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PE20090835A1 - Derivados de quinazolina como inhibidores de la pi3 quinasa - Google Patents

Derivados de quinazolina como inhibidores de la pi3 quinasa

Info

Publication number
PE20090835A1
PE20090835A1 PE2008001006A PE2008001006A PE20090835A1 PE 20090835 A1 PE20090835 A1 PE 20090835A1 PE 2008001006 A PE2008001006 A PE 2008001006A PE 2008001006 A PE2008001006 A PE 2008001006A PE 20090835 A1 PE20090835 A1 PE 20090835A1
Authority
PE
Peru
Prior art keywords
quinazoline derivatives
kinase inhibitors
quinazolinyl
pyridinyl
heteroaryl
Prior art date
Application number
PE2008001006A
Other languages
English (en)
Inventor
Nicholas D Adams
Joelle Lorraine Burgess
Michael Gerard Darcy
Steven David Knight
Kenneth Allen Newlander
Lance H Ridgers
Stanley J Schmidt
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40156899&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20090835(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of PE20090835A1 publication Critical patent/PE20090835A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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Abstract

REFERIDO A DERIVADOS DE QUINAZOLINAS DE FORMULA I DONDE R2 ES ARILO, HETEROARILO SUSTITUIDO O NO; R1 ES HETEROCICLOALQUILO, HETEROARILO, ARILO, ENTRE OTROS; R3 Y R4 SON CADA UNO H, HALOGENO, ACILO, ENTRE OTROS; n ES 1-2. SON COMPUESTOS PREFERIDOS: 4-(4-PIRIDINIL)-6-(1H-PIRROLO[2,3-b]PIRIDIN-5-IL)QUINAZOLINA; 5-[4-(1-PIPERIDINIL)-6-QUINAZOLINIL]-3-PIRIDINASULFONAMIDA; N-{2-CLORO-5-[4-(4-MORFOLINIL)-6-QUINAZOLINIL]3-PIRIDINIL}-N-METILETANOSULFONAMIDA; ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCESO DE PREPARACION Y A UN METODO DE TRATAMIENTO. DICHO COMPUESTO INHIBE LA ACTIVIDAD/FUNCION DE QUINASAS PI3 Y ES UTIL EN EL TRATAMIENTO DE TRASTORNOS AUTOINMUNES, ALERGIA, ASMA, ENTRE OTROS
PE2008001006A 2007-06-14 2008-06-12 Derivados de quinazolina como inhibidores de la pi3 quinasa PE20090835A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US94389907P 2007-06-14 2007-06-14

Publications (1)

Publication Number Publication Date
PE20090835A1 true PE20090835A1 (es) 2009-07-25

Family

ID=40156899

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008001006A PE20090835A1 (es) 2007-06-14 2008-06-12 Derivados de quinazolina como inhibidores de la pi3 quinasa

Country Status (9)

Country Link
US (2) US20100179144A1 (es)
EP (1) EP2167092A4 (es)
JP (1) JP2010532320A (es)
AR (1) AR066978A1 (es)
CL (1) CL2008001743A1 (es)
PE (1) PE20090835A1 (es)
TW (1) TW200918068A (es)
UY (1) UY31137A1 (es)
WO (1) WO2008157191A2 (es)

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JP5561702B2 (ja) 2007-08-02 2014-07-30 アムジエン・インコーポレーテツド Ｐｉ３キナーゼ調節剤および使用方法
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RU2018147217A (ru) 2011-09-30 2019-01-18 Вертекс Фармасьютикалз Инкорпорейтед Способы получения соединений, которые можно использовать в качестве ингибиторов киназы atr
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BR112014018106A2 (pt) 2012-02-06 2017-06-27 Glaxosmithkline Ip No 2 Ltd composto, uso de um composto, e, método para tratar uma doença fibrótica
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CN102746241B (zh) * 2012-07-02 2014-11-05 西安交通大学 2,3,5-三取代苯甲酰胺类化合物及其制备方法和用途
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CN107501275B (zh) 2012-12-07 2019-11-22 沃泰克斯药物股份有限公司 可用作atr激酶抑制剂的化合物
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