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PE20140502A1 - Pirimidinas sustituidas de diaminocarboxamida y diaminocarbonitrilo, composiciones de las mismas y metodos de tratamiento con las mismas - Google Patents

Pirimidinas sustituidas de diaminocarboxamida y diaminocarbonitrilo, composiciones de las mismas y metodos de tratamiento con las mismas

Info

Publication number
PE20140502A1
PE20140502A1 PE2013002388A PE2013002388A PE20140502A1 PE 20140502 A1 PE20140502 A1 PE 20140502A1 PE 2013002388 A PE2013002388 A PE 2013002388A PE 2013002388 A PE2013002388 A PE 2013002388A PE 20140502 A1 PE20140502 A1 PE 20140502A1
Authority
PE
Peru
Prior art keywords
same
diaminocarbonitrile
diaminocarboxamide
treatment
compositions
Prior art date
Application number
PE2013002388A
Other languages
English (en)
Inventor
Brydon L Bennett
Jan Elsner
Paul Erdman
Robert Hilgraf
Laurie Ann Lebrun
Meg Mccarrick
Mehran F Moghaddam
Mark A Nagy
Stephen Norris
David A Paisner
Marianne Sloss
William J Romanow
Yoshitaka Satoh
Jayashree Tikhe
Won Hyung Yoon
Mercedes Delgado
Original Assignee
Signal Pharm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Signal Pharm Llc filed Critical Signal Pharm Llc
Publication of PE20140502A1 publication Critical patent/PE20140502A1/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
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    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/38—One sulfur atom
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    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE PIRIMIDINAS SUSTITUIDAS DE DIAMINOCARBOXAMIDA Y DIAMINOCARBONITRILO DE FORMULA (I) DONDE R1 ES ALQUILO(C1-C8), CICLOALQUILO, HETEROCICLILO NO AROMATICO, ENTRE OTROS; R2 ES ALQUILO(C1-C8), CICLOALQUILO, ALQUILCICLOALQUILO O HETEROCICLILO NO AROMATICO. SON COMPUESTOS PREFERIDOS: 4-((1R,3R)-3-HIDROXICICLOHEXILAMINO)-2-((1R,4R)-4-METOXICICLOHEXILAMINO)PIRIMIDINA-5-CARBOXAMIDA; 2-((1R,4S)-4-ETOXICICLOHEXILAMINO)-4-((1S,2S)-2-HIDROXICICLOPENTILAMINO)PIRIMIDINA-5-CARBOXAMIDA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA QUINASA JNK SIENDO UTILES EN EL TRATAMIENTO DE ESTEATOHEPATITIS NO ALCOHOLICA, HEPATITIS, CIRROSIS
PE2013002388A 2011-04-22 2012-04-20 Pirimidinas sustituidas de diaminocarboxamida y diaminocarbonitrilo, composiciones de las mismas y metodos de tratamiento con las mismas PE20140502A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161478076P 2011-04-22 2011-04-22
US201161555339P 2011-11-03 2011-11-03

Publications (1)

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PE20140502A1 true PE20140502A1 (es) 2014-05-02

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AU2012245387A1 (en) 2013-03-28
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AU2012245387B2 (en) 2015-07-09
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AU2012245387C1 (en) 2016-05-05
BR112013022813A2 (pt) 2016-08-02
US10919865B2 (en) 2021-02-16
SI2699553T1 (sl) 2024-03-29
TWI548621B (zh) 2016-09-11
ZA201306471B (en) 2014-12-23
US10040770B2 (en) 2018-08-07
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