HK1197060A1 - Inhibitors of bruton's tyrosine kinase - Google Patents

Inhibitors of bruton's tyrosine kinase Download PDF

Info

Publication number: HK1197060A1
Authority: HK; Hong Kong
Prior art keywords: methyl; pyridin; oxo; ylamino; tert
Prior art date: 2011-08-17

Application number

HK14110443.6A

Other languages

English (en)

Chinese (zh)

Inventor

Christine Brotherton-Pleiss

Saul Jaime-Figueroa

Francisco Javier Lopez-Tapia

Yan Lou

Timothy D. Owens

Original Assignee

F. Hoffmann-La Roche Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2011-08-17

Filing date

2012-08-14

Publication date

2015-01-02

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46690498&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1197060(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2012-08-14 Application filed by F. Hoffmann-La Roche Ag filed Critical F. Hoffmann-La Roche Ag

2015-01-02 Publication of HK1197060A1 publication Critical patent/HK1197060A1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Rheumatology (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

HK14110443.6A 2011-08-17 2012-08-14 Inhibitors of bruton's tyrosine kinase HK1197060A1 (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US201161524374P	2011-08-17	2011-08-17
US61/524,374		2011-08-17
US201261649991P	2012-05-22	2012-05-22
US61/649,991		2012-05-22
PCT/EP2012/065844 WO2013024078A1 (en)	2011-08-17	2012-08-14	Inhibitors of bruton's tyrosine kinase

Publications (1)

Publication Number	Publication Date
HK1197060A1 true HK1197060A1 (en)	2015-01-02

Family

ID=46690498

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HK14110443.6A HK1197060A1 (en)	2011-08-17	2012-08-14	Inhibitors of bruton's tyrosine kinase

Country Status (23)

Country	Link
US (1)	US8889682B2 (xx)
EP (1)	EP2744804B1 (xx)
JP (1)	JP5823616B2 (xx)
KR (1)	KR20140052032A (xx)
CN (1)	CN103748088A (xx)
AR (1)	AR087543A1 (xx)
AU (1)	AU2012296888A1 (xx)
BR (1)	BR112014003582A2 (xx)
CA (1)	CA2841801A1 (xx)
CL (1)	CL2014000350A1 (xx)
CO (1)	CO6842020A2 (xx)
CR (1)	CR20140027A (xx)
EA (1)	EA024689B1 (xx)
EC (1)	ECSP14013212A (xx)
HK (1)	HK1197060A1 (xx)
IL (1)	IL230561A0 (xx)
MA (1)	MA35419B1 (xx)
MX (1)	MX349372B (xx)
PE (1)	PE20140865A1 (xx)
PH (1)	PH12014500128A1 (xx)
TW (1)	TW201311669A (xx)
WO (1)	WO2013024078A1 (xx)
ZA (1)	ZA201400739B (xx)

Families Citing this family (30)

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Publication number	Priority date	Publication date	Assignee	Title
JP5976826B2 (ja) *	2011-11-03	2016-08-24	エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト	Ｂｔｋ活性阻害剤としての８−フルオロフタラジン−１（２ｈ）−オン化合物
RU2628616C2 (ru)	2011-11-03	2017-08-21	Ф. Хоффманн-Ля Рош Аг	Бициклические соединения пиперазина
UA111756C2 (uk)	2011-11-03	2016-06-10	Ф. Хоффманн-Ля Рош Аг	Сполуки гетероарилпіридону та азапіридону як інгібітори тирозинкінази брутона
TW201326171A (zh)	2011-11-03	2013-07-01	Genentech Inc	烷基化哌□化合物
JP6182593B2 (ja)	2012-04-20	2017-08-16	アドヴィーナスセラピューティクスリミテッド	置換ヘテロ二環化合物、組成物及び医薬並びにそれらの用途
WO2013157021A1 (en)	2012-04-20	2013-10-24	Advinus Therapeutics Limited	Bicyclic compounds, compositions and medicinal applications thereof
MX2015001081A (es)	2012-07-24	2015-10-14	Pharmacyclics Inc	Mutaciones asociadas a resistencia a inhibidores de la tirosina cinasa de bruton (btk).
WO2014025976A1 (en)	2012-08-10	2014-02-13	Boehringer Ingelheim International Gmbh	Heteroaromatic compounds as bruton's tyrosine kinase (btk) inhibitors
EP2920162B1 (en) *	2012-11-16	2017-04-19	F. Hoffmann-La Roche AG	Inhibitors of bruton's tyrosine kinase
CN104968346B (zh) *	2012-11-30	2017-06-27	弗·哈夫曼-拉罗切有限公司	酪氨酸蛋白激酶抑制剂
RU2618529C2 (ru) *	2013-03-05	2017-05-04	Ф. Хоффманн-Ля Рош Аг	Ингибиторы тирозинкиназы брутона
CN104177338B (zh) *	2013-05-22	2018-04-03	南京勇山生物科技有限公司	一类布鲁顿激酶抑制剂
MX2015018038A (es) *	2013-07-03	2016-03-16	Hoffmann La Roche	Compuestos de heteroaril-piridona y aza-piridona-amida.
CA2919068C (en)	2013-07-26	2018-03-20	Carna Biosciences, Inc.	Triazine derivative
US20160221991A1 (en) *	2013-09-20	2016-08-04	Carna Biosciences, Inc.	Novel triazine derivative
JP6275846B2 (ja)	2013-12-05	2018-02-07	エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト	求電子性官能基を有するヘテロアリールピリドン及びアザ−ピリドン化合物
EP3042903B1 (en)	2015-01-06	2019-08-14	Impetis Biosciences Ltd.	Substituted hetero-bicyclic compounds, compositions and medicinal applications thereof
CN107428678B (zh)	2015-01-22	2021-01-01	赛诺菲-安万特德国有限公司	用于制备2-[4-(环丙烷羰基)苯基]-2-甲基-丙腈的方法
MX382526B (es)	2015-10-23	2025-03-13	Array Biopharma Inc	Compuestos de 2-piridazin-3(2h)-ona 2-aril sustituidas y 2-heteroaril sustituidas como inhibidores de las tirosina quinasas fgfr
EP3876939A4 (en)	2018-11-07	2022-08-10	Dana-Farber Cancer Institute, Inc.	Benzothiazole derivatives and 7-aza-benzothiazole derivatives as janus kinase 2 inhibitors and uses thereof
WO2020097396A1 (en)	2018-11-07	2020-05-14	Dana-Farber Cancer Institute, Inc.	Benzimidazole derivatives and aza-benzimidazole derivatives as janus kinase 2 inhibitors and uses thereof
US12509455B2 (en)	2018-11-07	2025-12-30	Dana-Farber Cancer Institute, Inc.	Imidazopyridine derivatives and aza-imidazopyridine derivatives as Janus kinase 2 inhibitors and uses thereof
US12180207B2 (en)	2018-12-19	2024-12-31	Array Biopharma Inc.	Substituted pyrazolo[1,5-a]pyridine compounds as inhibitors of FGFR tyrosine kinases
JP2022515197A (ja)	2018-12-19	2022-02-17	アレイバイオファーマインコーポレイテッド	がんを治療するためのｆｇｆｒ阻害剤としての７－（（３，５－ジメトキシフェニル）アミノ）キノキサリン誘導体
CA3181537A1 (en)	2020-05-06	2021-11-11	Ajax Therapeutics, Inc.	6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors
EP4267574B1 (en)	2020-12-23	2025-04-23	Ajax Therapeutics, Inc.	6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors
WO2023009709A1 (en) *	2021-07-29	2023-02-02	Ajax Therapeutics, Inc.	Pyrazolo piperazines as jak2 inhibitors
US12162881B2 (en)	2021-11-09	2024-12-10	Ajax Therapeutics, Inc.	Forms and compositions of inhibitors of JAK2
WO2023086319A1 (en)	2021-11-09	2023-05-19	Ajax Therapeutics, Inc.	6-he tero aryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors
CN115073299B (zh) *	2022-06-14	2024-06-25	爱斯特（成都）生物制药股份有限公司	一种制备2-氟-3-三氟甲基苯胺的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP5259739B2 (ja) *	2008-02-05	2013-08-07	エフ．ホフマン−ラロシュアーゲー	新規ピリジノン及びピリダジノン
US7683064B2 (en) *	2008-02-05	2010-03-23	Roche Palo Alto Llc	Inhibitors of Bruton's tyrosine kinase
MX2010013191A (es)	2008-06-24	2010-12-17	Hoffmann La Roche	Nuevas piridin-3-onas y piridazin-3-onas sustituidas.
US8299077B2 (en) *	2009-03-02	2012-10-30	Roche Palo Alto Llc	Inhibitors of Bruton's tyrosine kinase
AR082590A1 (es) *	2010-08-12	2012-12-19	Hoffmann La Roche	Inhibidores de la tirosina-quinasa de bruton
JP5976826B2 (ja) *	2011-11-03	2016-08-24	エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト	Ｂｔｋ活性阻害剤としての８−フルオロフタラジン−１（２ｈ）−オン化合物
WO2013085893A1 (en) *	2011-12-05	2013-06-13	Immunomedics, Inc.	Therapeutic use of anti-cd22 antibodies for inducing trogocytosis

2012
- 2012-08-14 CN CN201280038959.3A patent/CN103748088A/zh active Pending
- 2012-08-14 PH PH1/2014/500128A patent/PH12014500128A1/en unknown
- 2012-08-14 HK HK14110443.6A patent/HK1197060A1/xx unknown
- 2012-08-14 BR BR112014003582A patent/BR112014003582A2/pt not_active IP Right Cessation
- 2012-08-14 KR KR1020147006816A patent/KR20140052032A/ko not_active Ceased
- 2012-08-14 EA EA201490452A patent/EA024689B1/ru not_active IP Right Cessation
- 2012-08-14 CA CA2841801A patent/CA2841801A1/en active Pending
- 2012-08-14 WO PCT/EP2012/065844 patent/WO2013024078A1/en not_active Ceased
- 2012-08-14 AU AU2012296888A patent/AU2012296888A1/en not_active Abandoned
- 2012-08-14 PE PE2014000220A patent/PE20140865A1/es not_active Application Discontinuation
- 2012-08-14 EP EP12748200.8A patent/EP2744804B1/en not_active Not-in-force
- 2012-08-14 MX MX2014001653A patent/MX349372B/es active IP Right Grant
- 2012-08-14 JP JP2014525423A patent/JP5823616B2/ja not_active Expired - Fee Related
- 2012-08-14 TW TW101129401A patent/TW201311669A/zh unknown
- 2012-08-15 AR ARP120102984A patent/AR087543A1/es unknown
- 2012-08-16 US US13/586,958 patent/US8889682B2/en not_active Expired - Fee Related
2013
- 2013-12-30 CO CO13303019A patent/CO6842020A2/es not_active Application Discontinuation
2014
- 2014-01-20 IL IL230561A patent/IL230561A0/en unknown
- 2014-01-20 CR CR20140027A patent/CR20140027A/es unknown
- 2014-01-30 ZA ZA2014/00739A patent/ZA201400739B/en unknown
- 2014-02-12 CL CL2014000350A patent/CL2014000350A1/es unknown
- 2014-02-17 EC ECSP14013212 patent/ECSP14013212A/es unknown
- 2014-02-26 MA MA36783A patent/MA35419B1/fr unknown

Also Published As

Publication number	Publication date
KR20140052032A (ko)	2014-05-02
PH12014500128A1 (en)	2014-02-24
EA201490452A1 (ru)	2014-05-30
WO2013024078A1 (en)	2013-02-21
AU2012296888A1 (en)	2014-01-23
ZA201400739B (en)	2016-01-27
CO6842020A2 (es)	2014-01-20
EP2744804A1 (en)	2014-06-25
CN103748088A (zh)	2014-04-23
BR112014003582A2 (pt)	2017-03-14
ECSP14013212A (es)	2014-03-31
JP5823616B2 (ja)	2015-11-25
CA2841801A1 (en)	2013-02-21
US8889682B2 (en)	2014-11-18
PE20140865A1 (es)	2014-07-19
CL2014000350A1 (es)	2014-08-22
EP2744804B1 (en)	2017-05-17
MX2014001653A (es)	2014-03-21
CR20140027A (es)	2014-03-13
MA35419B1 (fr)	2014-09-01
MX349372B (es)	2017-07-26
US20130045965A1 (en)	2013-02-21
JP2014521734A (ja)	2014-08-28
IL230561A0 (en)	2014-03-31
EA024689B1 (ru)	2016-10-31
AR087543A1 (es)	2014-04-03
TW201311669A (zh)	2013-03-16

Publication	Publication Date	Title
HK1197060A1 (en)	2015-01-02	Inhibitors of bruton's tyrosine kinase
EP2603500B1 (en)	2014-11-19	Inhibitors of bruton's tyrosine kinase
EP2709997B1 (en)	2016-06-29	Inhibitors of bruton's tyrosine kinase
US8299077B2 (en)	2012-10-30	Inhibitors of Bruton's tyrosine kinase
EP2242749B1 (en)	2013-04-10	Novel pyridinones and pyridazinones
US9499548B2 (en)	2016-11-22	Inhibitors of bruton's tyrosine kinase
KR101673728B1 (ko)	2016-11-07	브루톤 티로신 키나아제의 억제제
HK1186186B (en)	2016-03-18	Inhibitors of bruton's tyrosine kinase
HK1194381B (en)	2016-04-15	Inhibitors of bruton's tyrosine kinase
HK1164859B (en)	2016-02-19	Inhibitors of bruton's tyrosine kinase