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PE20080113A1 - Quinolonas sustituidas iii - Google Patents

Quinolonas sustituidas iii

Info

Publication number
PE20080113A1
PE20080113A1 PE2007000136A PE2007000136A PE20080113A1 PE 20080113 A1 PE20080113 A1 PE 20080113A1 PE 2007000136 A PE2007000136 A PE 2007000136A PE 2007000136 A PE2007000136 A PE 2007000136A PE 20080113 A1 PE20080113 A1 PE 20080113A1
Authority
PE
Peru
Prior art keywords
hydroxy
cyane
carbonyl
halogen
ethyl
Prior art date
Application number
PE2007000136A
Other languages
English (en)
Inventor
Chantal Fuerstner
Kai Thede
Holger Zimmermann
David Brueckner
Kerstin Henninger
Dieter Lang
Rudolf Schohe-Loop
Original Assignee
Aicuris Gmbh And Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aicuris Gmbh And Co Kg filed Critical Aicuris Gmbh And Co Kg
Publication of PE20080113A1 publication Critical patent/PE20080113A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE R1 ES H, FLUOR, CLORO, TRIFLUOROMETILO; R3 ES HALOGENO, HIDROXI, ALCOXI C1-C4, CIANO, TRIFLUOROMETOXI, ENTRE OTROS; R4 ES ALQUILO C1-C6, CICLOALQUILO C3-C8, ENTRE OTROS; R7 Y R8 SON CADA UNO HALOGENO, HIDROXI, CIANO, TRIFLUOROMETILO, ENTRE OTROS; R9 ES H, HALOGENO, HIDROXI, CIANO, ENTRE OTROS; R10 ES A, B, C; * ES EL SITIO DE UNION AL ATOMO DE CARBONO; R2 ES HIDROXI, HIDROXI-CARBONILO, ALQUILAMINOCARBONILO C1-C6, ENTRE OTROS; R5 Y R6 SON CADA UNO H, HIDROXI, METILO, ETILO. SON COMPUESTOS PREFERIDOS: 1-[3-{[(2,4-DICLOROBENCIL)AMINO]CARBONIL}-6-FLUORO-8-METOXI-4-OXO-1-(2,2,2-TRIFLUOROETIL)-1,4-DIHIQUINOLIN-7-IL]PIPERIDIN-4-CARBOXILATO DE ETILO; 1-[3-({[2-CLORO-4-(TRIFLUOROMETOXI)BENCIL]AMINO}CARBONIL)-6-FLUORO-8-METOXI-4-OXO-1-(2,2,2-TRIFLUOROETIL)-1,4-DIHIDROQUINOLIN-7-IL]PIPERIDIN-4-CARBOXILATO DE ETILO; ENTRE OTROS. DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO Y/O PROFILAXIS DE ENFERMEDADES, PARTICULARMENTE CONTRA CITOMEGALOVIRUS
PE2007000136A 2006-02-09 2007-02-08 Quinolonas sustituidas iii PE20080113A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102006005861A DE102006005861A1 (de) 2006-02-09 2006-02-09 Substituierte Chinolone III

Publications (1)

Publication Number Publication Date
PE20080113A1 true PE20080113A1 (es) 2008-04-18

Family

ID=38283107

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000136A PE20080113A1 (es) 2006-02-09 2007-02-08 Quinolonas sustituidas iii

Country Status (27)

Country Link
US (1) US7977349B2 (es)
EP (1) EP1994020B1 (es)
JP (1) JP5198291B2 (es)
KR (1) KR101400568B1 (es)
CN (1) CN101379055B (es)
AR (1) AR059417A1 (es)
AT (1) ATE513826T1 (es)
AU (1) AU2007214006B2 (es)
BR (1) BRPI0706988A2 (es)
CA (1) CA2637204C (es)
CY (1) CY1111805T1 (es)
DE (1) DE102006005861A1 (es)
DK (1) DK1994020T3 (es)
DO (1) DOP2007000027A (es)
ES (1) ES2366970T3 (es)
IL (1) IL192662A (es)
MY (1) MY151590A (es)
PE (1) PE20080113A1 (es)
PL (1) PL1994020T3 (es)
PT (1) PT1994020E (es)
RU (1) RU2433125C2 (es)
SI (1) SI1994020T1 (es)
TW (1) TWI382980B (es)
UA (1) UA94934C2 (es)
UY (1) UY30135A1 (es)
WO (1) WO2007090579A2 (es)
ZA (1) ZA200806355B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR059339A1 (es) * 2006-02-09 2008-03-26 Chugai Pharmaceutical Co Ltd Derivados de la cumarina para trastornos proliferativos de celulas, composicion farmaceutica y agente terapeutico que los contiene
TW200811153A (en) 2006-06-23 2008-03-01 Japan Tobacco Inc 6-(heterocyclyl-substituted benzyl)-4-oxoquinoline compound and use thereof as HIV integrase inhibitor
DE102011101446A1 (de) 2011-05-10 2012-11-15 Aicuris Gmbh & Co. Kg Herstellung von "Dense Bodies" (DB)
JP7120549B2 (ja) 2016-12-15 2022-08-17 小野薬品工業株式会社 Ｔｒｅｋ（ｔｗｉｋ関連ｋチャネル）チャネルのアクチベータ

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB932487A (en) 1960-07-25 1963-07-31 D G Searle & Co Piperidine derivatives
DE3420743A1 (de) 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-dihalogen-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DK164287A (da) 1986-03-31 1987-10-01 Sankyo Co Quinolin-3-carboxylsyrederivater og fremgangsmaade til fremstilling deraf og deres anvendelse
DE3702393A1 (de) * 1987-01-28 1988-08-11 Bayer Ag 8-cyano-1-cyclopropyl-1,4-dihydro-4-oxo- 3-chinolincarbonsaeuren, verfahren zu ihrer herstellung und diese enthaltende antibakterielle mittel
AU618823B2 (en) 1988-07-20 1992-01-09 Sankyo Company Limited 4-oxoquinoline-3-carboxylic acid derivatives, their preparation and their use
US4959363A (en) 1989-06-23 1990-09-25 Sterling Drug Inc. Quinolonecarboxamide compounds, their preparation and use as antivirals.
DE4303657A1 (de) 1993-02-09 1994-08-11 Bayer Ag Neue Chinolon- und Naphthyridoncarbonsäurederivate
KR0169500B1 (ko) * 1993-08-13 1999-01-15 이우용 새로운 퀴놀론 카르복실산 유도체 및 그의 제조방법
FR2713116B1 (fr) 1993-11-30 1996-01-12 Techmetal Promotion Dispositif d'alimentation pour le dépôt par simple gravité d'un matériau granuleux sur la surface d'un métal liquide coulé en continu.
KR960004339A (ko) 1994-07-02 1996-02-23 임성기 신규한 퀴놀린계 화합물 및 그 의 제조방법
CA2225552A1 (en) 1995-08-02 1997-02-13 Chiroscience Limited Quinolones and their therapeutic use
EP0841927B1 (en) 1995-08-02 2004-01-28 Darwin Discovery Limited Quinolones and their therapeutic use
IL135036A0 (en) * 1997-09-15 2001-05-20 Procter & Gamble Antimicrobial quinolones, their compositions and uses
US6248739B1 (en) * 1999-01-08 2001-06-19 Pharmacia & Upjohn Company Quinolinecarboxamides as antiviral agents
DE19937024A1 (de) * 1999-08-05 2001-02-08 Bayer Ag Verwendung von Acylsulfonamido substituierten Polymethin-Farbstoffen als Fluoreszenz-Farbstoffe und/oder Marker
US6525049B2 (en) * 2000-07-05 2003-02-25 Pharmacia & Upjohn Company Pyrroloquinolones as antiviral agents
AU2001280091A1 (en) 2000-08-01 2002-02-13 Wockhardt Limited Inhibitors of cellular efflux pumps of microbes
GB0023918D0 (en) 2000-09-29 2000-11-15 King S College London Antiparasitic compounds
US6964966B2 (en) * 2001-04-25 2005-11-15 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
AR037097A1 (es) 2001-10-05 2004-10-20 Novartis Ag Compuestos acilsulfonamidas, composiciones farmaceuticas y el uso de dichos compuestos para la preparacion de un medicamento
WO2003050107A1 (en) 2001-12-13 2003-06-19 Wockhardt Limited New generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
MXPA05010776A (es) 2003-04-07 2006-05-25 Cylene Pharmaceuticals Inc Analogos sustituidos de quinobenzoxazina.
WO2005049602A1 (en) * 2003-11-18 2005-06-02 Warner-Lambert Company Llc Quinolone antibacterial agents
DE102004035203A1 (de) * 2004-07-21 2006-02-16 Bayer Healthcare Ag Substituierte Chinolone
DE102005030524A1 (de) 2005-06-30 2007-01-18 Aicuris Gmbh & Co. Kg Substituierte Chinolone II

Also Published As

Publication number Publication date
KR20080100248A (ko) 2008-11-14
CY1111805T1 (el) 2015-10-07
JP2009525999A (ja) 2009-07-16
DK1994020T3 (da) 2011-09-19
IL192662A0 (en) 2009-08-03
PL1994020T3 (pl) 2011-10-31
ES2366970T3 (es) 2011-10-27
EP1994020A2 (de) 2008-11-26
RU2008136079A (ru) 2010-03-20
DE102006005861A1 (de) 2007-08-23
RU2433125C2 (ru) 2011-11-10
CA2637204C (en) 2013-04-16
UY30135A1 (es) 2007-09-28
CN101379055B (zh) 2012-12-05
WO2007090579A3 (de) 2007-11-15
AU2007214006B2 (en) 2011-11-03
EP1994020B1 (de) 2011-06-22
CN101379055A (zh) 2009-03-04
US7977349B2 (en) 2011-07-12
IL192662A (en) 2013-04-30
JP5198291B2 (ja) 2013-05-15
ATE513826T1 (de) 2011-07-15
SI1994020T1 (sl) 2011-10-28
CA2637204A1 (en) 2007-08-16
AU2007214006A1 (en) 2007-08-16
TW200808757A (en) 2008-02-16
DOP2007000027A (es) 2007-10-31
AR059417A1 (es) 2008-04-09
ZA200806355B (en) 2010-02-24
MY151590A (en) 2014-06-13
UA94934C2 (uk) 2011-06-25
HK1125372A1 (zh) 2009-08-07
KR101400568B1 (ko) 2014-05-26
BRPI0706988A2 (pt) 2011-04-19
WO2007090579A2 (de) 2007-08-16
TWI382980B (zh) 2013-01-21
PT1994020E (pt) 2011-09-02
US20090181996A1 (en) 2009-07-16

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