PE20081163A1 - Profarmacos de penem - Google Patents
Profarmacos de penemInfo
- Publication number
- PE20081163A1 PE20081163A1 PE2007001558A PE2007001558A PE20081163A1 PE 20081163 A1 PE20081163 A1 PE 20081163A1 PE 2007001558 A PE2007001558 A PE 2007001558A PE 2007001558 A PE2007001558 A PE 2007001558A PE 20081163 A1 PE20081163 A1 PE 20081163A1
- Authority
- PE
- Peru
- Prior art keywords
- oxo
- penem
- drugs
- thyenyl
- azabicycle
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- HHXMXAQDOUCLDN-RXMQYKEDSA-N penem Chemical compound S1C=CN2C(=O)C[C@H]21 HHXMXAQDOUCLDN-RXMQYKEDSA-N 0.000 title 1
- SCVJRXQHFJXZFZ-KVQBGUIXSA-N 2-amino-9-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3h-purine-6-thione Chemical compound C1=2NC(N)=NC(=S)C=2N=CN1[C@H]1C[C@H](O)[C@@H](CO)O1 SCVJRXQHFJXZFZ-KVQBGUIXSA-N 0.000 abstract 2
- FYZUENZXIZCLAZ-UHFFFAOYSA-N 2-methylhept-2-enoic acid Chemical compound CCCCC=C(C)C(O)=O FYZUENZXIZCLAZ-UHFFFAOYSA-N 0.000 abstract 2
- -1 SULOPENEM COMPOUND Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 2
- 238000009472 formulation Methods 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 229950000153 sulopenem Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D499/887—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with a hetero atom or a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE REFIERE A UN COMPUESTO PROFARMACO SULOPENEM DE FORMULA I, DONDE R1 ES ALQUILO C2-C8. EL COMPUESTO SE ENCUENTRA CONTENIDA EN UNA FORMULACION EN UNA CANTIDAD DE 200mg A 4000mg. SON PREFERIDOS: (5R,6S)-6-[(1R)-1-HIDROXIETIL]-7-OXO-3-[[(1R,3S)-TETRAHIDRO-1-OXIDO-3-TIENIL]TIO]-4-TIA-1-AZABICICLO[3.2.0]HEPT-2-EN-2-CARBOXILATO DE (5-(3-METILPROPIL)-2-OXO-1,3-DIOXOL-4-IL)METILO; (5R,6S)-6-[(1R)-1-HIDROXIETIL]-7-OXO-3-[[(1R,3S)-TETRAHIDRO-1-OXIDO-3-TIENIL]TIO]-4-TIA-1-AZABICICLO[3.2.0]HEPT-2-EN-2-CARBOXILATO DE (5-PROPIL-2-OXO-1,3-DIOXOL-4-IL)METILO, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO DE PREPARACION Y COMPOSICIONES FARMACEUTICAS. DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE LA INFECCION
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86566906P | 2006-11-14 | 2006-11-14 | |
| US97881607P | 2007-10-10 | 2007-10-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20081163A1 true PE20081163A1 (es) | 2008-08-15 |
Family
ID=39190251
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2007001558A PE20081163A1 (es) | 2006-11-14 | 2007-11-12 | Profarmacos de penem |
Country Status (5)
| Country | Link |
|---|---|
| AR (1) | AR063799A1 (es) |
| CL (1) | CL2007003277A1 (es) |
| PE (1) | PE20081163A1 (es) |
| TW (1) | TW200829242A (es) |
| WO (1) | WO2008059367A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104016970A (zh) | 2007-10-10 | 2014-09-03 | 诺华股份有限公司 | 螺环吡咯烷类与其对抗hcv和hiv感染的应用 |
| CN119039295B (zh) * | 2024-08-16 | 2025-11-04 | 浙江大学 | 一种用于抗感染的前药及其应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6019908B2 (ja) * | 1980-04-30 | 1985-05-18 | カネボウ株式会社 | １，３−ジオキソレン−２−オン誘導体 |
| US4619924A (en) * | 1984-05-18 | 1986-10-28 | Pfizer Inc. | 2-alkylthiopenem derivatives |
| US5013729A (en) * | 1987-05-11 | 1991-05-07 | Pfizer Inc. | Diastereomeric 5R,6S-6-(1R-hydroxyethyl)-2-(cis-1-oxo-3-thiolanylthio)-2-penem-3-carboxylic acids |
-
2007
- 2007-11-09 WO PCT/IB2007/003531 patent/WO2008059367A1/en not_active Ceased
- 2007-11-12 PE PE2007001558A patent/PE20081163A1/es not_active Application Discontinuation
- 2007-11-13 TW TW096142900A patent/TW200829242A/zh unknown
- 2007-11-13 AR ARP070105046A patent/AR063799A1/es not_active Application Discontinuation
- 2007-11-14 CL CL200703277A patent/CL2007003277A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR063799A1 (es) | 2009-02-18 |
| WO2008059367A1 (en) | 2008-05-22 |
| TW200829242A (en) | 2008-07-16 |
| WO2008059367A8 (en) | 2008-10-09 |
| CL2007003277A1 (es) | 2008-05-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |