PE20070403A1 - COMPOSICION FARMACEUTICA QUE COMPRENDE CEFEPIME Y DERIVADOS DE 6-ALQUILIDEN-PENEM BICICLICOS COMO INHIBIDORES DE ß-LACTAMASA - Google Patents
COMPOSICION FARMACEUTICA QUE COMPRENDE CEFEPIME Y DERIVADOS DE 6-ALQUILIDEN-PENEM BICICLICOS COMO INHIBIDORES DE ß-LACTAMASAInfo
- Publication number
- PE20070403A1 PE20070403A1 PE2006000909A PE2006000909A PE20070403A1 PE 20070403 A1 PE20070403 A1 PE 20070403A1 PE 2006000909 A PE2006000909 A PE 2006000909A PE 2006000909 A PE2006000909 A PE 2006000909A PE 20070403 A1 PE20070403 A1 PE 20070403A1
- Authority
- PE
- Peru
- Prior art keywords
- pharmaceutical composition
- alkyliden
- bicyclic
- cefepime
- composition including
- Prior art date
Links
- HVFLCNVBZFFHBT-ZKDACBOMSA-N cefepime Chemical compound S([C@@H]1[C@@H](C(N1C=1C([O-])=O)=O)NC(=O)\C(=N/OC)C=2N=C(N)SC=2)CC=1C[N+]1(C)CCCC1 HVFLCNVBZFFHBT-ZKDACBOMSA-N 0.000 title abstract 3
- 229960002100 cefepime Drugs 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000003781 beta lactamase inhibitor Substances 0.000 title 1
- 229940126813 beta-lactamase inhibitor Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- NOJNFULGOQGBKB-UHFFFAOYSA-M sodium;3-[3-tert-butylsulfanyl-1-[[4-(6-ethoxypyridin-3-yl)phenyl]methyl]-5-[(5-methylpyridin-2-yl)methoxy]indol-2-yl]-2,2-dimethylpropanoate Chemical compound [Na+].C1=NC(OCC)=CC=C1C(C=C1)=CC=C1CN1C2=CC=C(OCC=3N=CC(C)=CC=3)C=C2C(SC(C)(C)C)=C1CC(C)(C)C([O-])=O NOJNFULGOQGBKB-UHFFFAOYSA-M 0.000 abstract 2
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 108020004256 Beta-lactamase Proteins 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 102000006635 beta-lactamase Human genes 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
- A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE: A) CEFEPIME; Y B) UN COMPUESTO DE FORMULA (I) QUE ES UN INHIBIDOR DE ß-LACTAMASA, DONDE A Y B SON H O HETEROARILO BICICLICO FUSIONADO DE FORMULA (2-A) O (2-B); X ES S U O; R5 ES H, ALQUILO(C1-C6), CICLOALQUILO(C5-C6), ENTRE OTROS; SIENDO COMPUESTOS PREFERIDOS: SAL DE SODIO DEL ACIDO (5R),(6Z)-6-(6,7-DIHIDRO-5H-PIRROLO[1,2-a]IMIDAZOL-2-ILMETILENO)-7-OXO-4-TIA-1-AZA-BICICLO[3.2.0]HEPT-2-ENO-CARBOXILICO Y SAL DE SODIO DEL ACIDO (5R),(6Z)-6-(5,6-DIHIDRO-8H-IMIDAZO[2,1-c][1,4]OXAZIN-2-ILMETILENO)-7-OXO-4-TIA-1-AZABICICLO[3.2.0]HEPT-2-ENO-2-CARBOXILICO. LA RELACION ENTRE EL CEFEPIME Y EL COMPUESTO DE FORMULA (I) ES DE 1:1 P/P HASTA 100:1 P/P. DICHA COMPOSICION ES UTIL EN EL TRATAMIENTO DE INFECCIONES BACTERIANAS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70280905P | 2005-07-27 | 2005-07-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20070403A1 true PE20070403A1 (es) | 2007-05-15 |
Family
ID=37110353
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2006000909A PE20070403A1 (es) | 2005-07-27 | 2006-07-26 | COMPOSICION FARMACEUTICA QUE COMPRENDE CEFEPIME Y DERIVADOS DE 6-ALQUILIDEN-PENEM BICICLICOS COMO INHIBIDORES DE ß-LACTAMASA |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20070129344A1 (es) |
| EP (1) | EP1906954A1 (es) |
| JP (1) | JP2009502934A (es) |
| KR (1) | KR20080032637A (es) |
| CN (1) | CN101232881A (es) |
| AR (1) | AR055096A1 (es) |
| AU (1) | AU2006275940A1 (es) |
| BR (1) | BRPI0613927A2 (es) |
| CA (1) | CA2615886A1 (es) |
| CR (1) | CR9691A (es) |
| EC (1) | ECSP088132A (es) |
| GT (1) | GT200600331A (es) |
| IL (1) | IL188843A0 (es) |
| NO (1) | NO20080314L (es) |
| PE (1) | PE20070403A1 (es) |
| RU (1) | RU2008102912A (es) |
| TW (1) | TW200727897A (es) |
| WO (1) | WO2007016134A1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR039774A1 (es) * | 2002-05-01 | 2005-03-02 | Wyeth Corp | 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas |
| AR039475A1 (es) * | 2002-05-01 | 2005-02-23 | Wyeth Corp | 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa |
| TW200716102A (en) * | 2005-06-01 | 2007-05-01 | Wyeth Corp | Bicyclic 6-alkylidene-penems as class-D β -lactamases inhibitors |
| US20090018332A1 (en) * | 2007-06-28 | 2009-01-15 | Wyeth | Processes For Preparing Bicyclic Oxazine Carboxaldehyde and Beta-Lactamase Inhibitors |
| CN103435617B (zh) * | 2013-08-22 | 2016-04-27 | 南京华安药业有限公司 | 一种6,7-二氢-5H-吡咯并[1,2-a]咪唑-2-甲醛的合成方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4206067A (en) * | 1978-10-02 | 1980-06-03 | Chevron Research Company | Thermally stabilized erosion-inhibited functional fluids containing perhalometal compounds and an organic base |
| EP0041768B1 (en) * | 1980-04-24 | 1987-11-11 | Beecham Group Plc | Beta-lactam compounds, their preparation and use |
| US4891369A (en) * | 1986-12-03 | 1990-01-02 | Taiho Pharmaceutical Company, Limited | 2β-Substituted-methylpenicillanic acid derivatives, and salts and esters thereof |
| NZ237202A (en) * | 1990-02-23 | 1994-01-26 | Bristol Myers Squibb Co | Composition containing beta-lactam antibiotic and cationic oligopeptide |
| CN1094353C (zh) * | 1994-04-25 | 2002-11-20 | 史密斯克莱·比奇曼公司 | 含有β－内酰胺酶抑制性青霉烯与β－内酰胺抗生素复合的药物制剂及其在治疗细菌感染中的应用 |
| OA11666A (en) * | 1998-10-15 | 2004-12-08 | Sarawak Medichem Pharmaceuticals Inc | Method and composition for treating and preventingtuberculosis. |
| GB9928290D0 (en) * | 1999-12-01 | 2000-01-26 | Univ Belfast | Process for preparing ambient temperature ionic liquids |
| US20040132708A1 (en) * | 2002-05-01 | 2004-07-08 | Wyeth | Process for preparing 6-alkylidene penem derivatives |
| AR039476A1 (es) * | 2002-05-01 | 2005-02-23 | Wyeth Corp | Proceso para preparar derivados de 6-alquiliden penem |
| AR039774A1 (es) * | 2002-05-01 | 2005-03-02 | Wyeth Corp | 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas |
| AR039475A1 (es) * | 2002-05-01 | 2005-02-23 | Wyeth Corp | 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa |
| AR046041A1 (es) * | 2003-10-03 | 2005-11-23 | Aventis Pharma Inc | Procedimiento para la preparacion de compuestos heterociclicos n-amino sustituidos |
-
2006
- 2006-07-26 CN CNA2006800274448A patent/CN101232881A/zh active Pending
- 2006-07-26 JP JP2008524089A patent/JP2009502934A/ja not_active Withdrawn
- 2006-07-26 US US11/493,178 patent/US20070129344A1/en not_active Abandoned
- 2006-07-26 AU AU2006275940A patent/AU2006275940A1/en not_active Abandoned
- 2006-07-26 PE PE2006000909A patent/PE20070403A1/es not_active Application Discontinuation
- 2006-07-26 GT GT200600331A patent/GT200600331A/es unknown
- 2006-07-26 WO PCT/US2006/028948 patent/WO2007016134A1/en not_active Ceased
- 2006-07-26 BR BRPI0613927-2A patent/BRPI0613927A2/pt not_active IP Right Cessation
- 2006-07-26 CA CA002615886A patent/CA2615886A1/en not_active Abandoned
- 2006-07-26 RU RU2008102912/04A patent/RU2008102912A/ru not_active Application Discontinuation
- 2006-07-26 KR KR1020087004743A patent/KR20080032637A/ko not_active Withdrawn
- 2006-07-26 EP EP06800335A patent/EP1906954A1/en not_active Withdrawn
- 2006-07-26 TW TW095127307A patent/TW200727897A/zh unknown
- 2006-07-27 AR ARP060103240A patent/AR055096A1/es unknown
-
2008
- 2008-01-17 IL IL188843A patent/IL188843A0/en unknown
- 2008-01-18 NO NO20080314A patent/NO20080314L/no not_active Application Discontinuation
- 2008-01-24 EC EC2008008132A patent/ECSP088132A/es unknown
- 2008-01-25 CR CR9691A patent/CR9691A/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0613927A2 (pt) | 2011-02-15 |
| RU2008102912A (ru) | 2009-09-10 |
| JP2009502934A (ja) | 2009-01-29 |
| CA2615886A1 (en) | 2007-02-08 |
| NO20080314L (no) | 2008-04-22 |
| CN101232881A (zh) | 2008-07-30 |
| ECSP088132A (es) | 2008-03-26 |
| AU2006275940A1 (en) | 2007-02-08 |
| TW200727897A (en) | 2007-08-01 |
| WO2007016134A1 (en) | 2007-02-08 |
| IL188843A0 (en) | 2008-08-07 |
| EP1906954A1 (en) | 2008-04-09 |
| GT200600331A (es) | 2007-02-26 |
| CR9691A (es) | 2008-04-02 |
| US20070129344A1 (en) | 2007-06-07 |
| WO2007016134A9 (en) | 2009-03-12 |
| AR055096A1 (es) | 2007-08-08 |
| KR20080032637A (ko) | 2008-04-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |