PE20110418A1 - Compuestos n-sulfonamido pirazolil policiclicos - Google Patents
Compuestos n-sulfonamido pirazolil policiclicosInfo
- Publication number
- PE20110418A1 PE20110418A1 PE2011000438A PE2011000438A PE20110418A1 PE 20110418 A1 PE20110418 A1 PE 20110418A1 PE 2011000438 A PE2011000438 A PE 2011000438A PE 2011000438 A PE2011000438 A PE 2011000438A PE 20110418 A1 PE20110418 A1 PE 20110418A1
- Authority
- PE
- Peru
- Prior art keywords
- sulfonil
- alkyl
- members
- sulfonamide
- polycyclic
- Prior art date
Links
- 229940124530 sulfonamide Drugs 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- GEAXLHPORCRESC-UHFFFAOYSA-N chlorocyclohexatriene Chemical class ClC1=CC=C=C[CH]1 GEAXLHPORCRESC-UHFFFAOYSA-N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- -1 AMINO Chemical class 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 102000002659 Amyloid Precursor Protein Secretases Human genes 0.000 abstract 1
- 108010043324 Amyloid Precursor Protein Secretases Proteins 0.000 abstract 1
- 206010012289 Dementia Diseases 0.000 abstract 1
- 201000010374 Down Syndrome Diseases 0.000 abstract 1
- WZKSXHQDXQKIQJ-UHFFFAOYSA-N F[C](F)F Chemical group F[C](F)F WZKSXHQDXQKIQJ-UHFFFAOYSA-N 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 206010044688 Trisomy 21 Diseases 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/18—Bridged systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Psychology (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
SE REFIERE A COMPUESTOS N-SULFONAMIDO PIRAZOLIL POLICICLICOS DE FORMULA (I) DONDE m Y n SON CADA UNO 0 O 1; A ES ARIL, CICLOALQUIL(C3-C8), HETEROARIL DE 5 A 7 MIEMBROS O HETEROCICLOALQUIL DE 3 A 8 MIEMBROS; B ES PIRAZOLIL, DIHIDROPIRAZOLIL, PIRAZOLONIL O PIRAZOLIDINONIL; C ES ARIL O HETEROARIL DE 5 A 7 MIEMBROS OPCIONALMENTE SUSTITUIDO CON HALOGENO, ALQUIL(C1-C6), CN, ENTRE OTROS; R25 ES H, ALQUIL(C1-C6), HALOALQUIL(C1-C6), CN, ENTRE OTROS; R51 ES H, ALQUIL(C1-C4), HALOGENO, AMINO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: (+)-10-[(4-CLOROFENIL)SULFONIL]-4,5,6,7,8,9-HEXAHIDRO-1H-4,8-EPIMINOCICLOOCTA[c]PIRAZOL-6-CARBONITRILO; (±)-10-[(4-CLOROFENIL)SULFONIL]-6-(3-METIL-1,2,4-OXADIAZOL-5-IL)-4,5,6,7,8,9-HEXAHIDRO-1H-4,8-EPIMINOCICLOOCTA[c]PIRAZOL; 5-CICLOPROPIL-9-{[4-(TRIFLUOROMETIL)FENIL]SULFONIL}-1,4,7,8-TETRAHIDRO-4,7-EPIMINOCICLOHEPTA[c]PIRAZOL; ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS INHIBEN LA LIBERACION Y/O SINTESIS DE PEPTIDOS B-AMILOIDES Y GAMMA SECRETASA SIENDO UTILES EN EL TRATAMIENTO DE LA ENFERMEDAD DE ALZHEIMER, ENFERMEDAD DE PARKINSON, SINDROME DE DOWN, DEMENCIA
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9479908P | 2008-09-05 | 2008-09-05 | |
| US9924108P | 2008-09-23 | 2008-09-23 | |
| US17327809P | 2009-04-28 | 2009-04-28 | |
| US22653209P | 2009-07-17 | 2009-07-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20110418A1 true PE20110418A1 (es) | 2011-06-22 |
Family
ID=41258775
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2011000438A PE20110418A1 (es) | 2008-09-05 | 2009-09-04 | Compuestos n-sulfonamido pirazolil policiclicos |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8283358B2 (es) |
| EP (1) | EP2346863A2 (es) |
| JP (1) | JP2012502051A (es) |
| KR (1) | KR20110055715A (es) |
| CN (1) | CN102203089A (es) |
| AR (1) | AR073497A1 (es) |
| AU (1) | AU2009289579A1 (es) |
| BR (1) | BRPI0918213A2 (es) |
| CA (1) | CA2736767A1 (es) |
| CL (1) | CL2011000405A1 (es) |
| CO (1) | CO6362008A2 (es) |
| EA (1) | EA201170421A1 (es) |
| EC (1) | ECSP11010947A (es) |
| IL (1) | IL211263A0 (es) |
| MA (1) | MA32688B1 (es) |
| MX (1) | MX2011002047A (es) |
| PE (1) | PE20110418A1 (es) |
| TW (1) | TW201014856A (es) |
| WO (1) | WO2010028213A2 (es) |
| ZA (1) | ZA201101994B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010028192A1 (en) | 2008-09-03 | 2010-03-11 | Repligen Corporation | Compositions including 6-aminohexanoic acid derivatives as hdac inhibitors |
| PE20110418A1 (es) | 2008-09-05 | 2011-06-22 | Elan Pharm Inc | Compuestos n-sulfonamido pirazolil policiclicos |
| US8957066B2 (en) | 2011-02-28 | 2015-02-17 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| JP6250403B2 (ja) | 2011-02-28 | 2017-12-20 | バイオマリン ファーマシューティカル インク | ヒストン脱アセチル化酵素阻害剤 |
| US10059723B2 (en) | 2011-02-28 | 2018-08-28 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| WO2014143666A1 (en) | 2013-03-15 | 2014-09-18 | Biomarin Pharmaceutical Inc. | Hdac inhibitors |
| CN114929235A (zh) * | 2020-01-03 | 2022-08-19 | 布鲁奥科制药有限公司 | 用于治疗cns病症的化合物和组合物 |
| CN111909217B (zh) * | 2020-08-20 | 2023-05-02 | 昆明贵金属研究所 | 一种双（二叔丁基-4-二甲氨基苯基膦）四溴双钯(ⅱ)化合物及其制备方法和用途 |
| CN115448892B (zh) * | 2022-09-19 | 2023-07-07 | 郑州铁路职业技术学院 | 一种苯并噻二唑杂环化合物的合成方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8727989D0 (en) * | 1987-11-30 | 1988-01-06 | Merck Sharp & Dohme | Therapeutic agents |
| EP0330788A1 (en) | 1988-03-01 | 1989-09-06 | Merrell Dow Pharmaceuticals Inc. | Use of quinolizine and quinolizinone derivatives in the manufacture of medicaments for the treatment of cardiac arrhythmia |
| WO2005113542A2 (en) | 2004-05-20 | 2005-12-01 | Elan Pharmaceuticals, Inc. | N-cyclic sulfonamido inhibitors of gamma secretase |
| JP2009504773A (ja) * | 2005-08-19 | 2009-02-05 | エラン ファーマシューティカルズ，インコーポレイテッド | ガンマセクレターゼの架橋ｎ−二環式スルホンアミド阻害剤 |
| TW200813054A (en) * | 2006-06-02 | 2008-03-16 | Elan Pharm Inc | Fused, tricyclic sulfonamide inhibitors of gamma secretase |
| CN101128035B (zh) | 2006-08-18 | 2011-08-24 | 中兴通讯股份有限公司 | 时分码分多址系统中信道间的定时方法 |
| US7977368B2 (en) * | 2007-05-25 | 2011-07-12 | Elan Pharmaceuticals, Inc. | Pyrazolopyrrolidines as inhibitors of gamma secretase |
| PE20110418A1 (es) | 2008-09-05 | 2011-06-22 | Elan Pharm Inc | Compuestos n-sulfonamido pirazolil policiclicos |
-
2009
- 2009-09-04 PE PE2011000438A patent/PE20110418A1/es not_active Application Discontinuation
- 2009-09-04 AU AU2009289579A patent/AU2009289579A1/en not_active Abandoned
- 2009-09-04 CA CA2736767A patent/CA2736767A1/en not_active Abandoned
- 2009-09-04 BR BRPI0918213A patent/BRPI0918213A2/pt not_active IP Right Cessation
- 2009-09-04 WO PCT/US2009/055987 patent/WO2010028213A2/en not_active Ceased
- 2009-09-04 AR ARP090103413A patent/AR073497A1/es not_active Application Discontinuation
- 2009-09-04 KR KR1020117007863A patent/KR20110055715A/ko not_active Withdrawn
- 2009-09-04 CN CN2009801426386A patent/CN102203089A/zh active Pending
- 2009-09-04 TW TW098129931A patent/TW201014856A/zh unknown
- 2009-09-04 JP JP2011526217A patent/JP2012502051A/ja active Pending
- 2009-09-04 US US12/554,134 patent/US8283358B2/en not_active Expired - Fee Related
- 2009-09-04 MX MX2011002047A patent/MX2011002047A/es unknown
- 2009-09-04 EA EA201170421A patent/EA201170421A1/ru unknown
- 2009-09-04 EP EP09792258A patent/EP2346863A2/en not_active Withdrawn
-
2011
- 2011-02-17 IL IL211263A patent/IL211263A0/en unknown
- 2011-02-24 CL CL2011000405A patent/CL2011000405A1/es unknown
- 2011-03-16 ZA ZA2011/01994A patent/ZA201101994B/en unknown
- 2011-03-31 CO CO11039494A patent/CO6362008A2/es not_active Application Discontinuation
- 2011-04-01 EC EC2011010947A patent/ECSP11010947A/es unknown
- 2011-04-01 MA MA33737A patent/MA32688B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ECSP11010947A (es) | 2011-07-29 |
| IL211263A0 (en) | 2011-04-28 |
| AR073497A1 (es) | 2010-11-10 |
| EA201170421A1 (ru) | 2012-01-30 |
| CA2736767A1 (en) | 2010-03-11 |
| KR20110055715A (ko) | 2011-05-25 |
| CL2011000405A1 (es) | 2011-07-01 |
| EP2346863A2 (en) | 2011-07-27 |
| ZA201101994B (en) | 2011-11-30 |
| AU2009289579A1 (en) | 2010-03-11 |
| MX2011002047A (es) | 2011-06-17 |
| JP2012502051A (ja) | 2012-01-26 |
| MA32688B1 (fr) | 2011-10-02 |
| WO2010028213A3 (en) | 2010-06-03 |
| CN102203089A (zh) | 2011-09-28 |
| BRPI0918213A2 (pt) | 2015-12-08 |
| US8283358B2 (en) | 2012-10-09 |
| US20100081680A1 (en) | 2010-04-01 |
| WO2010028213A2 (en) | 2010-03-11 |
| CO6362008A2 (es) | 2012-01-20 |
| TW201014856A (en) | 2010-04-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |