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PE20081397A1 - Moduladores no esteroides de receptores de progesterona - Google Patents

Moduladores no esteroides de receptores de progesterona

Info

Publication number
PE20081397A1
PE20081397A1 PE2008000016A PE2008000016A PE20081397A1 PE 20081397 A1 PE20081397 A1 PE 20081397A1 PE 2008000016 A PE2008000016 A PE 2008000016A PE 2008000016 A PE2008000016 A PE 2008000016A PE 20081397 A1 PE20081397 A1 PE 20081397A1
Authority
PE
Peru
Prior art keywords
alkyl
benzoxazin
ona
rac
alkenyl
Prior art date
Application number
PE2008000016A
Other languages
English (en)
Inventor
Wolfgang Schwede
Thomas Andrew Kirkland
Anja Schmidt
Ulrike Fuhrmann
Carsten Moeller
Andrea Rotgeri
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE102006061913A external-priority patent/DE102006061913A1/de
Priority claimed from DE102007023614A external-priority patent/DE102007023614A1/de
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of PE20081397A1 publication Critical patent/PE20081397A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/02—1,2-Oxazines; Hydrogenated 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

SE REFIERE A COMPUESTOS NO ESTEROIDES DE FORMULA (I) DONDE A ES H, ALQUILO(C1-C8), ALQUENILO(C2-C8), ALQUINILO(C2-C8), ENTRE OTROS; R1 Y R2 SON CADA UNO ALQUILO(C1-C5) O JUNTO AL ATOMO DE C AL QUE ESTAN UNIDOS FORMAN UN ANILLO DE 3 A 7 MIEMBROS; R3 ES H, ALQUILO(C1-C8), ALQUENILO(C2-C8), CICLOALQUILO(C3-C10), ENTRE OTROS; R4 ES UN ANILLO MONO O BICICLO DE 3 A 12 MIEMBROS AROMATICO O HETEROAROMATICO OPCIONALMENTE SUSTITUIDO CON L, EN DONDE L ES ALQUILO(C1-C8), ALQUENILO(C2-C8), ALQUINILO(C2-C8), ENTRE OTROS; X ES O O DOS ATOMOS DE H; Y ES (CH2)m, -C C- O -CH=CH-, DONDE m ES 0 O 1. SON COMPUESTOS PREFERIDOS: RAC-6-[4,4-DIMETIL-2,5-DIHIDROXI-2-FENILPENTANOILAMINO]-4-METIL-2,3-BENZOXAZIN-1-ONA, RAC-6-[4,4-DIMETIL-2,5-DIHIDROXI-2-(FENILMETIL)PENTANOILAMINO]-4-METIL-2,3-BENZOXAZIN-1-ONA, RAC-6-[3-CICLOHEXIL-2-HIDROXI-2-(FENILMETIL)PROPANOILAMINO]-4-METIL-2,3-BENZOXAZIN-1-ONA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES DE RECEPTORES DE PROGESTERONA SIENDO UTILES EN EL TRATAMIENTO DE ENDOMETRIOSIS, LEIOMIOMAS DEL UTERO, DISMENORREA
PE2008000016A 2006-12-21 2008-01-02 Moduladores no esteroides de receptores de progesterona PE20081397A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102006061913A DE102006061913A1 (de) 2006-12-21 2006-12-21 Nichtsteroidale Progesteronrezeptor-Modulatoren
DE102007023614A DE102007023614A1 (de) 2007-05-21 2007-05-21 Nichtsteroidale Progesteronrezeptor-Modulatoren

Publications (1)

Publication Number Publication Date
PE20081397A1 true PE20081397A1 (es) 2008-12-05

Family

ID=39456752

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008000016A PE20081397A1 (es) 2006-12-21 2008-01-02 Moduladores no esteroides de receptores de progesterona

Country Status (5)

Country Link
AR (1) AR064478A1 (es)
PE (1) PE20081397A1 (es)
TW (1) TW200835498A (es)
UY (1) UY30805A1 (es)
WO (1) WO2008077647A2 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103288669B (zh) * 2013-07-01 2015-06-24 南开大学 一种阿卓乳酸酰胺衍生物及应用
CN117402111A (zh) * 2023-10-12 2024-01-16 昆明理工大学 自由基引发烯烃与炔烃交叉偶联制备全碳季碳中心衍生物的方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8617652D0 (en) * 1986-07-18 1986-08-28 Ici Plc Acylanilide derivatives
GB8617653D0 (en) * 1986-07-18 1986-08-28 Ici Plc Amide derivatives
IE922316A1 (en) * 1991-07-17 1993-01-27 Smithkline Beecham Corp Retroviral protease inhibitors
US5733882A (en) * 1994-01-17 1998-03-31 Smithkline Beecham Corporation Retroviral protease inhibitors
DE19723722A1 (de) * 1997-05-30 1998-12-10 Schering Ag Nichtsteroidale Gestagene
DE19856475A1 (de) * 1998-11-27 2000-05-31 Schering Ag Nichtsteroidale Entzündungshemmer
DE10038639A1 (de) * 2000-07-28 2002-02-21 Schering Ag Nichtsteroidale Entzündungshemmer
CA2472746A1 (en) * 2002-01-14 2003-07-24 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical formulations containing them and uses thereof
HRP20040923A2 (en) * 2002-03-11 2004-12-31 Schering Ag 5-{2-hydroxy-3-[1-(3-trifluoromethylphenyl)-cyclopropyl]-propionylamino}-phtalide and related compounds with progesterone receptor modulating activity for use in fertility control and hormone replacement therapy
EP1344776A1 (en) * 2002-03-11 2003-09-17 Schering Aktiengesellschaft 5- 2-hydroxy-3-[1-(3-trifluoromethylphenyl)-cyclopropyl]-propionylamino -phtalide and 6- 2-hydroxy-3-[1-(3-trifluoromethylphenyl)-cyclopropyl]-propionylamino -4-methyl-2,3-benzoxazin-1-one derivatives with progesterone receptor modulating activity for use in fertility control, hormone replacement therapy and the treatment of gynecological disorders
CA2531060A1 (en) * 2003-07-01 2005-01-13 Schering Aktiengesellschaft Heterocyclically-substitued pentanol derivatives, process for their production and their use as anti-inflammatory agents
EP1869003B1 (en) * 2005-04-14 2013-05-15 Glaxo Group Limited Indazoles as glucocorticoid receptor ligands
DE102005030294A1 (de) * 2005-06-24 2007-01-04 Schering Ag Nichtsteroidale Progesteronrezeptor-Modulatoren
DE102005030292A1 (de) * 2005-06-24 2007-01-11 Schering Ag Nichtsteroidale Progesteronrezeptor-Modulatoren
DE102005030293A1 (de) * 2005-06-24 2007-01-04 Schering Ag Verwendung von nichtsteroidale Progesteronrezeptor-Modulatoren

Also Published As

Publication number Publication date
AR064478A1 (es) 2009-04-01
UY30805A1 (es) 2008-07-31
TW200835498A (en) 2008-09-01
WO2008077647A2 (de) 2008-07-03
WO2008077647A3 (de) 2008-10-16

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal