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PE20090718A1 - Derivados de espiroindolinona - Google Patents

Derivados de espiroindolinona

Info

Publication number
PE20090718A1
PE20090718A1 PE2008000875A PE2008000875A PE20090718A1 PE 20090718 A1 PE20090718 A1 PE 20090718A1 PE 2008000875 A PE2008000875 A PE 2008000875A PE 2008000875 A PE2008000875 A PE 2008000875A PE 20090718 A1 PE20090718 A1 PE 20090718A1
Authority
PE
Peru
Prior art keywords
diona
tetrahydrospiro
indol
chlorophenyl
triazine
Prior art date
Application number
PE2008000875A
Other languages
English (en)
Inventor
Jin-Jun Liu
Zhuming Zhang
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20090718A1 publication Critical patent/PE20090718A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

REFERIDA A UN COMPUESTO DE FORMULA I, DONDE X ES H, HALOGENO, CIANO, ENTRE OTROS; R1, R2, R3 Y R4 SON CADA UNO ALQUILO INFERIOR, ALQUENILO INFERIOR, ARILO, ENTRE OTROS; R ES H, ALQUILO INFERIOR SUSTITUIDO O NO. SON COMPUESTOS PREFERIDOS: (6'R,3R,8'S)-6-CLORO-8'-(3-CLOROFENIL)-6'-(5-FLUOR-2-METILFENIL)-2'-METIL-6',7',8',9'-TETRAHIDROESPIRO[3H-INDOL-3,7'-(2H-PIRIDO[2,1-c][1,2,4]TRIAZINA)]-2,3'(1H)-DIONA, (6'R,3R,8'S)-6-CLORO-8'-(3-CLOROFENIL)-2'-(3-DIMETILAMINO-PROPIL)-6'-(1-METILENO-PROPIL)-6', 7',8',9'-TETRAHIDROESPIRO-[3H-INDOL-3,7'-(2H-PIRIDO[2,1-c][1,2,4]TRIAZINA)-2,3'(1H)-DIONA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA FORMULACION PARA UNA SOLA UNIDAD DE DOSIFICACION ORAL. DICHOS COMPUESTOS TIENEN ACTIVIDAD INHIBIDORA DE LA INTERACCION MDM2-p53 Y SON UTILES EN EL TRATAMIENTO DE TRANSTORNOS DE PROLIFERACION CELULAR COMO EL CANCER
PE2008000875A 2007-05-23 2008-05-21 Derivados de espiroindolinona PE20090718A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US93136807P 2007-05-23 2007-05-23

Publications (1)

Publication Number Publication Date
PE20090718A1 true PE20090718A1 (es) 2009-06-20

Family

ID=39645560

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008000875A PE20090718A1 (es) 2007-05-23 2008-05-21 Derivados de espiroindolinona

Country Status (16)

Country Link
US (1) US7834179B2 (es)
EP (1) EP2152714B1 (es)
JP (1) JP2010527954A (es)
KR (1) KR20090130319A (es)
CN (1) CN101679448A (es)
AR (1) AR066659A1 (es)
AT (1) ATE549340T1 (es)
AU (1) AU2008253117A1 (es)
BR (1) BRPI0812155A2 (es)
CA (1) CA2687160A1 (es)
ES (1) ES2382139T3 (es)
IL (1) IL202020A0 (es)
MX (1) MX2009012595A (es)
PE (1) PE20090718A1 (es)
TW (1) TW200901994A (es)
WO (1) WO2008141975A1 (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7776875B2 (en) * 2007-12-19 2010-08-17 Hoffman-La Roche Inc. Spiroindolinone derivatives
US7723372B2 (en) 2008-03-19 2010-05-25 Hoffman-La Roche Inc. Spiroindolinone derivatives
US8217051B2 (en) * 2009-02-17 2012-07-10 Hoffmann-La Roche Inc. Spiroindolinone derivatives
JP2013510860A (ja) 2009-11-12 2013-03-28 ザ、リージェンツ、オブ、ザ、ユニバーシティ、オブ、ミシガン スピロ−オキシインドールｍｄｍ２アンタゴニスト
JO2998B1 (ar) * 2010-06-04 2016-09-05 Amgen Inc مشتقات بيبيريدينون كمثبطات mdm2 لعلاج السرطان
FR2967072B1 (fr) 2010-11-05 2013-03-29 Univ Dundee Procede pour ameliorer la production de virus et semences vaccinales influenza
KR101929188B1 (ko) 2010-11-12 2018-12-17 사노피 스피로­옥신돌 ｍｄｍ２ 길항제
CA2829188C (en) 2011-03-10 2016-10-18 Daiichi Sankyo Company, Limited Dispiropyrrolidine derivatives
SG194873A1 (en) 2011-05-11 2013-12-30 Sanofi Sa Spiro-oxindole mdm2 antagonists
MX352672B (es) 2011-09-27 2017-12-04 Amgen Inc Compuestos heterocíclicos como inhibidores de mdm2 para el tratamiento del cáncer.
TWI586668B (zh) 2012-09-06 2017-06-11 第一三共股份有限公司 二螺吡咯啶衍生物之結晶
WO2014089904A1 (en) 2012-12-10 2014-06-19 Abbvie Inc. Triazinone compounds
WO2014100065A1 (en) 2012-12-20 2014-06-26 Merck Sharp & Dohme Corp. Substituted imidazopyridines as hdm2 inhibitors
US11407721B2 (en) 2013-02-19 2022-08-09 Amgen Inc. CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer
CN105121407B (zh) 2013-02-28 2017-07-18 美国安进公司 用于治疗癌症的苯甲酸衍生物mdm2抑制剂
MX374513B (es) 2013-03-14 2025-03-06 Amgen Inc Compuestos de morfolinona de ácido heteroarilo como inhibidores mdm2 para el tratamiento de cáncer.
JOP20200296A1 (ar) 2013-06-10 2017-06-16 Amgen Inc عمليات صنع وأشكال بلورية من mdm2 مثبط
CN103435621B (zh) * 2013-07-26 2015-11-04 中国林业科学研究院林产化学工业研究所 螺环喹唑啉衍生物及其制备方法
US10576064B2 (en) 2014-07-03 2020-03-03 Boehringer Ingelheim International Gmbh Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-P53 inhibitors
EA038071B1 (ru) 2014-08-21 2021-07-01 Бёрингер Ингельхайм Интернациональ Гмбх СОЕДИНЕНИЕ СПИРО[3H-ИНДОЛ-3,2'-ПИРРОЛИДИН]-2(1H)-ОНА И ЕГО ПРОИЗВОДНЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ MDM2-p53
EP3260119B1 (en) 2015-02-20 2023-11-15 Daiichi Sankyo Company, Limited Combination method for treating cancer
CA2982435C (en) 2015-04-13 2020-05-26 Daiichi Sankyo Company, Limited Treatment method by combined use of mdm2 inhibitor and btk inhibitor
UA123905C2 (uk) 2015-10-09 2021-06-23 Бьорінгер Інгельхайм Інтернаціональ Гмбх Спіро[3h-індол-3,2'-піролідин]-2(1h)-онові сполуки та похідні як інгібітори мdm2-p53
WO2017201449A1 (en) 2016-05-20 2017-11-23 Genentech, Inc. Protac antibody conjugates and methods of use
US20190240210A1 (en) 2016-10-17 2019-08-08 Daiichi Sankyo Company, Limited Treatment Method by Combined Use of MDM2 Inhibitor and DNA Methyltransferase Inhibitor
EP3511334A1 (en) * 2018-01-16 2019-07-17 Adamed sp. z o.o. 1,2,3',5'-tetrahydro-2'h-spiro[indole-3,1'-pyrrolo[3,4-c]pyrrole]-2,3'-dione compounds as therapeutic agents activating tp53
WO2023056069A1 (en) 2021-09-30 2023-04-06 Angiex, Inc. Degrader-antibody conjugates and methods of using same
WO2024240858A1 (en) 2023-05-23 2024-11-28 Valerio Therapeutics Protac molecules directed against dna damage repair system and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2752738C (en) * 2005-02-22 2014-05-27 The Regents Of The University Of Michigan Small molecule inhibitors of mdm2 and uses thereof
JPWO2007013691A1 (ja) * 2005-07-29 2009-02-12 武田薬品工業株式会社 スピロ環化合物

Also Published As

Publication number Publication date
ES2382139T3 (es) 2012-06-05
CA2687160A1 (en) 2008-11-27
KR20090130319A (ko) 2009-12-22
AU2008253117A1 (en) 2008-11-27
MX2009012595A (es) 2009-12-07
EP2152714A1 (en) 2010-02-17
ATE549340T1 (de) 2012-03-15
IL202020A0 (en) 2010-06-16
US20080293723A1 (en) 2008-11-27
EP2152714B1 (en) 2012-03-14
US7834179B2 (en) 2010-11-16
JP2010527954A (ja) 2010-08-19
TW200901994A (en) 2009-01-16
WO2008141975A1 (en) 2008-11-27
CN101679448A (zh) 2010-03-24
BRPI0812155A2 (pt) 2019-09-24
AR066659A1 (es) 2009-09-02

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