PE20091524A1 - Derivados de 2-aminopirimidina - Google Patents
Derivados de 2-aminopirimidinaInfo
- Publication number
- PE20091524A1 PE20091524A1 PE2008002136A PE2008002136A PE20091524A1 PE 20091524 A1 PE20091524 A1 PE 20091524A1 PE 2008002136 A PE2008002136 A PE 2008002136A PE 2008002136 A PE2008002136 A PE 2008002136A PE 20091524 A1 PE20091524 A1 PE 20091524A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- pyrimidin
- methylamine
- amine
- atoms
- Prior art date
Links
- 150000005006 2-aminopyrimidines Chemical class 0.000 title 1
- LJXQPZWIHJMPQQ-UHFFFAOYSA-N pyrimidin-2-amine Chemical compound NC1=NC=CC=N1 LJXQPZWIHJMPQQ-UHFFFAOYSA-N 0.000 abstract 4
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 230000000172 allergic effect Effects 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 208000010668 atopic eczema Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000026278 immune system disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
REFERIDA A COMPUESTOS DERIVADOS DE 2-AMINO-PIRIMIDINA DE FORMULA (I), DONDE R1 ES (i) O (ii); R2 Y R3 FORMAN JUNTO AL ATOMO DE N AL QUE ESTAN UNIDOS, UN HETEROCICLICO SATURADO QUE PUEDE SER MONOCICLICO DE 4 A 7 ATOMOS, UN BICICLICO CON PUENTE DE 7 A 8 ATOMOS, UN BICICLICO FUSIONADO DE 8 A 12 ATOMOS, ENTRE OTROS; R4 Y R5 SON CADA UNO H, ALQUILO(C1-C4), ARILO, ENTRE OTROS; R6 ES ALQUILO(C1-C8), CICLOALQUILO(C3-C8)ALQUILO(C0-C6), Ar1-ALQUILO(C0-C4), ENTRE OTROS; Ar1 ES FENILO OPCIONALMENTE SUSTITUIDO POR HALO, CN, ALQUILO(C1-C4), ENTRE OTROS; R7 ES ANILLO HETEROCICLICO SATURADO MONOCILICO DE 4 A 7 ATOMOS QUE CONTIENE SOLO UN HETEROATOMO DE O, OPCIONALMENTE SUSTITUIDO POR HALO O ALQUILO(C1-C4); n ES 1, 2 O 3; p ES 0, 1 O 2. SON COMPUESTOS PREFERIDOS: 4-CICLOHEXILOXIMETIL-6-(3-(METILAMINO)AZETIDIN-1-IL)PIRIMIDIN-2-AMINA, 4-CICLOHEXILOXIMETIL-6-((3R)-3-(METILAMINO)PIRROLIDIN-1-IL)PIRIMIDIN-2-AMINA, 4-(CICLOPROPILMETOXIMETIL)-6-(3-(METILAMINO)AZETIDIN-1-IL)PIRIMIDIN-2-AMINA, ENTRE OTROS. SE REFIERE TAMBIEN A SU PROCEDIMIENTO DE PREPARACION Y A COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN. DICHOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR H4 SIENDO UTILES PARA EL TRATAMIENTO DEL DOLOR, ENFERMEDADES ALERGICAS, ENFERMEDADES INMUNOLOGICAS, ENTRE OTROS
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07382003 | 2007-12-19 | ||
| US3423908P | 2008-03-06 | 2008-03-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20091524A1 true PE20091524A1 (es) | 2009-09-25 |
Family
ID=39247222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2008002136A PE20091524A1 (es) | 2007-12-19 | 2008-12-18 | Derivados de 2-aminopirimidina |
Country Status (4)
| Country | Link |
|---|---|
| AR (1) | AR069813A1 (es) |
| PE (1) | PE20091524A1 (es) |
| TW (1) | TW200940529A (es) |
| WO (1) | WO2009077608A1 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CL2008000467A1 (es) | 2007-02-14 | 2008-08-22 | Janssen Pharmaceutica Nv | Compuestos derivados de 2-aminopirimidina, moduladores del receptor histamina h4; su procedimiento de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar un trastorno inflamatorio seleccionado de alegia, asma |
| EP2188274A4 (en) | 2007-08-03 | 2011-05-25 | Boehringer Ingelheim Int | VIRAL POLYMERASE HEMMER |
| NZ585370A (en) | 2007-12-19 | 2012-09-28 | Boehringer Ingelheim Int | Viral polymerase inhibitors |
| EP2201982A1 (en) | 2008-12-24 | 2010-06-30 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Histamine H4 receptor antagonists for the treatment of vestibular disorders |
| SI2493895T1 (sl) | 2009-10-29 | 2017-10-30 | Vectura Limited | Derivati heteroarila, ki vsebujejo N, kot inhibitorji JAK3 kinaze |
| CA2783209C (en) * | 2009-12-22 | 2017-03-14 | Msd Oss B.V. | Amino-heteroaryl derivatives as hcn blockers |
| EP2516420B8 (en) | 2009-12-23 | 2018-10-17 | Medicis Pharmaceutical Corporation | Aminoalkylpyrimidine derivatives as histamine h4 receptor antagonists |
| SI2858647T1 (sl) | 2012-06-08 | 2018-11-30 | Sensorion | Inhibitorji receptorja H4 za zdravljenje tinitusa |
| CN103922928A (zh) * | 2013-10-31 | 2014-07-16 | 北京利和知信科技有限公司 | 适用于制备烯烃聚合催化剂的环取代醚酸酯化合物 |
| GB201817047D0 (en) | 2018-10-19 | 2018-12-05 | Heptares Therapeutics Ltd | H4 antagonist compounds |
| GB202005858D0 (en) * | 2020-04-22 | 2020-06-03 | Heptares Therapeutics Ltd | H4 Antagonist compounds |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1505064A1 (en) * | 2003-08-05 | 2005-02-09 | Bayer HealthCare AG | 2-Aminopyrimidine derivatives |
| WO2005054239A1 (en) * | 2003-12-05 | 2005-06-16 | Bayer Healthcare Ag | 2-aminopyrimidine derivatives |
| KR20080043840A (ko) * | 2005-09-13 | 2008-05-19 | 팔라우 파르마 에스에이 | 히스타민 ｈ4 수용체 활성의 조정자로서 2-아미노피리미딘유도체 |
| NL2000323C2 (nl) * | 2005-12-20 | 2007-11-20 | Pfizer Ltd | Pyrimidine-derivaten. |
| EP2066645A2 (en) * | 2006-09-12 | 2009-06-10 | UCB Pharma S.A. | 2 amino-pyrimidine derivatives as h4 receptor antagonists, processes for preparing them and their use in pharmaceutical compositions |
-
2008
- 2008-12-18 TW TW097149459A patent/TW200940529A/zh unknown
- 2008-12-18 AR ARP080105538A patent/AR069813A1/es unknown
- 2008-12-18 WO PCT/EP2008/067949 patent/WO2009077608A1/en not_active Ceased
- 2008-12-18 PE PE2008002136A patent/PE20091524A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009077608A1 (en) | 2009-06-25 |
| TW200940529A (en) | 2009-10-01 |
| AR069813A1 (es) | 2010-02-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |