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PE20071031A1 - Derivados de tiadiazolidinona como inhibidores de ptpasas - Google Patents

Derivados de tiadiazolidinona como inhibidores de ptpasas

Info

Publication number
PE20071031A1
PE20071031A1 PE2006001571A PE2006001571A PE20071031A1 PE 20071031 A1 PE20071031 A1 PE 20071031A1 PE 2006001571 A PE2006001571 A PE 2006001571A PE 2006001571 A PE2006001571 A PE 2006001571A PE 20071031 A1 PE20071031 A1 PE 20071031A1
Authority
PE
Peru
Prior art keywords
ona
naphthalen
dioxo
hydrogen
tiadiazolidinone
Prior art date
Application number
PE2006001571A
Other languages
English (en)
Inventor
David Barnes
Gregory Raymond Bebernitz
Gary Mark Coppola
Katsumasa Nakajima
Travis Stams
Sidney Wolf Topiol
Thalaththani Ralalage Vedananda
James Richard Wareing
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37950917&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20071031(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20071031A1 publication Critical patent/PE20071031A1/es

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    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Abstract

REFERIDA A UN COMPUESTO DERIVADO DE TIADIAZOLIDINONA DE FORMULA (I), DONDE Q COMBINADO JUNTO CON LOS ATOMOS DE CARBONO CON LOS QUE ESTA UNIDO, FORMA UN ANILLO CARBOCICLICO O HETEROCICLICO DE 5 A 8 MIEMBROS, AROMATICO, O NO AROMATICO PARCIAL O COMPLETAMENTE SATURADO; R1 ES HIDROGENO, C(O)R6, C(O)NR7R8 O -C(O)OR9; R6 Y R7 SON HIDROGENO, CICLOALQUILO, ARILO, ARALQUILO, ENTRE OTROS; R8 Y R9 SON CICLOALQUILO, ARILO, ARALQUILO, ENTRE OTROS; R2, R3, R4 Y R5 SON HIDROGENO, HIDROXILO, HALOGENO, CIANO, NITRO, ALCOXILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 5-(3,6-DIHIDROXI-NAFTALEN-2-IL)-1,1-DIOXO-1,2,5-TIADIAZOLIDIN-3-ONA, SAL POTASICA DE 5-(3,7-DIHIDROXI-NAFTALEN-2-IL)-1,1-DIOXO-1,2,5-TIADIAZOLIDIN-3-ONA, 5-(7-BROMO-3-HIDROXI-NAFTALEN-2-IL)-1,1-DIOXO-1,2,5-TIADIAZOLIDIN-3-ONA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON INHIBIDORES DE LAS FOSFATASAS DE PROTEINA TIROSINA (PTPASAS) Y SON UTILES EN EL TRATAMIENTO DE LA RESISTENCIA A LA INSULINA ASOCIADA CON OBESIDAD, DIABETES MELLITUS, HIPERTENSION, HIPERTRIGLICERIDEMIA, ENTRE OTRAS
PE2006001571A 2005-12-08 2006-12-06 Derivados de tiadiazolidinona como inhibidores de ptpasas PE20071031A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US74857305P 2005-12-08 2005-12-08

Publications (1)

Publication Number Publication Date
PE20071031A1 true PE20071031A1 (es) 2007-11-15

Family

ID=37950917

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2006001571A PE20071031A1 (es) 2005-12-08 2006-12-06 Derivados de tiadiazolidinona como inhibidores de ptpasas
PE2010000531A PE20100733A1 (es) 2005-12-08 2006-12-06 Derivados de tiadiazolidinona como inhibidores de ptpasas

Family Applications After (1)

Application Number Title Priority Date Filing Date
PE2010000531A PE20100733A1 (es) 2005-12-08 2006-12-06 Derivados de tiadiazolidinona como inhibidores de ptpasas

Country Status (26)

Country Link
US (1) US7700633B2 (es)
EP (1) EP1963292B1 (es)
JP (1) JP2009519248A (es)
KR (1) KR20080074969A (es)
CN (1) CN101326173A (es)
AR (1) AR056838A1 (es)
AT (1) ATE546440T1 (es)
AU (1) AU2006321905B2 (es)
BR (1) BRPI0619600A2 (es)
CA (1) CA2629857A1 (es)
CR (1) CR10049A (es)
EC (1) ECSP088506A (es)
ES (1) ES2381280T3 (es)
IL (1) IL191549A0 (es)
MA (1) MA30202B1 (es)
NO (1) NO20083031L (es)
NZ (1) NZ568243A (es)
PE (2) PE20071031A1 (es)
PL (1) PL1963292T3 (es)
PT (1) PT1963292E (es)
RU (1) RU2008127254A (es)
TN (1) TNSN08249A1 (es)
TW (1) TW200732315A (es)
UA (1) UA94724C2 (es)
WO (1) WO2007067615A2 (es)
ZA (1) ZA200804074B (es)

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KR20080074970A (ko) * 2005-12-08 2008-08-13 노파르티스 아게 단백질 티로신 포스파타제 (ｐｔｐａｓｅ)에 의해 매개되는질병의 치료에 유용한 1,2,5-티아졸리딘 유도체
WO2008067527A1 (en) * 2006-12-01 2008-06-05 Novartis Ag Inhibitors of protein tyrosine phosphatase for the treatment of muscle atrophy and related disorders
AR066820A1 (es) * 2007-06-04 2009-09-16 Novartis Ag Compuestos de tiadiazolidin-3 ona
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AR128417A1 (es) * 2022-02-02 2024-05-08 Nerio Therapeutics Inc Inhibidores de la proteína tirosina fosfatasa y usos de estos
US20250134882A1 (en) * 2022-02-02 2025-05-01 Nerio Therapeutics, Inc. Protein tyrosine phosphatase inhibitors and uses thereof
CN119790052A (zh) * 2022-09-13 2025-04-08 金橘生物科技公司 苯并稠合的n-杂环及其用途
WO2024067802A1 (zh) * 2022-09-30 2024-04-04 深圳众格生物科技有限公司 蛋白酪氨酸磷酸酶抑制剂及其制备方法和医药用途
WO2024141015A1 (en) * 2022-12-30 2024-07-04 Insilico Medicine Ip Limited Protein tyrosine phosphatase inhibitors and uses thereof
CN118852335A (zh) * 2023-04-28 2024-10-29 中科中山药物创新研究院 噻二唑烷酮衍生物及其制备方法和应用
CN116496248B (zh) * 2023-05-06 2025-09-02 江苏艾科姆检测有限公司 一种溴氰虫酰胺杂质的合成方法
TW202500126A (zh) 2023-05-24 2025-01-01 美商金橘生物科技公司 雜環化合物及其用途
WO2025011570A1 (zh) * 2023-07-11 2025-01-16 深圳众格生物科技有限公司 蛋白酪氨酸磷酸酶抑制剂及其组合物、医药用途
CN117343052B (zh) * 2023-12-04 2024-02-06 英矽智能科技(上海)有限公司 蛋白酪氨酸磷酸酶抑制剂及其应用
WO2025242216A1 (zh) * 2024-05-24 2025-11-27 杭州百新生物医药科技有限公司 吲哚啉类化合物及其用途

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KR20080074966A (ko) * 2005-12-08 2008-08-13 노파르티스 아게 1,1,3-트리옥소-1,2,5-티아디아졸리딘 및 ｐｔｐ-ａｓｅ억제제로서의 그의 용도
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US7700633B2 (en) 2010-04-20
JP2009519248A (ja) 2009-05-14
PL1963292T3 (pl) 2012-07-31
ATE546440T1 (de) 2012-03-15
MA30202B1 (fr) 2009-02-02
AU2006321905B2 (en) 2011-08-11
NZ568243A (en) 2011-07-29
AR056838A1 (es) 2007-10-24
IL191549A0 (en) 2008-12-29
RU2008127254A (ru) 2010-01-20
BRPI0619600A2 (pt) 2011-10-11
WO2007067615A2 (en) 2007-06-14
PE20100733A1 (es) 2010-10-29
EP1963292B1 (en) 2012-02-22
ZA200804074B (en) 2009-03-25
US20080262050A1 (en) 2008-10-23
TNSN08249A1 (en) 2009-10-30
NO20083031L (no) 2008-08-28
ECSP088506A (es) 2008-07-30
KR20080074969A (ko) 2008-08-13
CA2629857A1 (en) 2007-06-14
WO2007067615A3 (en) 2007-11-15
CR10049A (es) 2008-08-25
UA94724C2 (en) 2011-06-10
CN101326173A (zh) 2008-12-17
AU2006321905A1 (en) 2007-06-14
TW200732315A (en) 2007-09-01
ES2381280T3 (es) 2012-05-24
PT1963292E (pt) 2012-05-10
EP1963292A2 (en) 2008-09-03

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