PE20091977A1 - Compuestos de quinuclidina como ligandos del receptor nicotinico de acetilcolina alfa-7 - Google Patents
Compuestos de quinuclidina como ligandos del receptor nicotinico de acetilcolina alfa-7Info
- Publication number
- PE20091977A1 PE20091977A1 PE2009000562A PE2009000562A PE20091977A1 PE 20091977 A1 PE20091977 A1 PE 20091977A1 PE 2009000562 A PE2009000562 A PE 2009000562A PE 2009000562 A PE2009000562 A PE 2009000562A PE 20091977 A1 PE20091977 A1 PE 20091977A1
- Authority
- PE
- Peru
- Prior art keywords
- nicotinium
- receptor
- alpha
- acetylcholine
- binders
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/20—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE QUINUCLIDINA DE FORMULA (I), DONDE R1 ES ISOXAZOLILO, PIRAZOLILO, OXAZOLILO, ENTRE OTROS. SON COMPUESTOS SELECCIONADOS: (R)-N-(6-(2,2,2-TRIFLUOROETOXI)PIRIMIDIN-4-IL)-4H-1'-AZASPIRO[OXAZOL-5,3'-BICICLO[2.2.2]OCTAN]-2-AMINA; (R)-N-(5-BROMO-4-ISOPROPILPIRIMIDIN-2-IL)-4H-1'-AZASPIRO[OXAZOL-5,3'-BICICLO[2.2.2]OCTAN]-2-AMINA; (R)-N-(5-BROMO-4-PIRIDIN-3-IL)PIRIMIDIN-2-IL)-4H-1'-AZASPIRO[OXAZOL-5,3'-BICICLO[2.2.2]OCTAN]-2-AMINA; ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO Y UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON LIGANDOS DEL RECEPTOR NICOTINICO (alfa)7 SIENDO UTIL EN EL TRATAMIENTO DE TRASTORNOS DEL SISTEMA NERVIOSO CENTRAL TALES COMO ESQUIZOFRENIA, ENFERMEDAD DE ALZHEIMER, ENTRE OTROS
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4721108P | 2008-04-23 | 2008-04-23 | |
| US12/423,299 US7863291B2 (en) | 2008-04-23 | 2009-04-14 | Quinuclidine compounds as alpha-7 nicotinic acetylcholine receptor ligands |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20091977A1 true PE20091977A1 (es) | 2010-01-15 |
Family
ID=41215599
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2009000562A PE20091977A1 (es) | 2008-04-23 | 2009-04-23 | Compuestos de quinuclidina como ligandos del receptor nicotinico de acetilcolina alfa-7 |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US7863291B2 (es) |
| EP (1) | EP2271650B1 (es) |
| JP (1) | JP5389905B2 (es) |
| KR (1) | KR20110015565A (es) |
| CN (1) | CN102066384B (es) |
| AR (1) | AR071215A1 (es) |
| AU (1) | AU2009239575B2 (es) |
| BR (1) | BRPI0911542A2 (es) |
| CA (1) | CA2722325A1 (es) |
| CL (1) | CL2009000975A1 (es) |
| CO (1) | CO6300941A2 (es) |
| CY (1) | CY1117045T1 (es) |
| DK (1) | DK2271650T3 (es) |
| EA (1) | EA017628B1 (es) |
| ES (1) | ES2553753T3 (es) |
| HR (1) | HRP20151111T1 (es) |
| HU (1) | HUE028302T2 (es) |
| IL (1) | IL208673A (es) |
| MX (1) | MX2010011374A (es) |
| NZ (1) | NZ588649A (es) |
| PE (1) | PE20091977A1 (es) |
| PL (1) | PL2271650T3 (es) |
| PT (1) | PT2271650E (es) |
| SI (1) | SI2271650T1 (es) |
| TW (1) | TWI431007B (es) |
| WO (1) | WO2009131926A1 (es) |
| ZA (1) | ZA201007527B (es) |
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| AU2009354790A1 (en) * | 2009-10-29 | 2012-06-14 | Bristol-Myers Squibb Company | Quinuclidine compounds as alpha-7 nicotinic acetylcholine receptor ligands |
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| EA025252B1 (ru) | 2010-07-22 | 2016-12-30 | Гайлид Сайэнсиз, Инк. | Способы и соединения для лечения вирусных инфекций paramyxoviridae |
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| KR102066297B1 (ko) | 2011-10-14 | 2020-01-14 | 암비트 바이오사이언시즈 코포레이션 | 헤테로사이클릭 화합물 및 이의 유형 3 수용체 티로신 키나아제의 조절인자로서의 용도 |
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-
2009
- 2009-04-14 US US12/423,299 patent/US7863291B2/en active Active
- 2009-04-20 DK DK09733949.3T patent/DK2271650T3/en active
- 2009-04-20 KR KR1020107026057A patent/KR20110015565A/ko not_active Ceased
- 2009-04-20 AU AU2009239575A patent/AU2009239575B2/en not_active Ceased
- 2009-04-20 HU HUE09733949A patent/HUE028302T2/en unknown
- 2009-04-20 ES ES09733949.3T patent/ES2553753T3/es active Active
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