PE20080970A1 - Derivados de quinazolinona 5-sustituida y composiciones que los comprenden y metodos para utilizarlos - Google Patents
Derivados de quinazolinona 5-sustituida y composiciones que los comprenden y metodos para utilizarlosInfo
- Publication number
- PE20080970A1 PE20080970A1 PE2007001298A PE2007001298A PE20080970A1 PE 20080970 A1 PE20080970 A1 PE 20080970A1 PE 2007001298 A PE2007001298 A PE 2007001298A PE 2007001298 A PE2007001298 A PE 2007001298A PE 20080970 A1 PE20080970 A1 PE 20080970A1
- Authority
- PE
- Peru
- Prior art keywords
- quinazolin
- piperidin
- oxo
- methyl
- alkyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- -1 5-SUBSTITUTED QUINAZOLINONE Chemical class 0.000 title 1
- 239000000203 mixture Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- QPDPRUJAFAJGRJ-UHFFFAOYSA-N 5-amino-2-methyl-1h-quinazolin-4-one Chemical compound NC1=CC=CC2=NC(C)=NC(O)=C21 QPDPRUJAFAJGRJ-UHFFFAOYSA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000033115 angiogenesis Effects 0.000 abstract 1
- 230000016396 cytokine production Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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