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PE20081544A1 - Derivados de benzotiazolona como agonistas beta - Google Patents

Derivados de benzotiazolona como agonistas beta

Info

Publication number
PE20081544A1
PE20081544A1 PE2008000009A PE2008000009A PE20081544A1 PE 20081544 A1 PE20081544 A1 PE 20081544A1 PE 2008000009 A PE2008000009 A PE 2008000009A PE 2008000009 A PE2008000009 A PE 2008000009A PE 20081544 A1 PE20081544 A1 PE 20081544A1
Authority
PE
Peru
Prior art keywords
ethyl
beta
alkyl
alaninamide
dihydro
Prior art date
Application number
PE2008000009A
Other languages
English (en)
Inventor
Stephen Connolly
Alexander Humphries
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of PE20081544A1 publication Critical patent/PE20081544A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/14—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/14—Thiadiazoles; Hydrogenated thiadiazoles condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)

Abstract

REFERIDA A UN DERIVADO DE BENZOTIAZOLONA DE FORMULA (I), DONDE Ra Y Rb SON H, ALQUILO C1-C3 O JUNTO CON EL ATOMO DE CARBONO AL CUAL ESTAN UNIDOS FORMAN UN ANILLO CICLOPROPILO O CICLOBUTILO; R1 ES UN ALFA O BETA ALQUILO C3-C12, CICLOALQUILO C3-C12, R28, ENTRE OTROS; R6 ES HALOALQUILO C1-C6, UN SISTEMA DE ANILLOS AROMATICO O HETEROAROMATICO DE 5 A 14 MIEMBROS, ENTRE OTROS; R2, R3, R5 Y R29 SON H O ALQUILO C1-C6; R4 ES H, OH, ALQUILO C1-C6; R28 ES UN HETEROCICLILO DE 4 A 7 MIEMBROS QUE COMPRENDE UN NITROGENO EN EL ANILLO, OXIGENO O AZUFRE, DONDE DICHO ANILLO ESTA OPCIONALMENTE SUSTITUIDO CON ALQUILO C1-C6, HALOGENO, ALCOXI C1-C6, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: SAL DE ACIDO BIS-TRIFLUOROACETICO DE N-(2-{[2-(4-HIDROXI-2-OXO-2,3-DIHIDRO-1,3-BENZOTIAZOL-7-IL)ETIL]AMINO}ETIL)-N-ISOPROPIL-N3-(2-FENILETIL)-BETA-ALANINAMIDA, SAL DE ACIDO BIS-TRIFLUOROACETICO DE N-CICLOPENTIL-N-(2-{[2-(4-HIDROXI-2-OXO-2,3-DIHIDRO-1,3-BENZOTIAZOL-7-IL)ETIL]AMINO}ETIL)-N3-(2-FENILETIL)-BETA-ALANINAMIDA, SAL DE ACIDO BIS-TRIFLUOROACETICO DE N3-[2-(4-CLOROFENIL)ETIL]-N-(2-{[2-(4-HIDROXI-2-OXO-2,3-DIHIDRO-1,3-BENZOTIAZOL-7-IL)ETIL]AMINO}ETIL)-N-ISOPROPIL-BETA-ALANINAMIDA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON AGONISTAS SELECTIVOS DEL RECEPTOR BETA 2 Y SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES DE LAS VIAS RESPIRATORIAS, HUESOS, DOLOR, ENTRE OTROS
PE2008000009A 2006-12-20 2008-01-02 Derivados de benzotiazolona como agonistas beta PE20081544A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87092206P 2006-12-20 2006-12-20
US91004507P 2007-04-04 2007-04-04
US95198007P 2007-07-26 2007-07-26

Publications (1)

Publication Number Publication Date
PE20081544A1 true PE20081544A1 (es) 2009-01-11

Family

ID=39167020

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008000009A PE20081544A1 (es) 2006-12-20 2008-01-02 Derivados de benzotiazolona como agonistas beta

Country Status (20)

Country Link
US (3) US7700782B2 (es)
EP (1) EP2121642B1 (es)
JP (1) JP2010513440A (es)
KR (1) KR20090091342A (es)
AR (1) AR064635A1 (es)
AT (1) ATE517879T1 (es)
AU (1) AU2007336075B2 (es)
BR (1) BRPI0722096A2 (es)
CA (1) CA2672811A1 (es)
CL (1) CL2007003765A1 (es)
CO (1) CO6190554A2 (es)
EC (1) ECSP099426A (es)
IL (1) IL199014A0 (es)
MX (1) MX2009006009A (es)
NO (1) NO20092691L (es)
PE (1) PE20081544A1 (es)
SA (1) SA07280728B1 (es)
TW (1) TW200833670A (es)
UY (1) UY30808A1 (es)
WO (1) WO2008075026A1 (es)

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BRPI0822693A2 (pt) 2008-05-13 2015-07-07 Astrazeneca Ab Derivados de quinuclidina como antagonistas do receptor muscarínico m3
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KR20110017456A (ko) 2008-06-18 2011-02-21 아스트라제네카 아베 호흡기 장애의 치료를 위한 베타2-아드레날린성 수용체 효능제로서 작용하는 벤족사지논 유도체
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Also Published As

Publication number Publication date
NO20092691L (no) 2009-09-16
MX2009006009A (es) 2009-06-16
WO2008075026A1 (en) 2008-06-26
UY30808A1 (es) 2008-07-31
HK1136572A1 (en) 2010-07-02
SA07280728B1 (ar) 2010-12-01
BRPI0722096A2 (pt) 2014-04-01
AU2007336075B2 (en) 2011-10-27
US20100249200A1 (en) 2010-09-30
EP2121642A1 (en) 2009-11-25
CO6190554A2 (es) 2010-08-19
US20100022491A1 (en) 2010-01-28
AU2007336075A1 (en) 2008-06-26
EP2121642B1 (en) 2011-07-27
US7700782B2 (en) 2010-04-20
AR064635A1 (es) 2009-04-15
US20080207698A1 (en) 2008-08-28
ECSP099426A (es) 2009-07-31
IL199014A0 (en) 2010-02-17
JP2010513440A (ja) 2010-04-30
CL2007003765A1 (es) 2008-08-22
CA2672811A1 (en) 2008-06-26
KR20090091342A (ko) 2009-08-27
TW200833670A (en) 2008-08-16
ATE517879T1 (de) 2011-08-15

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