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PE20081316A1 - COMPUESTOS HETEROCICLICOS QUE MODULAN LA ACTIVIDAD DE LA ESTEROIL-CoA-DESATURASA - Google Patents

COMPUESTOS HETEROCICLICOS QUE MODULAN LA ACTIVIDAD DE LA ESTEROIL-CoA-DESATURASA

Info

Publication number
PE20081316A1
PE20081316A1 PE2007001082A PE2007001082A PE20081316A1 PE 20081316 A1 PE20081316 A1 PE 20081316A1 PE 2007001082 A PE2007001082 A PE 2007001082A PE 2007001082 A PE2007001082 A PE 2007001082A PE 20081316 A1 PE20081316 A1 PE 20081316A1
Authority
PE
Peru
Prior art keywords
alkyl
steroil
desaturase
coa
modulate
Prior art date
Application number
PE2007001082A
Other languages
English (en)
Inventor
Natalie Dales
Julia Fonarev
Jianmin Fu
Rajender Kamboj
Vishnumurthy Kodumuru
Shifeng Liu
Natalia Pokrovskaia
Vandna Raina
Shaoyi Sun
Zaihui Zhang
Original Assignee
Novartis Ag
Xenon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39864516&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20081316(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag, Xenon Pharmaceuticals Inc filed Critical Novartis Ag
Publication of PE20081316A1 publication Critical patent/PE20081316A1/es

Links

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Child & Adolescent Psychology (AREA)

Abstract

SE REFIERE A COMPUESTOS DE FORMULA (I), EN DONDE X ES N O CH; Y ES NH, O, S O N-CH3; Q ES: a), b), ENTRE OTROS; W ES -N(R6)C(O)-, -R8-C(O)N(R6)-, -C(O)O-, ENTRE OTROS; V ES UN ENLACE O -C(O)-, -C(O)N(R6)-, ENTRE OTROS; R1 ES H, HALOGENO, ALQUILO, ARILO, ENTRE OTROS; R2 ES H, ALQUILO, ALQUENILO, ENTRE OTROS; R3 ES H, ALQUILO, ALCOXI, ENTRE OTROS; R6 ES H, ALQUILO, CIANO, CICLOALQUIL-ALQUILO; R7 ES H, ALQUILO, ARILO, ENTRE OTROS. SON SELECCIONADOS: N-BENCIL-2-(3-(4-FLUORO-FENIL)-5-METOXI-2-OXO-IMIDAZOLIDIN-1-IL)-4-METIL-TIAZOL-5-CARBOXAMIDA, N-BENCIL-2-(3-(4-FLUORO-FENIL)-5-HIDROXI-2-OXO-IMIDAZOLIDIN-1-IL)-4-METIL-TIAZOL-5-CARBOXAMIDA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO DE PREPARACION. ESTOS COMPUESTOS SON INHIBIDORES DE LA ESTEROIL-CoA-DESATURASA, SIENDO UTILES EN EL TRATAMIENTO DE ENFERMEDAD CARDIOVASCULAR, DIABETES, OBESIDAD, SINDROME METABOLICO Y SIMILARES
PE2007001082A 2006-08-15 2007-08-13 COMPUESTOS HETEROCICLICOS QUE MODULAN LA ACTIVIDAD DE LA ESTEROIL-CoA-DESATURASA PE20081316A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US82245906P 2006-08-15 2006-08-15

Publications (1)

Publication Number Publication Date
PE20081316A1 true PE20081316A1 (es) 2008-10-16

Family

ID=39864516

Family Applications (3)

Application Number Title Priority Date Filing Date
PE2007001082A PE20081316A1 (es) 2006-08-15 2007-08-13 COMPUESTOS HETEROCICLICOS QUE MODULAN LA ACTIVIDAD DE LA ESTEROIL-CoA-DESATURASA
PE2011000441A PE20110371A1 (es) 2006-08-15 2007-08-13 COMPUESTOS HETEROCICLICOS QUE MODULAN LA ACTIVIDAD DE LA ESTEROIL-CoA-DESATURASA
PE2011000443A PE20110341A1 (es) 2006-08-15 2007-08-13 COMPUESTOS HETEROCICLICOS QUE MODULAN LA ACTIVIDAD DE LA ESTEROIL-CoA-DESATURASA

Family Applications After (2)

Application Number Title Priority Date Filing Date
PE2011000441A PE20110371A1 (es) 2006-08-15 2007-08-13 COMPUESTOS HETEROCICLICOS QUE MODULAN LA ACTIVIDAD DE LA ESTEROIL-CoA-DESATURASA
PE2011000443A PE20110341A1 (es) 2006-08-15 2007-08-13 COMPUESTOS HETEROCICLICOS QUE MODULAN LA ACTIVIDAD DE LA ESTEROIL-CoA-DESATURASA

Country Status (27)

Country Link
US (2) US8063084B2 (es)
EP (1) EP2054408B1 (es)
JP (1) JP4972690B2 (es)
KR (4) KR20130036080A (es)
CN (1) CN101535303B (es)
AR (1) AR062360A1 (es)
AU (1) AU2007351498B2 (es)
BR (1) BRPI0716407A2 (es)
CA (1) CA2660201C (es)
CL (1) CL2007002348A1 (es)
CO (1) CO6241156A2 (es)
CR (1) CR10566A (es)
ES (1) ES2597453T3 (es)
GT (1) GT200900027A (es)
IL (1) IL196562A0 (es)
MA (1) MA30655B1 (es)
MX (1) MX2009001634A (es)
MY (1) MY153263A (es)
NO (1) NO20091083L (es)
NZ (2) NZ574222A (es)
PE (3) PE20081316A1 (es)
RU (1) RU2009109147A (es)
TN (1) TN2009000045A1 (es)
TW (1) TWI404718B (es)
UA (1) UA96766C2 (es)
WO (1) WO2008127349A2 (es)
ZA (1) ZA200900263B (es)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR062360A1 (es) 2006-08-15 2008-11-05 Novartis Ag Derivados heterociclicos que modulan la actividad de la estearoil-coa-desaturasa
CN101595105B (zh) * 2006-12-20 2013-01-23 诺瓦提斯公司 作为scd抑制剂的2-取代的5元杂环化合物
CA2696824A1 (en) 2007-08-28 2009-03-12 Irm Llc Compounds and compositions as kinase inhibitors
AU2013200845B2 (en) * 2008-02-20 2015-01-29 Xenon Pharmaceuticals Inc. Heterocyclic inhibitors of stearoyl-CoA desaturase
KR101584826B1 (ko) 2008-02-20 2016-01-18 노파르티스 아게 스테아로일-ＣｏＡ 데새투라제의 헤테로시클릭 억제제
UY31929A (es) 2008-06-25 2010-01-05 Irm Llc Compuestos y composiciones como inhibidores de cinasa
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