티로신 키나제의 억제제 |
| KR101737724B1 (ko) | 2013-03-05 | 2017-05-29 | 에프. 호프만-라 로슈 아게 | 브루톤 티로신 키나아제의 억제제 |
| CN104177338B (zh) * | 2013-05-22 | 2018-04-03 | 南京勇山生物科技有限公司 | 一类布鲁顿激酶抑制剂 |
| HK1214820A1 (zh) * | 2013-07-03 | 2016-08-05 | 豪夫迈．罗氏有限公司 | 杂芳基吡啶酮和氮杂-吡啶酮酰胺化合物 |
| WO2015012149A1 (ja) | 2013-07-26 | 2015-01-29 | カルナバイオサイエンス株式会社 | 新規トリアジン誘導体 |
| AU2014322239A1 (en) * | 2013-09-20 | 2016-04-14 | Carna Biosciences, Inc. | Novel triazine derivative |
| WO2015082583A1 (en) | 2013-12-05 | 2015-06-11 | F. Hoffmann-La Roche Ag | Heteroaryl pyridone and aza-pyridone compounds with electrophilic functionality |
| EP3042903B1 (en) | 2015-01-06 | 2019-08-14 | Impetis Biosciences Ltd. | Substituted hetero-bicyclic compounds, compositions and medicinal applications thereof |
| ES2738630T3 (es) | 2015-01-22 | 2020-01-24 | Sanofi Aventis Deutschland | Procedimiento para la producción de 2-[4-(ciclopropanocarbonil)fenil]-2-metil-propanonitrilo |
| EP3365335B1 (en) | 2015-10-23 | 2024-02-14 | Array Biopharma, Inc. | 2-aryl- and 2-heteroaryl-substituted 2-pyridazin-3(2h)-one compounds as inhibitors of fgfr tyrosine kinases |
| EP3877371A4 (en) | 2018-11-07 | 2022-07-27 | Dana-Farber Cancer Institute, Inc. | IMIDAZOPYRIDINE DERIVATIVES AND AZA-IMIDAZOPYRIDINE DERIVATIVES AS JANUS KINASE 2 INHIBITORS AND USES THEREOF |
| EP3876939A4 (en) | 2018-11-07 | 2022-08-10 | Dana-Farber Cancer Institute, Inc. | Benzothiazole derivatives and 7-aza-benzothiazole derivatives as janus kinase 2 inhibitors and uses thereof |
| WO2020097396A1 (en) | 2018-11-07 | 2020-05-14 | Dana-Farber Cancer Institute, Inc. | Benzimidazole derivatives and aza-benzimidazole derivatives as janus kinase 2 inhibitors and uses thereof |
| JP2022515198A (ja) | 2018-12-19 | 2022-02-17 | アレイ バイオファーマ インコーポレイテッド | ＦＧＦＲチロシンキナーゼの阻害剤としての置換ピラゾロ［１，５－ａ］ピリジン化合物 |
| WO2020131674A1 (en) | 2018-12-19 | 2020-06-25 | Array Biopharma Inc. | 7-((3,5-dimethoxyphenyl)amino)quinoxaline derivatives as fgfr inhibitors for treating cancer |
| CN115996917B (zh) | 2020-05-06 | 2025-10-28 | 艾捷斯治疗公司 | 作为jak2抑制剂的6-杂芳基氧基苯并咪唑和氮杂苯并咪唑 |
| US12043632B2 (en) | 2020-12-23 | 2024-07-23 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors |
| WO2023009709A1 (en) * | 2021-07-29 | 2023-02-02 | Ajax Therapeutics, Inc. | Pyrazolo piperazines as jak2 inhibitors |
| CA3234638A1 (en) | 2021-11-09 | 2023-05-19 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors |
| TW202325289A (zh) | 2021-11-09 | 2023-07-01 | 美商雅捷可斯治療公司 | Ｊａｋ２抑制劑之形式及組合物 |
| CN115073299B (zh) * | 2022-06-14 | 2024-06-25 | 爱斯特（成都）生物制药股份有限公司 | 一种制备2-氟-3-三氟甲基苯胺的方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7683064B2 (en) * | 2008-02-05 | 2010-03-23 | Roche Palo Alto Llc | Inhibitors of Bruton's tyrosine kinase |
| MY158411A (en) * | 2008-02-05 | 2016-10-14 | Hoffmann La Roche | Novel pyridinones and pyridazinones |
| WO2009156284A1 (en) | 2008-06-24 | 2009-12-30 | F. Hoffmann-La Roche Ag | Novel substituted pyridin-2-ones and pyridazin-3-ones |
| US8299077B2 (en) * | 2009-03-02 | 2012-10-30 | Roche Palo Alto Llc | Inhibitors of Bruton's tyrosine kinase |
| AR082590A1 (es) * | 2010-08-12 | 2012-12-19 | Hoffmann La Roche | Inhibidores de la tirosina-quinasa de bruton |
| EP2773632B1 (en) * | 2011-11-03 | 2017-04-12 | F. Hoffmann-La Roche AG | 8-fluorophthalazin-1(2h)-one compounds as inhibitors of btk activity |
| EP2788020A4 (en) * | 2011-12-05 | 2015-04-29 | Immunomedics Inc | THERAPEUTIC USE OF ANTI-CD22 ANTIBODIES FOR THE INDUCTION OF TROGO CYTOSIS |
-
2012
- 2012-08-14 CA CA2841801A patent/CA2841801A1/en active Pending
- 2012-08-14 HK HK14110443.6A patent/HK1197060A1/xx unknown
- 2012-08-14 EP EP12748200.8A patent/EP2744804B1/en not_active Not-in-force
- 2012-08-14 TW TW101129401A patent/TW201311669A/zh unknown
- 2012-08-14 PH PH1/2014/500128A patent/PH12014500128A1/en unknown
- 2012-08-14 PE PE2014000220A patent/PE20140865A1/es not_active Application Discontinuation
- 2012-08-14 MX MX2014001653A patent/MX349372B/es active IP Right Grant
- 2012-08-14 CN CN201280038959.3A patent/CN103748088A/zh active Pending
- 2012-08-14 KR KR1020147006816A patent/KR20140052032A/ko not_active Ceased
- 2012-08-14 JP JP2014525423A patent/JP5823616B2/ja not_active Expired - Fee Related
- 2012-08-14 BR BR112014003582A patent/BR112014003582A2/pt not_active IP Right Cessation
- 2012-08-14 WO PCT/EP2012/065844 patent/WO2013024078A1/en not_active Ceased
- 2012-08-14 EA EA201490452A patent/EA024689B1/ru not_active IP Right Cessation
- 2012-08-14 AU AU2012296888A patent/AU2012296888A1/en not_active Abandoned
- 2012-08-15 AR ARP120102984A patent/AR087543A1/es unknown
- 2012-08-16 US US13/586,958 patent/US8889682B2/en not_active Expired - Fee Related
-
2013
- 2013-12-30 CO CO13303019A patent/CO6842020A2/es not_active Application Discontinuation
-
2014
- 2014-01-20 CR CR20140027A patent/CR20140027A/es unknown
- 2014-01-20 IL IL230561A patent/IL230561A0/en unknown
- 2014-01-30 ZA ZA2014/00739A patent/ZA201400739B/en unknown
- 2014-02-12 CL CL2014000350A patent/CL2014000350A1/es unknown
- 2014-02-17 EC ECSP14013212 patent/ECSP14013212A/es unknown
- 2014-02-26 MA MA36783A patent/MA35419B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CO6842020A2 (es) | 2014-01-20 |
| WO2013024078A1 (en) | 2013-02-21 |
| MX2014001653A (es) | 2014-03-21 |
| BR112014003582A2 (pt) | 2017-03-14 |
| EA201490452A1 (ru) | 2014-05-30 |
| JP2014521734A (ja) | 2014-08-28 |
| EP2744804B1 (en) | 2017-05-17 |
| CR20140027A (es) | 2014-03-13 |
| EA024689B1 (ru) | 2016-10-31 |
| CN103748088A (zh) | 2014-04-23 |
| AR087543A1 (es) | 2014-04-03 |
| JP5823616B2 (ja) | 2015-11-25 |
| US20130045965A1 (en) | 2013-02-21 |
| CA2841801A1 (en) | 2013-02-21 |
| KR20140052032A (ko) | 2014-05-02 |
| TW201311669A (zh) | 2013-03-16 |
| ECSP14013212A (es) | 2014-03-31 |
| CL2014000350A1 (es) | 2014-08-22 |
| ZA201400739B (en) | 2016-01-27 |
| EP2744804A1 (en) | 2014-06-25 |
| MA35419B1 (fr) | 2014-09-01 |
| MX349372B (es) | 2017-07-26 |
| AU2012296888A1 (en) | 2014-01-23 |
| IL230561A0 (en) | 2014-03-31 |
| HK1197060A1 (en) | 2015-01-02 |
| PH12014500128A1 (en) | 2014-02-24 |
| US8889682B2 (en) | 2014-11-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |