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PE20100733A1 - Derivados de tiadiazolidinona como inhibidores de ptpasas - Google Patents

Derivados de tiadiazolidinona como inhibidores de ptpasas

Info

Publication number
PE20100733A1
PE20100733A1 PE2010000531A PE2010000531A PE20100733A1 PE 20100733 A1 PE20100733 A1 PE 20100733A1 PE 2010000531 A PE2010000531 A PE 2010000531A PE 2010000531 A PE2010000531 A PE 2010000531A PE 20100733 A1 PE20100733 A1 PE 20100733A1
Authority
PE
Peru
Prior art keywords
ptpase
thadiazolidin
ona
naphthalen
dioxo
Prior art date
Application number
PE2010000531A
Other languages
English (en)
Inventor
David Barnes
Gregory Raymond Bebernitz
Gary Mark Coppola
Katsumasa Nakajima
Travis Stams
Sidney Wolf Topiol
Thalaththani Ralalage Vedananda
James Richard Wareing
Original Assignee
Novartis Ag
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Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37950917&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20100733(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20100733A1 publication Critical patent/PE20100733A1/es

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    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
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Abstract

REFERIDA A UN DERIVADO DE TIADIAZOLIDINONA DE FORMULA (I), DONDE Q JUNTO CON LOS ATOMOS DE CARBONO A LOS QUE ESTA UNIDO FORMA UN ANILLO TAL COMO NAFTALENO, INDOL, INDANO, ENTRE OTROS; R1 ES H, C(O)-FENILO, C(O)-C(CH3)3; R2, R3, R4 Y R5 SON H, HIDROXILO, HALOGENO, CIANO, NITRO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 5-(3,6-DIHIDROXI-NAFTALEN-2-IL)-1,1-DIOXO-1,2,5-TIADIAZOLIDIN-3-ONA; 5-(7-BROMO-3-HIDROXI-NAFTALEN-2-IL)-1,1-DIOXO-1,2,5-TIADIAZOLIDIN-3-ONA; 5-(7-ETIL-3-HIDROXI-NAFTALEN-2-IL)-1,1-DIOXO-1,2,5-TIADIAZOLIDIN-3-ONA; ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA FOSFATASA DE PROTEINA TIROSINA (PTPasa), PARTICULARMENTE, PTPasa-1B Y PTPasa DE CELULAS-T (TC PTP) Y SON UTILES EN EL TRATAMIENTO DE RESISTENCIA A LA INSULINA, INTOLERANCIA A LA GLUCOSA, OBESIDAD, DIABETES MELLITUS, ENTRE OTRAS
PE2010000531A 2005-12-08 2006-12-06 Derivados de tiadiazolidinona como inhibidores de ptpasas PE20100733A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US74857305P 2005-12-08 2005-12-08

Publications (1)

Publication Number Publication Date
PE20100733A1 true PE20100733A1 (es) 2010-10-29

Family

ID=37950917

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2010000531A PE20100733A1 (es) 2005-12-08 2006-12-06 Derivados de tiadiazolidinona como inhibidores de ptpasas
PE2006001571A PE20071031A1 (es) 2005-12-08 2006-12-06 Derivados de tiadiazolidinona como inhibidores de ptpasas

Family Applications After (1)

Application Number Title Priority Date Filing Date
PE2006001571A PE20071031A1 (es) 2005-12-08 2006-12-06 Derivados de tiadiazolidinona como inhibidores de ptpasas

Country Status (26)

Country Link
US (1) US7700633B2 (es)
EP (1) EP1963292B1 (es)
JP (1) JP2009519248A (es)
KR (1) KR20080074969A (es)
CN (1) CN101326173A (es)
AR (1) AR056838A1 (es)
AT (1) ATE546440T1 (es)
AU (1) AU2006321905B2 (es)
BR (1) BRPI0619600A2 (es)
CA (1) CA2629857A1 (es)
CR (1) CR10049A (es)
EC (1) ECSP088506A (es)
ES (1) ES2381280T3 (es)
IL (1) IL191549A0 (es)
MA (1) MA30202B1 (es)
NO (1) NO20083031L (es)
NZ (1) NZ568243A (es)
PE (2) PE20100733A1 (es)
PL (1) PL1963292T3 (es)
PT (1) PT1963292E (es)
RU (1) RU2008127254A (es)
TN (1) TNSN08249A1 (es)
TW (1) TW200732315A (es)
UA (1) UA94724C2 (es)
WO (1) WO2007067615A2 (es)
ZA (1) ZA200804074B (es)

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CN118525016A (zh) * 2021-11-11 2024-08-20 卡里科生命科学有限责任公司 蛋白酪氨酸磷酸酶抑制剂及其使用方法
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WO2023150523A1 (en) * 2022-02-02 2023-08-10 Nerio Therapeutics, Inc. Protein tyrosine phosphatase inhibitors and uses thereof
WO2023150535A1 (en) * 2022-02-02 2023-08-10 Nerio Therapeutics, Inc. Protein tyrosine phosphatase inhibitors and uses thereof
CN119790052A (zh) * 2022-09-13 2025-04-08 金橘生物科技公司 苯并稠合的n-杂环及其用途
WO2024067802A1 (zh) * 2022-09-30 2024-04-04 深圳众格生物科技有限公司 蛋白酪氨酸磷酸酶抑制剂及其制备方法和医药用途
WO2024141015A1 (en) * 2022-12-30 2024-07-04 Insilico Medicine Ip Limited Protein tyrosine phosphatase inhibitors and uses thereof
CN118852335A (zh) * 2023-04-28 2024-10-29 中科中山药物创新研究院 噻二唑烷酮衍生物及其制备方法和应用
CN116496248B (zh) * 2023-05-06 2025-09-02 江苏艾科姆检测有限公司 一种溴氰虫酰胺杂质的合成方法
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CN120004876A (zh) * 2023-11-16 2025-05-16 英矽智能科技(上海)有限公司 蛋白酪氨酸磷酸酶抑制剂及其应用
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CN101321743A (zh) * 2005-12-08 2008-12-10 诺瓦提斯公司 作为ptp-酶抑制剂的1,1,3-三氧代-1,2,5-噻二唑烷和它们的用途
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ES2381280T3 (es) 2012-05-24
AU2006321905B2 (en) 2011-08-11
CA2629857A1 (en) 2007-06-14
US20080262050A1 (en) 2008-10-23
AR056838A1 (es) 2007-10-24
PL1963292T3 (pl) 2012-07-31
NO20083031L (no) 2008-08-28
KR20080074969A (ko) 2008-08-13
BRPI0619600A2 (pt) 2011-10-11
WO2007067615A2 (en) 2007-06-14
CN101326173A (zh) 2008-12-17
EP1963292A2 (en) 2008-09-03
US7700633B2 (en) 2010-04-20
CR10049A (es) 2008-08-25
JP2009519248A (ja) 2009-05-14
IL191549A0 (en) 2008-12-29
WO2007067615A3 (en) 2007-11-15
PE20071031A1 (es) 2007-11-15
PT1963292E (pt) 2012-05-10
ECSP088506A (es) 2008-07-30
AU2006321905A1 (en) 2007-06-14
TW200732315A (en) 2007-09-01
ATE546440T1 (de) 2012-03-15
ZA200804074B (en) 2009-03-25
UA94724C2 (en) 2011-06-10
MA30202B1 (fr) 2009-02-02
RU2008127254A (ru) 2010-01-20
NZ568243A (en) 2011-07-29
TNSN08249A1 (en) 2009-10-30
EP1963292B1 (en) 2012-02-22

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