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PE20090106A1 - Derivados de eritromicina como agentes antibacterianos - Google Patents

Derivados de eritromicina como agentes antibacterianos

Info

Publication number
PE20090106A1
PE20090106A1 PE2008000454A PE2008000454A PE20090106A1 PE 20090106 A1 PE20090106 A1 PE 20090106A1 PE 2008000454 A PE2008000454 A PE 2008000454A PE 2008000454 A PE2008000454 A PE 2008000454A PE 20090106 A1 PE20090106 A1 PE 20090106A1
Authority
PE
Peru
Prior art keywords
methyl
hydroxy
naphthyridin
azethydin
descladinosyl
Prior art date
Application number
PE2008000454A
Other languages
English (en)
Inventor
Richard Allen Buzon
Mark Edward Flanagan
Zhengong Bryan Li
Thomas Victor Magee
Mark Carl Noe
Usa Datta Reilly
Daniel William Widlicka
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PE20090106A1 publication Critical patent/PE20090106A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08Hetero rings containing eight or more ring members, e.g. erythromycins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

REFERIDA A UN DERIVADO DE ERITROMICINA DE FORMULA (I), DONDE R1 ES 3-HIDROXI-[1,5-NAFTIRIDIN-4-ILO, 3-HIDROXI-[1,6]-NAFTIRIDIN-4-ILO, 3-HIDROXI-[1,7]-NAFTIRIDIN-4-ILO, OPCIONALMENTE SUSTITUIDOS CON ALQUILO C1-C3, CICLOPROPILO Y CICLOBUTILO; R2 ES H, METILO, ETILO; X ES H O FLUOR. SON COMPUESTOS PREFERIDOS: FUMARATO DE 3-DESCLADINOSIL-11,12-DIDESOXI-6-O-METIL-3-OXO-12,11-(OXICARBONIL-(1-((3-HIDROXI-[1,5]-NAFTIRIDIN-4-IL)METIL)-AZETIDIN-3-IL)-IMINO)-ERITROMICINA A, FUMARATO DE 3-DESCLADINOSIL-11,12-DIDESOXI-6-O-METIL-3-OXO-12,11-(OXICARBONIL-(1-((3-HIDROXI-[1,6]-NAFTIRIDIN-4-IL)METIL)-AZETIDIN-3-IL)-IMINO)-ERITROMICINA A, FUMARATO DE 3-DESCLADINOSIL-11,12-DIDESOXI-6-O-METIL-3-OXO-12,11-(OXICARBONIL-(1-((3-HIDROXI-8-METIL-[1,5-NAFTIRIDIN-4-IL)METIL)-AZETIDIN-3-IL)-IMINO)-ERITROMICINA A, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS TIENEN ACTIVIDAD ANTIBACTERIANA Y ANTIPROTOZOARIA Y SON UTILES EN EL TRATAMIENTO DE INFECCIONES DEL TRACTO RESPIRATORIO, SINUSITIS, NEUMONIA DE ORIGEN COMUNITARIO, ENTRE OTROS
PE2008000454A 2007-03-13 2008-03-11 Derivados de eritromicina como agentes antibacterianos PE20090106A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89447507P 2007-03-13 2007-03-13
US2337008P 2008-01-24 2008-01-24

Publications (1)

Publication Number Publication Date
PE20090106A1 true PE20090106A1 (es) 2009-02-08

Family

ID=39760163

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008000454A PE20090106A1 (es) 2007-03-13 2008-03-11 Derivados de eritromicina como agentes antibacterianos

Country Status (28)

Country Link
US (1) US20080293646A1 (es)
EP (1) EP2125851B1 (es)
JP (1) JP4468487B1 (es)
KR (1) KR20090110381A (es)
CN (1) CN101631795A (es)
AP (1) AP2009004985A0 (es)
AR (1) AR065724A1 (es)
AT (1) ATE471943T1 (es)
AU (1) AU2008224633A1 (es)
BR (1) BRPI0809002A2 (es)
CA (1) CA2680527A1 (es)
CL (1) CL2008000695A1 (es)
CR (1) CR10998A (es)
CU (1) CU20090155A7 (es)
DE (1) DE602008001611D1 (es)
DO (1) DOP2009000214A (es)
EA (1) EA200901059A1 (es)
EC (1) ECSP099627A (es)
IL (1) IL200613A0 (es)
MA (1) MA31252B1 (es)
MX (1) MX2009009074A (es)
PA (1) PA8772401A1 (es)
PE (1) PE20090106A1 (es)
SV (1) SV2009003368A (es)
TN (1) TN2009000374A1 (es)
TW (1) TW200848061A (es)
UY (1) UY30957A1 (es)
WO (1) WO2008110918A2 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112014022106B1 (pt) * 2012-03-06 2022-08-02 Pfizer Inc Derivados macrocíclicos, combinação, composição e usos na fabricação de um medicamento para o tratamento de doenças
CA3130061C (en) 2013-04-04 2024-05-28 President And Fellows Of Harvard College Macrolides and methods of their preparation and use
WO2016057798A1 (en) 2014-10-08 2016-04-14 President And Fellows Of Harvard College 14-membered ketolides and methods of their preparation and use
EP3273969A4 (en) 2015-03-25 2018-11-21 President and Fellows of Harvard College Macrolides with modified desosamine sugars and uses thereof
CN105924451B (zh) * 2016-04-27 2017-12-15 国家海洋局第三海洋研究所 具有抗茶叶致病真菌活性的大环内酯化合物及制备与用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2233493A1 (en) * 2004-12-21 2010-09-29 Pfizer Products Inc. Macrolides

Also Published As

Publication number Publication date
TW200848061A (en) 2008-12-16
WO2008110918A3 (en) 2009-01-29
EP2125851B1 (en) 2010-06-23
AU2008224633A1 (en) 2008-09-18
CR10998A (es) 2009-09-11
AR065724A1 (es) 2009-06-24
DE602008001611D1 (en) 2010-08-05
ECSP099627A (es) 2009-10-30
PA8772401A1 (es) 2008-11-19
UY30957A1 (es) 2008-10-31
EA200901059A1 (ru) 2010-02-26
CU20090155A7 (es) 2011-04-26
CN101631795A (zh) 2010-01-20
TN2009000374A1 (fr) 2010-12-31
ATE471943T1 (de) 2010-07-15
CA2680527A1 (en) 2008-09-18
IL200613A0 (en) 2010-05-17
JP2010521448A (ja) 2010-06-24
JP4468487B1 (ja) 2010-05-26
EP2125851A2 (en) 2009-12-02
SV2009003368A (es) 2009-11-09
MA31252B1 (fr) 2010-03-01
MX2009009074A (es) 2009-09-28
BRPI0809002A2 (pt) 2014-11-11
WO2008110918A2 (en) 2008-09-18
DOP2009000214A (es) 2009-10-31
AP2009004985A0 (en) 2009-10-31
CL2008000695A1 (es) 2008-09-22
US20080293646A1 (en) 2008-11-27
KR20090110381A (ko) 2009-10-21

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Legal Events

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