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PE20090954A1 - Acidos 6-fenilnicotinicos sustituidos como moduladores de ppar-alfa - Google Patents

Acidos 6-fenilnicotinicos sustituidos como moduladores de ppar-alfa

Info

Publication number
PE20090954A1
PE20090954A1 PE2008001459A PE2008001459A PE20090954A1 PE 20090954 A1 PE20090954 A1 PE 20090954A1 PE 2008001459 A PE2008001459 A PE 2008001459A PE 2008001459 A PE2008001459 A PE 2008001459A PE 20090954 A1 PE20090954 A1 PE 20090954A1
Authority
PE
Peru
Prior art keywords
methyl
alkyl
ppar
methylphenyl
fluoro
Prior art date
Application number
PE2008001459A
Other languages
English (en)
Inventor
Lars Barfacker
Barbara Albrecht-Kupper
Peter Kolkhof
Grande Yolanda Cancho
Adam Nitsche
Heinrich Meier
Carsten Schmeck
Jens Schamberger
Klemens Lustig
Original Assignee
Bayer Healthcare Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag filed Critical Bayer Healthcare Ag
Publication of PE20090954A1 publication Critical patent/PE20090954A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

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Abstract

REFERIDA A UN DERIVADO DE ACIDO FENIL-NICOTINICO DE FORMULA (I), DONDE UNO DE A Y D REPRESENTA N Y EL OTRO REPRESENTA CR7; R7 ES H, METILO O ETILO; R1 ES ALQUILO C3-C10, CICLOALQUILO C3-C7, -NRARB, ENTRE OTROS; RA ES H O ALQUILO C1-C3; RB ES ALQUILO C1-C10, CICLOALQUILO C3-C7, ENTRE OTROS; R2 ES ALQUILO C1-C3 OPCIONALMENTE SUSTITUIDO CON FLUOR O CICLOPROPILO; R3 ES H O F; R4 ES H, Cl, F O METILO; R5 ES H, HALOGENO, NITRO, CIANO, METILO, ENTRE OTROS; R6 ES H, F, Cl O METILO. SON COMPUESTOS PREFERIDOS: ACIDO 6-(3-FLUORO-4-METILFENIL)-2-ISOBUTIL-4-(TRIFLUOROMETIL)NICOTINICO, ACIDO 6-(3-FLUORO-4-METILFENIL)-2-ISOPROPOXI-4-(TRIFLUOROMETIL)NICOTINICO, ACIDO 6-(3-FLUORO-4-METILFENIL)-4-ISOBUTIL-2-METILNICOTINICO, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON MODULADORES DEL RECEPTOR ACTIVADO POR EL PROLIFERADOR DE PEROXISOMA (PPAR-ALFA) Y SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES CARDIOVASCULARES, ENFERMEDADES METABOLICAS, ENTRE OTRAS
PE2008001459A 2007-09-07 2008-08-28 Acidos 6-fenilnicotinicos sustituidos como moduladores de ppar-alfa PE20090954A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102007042754A DE102007042754A1 (de) 2007-09-07 2007-09-07 Substituierte 6-Phenylnikotinsäuren und ihre Verwendung

Publications (1)

Publication Number Publication Date
PE20090954A1 true PE20090954A1 (es) 2009-07-24

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Family Applications (1)

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PE2008001459A PE20090954A1 (es) 2007-09-07 2008-08-28 Acidos 6-fenilnicotinicos sustituidos como moduladores de ppar-alfa

Country Status (16)

Country Link
US (1) US8143411B2 (es)
EP (1) EP2197846A1 (es)
JP (1) JP2010538025A (es)
KR (1) KR20100066545A (es)
AU (1) AU2008298021A1 (es)
BR (1) BRPI0816372A2 (es)
CA (1) CA2698471A1 (es)
CL (1) CL2008002537A1 (es)
DE (1) DE102007042754A1 (es)
MX (1) MX2010002565A (es)
NZ (1) NZ583697A (es)
PA (1) PA8794401A1 (es)
PE (1) PE20090954A1 (es)
TW (1) TW200914002A (es)
UY (1) UY31310A1 (es)
WO (1) WO2009033561A1 (es)

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JP2010538025A (ja) 2010-12-09
US8143411B2 (en) 2012-03-27
NZ583697A (en) 2012-04-27
PA8794401A1 (es) 2009-07-23
TW200914002A (en) 2009-04-01
CA2698471A1 (en) 2009-03-19
BRPI0816372A2 (pt) 2015-02-24
US20100234432A1 (en) 2010-09-16
MX2010002565A (es) 2010-04-30
CL2008002537A1 (es) 2009-03-20
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WO2009033561A1 (de) 2009-03-19
KR20100066545A (ko) 2010-06-17

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