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PE20091811A1 - DERIVADOS DE IMIDAZOLIDINONA COMO INHIBIDORES DE 11b-HSD1 - Google Patents

DERIVADOS DE IMIDAZOLIDINONA COMO INHIBIDORES DE 11b-HSD1

Info

Publication number
PE20091811A1
PE20091811A1 PE2009000571A PE2009000571A PE20091811A1 PE 20091811 A1 PE20091811 A1 PE 20091811A1 PE 2009000571 A PE2009000571 A PE 2009000571A PE 2009000571 A PE2009000571 A PE 2009000571A PE 20091811 A1 PE20091811 A1 PE 20091811A1
Authority
PE
Peru
Prior art keywords
halogen
ona
hexahydro
imidazol
hsd1
Prior art date
Application number
PE2009000571A
Other languages
English (en)
Inventor
Jean Ackermann
Kurt Amrein
Bernd Kuhn
Alexander V Mayweg
Werner Neidhart
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40790778&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20091811(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20091811A1 publication Critical patent/PE20091811A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE IMIDAZOLIDINONA DE FORMULA (I) DONDE R1 ES BORNILO, FENILALQUILO, ADAMANTILO, ENTRE OTROS; R2 Y R3 JUNTO AL ATOMO DE N* Y DE C* FORMAN (E), (F), (G), ENTRE OTROS, DONDE UNO DE R7 Y R8 ES H O HALOGENO Y EL OTRO ES H, HALOGENO, OH, ALCOXI O ARILALCOXI; UNO DE R13 Y R14 ES H O HALOGENO Y EL OTRO ES H, HALOGENO, OH, ALCOXI O ARILALCOXI; R4 ES H, ALQUILO, CICLOALQUILO, ARILO, ENTRE OTROS; A ES CR5R6 O CARBONILO, DONDE R5 Y R6 SON CADA UNO H. SON COMPUESTOS PREFERIDOS: (S)-2-((Z)-5-HIDROXI-ADAMANTAN-2-IL)-7a-METIL-HEXAHIDRO-PIRROLO[1,2-c]IMIDAZOL-3-ONA, (S)-2-((Z)-5-HIDROXI-ADAMANTAN-2-IL)-HEXAHIDRO-PIRROLO[1,2-c]IMIDAZOL-3-ONA, (S)-2-FENIL-HEXAHIDRO-PIRROLO[1,2-c]IMIDAZOL-3-ONA, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA ENZIMA 11BETA-HIDROXIESTEROIDE-DESHIDROGENASA DE TIPO 1 (11BETA-HSD1) SIENDO UTILES PARA EL TRATAMIENTO DE LA DIABETES, OBESIDAD, DISLIPIDEMIA
PE2009000571A 2008-04-30 2009-04-27 DERIVADOS DE IMIDAZOLIDINONA COMO INHIBIDORES DE 11b-HSD1 PE20091811A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08155430 2008-04-30

Publications (1)

Publication Number Publication Date
PE20091811A1 true PE20091811A1 (es) 2009-11-21

Family

ID=40790778

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2009000571A PE20091811A1 (es) 2008-04-30 2009-04-27 DERIVADOS DE IMIDAZOLIDINONA COMO INHIBIDORES DE 11b-HSD1

Country Status (18)

Country Link
US (1) US8124636B2 (es)
EP (1) EP2280970B1 (es)
JP (1) JP2011520790A (es)
KR (1) KR20110008198A (es)
CN (1) CN102015706B (es)
AR (1) AR071512A1 (es)
AU (1) AU2009242248A1 (es)
BR (1) BRPI0910549A2 (es)
CA (1) CA2722487A1 (es)
CL (1) CL2009001019A1 (es)
ES (1) ES2445094T3 (es)
IL (1) IL208626A0 (es)
MX (1) MX2010011642A (es)
PE (1) PE20091811A1 (es)
RU (1) RU2538986C2 (es)
TW (1) TW200946535A (es)
WO (1) WO2009132986A1 (es)
ZA (1) ZA201007431B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
PE20130781A1 (es) 2010-07-06 2013-07-20 Astrazeneca Ab Agentes terapeuticos 976
US8497288B2 (en) * 2011-05-09 2013-07-30 Hoffmann-La Roche Inc. Hexahydropyrroloimidazolone compounds
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en) 2011-09-27 2015-10-21 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP3235813A1 (en) 2016-04-19 2017-10-25 Cidqo 2012, S.L. Aza-tetra-cyclo derivatives
MX2022004144A (es) * 2019-10-07 2022-06-14 De Shaw Res Llc Compuestos heterobiciclicos de arilo como bloqueadores del canal de potasio tipo shaker kv1.3.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3809390A1 (de) * 1988-03-16 1989-09-28 Schering Ag Perhydro-imidazopyridine und -pyrroloimidazole, verfahren zu ihrer herstellung und ihre verwendung als herbizide mittel
DE69937307T2 (de) * 1998-12-24 2008-02-07 Astellas Pharma Inc. Imidazol verbindungen und ihre medizinische verwendung
JP2005500270A (ja) 2001-05-29 2005-01-06 ギルフォード ファーマシュウティカルズ インコーポレイテッド 手術の結果として発生した神経損傷を治療するための方法
TW200407324A (en) * 2002-05-17 2004-05-16 Bristol Myers Squibb Co Bicyclic modulators of androgen receptor function
CN101039908B (zh) * 2004-08-30 2010-06-23 詹森药业有限公司 作为11-β羟甾类脱氢酶抑制剂的三环内酰胺衍生物
EP2039695A4 (en) * 2006-07-11 2010-09-15 Takeda Pharmaceutical BICYCLIC HETEROCYLIC COMPOUND AND ITS USE
WO2008044656A1 (fr) * 2006-10-06 2008-04-17 Taisho Pharmaceutical Co., Ltd. Dérivé d'imidazolidinone
KR101118410B1 (ko) * 2006-10-19 2012-04-23 에프. 호프만-라 로슈 아게 당뇨병을 위한 11베타-에이치에스디1 억제제로서의 이미다졸론 및 이미다졸리딘온 유도체

Also Published As

Publication number Publication date
RU2010148534A (ru) 2012-06-10
ZA201007431B (en) 2013-03-27
RU2538986C2 (ru) 2015-01-10
CL2009001019A1 (es) 2011-01-07
WO2009132986A1 (en) 2009-11-05
AU2009242248A1 (en) 2009-11-05
KR20110008198A (ko) 2011-01-26
BRPI0910549A2 (pt) 2016-04-19
AR071512A1 (es) 2010-06-23
TW200946535A (en) 2009-11-16
MX2010011642A (es) 2010-11-25
CN102015706A (zh) 2011-04-13
CA2722487A1 (en) 2009-11-05
ES2445094T3 (es) 2014-02-28
EP2280970B1 (en) 2014-01-08
EP2280970A1 (en) 2011-02-09
US8124636B2 (en) 2012-02-28
JP2011520790A (ja) 2011-07-21
IL208626A0 (en) 2010-12-30
US20090275573A1 (en) 2009-11-05
CN102015706B (zh) 2014-07-16

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