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MX2023005747A - Inhibidores de gcn2 y perk quinasas y metodos de uso de los mismos. - Google Patents

Inhibidores de gcn2 y perk quinasas y metodos de uso de los mismos.

Info

Publication number
MX2023005747A
MX2023005747A MX2023005747A MX2023005747A MX2023005747A MX 2023005747 A MX2023005747 A MX 2023005747A MX 2023005747 A MX2023005747 A MX 2023005747A MX 2023005747 A MX2023005747 A MX 2023005747A MX 2023005747 A MX2023005747 A MX 2023005747A
Authority
MX
Mexico
Prior art keywords
gcn2
methods
kinase inhibitors
perk
perk kinase
Prior art date
Application number
MX2023005747A
Other languages
English (en)
Inventor
Patrick Kearney
Daniel L Flynn
Bourdonnec Bertrand Le
Yu Mi Ahn
Jeffery Zwicker
Gada Al-Ani
Salim Javed
Kristen Stoltz
Original Assignee
Deciphera Pharmaceuticals Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deciphera Pharmaceuticals Llc filed Critical Deciphera Pharmaceuticals Llc
Publication of MX2023005747A publication Critical patent/MX2023005747A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compuestos que son inhibidores de una GCN2 quinasa o de una PERK quinasa, y métodos de tratamiento con dichos compuestos de enfermedades que incluyen enfermedades asociadas a una GCN2 quinasa o a una PERK quinasa.
MX2023005747A 2020-11-18 2021-11-17 Inhibidores de gcn2 y perk quinasas y metodos de uso de los mismos. MX2023005747A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063115496P 2020-11-18 2020-11-18
US202163185846P 2021-05-07 2021-05-07
PCT/US2021/059678 WO2022109001A1 (en) 2020-11-18 2021-11-17 Gcn2 and perk kinase inhibitors and methods of use thereof

Publications (1)

Publication Number Publication Date
MX2023005747A true MX2023005747A (es) 2023-07-28

Family

ID=78844846

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2023005747A MX2023005747A (es) 2020-11-18 2021-11-17 Inhibidores de gcn2 y perk quinasas y metodos de uso de los mismos.

Country Status (14)

Country Link
US (2) US11912668B2 (es)
EP (1) EP4247795A1 (es)
JP (1) JP2023549540A (es)
KR (1) KR20230121758A (es)
AU (1) AU2021381949A1 (es)
BR (1) BR112023009531A2 (es)
CA (1) CA3198943A1 (es)
CL (1) CL2023001399A1 (es)
CO (1) CO2023006705A2 (es)
IL (1) IL302807A (es)
MX (1) MX2023005747A (es)
PE (1) PE20231311A1 (es)
TW (1) TW202237568A (es)
WO (1) WO2022109001A1 (es)

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EP4399210A1 (en) * 2021-09-10 2024-07-17 Black Diamond Therapeutics, Inc. 6-aza-quinoline derivatives and related uses
IL313034A (en) * 2021-12-03 2024-07-01 Deciphera Pharmaceuticals Llc Heterocyclic compounds as gcn2 and perk kinase inhibitors
WO2023159322A1 (en) * 2022-02-25 2023-08-31 Ontario Institute For Cancer Research (Oicr) Quinazoline derivatives as inhibitors of the gcn2 kinase, compositions and uses thereof
JP2025512992A (ja) * 2022-04-08 2025-04-22 アレスタ・セラピューティクス・ベスローテン・フェンノートシャップ Ｇｃｎ２モジュレーター化合物
CA3252213A1 (en) * 2022-05-11 2023-11-16 Ip2Ipo Innovations Limited GCN2 INHIBITOR
CN119343346A (zh) * 2022-06-08 2025-01-21 韩国化学研究院 苯磺酰胺衍生物、其制备方法及含有其作为活性成分的预防或治疗癌症的药物组合物
GEAP202516749A (en) * 2022-10-14 2025-07-25 Black Diamond Therapeutics Inc Methods of treating cancers using isoquinoline or 6-aza-quinoline derivatives
WO2025043350A1 (en) * 2023-08-30 2025-03-06 Ontario Institute For Cancer Research (Oicr) Triazolopyridopyrimidine and dihydroimidazopyridopyrimidine derivatives as inhibitors of the gcn2 kinase, compositions and uses thereof
WO2025043349A1 (en) * 2023-08-30 2025-03-06 Ontario Institute For Cancer Research (Oicr) Pyrimidopyridone and pteridone derivatives as inhibitors of the gcn2 kinase, compositions and uses thereof
WO2025076441A1 (en) * 2023-10-06 2025-04-10 Alesta Therapeutics BV Compounds of gcn2 modulators

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