AR070930A1 - Derivados de pirrolidinilo y tiofeno, composiciones farmaceuticas que los contienen y usos de los mismos para el tratamiento de enfermedades asociadas con inhibidores de reabsorcion de monoaminas,tales como trastornos depresivos y ansioliticos, entre otros. - Google Patents
Derivados de pirrolidinilo y tiofeno, composiciones farmaceuticas que los contienen y usos de los mismos para el tratamiento de enfermedades asociadas con inhibidores de reabsorcion de monoaminas,tales como trastornos depresivos y ansioliticos, entre otros.Info
- Publication number
- AR070930A1 AR070930A1 ARP090100963A ARP090100963A AR070930A1 AR 070930 A1 AR070930 A1 AR 070930A1 AR P090100963 A ARP090100963 A AR P090100963A AR P090100963 A ARP090100963 A AR P090100963A AR 070930 A1 AR070930 A1 AR 070930A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- reabsortion
- othyllitizes
- ansiolitral
- pirrolidinyl
- Prior art date
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 2
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 title 1
- 230000003001 depressive effect Effects 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 8
- 125000003545 alkoxy group Chemical group 0.000 abstract 5
- 125000001188 haloalkyl group Chemical group 0.000 abstract 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 5
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical group 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000005885 heterocycloalkylalkyl group Chemical group 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Reivindicacion 1: Un compuesto de la formula 1; o un enantiomero, diastereomero o una sal farmacéuticamente aceptable del mismo, en la que: uno Z1 y Z2 es N(Ra) y el otro es CH2; X es CH o N; Y es CH o N; m es el numero 0 o 1; R es hidroxi, halogeno, alquilo inferior o alcoxi inferior; Q es CH, C(Rb) o N; Ra es H, alquilo inferior o bencilo; Ra' es H, alquilo inferior, cicloalquil-alquilo, -S(=O)2Rc, -C(=O)N(Rc)2 o S(=O)2N(Rc)2; n es el numero 0 o 1; cada Rb es con independencia Rb' o Rö; Rb' es hidroxi, halogeno, -C(=O)(Rc), -C(=O)O(Rc), -OC(=O)- (Rc), -N(Rc)2, -C(=O)N(Rc)2, -NHC(=O)(Rc), -CN, -S(=O)2Rc o -S(=O)2N(Rc)2; Rbö es alquilo inferior, alquenilo inferior, alquinilo inferior, alcoxi inferior, haloalquilo inferior, fenilo, cicloalquilo, cicloalquil-alquilo, heterocicloalquilo, heterocicloalquil-alquilo, opcionalmente sustituido por uno o más Rc; cada Rc es con independencia Rd o Re; Rd es H; Re es alquilo inferior, haloalquilo inferior, cicloalquilo, fenilo, heterocicloalquilo o heteroarilo, opcionalmente sustituido por uno o más Re'; cada Re' es con independencia hidroxi, halogeno, amino, alquilo inferior, alquenilo inferior, alquinilo inferior, alcoxi inferior, haloalquilo inferior o -CN; R2a y R2b son con independencia entre sí H, hidroxi, alquilo inferior, haloalquilo inferior o alcoxi inferior; r es el numero 0, 1 o 2; y R3 es halogeno, hidroxi, alquilo inferior, haloalquilo inferior o alcoxi inferior.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3816008P | 2008-03-20 | 2008-03-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR070930A1 true AR070930A1 (es) | 2010-05-12 |
Family
ID=40651460
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090100963A AR070930A1 (es) | 2008-03-20 | 2009-03-18 | Derivados de pirrolidinilo y tiofeno, composiciones farmaceuticas que los contienen y usos de los mismos para el tratamiento de enfermedades asociadas con inhibidores de reabsorcion de monoaminas,tales como trastornos depresivos y ansioliticos, entre otros. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20110021556A1 (es) |
| EP (1) | EP2257545B1 (es) |
| JP (1) | JP2011515355A (es) |
| KR (1) | KR101209373B1 (es) |
| CN (1) | CN101977907A (es) |
| AR (1) | AR070930A1 (es) |
| AT (1) | ATE522519T1 (es) |
| AU (1) | AU2009226868A1 (es) |
| BR (1) | BRPI0909737A2 (es) |
| CA (1) | CA2718736A1 (es) |
| CL (1) | CL2009000665A1 (es) |
| ES (1) | ES2370593T3 (es) |
| IL (1) | IL207223A0 (es) |
| MX (1) | MX2010009147A (es) |
| PE (1) | PE20091649A1 (es) |
| TW (1) | TW200942529A (es) |
| WO (1) | WO2009115427A1 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013538800A (ja) * | 2010-08-10 | 2013-10-17 | アッヴィ・インコーポレイテッド | 新規ｔｒｐｖ３モジュレーター |
| US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
| CA2905242C (en) | 2013-03-15 | 2016-11-29 | Pfizer Inc. | Indole compounds that activate ampk |
| CN110662541B (zh) * | 2017-03-12 | 2023-02-10 | 王晓冬 | 多环胺作为阿片受体调节剂 |
| US11584765B2 (en) | 2017-03-12 | 2023-02-21 | Ecstasy LLC | Polycyclic amines as sigma receptor modulators |
| US11787780B2 (en) * | 2020-06-22 | 2023-10-17 | Corcept Therapeutics Incorporated | Quaternary indazole glucocorticoid receptor antagonists |
| CN116897043A (zh) * | 2020-07-01 | 2023-10-17 | 艾斯特希有限责任公司 | 用于阿片受体调节的多环胺 |
| MX2024007590A (es) | 2021-12-21 | 2024-08-20 | Corcept Therapeutics Inc | Antagonistas piperazino indazólicos del receptor de glucocorticoides. |
| AU2022421212A1 (en) | 2021-12-21 | 2024-07-04 | Corcept Therapeutics Incorporated | Bicyclic indazole glucocorticoid receptor antagonists |
| CN117285452A (zh) * | 2023-09-19 | 2023-12-26 | 苏州雄鹰笔墨新材料有限公司 | 一种取代琥珀酰亚胺及其制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5079202B2 (ja) * | 2000-07-18 | 2012-11-21 | 大日本住友製薬株式会社 | セロトニン再取り込み阻害剤 |
| TWI439452B (zh) * | 2005-05-13 | 2014-06-01 | Otsuka Pharma Co Ltd | 吡咯烷化合物（二） |
| ES2401129T3 (es) * | 2006-12-19 | 2013-04-17 | F. Hoffmann-La Roche Ag | Derivados de heteroaril-pirrolidinil- y -piperidinil-cetona |
-
2009
- 2009-03-10 EP EP09722963A patent/EP2257545B1/en not_active Not-in-force
- 2009-03-10 CA CA2718736A patent/CA2718736A1/en not_active Abandoned
- 2009-03-10 ES ES09722963T patent/ES2370593T3/es active Active
- 2009-03-10 US US12/922,656 patent/US20110021556A1/en not_active Abandoned
- 2009-03-10 AT AT09722963T patent/ATE522519T1/de active
- 2009-03-10 WO PCT/EP2009/052748 patent/WO2009115427A1/en not_active Ceased
- 2009-03-10 CN CN2009801100150A patent/CN101977907A/zh active Pending
- 2009-03-10 MX MX2010009147A patent/MX2010009147A/es active IP Right Grant
- 2009-03-10 KR KR1020107020629A patent/KR101209373B1/ko not_active Expired - Fee Related
- 2009-03-10 AU AU2009226868A patent/AU2009226868A1/en not_active Abandoned
- 2009-03-10 BR BRPI0909737-6A patent/BRPI0909737A2/pt not_active IP Right Cessation
- 2009-03-10 JP JP2011500151A patent/JP2011515355A/ja active Pending
- 2009-03-17 TW TW098108642A patent/TW200942529A/zh unknown
- 2009-03-18 AR ARP090100963A patent/AR070930A1/es unknown
- 2009-03-19 CL CL2009000665A patent/CL2009000665A1/es unknown
- 2009-03-20 PE PE2009000424A patent/PE20091649A1/es not_active Application Discontinuation
-
2010
- 2010-07-26 IL IL207223A patent/IL207223A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2009226868A1 (en) | 2009-09-24 |
| EP2257545B1 (en) | 2011-08-31 |
| US20110021556A1 (en) | 2011-01-27 |
| KR20100118601A (ko) | 2010-11-05 |
| ES2370593T3 (es) | 2011-12-20 |
| CL2009000665A1 (es) | 2010-04-09 |
| BRPI0909737A2 (pt) | 2019-03-06 |
| EP2257545A1 (en) | 2010-12-08 |
| MX2010009147A (es) | 2010-09-07 |
| KR101209373B1 (ko) | 2012-12-06 |
| CA2718736A1 (en) | 2009-09-24 |
| WO2009115427A1 (en) | 2009-09-24 |
| TW200942529A (en) | 2009-10-16 |
| PE20091649A1 (es) | 2009-11-04 |
| ATE522519T1 (de) | 2011-09-15 |
| IL207223A0 (en) | 2010-12-30 |
| CN101977907A (zh) | 2011-02-16 |
| JP2011515355A (ja) | 2011-05-19 |
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