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PE20080988A1 - Compuestos triciclicos fusionados de sulfonamida como inhibidores de gama-secretasa - Google Patents

Compuestos triciclicos fusionados de sulfonamida como inhibidores de gama-secretasa

Info

Publication number
PE20080988A1
PE20080988A1 PE2007000685A PE2007000685A PE20080988A1 PE 20080988 A1 PE20080988 A1 PE 20080988A1 PE 2007000685 A PE2007000685 A PE 2007000685A PE 2007000685 A PE2007000685 A PE 2007000685A PE 20080988 A1 PE20080988 A1 PE 20080988A1
Authority
PE
Peru
Prior art keywords
alkyl
gama
sulfonamide
pirazol
dihydro
Prior art date
Application number
PE2007000685A
Other languages
English (en)
Inventor
Andrei W Konradi
Gary Probst
Albert W Garofalo
Roy Horn
Martin L Neitzel
Anh P Truong
Danielle L Aubele
Christopher Semko
Original Assignee
Elan Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharm Inc filed Critical Elan Pharm Inc
Publication of PE20080988A1 publication Critical patent/PE20080988A1/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
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    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems

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Abstract

SE REFIERE A COMPUESTOS TRICICLICOS FUSIONADOS DE SULFONAMIDA DE FORMULA (I), EN DONDE C ES CICLOALQUILO, ARILO, HETEROCICLOALQUILO O HETEROARILO, SUSTITUIDOS CON 1 A 4 GRUPOS DE HALOGENO, ALQUILO(C1-C6), ENTRE OTROS; EL ANILLO A ES ARILO, CICLOALQUILO, HETEROARILO O HETEROCICLOALQUILO, OPCIONALMENTE SUSTITUIDOS CON HALOGENO, ALQUILO(C1-C6), ENTRE OTROS; EL ANILLO B ES HETEROARILO O HETEROCICLOALQUILO, OPCIONALMENTE SUSTITUIDO CON ALQUILO(C1-C6), ALCOXI(C1-C6), NR'R'', ENTRE OTROS; R1 ES H O ALQUILO(C1-C6); R2 ES H, ALQUILO(C1-C6), -NO2, -C(O)OR', ENTRE OTROS. SON COMPUESTOS PREFERIDOS; 5-[(4-CLOROFENIL)SULFONIL]-4,5-DIHIDRO-1H-PIRAZOL[4,3-c]QUINOLINA, 5-(4-CLOROFENILSULFONIL)-7-FLUORO-4-METIL-4,5-DIHIDRO-2H-PIRAZOL[4,3-c]QUINOLINA, 4-CICLOPROPIL-7,8-DIFLUORO-5-(TIOFEN-2-ILSULFONIL)-4,5-DIHIDRO-2H-PIRAZOL[4,3-e]PIRIMIDINA. TAMBIEN SE REFIERE A UN PROCEDIMIENTO DE PREPARACION Y COMPOSICION FARMACEUTICA. ESTOS COMPUESTOS INHIBEN LA SINTESIS Y LIBERACION DEL PEPTIDO ß-AMILOIDE, GAMA-SECRETASA, SIENDO UTILES EN EL TRATAMIENTO Y PREVENCION DE TRANSTORNOS COGNITIVOS, COMO ALZHEIMER O DEMENCIA
PE2007000685A 2006-06-02 2007-06-01 Compuestos triciclicos fusionados de sulfonamida como inhibidores de gama-secretasa PE20080988A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US81043106P 2006-06-02 2006-06-02
US87693206P 2006-12-22 2006-12-22
US92277107P 2007-04-10 2007-04-10

Publications (1)

Publication Number Publication Date
PE20080988A1 true PE20080988A1 (es) 2008-08-15

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PE2007000685A PE20080988A1 (es) 2006-06-02 2007-06-01 Compuestos triciclicos fusionados de sulfonamida como inhibidores de gama-secretasa

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US (1) US20080021056A1 (es)
EP (2) EP2038280A2 (es)
JP (1) JP2009539773A (es)
KR (1) KR20090015159A (es)
CN (2) CN102850349A (es)
AR (1) AR061161A1 (es)
AU (1) AU2007256860A1 (es)
BR (1) BRPI0712123A2 (es)
CA (1) CA2651550A1 (es)
EA (1) EA200870577A1 (es)
EC (1) ECSP089019A (es)
IL (1) IL195078A0 (es)
MA (1) MA30532B1 (es)
MX (1) MX2008014947A (es)
MY (1) MY169274A (es)
NO (1) NO20085323L (es)
NZ (1) NZ572885A (es)
PE (1) PE20080988A1 (es)
SG (1) SG172629A1 (es)
TW (1) TW200813054A (es)
UY (1) UY30377A1 (es)
WO (1) WO2007143523A2 (es)

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CN110526913B (zh) * 2019-08-30 2022-04-29 中国药科大学 一种抗凝药物阿哌沙班相关物质的制备方法
CN110885329B (zh) * 2019-12-16 2020-12-15 诚达药业股份有限公司 一种1,7-萘啶衍生物的合成方法
JP7732999B2 (ja) 2020-04-03 2025-09-02 バーテックス ファーマシューティカルズ インコーポレイテッド アルファ１－アンチトリプシンのモジュレーター
CN114853707B (zh) * 2022-06-13 2024-01-26 上饶师范学院 一种合成二氟氢甲基化2,3-二氢苯并吡喃-4-酮衍生物的方法

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CN101501032B (zh) 2012-10-10
UY30377A1 (es) 2008-01-02
CN101501032A (zh) 2009-08-05
NO20085323L (no) 2009-02-24
WO2007143523A3 (en) 2008-06-12
MA30532B1 (fr) 2009-06-01
WO2007143523A8 (en) 2008-01-31
MY169274A (en) 2019-03-21
IL195078A0 (en) 2009-08-03
EP2450358A1 (en) 2012-05-09
JP2009539773A (ja) 2009-11-19
EP2038280A2 (en) 2009-03-25
KR20090015159A (ko) 2009-02-11
ECSP089019A (es) 2009-02-27
AR061161A1 (es) 2008-08-06
EA200870577A1 (ru) 2009-06-30
CN102850349A (zh) 2013-01-02
AU2007256860A1 (en) 2007-12-13
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SG172629A1 (en) 2011-07-28
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