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PE20081262A1 - Derivados de fenilo como moduladores de cinasas y composiciones - Google Patents

Derivados de fenilo como moduladores de cinasas y composiciones

Info

Publication number
PE20081262A1
PE20081262A1 PE2007001422A PE2007001422A PE20081262A1 PE 20081262 A1 PE20081262 A1 PE 20081262A1 PE 2007001422 A PE2007001422 A PE 2007001422A PE 2007001422 A PE2007001422 A PE 2007001422A PE 20081262 A1 PE20081262 A1 PE 20081262A1
Authority
PE
Peru
Prior art keywords
alkyl
phenyl
modulators
kinases
derivatives
Prior art date
Application number
PE2007001422A
Other languages
English (en)
Inventor
Donatella Chianelli
Christopher Cow
Yun He
Songchun Jiang
Xiaolin Li
Xiadong Liu
Zuosheng Liu
Jon Loren
Valentina Molteni
Juliet Nabakka
Pingda Ren
Taebo Sim
Xiaodong Wang
Shuli You
Original Assignee
Irm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39027274&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20081262(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Irm Llc filed Critical Irm Llc
Publication of PE20081262A1 publication Critical patent/PE20081262A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Neurosurgery (AREA)
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  • Immunology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Addiction (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)

Abstract

REFERIDA A UN COMPUESTO DERIVADO DE FENILO DE FORMULA (1), DONDE Y Y Z SON CR O N; L ES NR-C(O), C(O)NR, ENTRE OTROS; R1 Y R3 SON HALOGENO, (CR2)kR6, (CR2)kNR7R8, ENTRE OTROS; R2 ES (CR2)kR6, (CR2)1-4OR9, ALQUILO C1-C6, ENTRE OTROS; R4 ES (CR2)kR6, ALQUILO C1-C6, ALQUENILO C2-C6, ENTRE OTROS; R5 ES H, HALOGENO, ALQUILO C1-C6; R6 ES UN CICLOALQUILO DE 3 A 7 CARBONOS, ARILO DE 5 A 12 MIEMBROS, ENTRE OTROS; R7 Y R8 SON H, (CR2)kNR7R8, ALQUILO C1-C6, ENTRE OTROS; R9 ES H, ALQUILO C1-C6, ALQUENILO C2-C6, ENTRE OTROS; R ES H, ALQUILO C1-C6, ENTRE OTROS; k ES UN ENTERO DE 0 A 6; n ES UN ENTERO DE 0 A 2. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES DE CINASAS DE PROTEINA TALES COMO C-KIT, PDGFR ALFA, PDGFR BETA, Abl, ENTRE OTRAS Y SON UTILES EN EL TRATAMIENTO DE TRANSTORNOS NEOPLASICOS, ALERGICOS, INFLAMATORIOS, ENTRE OTROS
PE2007001422A 2006-10-20 2007-10-19 Derivados de fenilo como moduladores de cinasas y composiciones PE20081262A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US86243006P 2006-10-20 2006-10-20

Publications (1)

Publication Number Publication Date
PE20081262A1 true PE20081262A1 (es) 2008-10-29

Family

ID=39027274

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007001422A PE20081262A1 (es) 2006-10-20 2007-10-19 Derivados de fenilo como moduladores de cinasas y composiciones

Country Status (25)

Country Link
US (2) US7678792B2 (es)
EP (1) EP2076513A1 (es)
JP (1) JP2010506948A (es)
KR (1) KR101079520B1 (es)
CN (1) CN101528744A (es)
AR (1) AR063343A1 (es)
AU (1) AU2007309279B2 (es)
BR (1) BRPI0718162A2 (es)
CA (1) CA2667010A1 (es)
CL (1) CL2007003005A1 (es)
CO (1) CO6170361A2 (es)
CR (1) CR10717A (es)
EA (1) EA200900573A1 (es)
EC (1) ECSP099353A (es)
IL (1) IL197875A0 (es)
MA (1) MA30888B1 (es)
MX (1) MX2009004141A (es)
NI (1) NI200900061A (es)
NO (1) NO20091949L (es)
PE (1) PE20081262A1 (es)
SM (1) SMP200900027B (es)
TN (1) TN2009000145A1 (es)
TW (1) TW200825081A (es)
WO (1) WO2008051757A1 (es)
ZA (1) ZA200902711B (es)

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